trinickel disulfide (CAS 12035-72-2) — Safety Data Sheet

Safety data sheet documentation for trinickel disulfide (CAS 12035-72-2), compiled to REACH Annex II with classification read against the harmonised entry in CLP Annex VI (H350i, H341, H331, H372). Two options: a working draft sent by e-mail immediately, or a signed card issued within 72 hours of complete input. The item supplied is a document — MolGod.org does not sell, supply or ship chemical substances.

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REACH 2020/878
v4 · 07.09.2026
Scarica la scheda di dati di sicurezza (PDF)CAS 12035-72-2 · PDF · 186 KBBozza di lavoro — non ancora revisionata né approvata.

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🧬 Visualizzatore di molecole 3D
Caricamento molecola...
Modello 3D NICKEL SULFIDE (Ni3S2), CAS 12035-72-2, formula molecolare Ni₃S₂, massa molare 240.22 g/mol

Dati trascritti da registri normativi e letteratura tecnica, con indicazione della fonte e dell'edizione. Non sostituiscono la scheda di dati di sicurezza del fornitore. I campi privi di fonte registrata sono contrassegnati come tali.

📊 Dati chimico-fisici — CAS 12035-72-2
📊 Proprietà fisico-chimiche

Riferimento rapido

Formula: Ni₃S₂
MW: 240.22 g/mol
CAS: 12035-72-2
Aspetto: Cristalli esagonali
🔬 Proprietà avanzate

Identificatori chimici

SMILES: S=[Ni].S=[Ni].[Ni]

Ultimo aggiornamento: 2026-08-25

Panoramica chimica: NICKEL SULFIDE (Ni3S2)
Formula molecolareNi₃S₂[1]
Peso molecolare240.22 g/mol[1]
Punto di fusione790 °C[1]
Densità5.82 g/cm³[1]
Nome IUPACnickel;sulfanylidenenickel[1]
SMILESS=[Ni].S=[Ni].[Ni][1]
InChIKeyYGHCWPXPAHSSNA-UHFFFAOYSA-N[1]

Sinonimi: RefChem:927714 · CHEBI:144804 · 234-829-6 · 12035-72-2 · alpha nickel subsulfide

Fonti dei dati: PubChem (NLM/NIH)
Ultimo aggiornamento: 2026-08-25

📚 Riferimenti scientifici (Chicago Author-Date) (1 sources)
  1. PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. ↗ si applica a: Formula molecolare · Peso molecolare · Punto di fusione · Densità · Nome IUPAC · SMILES · InChIKey

RICERCA SCIENTIFICA

[1]PubMed2023
Oller AR, Buxton S, March TH et al.. (2023). "Comparative pulmonary and genotoxic responses to inhaled nickel subsulfide and nickel sulfate in F344 rats.". Journal of applied toxicology : JAT. https:/
[2]PubMed2011
Huggins FE, Galbreath KC, Eylands KE et al.. (2011). "Determination of nickel species in stack emissions from eight residual oil-fired utility steam-generating units.". Environmental science & technol
[3]PubMed2011
Kasprzak KS, Diwan BA, Kaczmarek MZ et al.. (2011). "Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock
[4]PubMed2002
Barchowsky A, Soucy NV, O'Hara KA et al.. (2002). "A novel pathway for nickel-induced interleukin-8 expression.". The Journal of biological chemistry. https://doi.org/10.1074/jbc.M202941200
[5]PubMed1998
Mayer C, Klein RG, Wesch H et al.. (1998). "Nickel subsulfide is genotoxic in vitro but shows no mutagenic potential in respiratory tract tissues of BigBlue rats and Muta Mouse mice in vivo after inha
[6]Europe PMC1996
(1996). "NTP Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CAS No. 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies).".
[7]PubMed1994
Shi X, Dalal N, Kasprzak KS. (1994). "Enhanced generation of hydroxyl radical and sulfur trioxide anion radical from oxidation of sodium sulfite, nickel(II) sulfite, and nickel subsulfide in the prese
[8]PubMed1990
Arrouijal FZ, Hildebrand HF, Vophi H et al.. (1990). "Genotoxic activity of nickel subsulphide alpha-Ni3S2.". Mutagenesis. https://doi.org/10.1093/mutage/5.6.583
📚 Riferimenti scientifici (Chicago Author-Date) 13 refs · 3 baz

MOLECULE Bibliografia per-CAS (live da 13+ banche dati)

Fonti: db:pubmed (11) · db:Europe PMC (1) · db:crossref (1)

  1. db:pubmed Oller AR, Buxton S, March TH et al.. (2023). "Comparative pulmonary and genotoxic responses to inhaled nickel subsulfide and nickel sulfate in F344 rats.". Journal of applied toxicology : JAT. https://doi.org/10.1002/jat.4422 →
  2. db:pubmed Huggins FE, Galbreath KC, Eylands KE et al.. (2011). "Determination of nickel species in stack emissions from eight residual oil-fired utility steam-generating units.". Environmental science & technology. https://doi.org/10.1021/es200823a →
  3. db:pubmed Kasprzak KS, Diwan BA, Kaczmarek MZ et al.. (2011). "Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice.". Toxicology and applied pharmacology. https://doi.org/10.1016/j.taap.2011.08.015 →
  4. db:pubmed Barchowsky A, Soucy NV, O'Hara KA et al.. (2002). "A novel pathway for nickel-induced interleukin-8 expression.". The Journal of biological chemistry. https://doi.org/10.1074/jbc.M202941200 →
  5. db:pubmed Mayer C, Klein RG, Wesch H et al.. (1998). "Nickel subsulfide is genotoxic in vitro but shows no mutagenic potential in respiratory tract tissues of BigBlue rats and Muta Mouse mice in vivo after inhalation.". Mutation research. https://doi.org/10.1016/s1383-5718(98)00140-5 →
  6. db:Europe PMC (1996). "NTP Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CAS No. 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies).".
  7. db:pubmed Shi X, Dalal N, Kasprzak KS. (1994). "Enhanced generation of hydroxyl radical and sulfur trioxide anion radical from oxidation of sodium sulfite, nickel(II) sulfite, and nickel subsulfide in the presence of nickel(II) complexes.". Environmental health perspectives. https://doi.org/10.1289/ehp.94102s391 →
  8. db:pubmed Arrouijal FZ, Hildebrand HF, Vophi H et al.. (1990). "Genotoxic activity of nickel subsulphide alpha-Ni3S2.". Mutagenesis. https://doi.org/10.1093/mutage/5.6.583 →
  9. db:pubmed Lumb GD, Sunderman FW Sr, Schneider HP. (1985). "Nickel-induced malignant tumors.". Annals of clinical and laboratory science.
  10. db:pubmed Sunderman FW Jr, Marzouk A, Hopfer SM et al.. (1985). "Increased lipid peroxidation in tissues of nickel chloride-treated rats.". Annals of clinical and laboratory science.
  11. db:pubmed Ciccarelli RB, Wetterhahn KE. (1984). "Molecular basis for the activity of nickel.". IARC scientific publications.
  12. db:pubmed Sunderman FW Jr. (1983). "Organ and species specificity in nickel subsulfide carcinogenesis.". Basic life sciences. https://doi.org/10.1007/978-1-4684-4400-1_6 →
  13. db:crossref Martin Moskovits, Daniel P. DiLella. (1980). "Trinickel". The Journal of Chemical Physics. https://doi.org/10.1063/1.439461 →
Stato normativo della sostanza
Questa sostanza è soggetta a requisiti normativi: gestione dei rifiuti pericolosi (BDO — norma nazionale, Polonia). Dettagli nella sezione "Stato normativo (REACH/ECHA/CLP)" e nella scheda SDS. Informazione normativa — non limita l'acquisto nel negozio.
🧮 Calcolatore stechiometrico
🧪 Dati chimici
Numero CAS
12035-72-2
Formula molecolare
Ni₃S₂
Massa molare
240.22 g/mol
Nome IUPAC (EN)
nickel;sulfanylidenenickel
SMILES
S=[Ni].S=[Ni].[Ni]
InChIKey
YGHCWPXPAHSSNA-UHFFFAOYSA-N
📚 Related literature (3 articoli)

Matched automatically from public bibliographic databases by text similarity. Not curated for this substance, and not part of the safety data sheet.

D. M. Pasquariello, R. Kershaw, J. D. Passaretti et al. · (1984) · Inorganic Chemistry
Kusal K. Das, R. Chandramouli Reddy, Ishwar B. Bagoji et al. · (2018) · Journal of Basic and Clinical Physiology and Pharmacology
Filtra:
Ordina:
📈 Cronologia delle pubblicazioni
1984
1996
2018
📡 Data sources

The data in this widget comes from the following verified scientific sources:

  • PubChem — National Center for Biotechnology Information (NCBI/NIH), USA
  • ChEMBL — European Bioinformatics Institute (EMBL-EBI), UK
  • NIST WebBook — National Institute of Standards and Technology, USA

Data is cached locally for speed — the widget also works offline.

⚗️ Physicochemical properties
Density
5.82

Source: PubChem, NIST WebBook. Last updated: 2026-08-25

🔍 Identificatori esterni
10 su 16 sistemi ID63%
DatabaseIdentificatoreAzioni
CAS Registry Number12035-72-2Apri →
PubChem CID25199732[1]Apri →
InChIKeyYGHCWPXPAHSSNA-UHFFFAOYSA-N[1]Apri →
InChIInChI=1S/3Ni.2S[1]
SMILESS=[Ni].S=[Ni].[Ni][1]
EC Number234-829-6[2]Apri →
ChemSpider52083036[3]Apri →
MeSH UID (NLM)C017557Apri →
UNII (FDA)ZK2A2WV92ZApri →
WikiData QIDQ13896593Apri →

Fonti: PubChem (NIH), Wikidata SPARQL, KEGG, ChEMBL (EBI), CompTox CTX (EPA).

📚 Riferimenti scientifici (Chicago Author-Date) (3 sources)
  1. PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. ↗ si applica a: PubChem CID · InChIKey · InChI · SMILES
  2. ECHA. EC Inventory — EINECS, ELINCS, NLP and List Numbers assigned under REACH. Helsinki: European Chemicals Agency. ↗ si applica a: EC Number
  3. ChemSpider. Royal Society of Chemistry, chemical structure database. ↗ si applica a: ChemSpider

Ulteriori letture

Pubblicazioni tematicamente correlate a questo CAS. Non sono la fonte di alcun valore riportato in questa scheda.

Bibliografia (estesa) (6)

  1. ★★☆☆☆ CROSSREF 🔓 OPEN ❓ non verificato Pasquariello, D. M., Kershaw, R., Passaretti, J. D., Dwight, K., Wold, A.. 1984. "Low-temperature synthesis and properties of cobalt sulfide (Co9S8), nickel sulfide (Ni3S2), and iron sulfide (Fe7S8)." Inorganic Chemistry 23 (7): 872-874. https://doi.org/10.1021/ic00175a016. link [consultato: 2026-10-11] CC0 (metadata)
  2. ★★☆☆☆ CROSSREF 🔓 OPEN ❓ non verificato PASQUARIELLO, D. M., KERSHAW, R., PASSARETTI, J. D., DWIGHT, K., WOLD, A.. 1984. "ChemInform Abstract: LOW‐TEMPERATURE SYNTHESIS AND PROPERTIES OF COBALT SULFIDE (CO9S8), NICKEL SULFIDE (NI3S2), AND IRON SULFIDE (FE7S8)." Chemischer Informationsdienst 15 (25). https://doi.org/10.1002/chin.198425040. link [consultato: 2026-10-11] CC0 (metadata)
  3. ★★☆☆☆ CROSSREF 🔓 OPEN ❓ non verificato WEISS, J.. 1982. "ChemInform Abstract: METAL‐NITROGEN SULFIDE COMPOUNDS. PT. 12. ((S3NNI)3S2)‐‐NICKEL SULFIDE (NI3S2) CLUSTER WITH S3N‐ CHELATE LIGANDS." Chemischer Informationsdienst 13 (50). https://doi.org/10.1002/chin.198250036. link [consultato: 2026-10-11] CC0 (metadata)
  4. ★★☆☆☆ CROSSREF 🔓 OPEN ❓ non verificato Stokłosa, A., Stringer, J.. 1977. "Defect structure and chemical diffusion in nickel sulfide β-Ni3S2." Oxidation of Metals 11 (5): 277-288. https://doi.org/10.1007/bf00606062. link [consultato: 2026-10-11] CC0 (metadata)
  5. ★★☆☆☆ CROSSREF 🔓 OPEN ❓ non verificato Corbeil, Lynette B.. 1968. "Antigenicity of rhabdomyosarcomas induced by nickel sulfide (Ni3S2)." Cancer 21 (2): 184-189. https://doi.org/10.1002/1097-0142(196802)21:2<184::aid-cncr2820210204>3.0.co;2-9. link [consultato: 2026-10-11] CC0 (metadata)
  6. ½☆☆☆☆ CANONICAL_PAPERS ❓ ? 1996. "NTP Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CAS No. 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies)." National Toxicology Program technical report series. [consultato: 2026-10-11]
📡 Spettroscopia — CAS 12035-72-2
📊 Banche dati di spettri spettroscopici — dati inline 8 sources

Gli spettri vengono recuperati su richiesta da 9 fonti. Ogni spettro viene salvato nel nostro database — l'apertura successiva = zero richieste all'API esterna. Scarica JCAMP-DX / CSV / PNG per ogni spettro senza dover cercare.

IR IR (Infrared) — NIST WebBook
Public domain (US Federal)
▶ Clicca per caricare lo spettro
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— points
📚 NIST Chemistry WebBook, SRD 69
MS (NIST) Mass Spectrum (EI) — NIST WebBook
Public domain (US Federal)
▶ Clicca per caricare lo spettro
🔗 Source
— points
📚 NIST Standard Reference Database 1A
UV-Vis UV/Visible Absorption — NIST WebBook
Public domain (US Federal)
▶ Clicca per caricare lo spettro
🔗 Source
— points
📚 NIST Chemistry WebBook, SRD 69
MS (MoNA) MoNA — MassBank of North America
CC-BY 4.0
▶ Clicca per caricare lo spettro
🔗 Source
— points
📚 MassBank of North America (UC Davis) DOI: 10.1002/jms.1777
IR/NMR/MS (SDBS) SDBS — Spectral Database for Organic Compounds (Japan AIST)
Free for non-commercial

Fonte di riferimento — nessuna API pubblica. Apri nella banca dati esterna:

🔗 IR/NMR/MS (SDBS) →
📚 SDBSWeb: https://sdbs.db.aist.go.jp (AIST, Japan)
JP Monograph Japanese Pharmacopoeia — Monographs
Reference only

Fonte di riferimento — nessuna API pubblica. Apri nella banca dati esterna:

🔗 JP Monograph →
📚 Japanese Pharmacopoeia 18th Edition (2021)
WHO INN WHO — International Nonproprietary Names
WHO Model Lists (free)

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🔗 WHO INN →
📚 WHO INN Programme
DOAJ DOAJ — Directory of Open Access Journals
OA journal index (mixed)

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🔗 DOAJ →
📚 DOAJ — doaj.org
🔬 Spettri interattivi (live — NIST / MoNA / NMRShiftDB / SDBS) (2)

Dati recuperati in tempo reale da più fonti (priority-chain). JCAMP-DX / CSV / PNG disponibili per il download sotto ogni spettro.

IR — infrarosso in trasformata di Fourier

Caricamento IR — infrarosso in trasformata di Fourier…

MS — spettrometria di massa (EI 70eV)

Caricamento MS — spettrometria di massa (EI 70eV)…

Proprietà strutturali

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❓ Domande frequenti (3)
What is NICKEL SULFIDE (Ni3S2)?
NICKEL SULFIDE (Ni3S2) (CAS 12035-72-2) is a chemical compound with the molecular formula Ni₃S₂ and a molecular weight of 240.22 g/mol.
Utile?
What is the CAS number of NICKEL SULFIDE (Ni3S2)?
The CAS number for NICKEL SULFIDE (Ni3S2) is 12035-72-2.
Utile?
What is the chemical formula of NICKEL SULFIDE (Ni3S2)?
The molecular formula of NICKEL SULFIDE (Ni3S2) is Ni₃S₂.
Utile?
➕ Suggerisci una domanda
Scarica i file di struttura

File di struttura molecolare dal database PubChem (NIH). Compatibili con i programmi: Avogadro, PyMOL, Jmol, ChemDraw.

Fonte: PubChem, National Library of Medicine (NIH). CID: 25199732

🔄 Convertitore di unità di concentrazione LIVE

Inserisci la concentrazione NICKEL SULFIDE (Ni3S2) in qualsiasi unità — il resto verrà calcolato automaticamente.

MW: 240.22 g/mol · IUPAC Gold Book ↗

⚗️ Formule di conversione + citazioni (per formula)
ConversionFormulaAccuratezzaSource
% (w/v) ↔ molarityc (mol/L) = (% × 10) / MW±0.5% rel. when density ≈ 1.0 g/mLIUPAC (2019)
millimolar ↔ molarc (mol/L) = mM × 10⁻³ExactCohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
molarity (mol/L)c = n/V = (m/MW)/V±0.1% (depends on MW precision)IUPAC (2019)
parts per million (mg/L) ↔ molarityc (mol/L) = ppm / (1000 × MW); equivalently ppm = mg/L for dilute aqueous±1% (density-independent for dilute solutions)IUPAC (2019)
mg/mL ↔ molarityc (mol/L) = (mg/mL × 1000) / MW / 1000 = mg/mL / MW × 1±0.2%Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
g/L ↔ molarityc (mol/L) = (g/L) / MW±0.1% (depends on MW precision)Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
mmol/L ↔ molarityc (mol/L) = mmol/L × 10⁻³ExactCohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
Celsius ↔ KelvinT(K) = t(°C) + 273.15±0.01 K (ITS-90 scale)BIPM (Bureau International des Poids et Mesures) (2019)
Celsius ↔ FahrenheitT(°F) = T(°C) × 9/5 + 32±0.1 °FThompson A, Taylor BN (2008)
density-corrected % ↔ molarityc (mol/L) = (%w/w × ρ × 10) / MW, ρ in g/mL±0.1% when ρ known to 3 decimalsCohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
📚 Bibliografia (8 fonti autorevoli)
  1. Thompson A, Taylor BN (2008). Guide for the Use of the International System of Units (SI). NIST Special Publication 811 · DOI: 10.6028/NIST.SP.811-2008
    → Primary SI standard for US scientific usage
  2. Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007). Quantities, Units and Symbols in Physical Chemistry — The IUPAC Green Book. RSC Publishing, 3rd ed. · DOI: 10.1039/9781847557889 · ISBN: 978-0-85404-433-7
    → Canonical IUPAC guide for chemistry quantities/units
  3. BIPM (Bureau International des Poids et Mesures) (2019). The International System of Units (SI), 9th edition. BIPM · ↗
    → International SI definitions (incl. redefined kilogram 2019)
  4. ISO/IEC (2022). Quantities and units — Part 1: General. International Organization for Standardization — ISO 80000-1:2022 · ↗
    → General rules for physical quantities and units
  5. ISO/IEC (2019). Quantities and units — Part 9: Physical chemistry and molecular physics. International Organization for Standardization — ISO 80000-9:2019 · ↗
    → Concentration / molality / amount-of-substance conventions
  6. Tiesinga E, Mohr PJ, Newell DB, Taylor BN (2021). CODATA recommended values of the fundamental physical constants: 2018. Rev. Mod. Phys. 93(2):025010 · DOI: 10.1103/RevModPhys.93.025010
    → Avogadro, gas constant, molar volume (2019 SI revision)
  7. IUPAC (2019). Compendium of Chemical Terminology — the IUPAC Gold Book (online). IUPAC · DOI: 10.1351/goldbook
    → Definitions of mass fraction, molality, normality, ppm, activity
  8. Mills IM, Cvitaš T, Homann K, Kallay N, Kuchitsu K (1988). Quantities, Units and Symbols in Physical Chemistry. Blackwell Scientific Publications, 1st ed. · ISBN: 0-632-01773-5
    → Historical predecessor of IUPAC Green Book
Strutture molecolari simili

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🧪 Procedura guidata di preparazione della soluzione WIZARD
① Seleziona la concentrazione
② Volume finale
③ Solvente

Calcoli secondo: IUPAC Gold Book ↗, Merck ↗

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🛡️ Sicurezza — CAS 12035-72-2
Avviso sulle limitazioni dei dati. Le informazioni sulla sicurezza contenute in questa pagina hanno carattere informativo e non sostituiscono la scheda di dati di sicurezza (SDS) completa. Prima di utilizzare il prodotto, consultare la scheda di dati di sicurezza aggiornata del produttore e le linee guida GHS/CLP. La classificazione CLP riguarda la sostanza pura bulk, non i preparati commerciali.

Classificazione GHS/CLP — Regolamento (CE) n. 1272/2008 + UN GHS Rev. 9 (2021).

⚠️ Pericolo (Danger)
GHS06 — Tossico
GHS06 Tossico
GHS07 — Irritante / nocivo
GHS07 Irritante / nocivo
GHS08 — Pericolo per la salute
GHS08 Pericolo per la salute
GHS09 — Pericolo per l'ambiente
GHS09 Pericolo per l'ambiente

🚨 Indicazioni di pericolo (H)

  • H350i — Può provocare il cancro se inalato.
  • H341 — Sospettato di provocare alterazioni genetiche.
  • H331 — Tossico se inalato.
  • H372 — Provoca danni agli organi in caso di esposizione prolungata o ripetuta.
  • H317 — Può provocare una reazione allergica cutanea.
  • H400 — Molto tossico per gli organismi acquatici.
  • H410 — Molto tossico per gli organismi acquatici con effetti di lunga durata.

🛡 Consigli di prudenza (P)

  • P203 — Procurarsi, leggere e seguire tutte le istruzioni di sicurezza prima dell’uso.

✓ Classificazione armonizzata ai sensi dell'allegato VI del regolamento CLP (CE) 1272/2008 (classificazione ufficiale, vincolante). Numero indice: 028-007-00-4.

Riferimento (Chicago): European Chemicals Agency. "trinickel disulfide; nickel subsulfide, Index No. 028-007-00-4." In Table 3 of Annex VI to Regulation (EC) No 1272/2008 (CLP Regulation), 23rd Adaptation to Technical Progress (harmonised list as of 2026-07-07). Helsinki: European Chemicals Agency, 2026. https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp.

Traduzioni: Regolamento CLP (CE) 1272/2008, Allegato III e IV. Dati: PubChem/NLM.

📚 Riferimenti scientifici consolidati — Chicago Author-Date 10 sources

Riferimenti raccolti da tutte le schede del Safety Hub. CAS: 12035-72-2 · PubChem ↗

  1. Parlament Europejski i Rada UE. 2008. "Regulation (EC) nr 1272/2008 w sprawie klasyfikacji, oznakowania i pakowania substancji (CLP)." Dz.Urz. UE L 353. [↗] GHS, Normative
  2. United Nations Economic Commission for Europe (UNECE). 2021. "Globally Harmonized System of Classification and Labelling of Chemicals (GHS), Ninth Revised Edition." United Nations, Geneva. [↗] GHS
  3. Goldfrank, Lewis R., Robert S. Hoffman, Mary Ann Howland, et al.. 2019. "Goldfrank's Toxicologic Emergencies, 11th ed.." McGraw-Hill Education, New York. ISBN 978-1-25-985961-8. Primo soccorso, Tossicologia
  4. National Institute for Occupational Safety and Health (NIOSH). 2023. "NIOSH Pocket Guide to Chemical Hazards (DHHS Publ. 2005-149)." U.S. Department of Health and Human Services / CDC, Cincinnati, OH. [↗] Primo soccorso, DPI, Tossicologia
  5. European Committee for Standardization (CEN). 2016. "EN 374-1:2016 — Protective gloves against dangerous chemicals and micro-organisms." CEN, Brussels. [↗] DPI
  6. UNECE. 2023. "European Agreement Concerning the International Carriage of Dangerous Goods by Road (ADR 2025)." United Nations, Geneva. [↗] Smaltimento, Normative
  7. National Fire Protection Association (NFPA). 2022. "NFPA 400 — Hazardous Materials Code." NFPA, Quincy, MA. [↗] Stoccaggio
  8. Urben, P.G. (ed.). 2017. "Bretherick's Handbook of Reactive Chemical Hazards, 8th ed.." Butterworth-Heinemann / Elsevier, Oxford. [↗] Stoccaggio
  9. Ministerstwo Klimatu i Środowiska RP. 2023. "Baza danych o produktach i opakowaniach oraz o gospodarce odpadami (BDO)." Ministerstwo Klimatu i Środowiska, Warszawa. Norme nazionali — Polonia [↗] Smaltimento
  10. International Agency for Research on Cancer (IARC / WHO). 2024. "IARC Monographs on the Identification of Carcinogenic Hazards to Humans — List of Classifications." WHO, Lyon. [↗] Tossicologia

Le schede con riferimenti propri (Emergency, PPE, Storage, Waste) contengono ulteriori voci bibliografiche all'interno delle rispettive sezioni.

📈 Statistica analitica (t-test · RSD · Grubbs · Q-Dixon) ICH Q2

Incolla una serie di misure replicate (CSV oppure un numero per riga). Il calcolatore calcolerà la media, la deviazione standard e il 95% CI, e rileverà gli outlier (Grubbs + Dixon Q).

Separatore: virgola, spazio, tab, nuova riga. Min 3 misurazioni.
📐 Formule statistiche
  • x̄ = Σxᵢ / n — media aritmetica
  • s² = Σ(xᵢ - x̄)² / (n-1) — varianza campionaria
  • s = √s² — deviazione standard
  • RSD% = (s / x̄) × 100% — deviazione standard relativa
  • CI₉₅ = x̄ ± t(0.05, n-1) × s / √n — Student's t
  • G = |xᵢ - x̄| / s — test di Grubbs
  • Q = |xsuspect - xnearest| / |xmax - xmin| — Dixon Q-test

Fonte: ICH Q2(R2) Validation of Analytical Procedures · ICH PDF ↗

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Passo 1: Scegli un sistema tampone

📜 Cronologia delle ricette (ultime 10)
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🧪 Solubilità e compatibilità con i solventi
Molecola
NICKEL SULFIDE (Ni3S2)
Formula
Ni₃S₂
logP (XLogP3)
—
Massa (g/mol)
240.22
Polarità
—

⚠️ Composto ionico / inorganico — i parametri di Hansen (δD/δP/δH) non sono applicabili: la dissoluzione è governata dall'energia del reticolo cristallino e dalla solvatazione degli ioni, non dalla coesione molecolare. Blocco HSP e sfera di Hansen omessi. Colonne dipendenti dagli HSP (Compat./Ra/Visuale) contrassegnate „n/d" — basare la selezione del solvente su dati sperimentali.

Ra < R₀ = buona miscibilità · Ra < 1,5×R₀ = al limite · oltre = scarsa (R₀ — raggio della sfera di Hansen di questa molecola)

Solvente Compat. Ra Visuale GC-MS HPLC Applications Riferimenti
Water (H₂O)n/d—non applicabile✗ NoA (aqueous) (RP)
buffercell cultureanalyticalextraction (hydrophilic)
Ethanol (EtOH)n/d—non applicabile✗ NoA/B modifier (RP/NP)
extractionspectroscopy (UV-Vis)synthesisHPLC modifier
Methanol (MeOH)n/d—non applicabile✗ NoA/B (RP) (RP)
HPLC (eluent)LC-MSKarl FischerUV-transparent to 205 nm
Acetonen/d—non applicabile✗ NoB modifier (NP)
GC headspacecrystallisationdegreasingsynthesis
Acetonitrile (ACN)n/d—non applicabile✗ NoB (RP) (RP)
HPLC eluent (gold standard)LC-MS (low UV cut-off, 190 nm)peptide analysis
DMSOn/d—non applicabile✗ NoN/A (N/A)
NMR (d6-DMSO)cell biology (cryopreservation)drug deliverysynthesis
THFn/d—non applicabile✗ NoB (NP) (NP)
GPC/SEC (polymer analysis)Grignard synthesisorganometallics
DCM (CH₂Cl₂)n/d—non applicabile✓ YesB (NP) (NP)
extractionNP-HPLCGC-MScrystallisation (anti-solvent)
Chloroform (CHCl₃)n/d—non applicabile✓ YesN/A (toxic) (N/A)
NMR (CDCl3)lipid extraction (Folch method)NP-TLC
Hexanen/d—non applicabile✓ YesA (NP) (NP)
NP-HPLCoil extraction (lipids)GC-MSTLC (NP)
Toluenen/d—non applicabile✓ YesB (NP) (NP)
NMR (d8-toluene)synthesisazeotropic drying (Dean-Stark)
📚 Riferimenti scientifici per i solventi (Chicago Author-Date) — clicca per espandere

11 solventi · 54 citazioni complete (NIST/CRC/IARC/Hansen/Reichardt/Smallwood/Wypych/Armarego/Snyder/GESTIS) — di seguito.

Water (H₂O)
  1. NIST — NIST Chemistry WebBook — Water (CAS 7732-18-5)
  2. CRC — CRC Handbook of Chemistry and Physics, 104th ed., Sec. 8 (Properties of Water)
  3. IAPWS — IAPWS Release on Static Dielectric Constant of Water
  4. Reichardt 2011 — Solvents and Solvent Effects in Organic Chemistry
  5. GESTIS — GESTIS Substance Database — Water
Ethanol (EtOH)
  1. NIST — NIST Chemistry WebBook — Ethanol (CAS 64-17-5)
  2. CRC — CRC Handbook — Ethanol physical constants
  3. Snyder & Kirkland — Modern Liquid Chromatography — Ethanol eluotropic
  4. Smallwood — Handbook of Organic Solvent Properties — Ethanol
  5. GESTIS — GESTIS Substance Database — Ethanol
Methanol (MeOH)
  1. NIST — NIST Chemistry WebBook — Methanol (CAS 67-56-1)
  2. CRC — CRC Handbook — Methanol physical constants
  3. Snyder & Kirkland — Modern Liquid Chromatography — MeOH eluotropic, eo=0.95
  4. GESTIS — GESTIS Substance Database — Methanol
Acetone
  1. NIST — NIST Chemistry WebBook — Acetone (CAS 67-64-1)
  2. CRC — CRC Handbook — Acetone physical & thermodynamic constants
  3. Hansen 2007 — Hansen Solubility Parameters — Acetone (dD=15.5, dP=10.4, dH=7.0)
  4. Smallwood — Handbook of Organic Solvent Properties — Acetone
  5. GESTIS — GESTIS Substance Database — Acetone
Acetonitrile (ACN)
  1. NIST — NIST Chemistry WebBook — Acetonitrile (CAS 75-05-8)
  2. CRC — CRC Handbook — Acetonitrile constants
  3. Snyder & Kirkland — Modern Liquid Chromatography — ACN gold-standard HPLC eluent
  4. Reichardt 2011 — Solvents and Solvent Effects — ACN dipolar aprotic
  5. GESTIS — GESTIS Substance Database — Acetonitrile
DMSO
  1. NIST — NIST Chemistry WebBook — DMSO (CAS 67-68-5)
  2. Wypych 2019 — Handbook of Solvents Vol. 1 — DMSO comprehensive properties
  3. Hansen 2007 — HSP — DMSO (dD=18.4, dP=16.4, dH=10.2)
  4. Reichardt 2011 — Solvents and Solvent Effects — DMSO E_T(30)=45.1, dipolar aprotic
  5. GESTIS — GESTIS Substance Database — DMSO
THF
  1. NIST — NIST Chemistry WebBook — THF (CAS 109-99-9)
  2. Armarego 2009 — Purification of Laboratory Chemicals — THF drying & peroxide test
  3. Hansen 2007 — Hansen Solubility Parameters — THF (dD=16.8, dP=5.7, dH=8.0)
  4. Smallwood — Handbook of Organic Solvent Properties — THF
  5. GESTIS — GESTIS Substance Database — Tetrahydrofuran
DCM (CH₂Cl₂)
  1. NIST — NIST Chemistry WebBook — Dichloromethane (CAS 75-09-2)
  2. IARC 71 — IARC Monograph 71 — DCM (Group 2A carcinogen)
  3. Hansen 2007 — Hansen Solubility Parameters — DCM (dD=18.2, dP=6.3, dH=6.1)
  4. Reichardt 2011 — Solvents and Solvent Effects — DCM polarity index
  5. GESTIS — GESTIS Substance Database — Dichloromethane
Chloroform (CHCl₃)
  1. NIST — NIST Chemistry WebBook — Chloroform (CAS 67-66-3)
  2. IARC 73 — IARC Monograph 73 — Chloroform (Group 2B carcinogen)
  3. Hansen 2007 — Hansen Solubility Parameters — CHCl3 (dD=17.8, dP=3.1, dH=5.7)
  4. Reichardt 2011 — Solvents and Solvent Effects — CHCl3 H-bond donor strength
  5. GESTIS — GESTIS Substance Database — Chloroform
n-Hexane
  1. NIST — NIST Chemistry WebBook — n-Hexane (CAS 110-54-3)
  2. ATSDR n-Hexane — ATSDR Toxicological Profile for n-Hexane — neuropatia periferica (l'n-esano NON è un cancerogeno secondo la IARC)
  3. Hansen 2007 — Hansen Solubility Parameters — n-Hexane (dD=14.9, dP=0, dH=0)
  4. Snyder & Kirkland — Modern Liquid Chromatography — n-Hexane NP standard, eo=0.00
  5. GESTIS — GESTIS Substance Database — n-Hexane
Toluene
  1. NIST — NIST Chemistry WebBook — Toluene (CAS 108-88-3)
  2. IARC 71 — IARC Monograph 71 — Toluene
  3. Hansen 2007 — Hansen Solubility Parameters — Toluene (dD=18.0, dP=1.4, dH=2.0)
  4. Smallwood — Handbook of Organic Solvent Properties — Toluene
  5. GESTIS — GESTIS Substance Database — Toluene
Teoria della solubilità (applicata nella previsione della compatibilità):
  1. Yalkowsky, Samuel H., and Shri C. Valvani. 1980. "Solubility and Partitioning I: Solubility of Nonelectrolytes in Water." Journal of Pharmaceutical Sciences 69 (8): 912–922. https://doi.org/10.1002/jps.2600690814 — General Solubility Equation (GSE): logS = 0.5 − logP − 0.01(MP−25).
  2. Hansen, Charles M. 2007. Hansen Solubility Parameters: A User's Handbook. 2nd ed. CRC Press. https://doi.org/10.1201/9781420006834 — Tripletta HSP (dD, dP, dH) + formula Ra.
  3. Stefanis, E., and C. Panayiotou. 2008. "Prediction of Hansen Solubility Parameters with a New Group-Contribution Method." Int J Thermophys 29: 568–585. https://doi.org/10.1007/s10765-008-0415-z
  4. Reichardt, Christian, and Thomas Welton. 2011. Solvents and Solvent Effects in Organic Chemistry. 4th ed. Wiley-VCH. https://doi.org/10.1002/9783527632220 — E_T(30) polarity scale, solvatochromism.
  5. Snyder, Lloyd R., Joseph J. Kirkland, and John W. Dolan. 2010. Introduction to Modern Liquid Chromatography. 3rd ed. Wiley. https://doi.org/10.1002/9780470508183 — Eluotropic series, polarity index.
  6. Van Krevelen, D. W., and K. Te Nijenhuis. 2009. Properties of Polymers. 4th ed. Elsevier. https://doi.org/10.1016/B978-0-08-054819-7.X0001-5 — Hoftyzer–Van Krevelen group contribution for dD/dP/dH from SMILES.
  7. Marcus, Yizhak. 1998. The Properties of Solvents. Wiley Series in Solution Chemistry, Vol. 4. ISBN 9780471983699 — Set tabulare completo di 250+ solventi (ε, μ, donicità, numeri di accettore).
  8. PubChem Compound Database — CAS 12035-72-2 lookup ↗ — logP (XLogP3), water solubility experimental + predicted.

Bibliografia completa nell'accordion RIFERIMENTI (in fondo alla pagina) — Chicago Manual of Style 17th ed., Author-Date.

⚗️ Verifica la compatibilità della reazione
3 0 0
Salute: 3/4
Infiammabilità: 0/4
Reattività: 0/4
Secondo NFPA 704 / calcolato dai codici H

Verifica se NICKEL SULFIDE (Ni3S2) è compatibile con un altro reagente

📦 Matrice di compatibilità di stoccaggio
Acidi Bases Ossidanti Infiammabile Tossico Gazy
Acidi ✓ ✗ ✗ ✗ ⚠ ✗
Bases ✗ ✓ ⚠ ⚠ ⚠ ⚠
Ossidanti ✗ ⚠ ✓ ✗ ⚠ ✗
Infiammabile ✗ ⚠ ✗ ✓ ⚠ ✗
Tossico ⚠ ⚠ ⚠ ⚠ ✓ ⚠
Gazy ✗ ⚠ ✗ ✗ ⚠ ✓
✓ Conservabili insieme · ⚠ Attenzione · ✗ NON conservare insieme · OSHA Chemical Segregation ↗

Dati di compatibilità da: Bretherick's Handbook (7th ed.) ↗, GESTIS ↗, ECHA REACH ↗, NFPA 704 ↗

🧮 Calcolatori da laboratorio (8)
Dilution (C₁V₁=C₂V₂)
Molarità (M=n/V)
Tampone pH (Henderson-Hasselbalch)
Beer-Lambert (A=εcl)
Massa → Moli
Concentration % → M
ppm → mg/L
Temperatura C↔F↔K

Formule verificate: IUPAC Gold Book ↗, DOI ↗

📊 Database di spettri spettroscopici
📋 Generatore di protocolli di laboratorio

Protocollo generato sulla base di: GHS SDS, Aldrich Lab Guide ↗

🏷️ Generatore di etichette (QR)
Trinickel Disulfide• alpha nickel subsulfide / Heazlewoodite• IUPAC: nickel;sulfanylidenenickel• CAS: 12035-72-2• EC: 234-829-6• Formula: Ni3S2• Massa: 240.22 g/molPERICOLOINDICAZIONI DI PERICOLO GHS:H350i H341 H331 H372 H317 H400 H410P203: Procurarsi, leggere e seguire tutte le istruzioni di sicurezza primadell’uso.Solo per uso di laboratorio!Nonsensia Ltd124-128 City Road, EC1V 2NX London[email protected]molgod.orgN. lotto: Massa netta:
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Ricette predefinite:
📚 Panoramica della letteratura scientifica — CAS 12035-72-2
⭐ Risultati principali (letteratura scientifica) 5 publications
🏆 CAS 12035-72-2 — multi-criteria ranking (W12): 30% citazioni · 20% recency · 20% topic · 15% historical · 15% open access.
  1. #1
    Gao J; Ma R; Poovan F et al. (2023) · Nature communications
    Perché è importante: Must-cite (canone) · recente (2023)
    SCORE 8.31 Industria MUST-CITE Citazioni: 15 DOI ↗
  2. #2
    Simona C; Jacopo F; Maria Enrica G et al. (2018) · International journal of analytical chemistry
    Perché è importante: Must-cite (canone)
    SCORE 3.83 Analitica MUST-CITE Citazioni: 2 DOI ↗
  3. #3
    NTP Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CAS No. 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies).
    (1996) · National Toxicology Program technical report series
    Perché è importante: Must-cite (canone)
    SCORE 3.34 Meccanismo MUST-CITE Citazioni: 12
  4. #4
    Huggins FE; Galbreath KC; Eylands KE et al. (2011) · Environmental science & technology
    Perché è importante: Must-cite (canone)
    SCORE 1.1 Analitica MUST-CITE DOI ↗
  5. #5
    Mayer C; Klein RG; Wesch H et al. (1998) · Mutation research
    Perché è importante: Must-cite (canone)
    SCORE 0 Farmacologia MUST-CITE DOI ↗

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Documentazione

Quali documenti esistono, a quale livello di revisione, in quali lingue e quando ciascuno è stato rilasciato.

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This covers the checks we performed and named. It does not cover registration status, tonnage, or your role in the supply chain — those are not ours to hold, and a guarantee that pretended otherwise would be worth nothing.

For trinickel disulfide (CAS 12035-72-2) the documentation obligation begins before the first shipment. This page sets out what the safety data sheet has to establish.

trinickel disulfide (CAS 12035-72-2) at a glance

  • Substance – trinickel disulfide
  • CAS number – 12035-72-2
  • EC number – 234-829-6 [1];- [2]
  • CLP Annex VI index number – 028-007-00-4
  • Also known as – nickel subsulfide
  • Hazard statements – H350i; H341 (suspected of causing genetic defects); H331 (toxic if inhaled); H372 (causes damage to organs through prolonged or repeated exposure); H317 (may cause an allergic skin reaction); H400 (very toxic to aquatic life)
  • Hazard classes – Carc. 1A, Muta. 2, Acute Tox. 3, STOT RE 1, Skin Sens. 1, Aquatic Acute 1
  • Label pictograms – GHS06, GHS08, GHS09
  • Signal word – Danger
  • Concentration limits / M-factor / ATE – inhalation: ATE = 0.92 mg/L dusts or mists
  • Entry current as of – ATP17
  • CMR classification – yes, classified as carcinogenic, mutagenic or toxic for reproduction
  • Documentation issued – safety data sheet in REACH Annex II structure; working draft or signed card
  • What is supplied – a document. MolGod.org does not sell, supply or ship chemical substances.

How is trinickel disulfide classified for road, sea and air transport?

Carriers and forwarders handling trinickel disulfide compare section 14 against the shipping papers before loading. Any disagreement stops the consignment at the point where correcting it is most expensive.

What must the label for trinickel disulfide contain?

The supply label for trinickel disulfide is generated from the same classification that drives the safety data sheet: pictograms selected by precedence, one signal word derived from the highest hazard class present, and the hazard statements H350i, H341, H331… reproduced in full. Where the container is too small to carry the complete set at a legible size, there are lawful ways to handle it and unlawful ones that look identical to a non-specialist.

What is the CLP classification of trinickel disulfide?

The harmonised classification for CAS 12035-72-2 carries 7 hazard statements: H350i, H341, H331, H372, H317, H400, H410. In plain terms this means H350i; suspected of causing genetic defects; toxic if inhaled; causes damage to organs through prolonged or repeated exposure. A harmonised entry is binding across the Union — an importer may not soften it, and a self-classification that diverges from it will not survive an enforcement check.

Can I import trinickel disulfide into the EU?

Bringing trinickel disulfide into the Union is a documentation exercise before it is a logistics one. The file has to exist at the moment of import, not at the moment somebody asks for it, and for nickel compounds it is examined in the context of metal-compound consignments under authorisation pressure. Index 028-007-00-4 fixes the classification that section 2 must reproduce.

What is the EC number for trinickel disulfide?

Alongside CAS 12035-72-2, this substance carries EC number 234-829-6 [1];- [2] and Annex VI index 028-007-00-4. European documentation is built around the EC number as often as around the CAS: registration dossiers, the candidate list and customs systems key on it. A safety data sheet quoting only one of the two forces every downstream reader to look up the other.

Where is regulatory status recorded for trinickel disulfide?

Whether CAS 12035-72-2 carries obligations beyond classification — candidate list entry, authorisation, restriction — belongs in section 15. Customers increasingly request a written statement on this point before placing an order, and the sheet is the natural place for it.

Target organ toxicity in the sheet

Specific target organ toxicity (H372) obliges the sheet to state the route of exposure and, where established, the organ affected. This is one of the few places where a generic phrase is treated as a defect rather than as caution: an unspecified organ leaves the downstream user unable to build an exposure scenario.

What concentration limits apply to trinickel disulfide?

Acute toxicity estimate stated in the register: inhalation: ATE = 0,92 mg/l.

Stability, reactivity and incompatibilities

The reactivity information for CAS 12035-72-2 provided under Section 10 must be sufficiently detailed and actionable. While stating ‘avoid strong oxidizing agents’ offers a general category, specifying the exact chemical classes that react with the substance in question provides clearer guidance on appropriate handling and precautionary measures.

Disposal route and waste classification

Section 13 for CAS 12035-72-2 outlines the disposal method and procedures for contaminated packaging. Laboratories are subject to audits to ensure their waste management practices align with the information provided in this section. Any ambiguity or lack of specificity in this section may result in findings against the laboratory rather than the supplier, as it is responsible for adhering to the declared waste stream.

Is trinickel disulfide classified as a CMR substance?

CAS 12035-72-2 is classified as a CMR substance (H350i). That status changes the obligations attached to every shipment: workplace exposure documentation, restrictions on supply to the general public, and substitution pressure from downstream users who must justify continued use. A safety data sheet for a CMR substance is read more closely than any other, because the classification itself invites scrutiny.

Identifiers that must agree

Identity verification must be conducted prior to hazard assessment. If discrepancies exist between the label, safety data sheet, and certificate regarding the CAS 12035-72-2 number or if the index 028-007-00-4 refers to a location where the name does not match, a reviewer will lose trust in all three documents simultaneously, despite their internal consistency. This is because inconsistencies among these key documentation elements undermine their reliability as a unified source of information.

What Annex VI notes and concentration limits apply to trinickel disulfide?

The register also records inhalation: ATE = 0.92 mg/L dusts or mists for this entry. Specific concentration limits, M-factors and acute toxicity estimates override the generic cut-off values, so a mixture calculation that ignores them will classify the mixture wrongly in both directions.

Which GHS pictograms apply to trinickel disulfide?

The label for trinickel disulfide carries GHS06 (skull and crossbones), GHS08 (health hazard), GHS09 (environment), with the signal word Danger. These are not chosen by the supplier: CLP Annex VI states them for CAS 12035-72-2, and the precedence rules in Annex I decide which pictogram is dropped when two would say the same thing. A label showing a different set from the register is wrong even if every hazard statement on it is correct.

Protective equipment and exposure controls

When conducting a risk assessment for trinickel disulfide, laboratories must begin by referring to Section 8. If an occupational exposure limit is in place, it is essential to clearly state this limit along with its source and the corresponding averaging period. In cases where no such limit exists, the documentation should explicitly indicate this fact rather than leaving the relevant field blank.

Questions about documentation for trinickel disulfide

Can I check whether my existing sheet is still valid?

Yes. A section-by-section reading against Annex II and the current harmonised entry establishes that in one pass, and a sheet that passes is reported as passing.

Do I need a safety data sheet to import trinickel disulfide into the EU?

Yes. A sheet compiled to Annex II of REACH must exist before the first consignment moves, and it must be held by the entity placing the substance on the Union market.

What is the CAS number of trinickel disulfide?

CAS 12035-72-2. In CLP Annex VI the same substance carries index number 028-007-00-4, and both identifiers should appear in the documentation.

Is trinickel disulfide a CMR substance?

Yes. The harmonised classification places it among substances classified as carcinogenic, mutagenic or toxic for reproduction, which changes workplace documentation and supply restrictions.

MolGod.org issues documentation and does not sell, supply or ship chemical substances. CAS 12035-72-2 identifies the subject of this document.

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📄 Certificati di Analisi (CoA) CAS 12035-72-2 nessuno

Nessun certificato per questo prodotto nel database.

📚 Riferimenti scientifici (Chicago Author-Date) — fare clic per espandere

Standard di gestione dei lotti e di certificazione di laboratorio — 13 fonti indipendenti (ICH Q1/Q3/Q6/Q7/Q10 + ISO 17025 + WHO TRS + 21 CFR 211 + EMA + USP + Ph.Eur. + PIC/S + IPEC-PQG).

  1. International Council for Harmonisation (ICH). 2000. "Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients." ICH Expert Working Group. [link ↗] — GMP for APIs — adopted by EMA, FDA, MHLW
  2. International Organization for Standardization. 2017. "ISO/IEC 17025:2017 General requirements for the competence of testing and calibration laboratories." ISO. [link ↗] — Lab accreditation standard underpinning every CoA
  3. World Health Organization. 2010. "WHO Good Manufacturing Practices for Pharmaceutical Products: Main Principles (WHO Technical Report Series No. 957, Annex 3)." WHO Press. [link ↗] — WHO TRS No. 957 — global reference for GMP
  4. International Council for Harmonisation (ICH). 2003. "ICH Q1A(R2): Stability Testing of New Drug Substances and Products." International Council for Harmonisation. [link ↗] — Source for batch shelf-life and retest dating
  5. International Council for Harmonisation (ICH). 2006. "ICH Q3A(R2): Impurities in New Drug Substances." ICH. [link ↗]
  6. International Council for Harmonisation (ICH). 1999. "ICH Q6A: Specifications for New Drug Substances and Products." ICH. [link ↗] — CoA acceptance-criteria specification standard
  7. International Council for Harmonisation (ICH). 2008. "ICH Q10: Pharmaceutical Quality System." ICH. [link ↗]
  8. U.S. Food and Drug Administration. 2024. "21 CFR Part 211: Current Good Manufacturing Practice for Finished Pharmaceuticals." US Code of Federal Regulations. [link ↗] — US legal mandate (Subpart J — Records and Reports)
  9. European Medicines Agency. 2014. "Guideline on Process Validation for Finished Products — Information and Data to Be Provided EMA/CHMP/CVMP/QWP/BWP/70278/2012." European Medicines Agency. [link ↗]
  10. United States Pharmacopeial Convention. 2024. "United States Pharmacopeia and National Formulary, USP 47-NF 42." USP. [link ↗]
  11. European Pharmacopoeia Commission. 2024. "European Pharmacopoeia 11th Edition." Council of Europe — EDQM. [link ↗]
  12. Pharmaceutical Inspection Co-operation Scheme (PIC/S). 2021. "Guide to Good Manufacturing Practice for Medicinal Products PE 009-15." PIC/S Secretariat, Geneva. [link ↗] — Cross-recognized GMP for 54 inspectorates worldwide
  13. International Pharmaceutical Excipients Council (IPEC) and Pharmaceutical Quality Group (PQG). 2017. "Joint IPEC-PQG Good Manufacturing Practices Guide for Pharmaceutical Excipients." IPEC-Americas. [link ↗] — Excipient-grade CoA standard for non-API ingredients
Dati da PubChemFonte: PubChem (NIH)
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📚 RIFERIMENTI (Bibliografia complessiva, Chicago Author-Date) 78 elementi

Tutte le fonti scientifiche citate negli accordion sopra per il CAS 12035-72-2.Formato: Chicago Manual of Style 17ª ed., sistema Author-Date.

🗄️ Banche dati scientifiche

  1. PubChem. n.d. PubChem Compound Summary: CAS 12035-72-2. Bethesda, MD: National Center for Biotechnology Information (NCBI), National Library of Medicine.
  2. NIST. n.d. NIST Chemistry WebBook: CAS 12035-72-2. Gaithersburg, MD: National Institute of Standards and Technology. https://webbook.nist.gov/cgi/cbook.cgi?ID=12035-72-2.
  3. AIST. n.d. Spectral Database for Organic Compounds (SDBS): CAS 12035-72-2. Tsukuba, Japan: National Institute of Advanced Industrial Science and Technology. https://sdbs.db.aist.go.jp/.
  4. Linstrom, Peter J., and William G. Mallard, eds. n.d. NIST Chemistry WebBook: NIST Standard Reference Database Number 69. Gaithersburg, MD: National Institute of Standards and Technology. https://doi.org/10.18434/T4D303.

📐 Standard / Linee guida

  1. ICH. 2003. "Stability Testing of New Drug Substances and Products: Q1A(R2)." Geneva: International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. https://database.ich.org/sites/default/files/Q1A%28R2%29%20Guideline.pdf.
  2. National Fire Protection Association (NFPA). 2024. "NFPA 30: Flammable and Combustible Liquids Code." NFPA, Quincy, MA. https://www.nfpa.org/codes-and-standards/all-codes-and-standards/list-of-codes-and-standards/detail?code=30.
  3. Occupational Safety and Health Administration (OSHA). 2023. "29 CFR 1910.106 — Flammable Liquids." U.S. Department of Labor, Federal Register. https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.106.
  4. European Chemicals Agency (ECHA). 2024. "Annex VI to Regulation (EC) No 1272/2008 (CLP) — Harmonised Classification and Labelling." ECHA, Helsinki / Official Journal of the European Union. https://echa.europa.eu/regulations/clp/clp-classification.
  5. European Committee for Standardization (CEN). 2016. "EN 374-1:2016 — Protective gloves against dangerous chemicals and micro-organisms — Part 1: Terminology and performance requirements for chemical risks." CEN, Brussels. https://standards.cencenelec.eu/dyn/www/f?p=205:110:::::FSP_PROJECT,FSP_ORG_ID:38536,6080&cs=1B0DAA8B85DF42E4A2C70E5D71F0BFA32.
  6. European Committee for Standardization (CEN). 2001. "EN 166:2001 — Personal eye-protection — Specifications." CEN, Brussels. https://standards.cencenelec.eu/dyn/www/f?p=CEN:110:0::::FSP_PROJECT:6541&cs=1F1A4E0A78C4DB6A28DBE2E8C29D89DCF.
  7. European Committee for Standardization (CEN). 2009. "EN 14605:2005+A1:2009 — Protective clothing against liquid chemicals — Performance requirements for clothing with liquid-tight (Type 3) or spray-tight (Type 4) connections." CEN, Brussels. https://standards.cencenelec.eu/dyn/www/f?p=CEN:110:0::::FSP_PROJECT:21581&cs=1A04A2D3C7CC58E9E6CB58D55F7EBFB7E.
  8. National Institute for Occupational Safety and Health (NIOSH). 2017. "Recommendations for Chemical Protective Clothing: A Companion to the NIOSH Pocket Guide." U.S. Department of Health & Human Services / CDC. https://www.cdc.gov/niosh/ncpc/default.html.
  9. Occupational Safety and Health Administration (OSHA). 2011. "Personal Protective Equipment — General requirements." U.S. Department of Labor — 29 CFR 1910.132. https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.132.

📖 Libri

  1. Hansen, Charles M. 2007. Hansen Solubility Parameters: A User's Handbook, 2nd ed.. Boca Raton, FL: CRC Press. https://www.routledge.com/Hansen-Solubility-Parameters-A-Users-Handbook/Hansen/p/book/9780849372483.
  2. Barton, Allan F. M. 1991. CRC Handbook of Solubility Parameters and Other Cohesion Parameters: 2nd ed.. Boca Raton, FL: CRC Press. https://www.routledge.com/CRC-Handbook-of-Solubility-Parameters-and-Other-Cohesion-Parameters/Barton/p/book/9780849301766.
  3. Connors, Kenneth A., Gordon L. Amidon, and Valentino J. Stella. 1986. Chemical Stability of Pharmaceuticals: A Handbook for Pharmacists, 2nd ed.. New York: Wiley. https://doi.org/10.1002/0471734683.
  4. Rumble, John R., ed. 2019. CRC Handbook of Chemistry and Physics: 100th Edition. Boca Raton, FL: CRC Press. https://hbcp.chemnetbase.com/.
  5. Urben, Peter G. 2017. Bretherick's Handbook of Reactive Chemical Hazards, 8th Edition. Academic Press / Elsevier, Oxford. https://www.sciencedirect.com/book/9780081010594.

📄 Articoli scientifici (peer-reviewed)

  1. Stefanis, Emmanuel, and Costas Panayiotou. 2008. "Prediction of Hansen Solubility Parameters with a New Group-Contribution Method." International Journal of Thermophysics 29: 568-585. https://doi.org/10.1007/s10765-008-0415-z.
  2. Stoll, Vincent S., and John S. Blanchard. 1990. "Buffers: Principles and Practice: In Methods in Enzymology, vol. 182." San Diego: Academic Press. https://doi.org/10.1016/0076-6879(90)82008-P.

🌐 Siti web

  1. ECHA. 2023. "Guidance on the Application of the CLP Criteria." European Chemicals Agency. https://echa.europa.eu/guidance-documents/guidance-on-clp.
  2. European Parliament. 2006. "Regulation (EC) No 1907/2006 (REACH)." Official Journal of the European Union L 396: 1–849.
  3. ECHA. 2023. "Candidate List of Substances of Very High Concern for Authorisation." European Chemicals Agency. https://echa.europa.eu/candidate-list-table.
  4. European Parliament. 2008. "Regulation (EC) No 1272/2008 on Classification, Labelling and Packaging of Substances and Mixtures (CLP)." Official Journal of the European Union L 353: 1–1355.
  5. ECHA. 2017. "Guidance on the Compilation of Safety Data Sheets." Version 3.1. European Chemicals Agency. ECHA-17-G-01-EN. https://echa.europa.eu/documents/10162/23047722/sds_en.pdf.
  6. ECHA. 2022. "Restrictions Under REACH — Annex XVII." European Chemicals Agency. https://echa.europa.eu/substances-restricted-under-reach.
  7. United Nations. 2021. Globally Harmonized System of Classification and Labelling of Chemicals (GHS). 9th revised ed. ST/SG/AC.10/30/Rev.9. New York and Geneva: United Nations. https://unece.org/ghs-rev9-2021.
  8. ECHA. 2020. "Understanding REACH." European Chemicals Agency. https://echa.europa.eu/regulations/reach/understanding-reach.
  9. ECHA — Allegato VI del CLP (classificazione armonizzata, ATP 23; 2026-07-07) https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp.
  10. United States Pharmacopeial Convention. 2024. "USP <621> Chromatography." In United States Pharmacopeia and National Formulary, USP 47-NF 42. Rockville, MD: USP. https://www.uspnf.com/.
  11. European Pharmacopoeia Commission. 2024. "2.2.46 Chromatographic Separation Techniques." In European Pharmacopoeia, 11th ed. Strasbourg: Council of Europe — EDQM. https://www.edqm.eu/en/european-pharmacopoeia-ph-eur-11th-edition.
  12. International Council for Harmonisation (ICH). 2022. "ICH Q2(R2): Validation of Analytical Procedures." International Council for Harmonisation. https://database.ich.org/sites/default/files/ICH_Q2%28R2%29_Guideline_2022_1130.pdf.
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  27. United Nations Economic Commission for Europe. 2024. European Agreement Concerning the International Carriage of Dangerous Goods by Road (ADR), Applicable as from 1 January 2025 (ECE/TRANS/352). Geneva: UNECE. https://unece.org/transport/dangerous-goods/adr-2025-edition.
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  29. International Maritime Organization. 2024. International Maritime Dangerous Goods (IMDG) Code, 2024 Edition (Amendment 42-24). London: IMO. https://www.imo.org/en/OurWork/Safety/Pages/DangerousGoods-default.aspx.
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  33. Ministerstwo Klimatu i Środowiska Rzeczypospolitej Polskiej. 2020. "Rozporządzenie Ministra Klimatu z dnia 2 stycznia 2020 r. w sprawie katalogu odpadów." Dziennik Ustaw RP 2020 poz. 10. https://isap.sejm.gov.pl/isap.nsf/DocDetails.xsp?id=WDU20200000010. Norme nazionali — Polonia
  34. Główny Inspektorat Ochrony Środowiska (GIOŚ). 2024. "Baza Danych O Odpadach (BDO) — System rejestracji firm utylizacyjnych." Ministerstwo Klimatu i Środowiska. https://bdo.mos.gov.pl/. Norme nazionali — Polonia
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  50. International Council for Harmonisation (ICH). 2006. "ICH Q3A(R2): Impurities in New Drug Substances." ICH. https://database.ich.org/sites/default/files/Q3A%28R2%29%20Guideline.pdf.
  51. International Council for Harmonisation (ICH). 1999. "ICH Q6A: Specifications for New Drug Substances and Products." ICH. https://database.ich.org/sites/default/files/Q6A%20Guideline.pdf.
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📜 Licenza e provenienza
Modello
NICKEL SULFIDE (Ni3S2) · 12035-72-2
InChIKey
YGHCWPXPAHSSNA-UHFFFAOYSA-N
Scheda di licenza e provenienza
NICKEL SULFIDE (Ni3S2) (CAS 12035-72-2) →
Scheda molecolare MolGod
NICKEL SULFIDE (Ni3S2) →
Dati di origine
PubChem CID 25199732 ↗
Informazioni sul modello
non ancora pubblicato

Questa licenza si applica alla mesh STL creata da MolGod, non automaticamente al materiale di origine di terzi.