dibutyltin dichloride (CAS 683-18-1) — Safety Data Sheet
Safety data sheet documentation for dibutyltin dichloride (CAS 683-18-1), compiled to REACH Annex II with classification read against the harmonised entry in CLP Annex VI (H341, H360FD, H330, H312). Two options: a working draft sent by e-mail immediately, or a signed card issued within 72 hours of complete input. The item supplied is a document — MolGod.org does not sell, supply or ship chemical substances.
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Section 9 — physicochemical properties: 8 of 22 established.
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Identity CAS · EC · IUPAC · synonyms · molecular formula · molecular weight
Structure 2D · 3D · SMILES · InChI · InChIKey
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A digital PDF safety data sheet in the sixteen-section structure of REACH Annex II (Regulation 1907/2006).
Substance identification, hazard classification, physicochemical, toxicological and ecological information, and regulatory references.
Classification read against the harmonised entry in CLP Annex VI where one exists for the substance.
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sources.txt — every citation with the date it was read.
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3D model Dibutyltin dichloride, CAS 683-18-1, molecular formula C₈H₁₈Cl₂Sn, molar mass 303.84 g/mol
Data transcribed from regulatory registers and technical literature, with the source and edition stated. It does not replace the supplier's safety data sheet. Fields without a recorded source are marked as such.
📊 Physicochemical data — CAS 683-18-1
📊Physicochemical properties
Quick Reference
Formula:C₈H₁₈Cl₂Sn
MW:303.84 g/mol
CAS:683-18-1
Appearance:White crystalline solid
🔬 Advanced Properties
Chemical Identifiers
SMILES:CCCC[Sn](CCCC)(Cl)Cl
Last updated: 2026-08-25
📐Physical & Chemical Properties (DB)
3 fields MolGod Score: Reliable
PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. ↗
applies to: Melting point · Boiling point · Water solubility
NIST. Chemistry WebBook, SRD 69. National Institute of Standards and Technology. ↗
applies to: Melting point
Physicochemical values are derived from the independent, peer-reviewed sources listed above.
PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. ↗
applies to: Molecular formula · Molecular weight · Melting point · Boiling point · IUPAC name · SMILES · InChIKey
NIST. Chemistry WebBook, SRD 69. National Institute of Standards and Technology. ↗
applies to: Melting point
Lu Y, Tang H, Wang X et al.. (2022). "Dibutyltin dichloride exposure affects mouse oocyte quality by inducing spindle defects and mitochondria dysfunction.". Chemosphere. https://doi.org/10.1016/j.che
Xu X, Yu H, Sun L et al.. (2020). "Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway.". Molecular m
Lütt F, Ehlers L, Nizze H et al.. (2020). "Different characteristics of chronic dibutyltin dichloride-induced pancreatitis and cholangitis in mouse and rat.". Hepatobiliary & pancreatic diseases inter
Lee JM, Lee KG, Choi HS et al.. (2018). "Increased heat shock protein 70 expression attenuates pancreatic fibrosis induced by dibutyltin dichloride.". Scandinavian journal of gastroenterology. https:/
Furukawa S, Tsuji N, Kobayashi Y et al.. (2017). "Effect of dibutyltin on placental and fetal toxicity in rat.". The Journal of toxicological sciences. https://doi.org/10.2131/jts.42.741
M Ema. (2003). "Protective effects of progesterone on implantation failure induced by dibutyltin dichloride in rats". Toxicology Letters. https://doi.org/10.1016/s0378-4274(03)00152-8
Nagashio Y, Hirohata Y, Akiyama T et al.. (2002). "Dibutyltin dichloride modifies amylase release from isolated rat pancreatic acini.". Pancreas. https://doi.org/10.1097/00006676-200207000-00014
MOLECULE
Per-CAS bibliography (live from 13+ databases)
Sources: db:pubmed (6) · db:crossref (7)
db:pubmed
Lu Y, Tang H, Wang X et al.. (2022). "Dibutyltin dichloride exposure affects mouse oocyte quality by inducing spindle defects and mitochondria dysfunction.". Chemosphere. https://doi.org/10.1016/j.chemosphere.2022.133959 →
db:pubmed
Xu X, Yu H, Sun L et al.. (2020). "Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway.". Molecular medicine reports. https://doi.org/10.3892/mmr.2020.10995 →
db:pubmed
Lütt F, Ehlers L, Nizze H et al.. (2020). "Different characteristics of chronic dibutyltin dichloride-induced pancreatitis and cholangitis in mouse and rat.". Hepatobiliary & pancreatic diseases international : HBPD INT. https://doi.org/10.1016/j.hbpd.2019.10.007 →
db:crossref
Xiande Huang, Taoye Ma, Yongsheng Yin. (2018). "Dibutyltin Dichloride Retards Leydig Cell Developmental Regeneration in Adult Rat Testis". Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2018.01320 →
db:pubmed
Lee JM, Lee KG, Choi HS et al.. (2018). "Increased heat shock protein 70 expression attenuates pancreatic fibrosis induced by dibutyltin dichloride.". Scandinavian journal of gastroenterology. https://doi.org/10.1080/00365521.2018.1516799 →
db:pubmed
Furukawa S, Tsuji N, Kobayashi Y et al.. (2017). "Effect of dibutyltin on placental and fetal toxicity in rat.". The Journal of toxicological sciences. https://doi.org/10.2131/jts.42.741 →
db:crossref
M Ema. (2003). "Protective effects of progesterone on implantation failure induced by dibutyltin dichloride in rats". Toxicology Letters. https://doi.org/10.1016/s0378-4274(03)00152-8 →
db:pubmed
Nagashio Y, Hirohata Y, Akiyama T et al.. (2002). "Dibutyltin dichloride modifies amylase release from isolated rat pancreatic acini.". Pancreas. https://doi.org/10.1097/00006676-200207000-00014 →
db:crossref
M Ema. (2000). "Adverse effects of dibutyltin dichloride on initiation and maintenance of rat pregnancy". Reproductive Toxicology. https://doi.org/10.1016/s0890-6238(00)00095-2 →
db:crossref
K.W. Thomulka, J.H. Lange. (1996). "A Mixture Toxicity Study Employing Combinations of Tributyltin Chloride, Dibutyltin Dichloride, and Tin Chloride Using the Marine BacteriumVibrio harveyias the Test Organism". Ecotoxicology and Environmental Safety. https://doi.org/10.1006/eesa.1996.0047 →
db:crossref
J. Merkord, G. Hennighausen. (1989). "Acute pancreatitis and bile duct lesions in rat induced by dibutyltin dichloride". Experimental pathology. https://doi.org/10.1016/s0232-1513(89)80113-6 →
db:crossref
A.P. Li, A.R. Dahl, J.O. Hill. (1982). "In vitro cytotoxicity and genotoxicity of dibutyltin dichloride and dibutylgermanium dichloride". Toxicology and Applied Pharmacology. https://doi.org/10.1016/0041-008x(82)90245-9 →
db:crossref
R. T. Skeel, C. E. Bricker. (1961). "Spectrophotometric Determination of Dibutyltin Dichloride". Analytical Chemistry. https://doi.org/10.1021/ac60171a036 →
Regulatory status of the substance
This substance is subject to regulatory requirements: hazardous waste management (BDO — national rule, Poland). Details in the \"Regulatory Status (REACH/ECHA/CLP)\" section and on the SDS. Regulatory information — does not restrict purchase in this store.
🧮 Stoichiometry Calculator
🧪 Chemical Data
CAS Number
683-18-1
Molecular formula
C₈H₁₈Cl₂Sn
Molar mass
303.84 g/mol
IUPAC name (EN)
dibutyl(dichloro)stannane
SMILES
CCCC[Sn](CCCC)(Cl)Cl
InChIKey
RJGHQTVXGKYATR-UHFFFAOYSA-L
📡 Data sources
The data in this widget comes from the following verified scientific sources:
PubChem — National Center for Biotechnology Information (NCBI/NIH), USA
ChEMBL — European Bioinformatics Institute (EMBL-EBI), UK
NIST WebBook — National Institute of Standards and Technology, USA
Data is cached locally for speed — the widget also works offline.
⚗️ Physicochemical properties
Temp. topnienia
42.9
Density
1.36
Source: PubChem, NIST WebBook. Last updated: 2026-08-25
Spectra are fetched on demand from 9 sources. Each spectrum is stored in our database — the next time it is opened there are zero requests to the external API. Download JCAMP-DX / CSV / PNG for every spectrum without searching.
Type of data: Predicted (calculated by nmrshiftdb2, not measured) — inferred: the source file carries no deposited measurement Basis: the file returned by the NMRShiftDB search-or-predict service is a JCAMP-DX LINK block with spectrometer frequency 0, and its values match no deposited NMRShiftDB spectrum of this compound on record at MolGod.
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🔗 Source
About the downloads (Type of data: Predicted (calculated by nmrshiftdb2, not measured) — inferred: the source file carries no deposited measurement) JCAMP: the NMRShiftDB file as received (JCAMP-DX 5.01 text). It is a peak list: chemical shift in ppm. MolGod adds header lines stating the type of data; the values are unchanged. CSV: the same peak list in two columns. The second column repeats the shift value; it is not a signal intensity. Lines starting with # state the type of data. PNG: a picture of the plot above, with the type of data written on it. Use: where signals are expected or were reported (chemical shift positions). Not included or guaranteed: intensities, multiplicities, coupling constants, line shapes, and solvent or temperature unless stated. A predicted list is not a measurement and cannot serve as a reference spectrum for identity or purity testing. Downloads become active after Show.
Data is fetched once (JCAMP-DX parser) and stored in the plugin's local database. No duplicate downloads, no NIST queries on subsequent openings. Licences respected (only a deep link plus our own visualisation is published).
Data retrieved live from multiple sources (priority chain). JCAMP-DX / CSV / PNG available for download under each spectrum.
IR — Fourier-transform infrared
Loading IR — Fourier-transform infrared…
MS — Mass spectrometry (EI 70eV)
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🔎 Spectrum Search (JCAMP-DX)
Upload a JCAMP-DX file (.jdx, .dx, .jcm) — the system will calculate the cosine similarity against all spectra in the database and display the TOP 10 matches.
📚 Bibliography (Chicago)
McLafferty, Fred W., ed. 2018. Wiley Registry of Mass Spectral Data. 11th ed. Hoboken, NJ: Wiley. A reference MS library (~775k spectra).
Stein, Stephen E., and Donald R. Scott. 1994. "Optimization and Testing of Mass Spectral Library Search Algorithms for Compound Identification." Journal of the American Society for Mass Spectrometry 5 (9): 859–866. The cosine + dot-product algorithm of NIST MS Search.
McDonald, Robert S., and Paul A. Wilks Jr. 1988. "JCAMP-DX: A Standard Form for Exchange of Infrared Spectra in Computer Readable Form." Applied Spectroscopy 42 (1): 151–162. The JCAMP-DX specification (extended to 5.01 for NMR/MS).
McLafferty, Fred W., and František Tureček. 1993. "Interpretation of Mass Spectra." 4th ed. Mill Valley, CA: University Science Books. Cosine-similarity matching and MS fragmentation — the foundation of the search algorithm.
Sumner, Lloyd W., Alexander Amberg, Dave Barrett, Michael H. Beale, Richard Beger, Clare A. Daykin, Teresa W.-M. Fan, et al. 2007. "Proposed Minimum Reporting Standards for Chemical Analysis." Metabolomics 3 (3): 211–221. MSI Level 1-4 — confidence-level standards for spectral matching.
Stein, Stephen E. 1999. "An Integrated Method for Spectrum Extraction and Compound Identification from Gas Chromatography/Mass Spectrometry Data." Journal of the American Society for Mass Spectrometry 10 (8): 770–781. The AMDIS algorithm — deconvolution + library match (NIST).
Lindon, John C., George E. Tranter, and David W. Koppenaal, eds. 2017. "Encyclopedia of Spectroscopy and Spectrometry." 3rd ed. Amsterdam: Academic Press. Encyclopedia entries on spectral library searching.
Smith, Brian C. 2011. "Fundamentals of Fourier Transform Infrared Spectroscopy." 2nd ed. Boca Raton, FL: CRC Press. FT-IR and the JCAMP-DX format for transmission spectra.
Larkin, Peter. 2017. "Infrared and Raman Spectroscopy: Principles and Spectral Interpretation." 2nd ed. Amsterdam: Elsevier. Principles of IR/Raman library matching and peak preprocessing.
Structural properties
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❓ Frequently asked questions (3)
What is Dibutyltin dichloride?
Dibutyltin dichloride (CAS 683-18-1) is a chemical compound with the molecular formula C₈H₁₈Cl₂Sn and a molecular weight of 303.84 g/mol.
Helpful?
What is the CAS number of Dibutyltin dichloride?
The CAS number for Dibutyltin dichloride is 683-18-1.
Helpful?
What is the chemical formula of Dibutyltin dichloride?
The molecular formula of Dibutyltin dichloride is C₈H₁₈Cl₂Sn.
Helpful?
➕ Suggest a question
Download structure files
Molecular structure files from the PubChem database (NIH). Compatible with Avogadro, PyMOL, Jmol, and ChemDraw.
Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
g/L ↔ molarity
c (mol/L) = (g/L) / MW
±0.1% (depends on MW precision)
Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
mmol/L ↔ molarity
c (mol/L) = mmol/L × 10⁻³
Exact
Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
Celsius ↔ Kelvin
T(K) = t(°C) + 273.15
±0.01 K (ITS-90 scale)
BIPM (Bureau International des Poids et Mesures) (2019)
Celsius ↔ Fahrenheit
T(°F) = T(°C) × 9/5 + 32
±0.1 °F
Thompson A, Taylor BN (2008)
density-corrected % ↔ molarity
c (mol/L) = (%w/w × ρ × 10) / MW, ρ in g/mL
±0.1% when ρ known to 3 decimals
Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
📚 Bibliography (8 authoritative sources)
Thompson A, Taylor BN (2008). Guide for the Use of the International System of Units (SI). NIST Special Publication 811 · DOI: 10.6028/NIST.SP.811-2008 → Primary SI standard for US scientific usage
Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007). Quantities, Units and Symbols in Physical Chemistry — The IUPAC Green Book. RSC Publishing, 3rd ed. · DOI: 10.1039/9781847557889 · ISBN: 978-0-85404-433-7 → Canonical IUPAC guide for chemistry quantities/units
BIPM (Bureau International des Poids et Mesures) (2019). The International System of Units (SI), 9th edition. BIPM · ↗ → International SI definitions (incl. redefined kilogram 2019)
ISO/IEC (2022). Quantities and units — Part 1: General. International Organization for Standardization — ISO 80000-1:2022 · ↗ → General rules for physical quantities and units
ISO/IEC (2019). Quantities and units — Part 9: Physical chemistry and molecular physics. International Organization for Standardization — ISO 80000-9:2019 · ↗ → Concentration / molality / amount-of-substance conventions
Tiesinga E, Mohr PJ, Newell DB, Taylor BN (2021). CODATA recommended values of the fundamental physical constants: 2018. Rev. Mod. Phys. 93(2):025010 · DOI: 10.1103/RevModPhys.93.025010 → Avogadro, gas constant, molar volume (2019 SI revision)
IUPAC (2019). Compendium of Chemical Terminology — the IUPAC Gold Book (online). IUPAC · DOI: 10.1351/goldbook → Definitions of mass fraction, molality, normality, ppm, activity
Mills IM, Cvitaš T, Homann K, Kallay N, Kuchitsu K (1988). Quantities, Units and Symbols in Physical Chemistry. Blackwell Scientific Publications, 1st ed. · ISBN: 0-632-01773-5 → Historical predecessor of IUPAC Green Book
Data limitations notice. The safety information on this page is for reference only and does not replace a full safety data sheet (SDS). Before using the product, consult the manufacturer's current safety data sheet and the GHS/CLP guidance. The CLP classification applies to the pure bulk substance, not to commercial formulations.
GHS/CLP classification — Regulation (EC) No 1272/2008 + UN GHS Rev. 9 (2021).
H360FD — May damage fertility. May damage the unborn child
H330 — Fatal if inhaled
H312 — Harmful in contact with skin
H301 — Toxic if swallowed
H372 — Causes damage to organs through prolonged or repeated exposure
H314 — Causes severe skin burns and eye damage
H400 — Very toxic to aquatic life
H410 — Very toxic to aquatic life with long lasting effects
🛡 Precautionary statements (P)
P203 — Obtain, read and follow all safety instructions before use
✓ Harmonised classification pursuant to Annex VI of the CLP Regulation (EC) 1272/2008 (official, binding classification). Index number: 050-022-00-X.
Reference (Chicago): European Chemicals Agency. "dibutyltin dichloride; (DBTC), Index No. 050-022-00-X." In Table 3 of Annex VI to Regulation (EC) No 1272/2008 (CLP Regulation), 23rd Adaptation to Technical Progress (harmonised list as of 2026-07-07). Helsinki: European Chemicals Agency, 2026. https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp.
Translations: CLP Regulation (EC) 1272/2008, Annexes III and IV. Data: PubChem/NLM.
☢️ Toxicological data (IARC + EPA CTX)
🧬 IARC Carcinogen Classification
IARC classification:
No individual IARC entry for this CAS
No separate IARC monograph in the checked lists — this is NOT confirmation of a lack of carcinogenicity. Check the CLP/GHS classification (CMR / GHS section).
The codes below are additional supplier self-classifications (self-classification, ECHA C&L / PubChem notifications) — supplementary to the binding harmonized Annex VI classification above; they may be redundant.
Lu Y, Tang H, Wang X et al.. (2022). "Dibutyltin dichloride exposure affects mouse oocyte quality by inducing spindle defects and mitochondria dysfunction.". Chemosphere. https://doi.org/10.1016/j.chemosphere.2022.133959 [DOI]
Xu X, Yu H, Sun L et al.. (2020). "Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway.". Molecular medicine reports. https://doi.org/10.3892/mmr.2020.10995 [DOI]
Lütt F, Ehlers L, Nizze H et al.. (2020). "Different characteristics of chronic dibutyltin dichloride-induced pancreatitis and cholangitis in mouse and rat.". Hepatobiliary & pancreatic diseases international : HBPD INT. https://doi.org/10.1016/j.hbpd.2019.10.007 [DOI]
Xiande Huang, Taoye Ma, Yongsheng Yin. (2018). "Dibutyltin Dichloride Retards Leydig Cell Developmental Regeneration in Adult Rat Testis". Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2018.01320 [DOI]
Lee JM, Lee KG, Choi HS et al.. (2018). "Increased heat shock protein 70 expression attenuates pancreatic fibrosis induced by dibutyltin dichloride.". Scandinavian journal of gastroenterology. https://doi.org/10.1080/00365521.2018.1516799 [DOI]
Furukawa S, Tsuji N, Kobayashi Y et al.. (2017). "Effect of dibutyltin on placental and fetal toxicity in rat.". The Journal of toxicological sciences. https://doi.org/10.2131/jts.42.741 [DOI]
M Ema. (2003). "Protective effects of progesterone on implantation failure induced by dibutyltin dichloride in rats". Toxicology Letters. https://doi.org/10.1016/s0378-4274(03)00152-8 [DOI]
Nagashio Y, Hirohata Y, Akiyama T et al.. (2002). "Dibutyltin dichloride modifies amylase release from isolated rat pancreatic acini.". Pancreas. https://doi.org/10.1097/00006676-200207000-00014 [DOI]
M Ema. (2000). "Adverse effects of dibutyltin dichloride on initiation and maintenance of rat pregnancy". Reproductive Toxicology. https://doi.org/10.1016/s0890-6238(00)00095-2 [DOI]
K.W. Thomulka, J.H. Lange. (1996). "A Mixture Toxicity Study Employing Combinations of Tributyltin Chloride, Dibutyltin Dichloride, and Tin Chloride Using the Marine BacteriumVibrio harveyias the Test Organism". Ecotoxicology and Environmental Safety. https://doi.org/10.1006/eesa.1996.0047 [DOI]
J. Merkord, G. Hennighausen. (1989). "Acute pancreatitis and bile duct lesions in rat induced by dibutyltin dichloride". Experimental pathology. https://doi.org/10.1016/s0232-1513(89)80113-6 [DOI]
A.P. Li, A.R. Dahl, J.O. Hill. (1982). "In vitro cytotoxicity and genotoxicity of dibutyltin dichloride and dibutylgermanium dichloride". Toxicology and Applied Pharmacology. https://doi.org/10.1016/0041-008x(82)90245-9 [DOI]
R. T. Skeel, C. E. Bricker. (1961). "Spectrophotometric Determination of Dibutyltin Dichloride". Analytical Chemistry. https://doi.org/10.1021/ac60171a036 [DOI]
International Agency for Research on Cancer (IARC). 2024. "IARC Monographs on the Identification of Carcinogenic Hazards to Humans." Lyon: IARC. 🔗
U.S. EPA. 2024. "ECOTOX Knowledgebase." Washington, DC: U.S. Environmental Protection Agency. 🔗
🚨 Emergency procedure — chemical spillToxic
CAS 683-18-1GHS:H341H360FDH330H312H301H372H314H400H410⚠️ EVACUATION (10m)💨 Ventilation
🥽 PPE — Personal protective equipment
Goggles:Yes
Suit:lab coat
Face shield:Yes
Respirator:SCBA (self-contained breathing apparatus) — EN 137:2006
📦 Small spill (<1L) — absorbent: inert mineral / HEPA-filter vacuum (for dusts)
⚠️ GENERIC procedure derived from the GHS classification (no curated data for this CAS). Always follow the supplier's current Safety Data Sheet (SDS).
1. Restrict access; ventilate.
2. Resistant PPE + respiratory protection (dust: P2/P3 half-mask; vapors: per SDS).
3. Collect mechanically into a sealed, labeled container; minimize dust/vapor generation.
4. Wash the area with water; treat residues and absorbent as hazardous waste.
Additional properties from GHS:
• corrosive (e.g. H314) — protect skin and eyes, neutralize
• health hazard (CMR / STOT / aspiration) — minimize exposure
• irritant — avoid skin/eye contact and dust inhalation
• hazardous to the environment — prevent entry into drains, soil and water
🛢️ Large spill (>1L) ⚠️ Hazardous material
1. Evacuate; entry only in full PPE with respiratory protection.
2. Contain; avoid raising dust and dispersing the substance.
3. Collect mechanically into a labeled UN container; hand over to an authorized company (BDO — national rule, Poland).
4. Report the incident per the OHS procedure; on release to the environment notify the Regional Environmental Inspectorate (WIOŚ) (national rule — Poland).
🩹 First aid
🧴 Skin
1. Remove contaminated clothing.
2. Rinse the skin with plenty of water for ≥15 min.
3. Do NOT neutralize on the skin; burns → hospital.
3. The substance may be absorbed through the skin — monitor symptoms / see a doctor.
👁️ Eyes
1. Rinse IMMEDIATELY for ≥30 min, eyelids held open; remove contact lenses.
2. ALWAYS see an ophthalmologist.
🫁 Inhalation
1. Move the casualty to fresh air, comfortable position.
2. If short of breath — oxygen / doctor.
3. Delayed pulmonary edema possible — observe.
🍽️ Ingestion
1. Rinse the mouth with water; do NOT induce vomiting.
2. Poison Control Center (Poland): +48 42 631 47 24.
3. Drink water/milk; do NOT give NaHCO3 (CO2 → perforation risk).
🌍 Environment:
Water: High; Soil: Medium; ❌ Do not release into drains; Waste Code: 16 05 06*
📚 Scientific references (Chicago Author-Date) — 8
European Chemicals Agency (ECHA). 2020. Guidance on the Compilation of Safety Data Sheets — Section 6: Accidental Release Measures. ECHA.
[link ↗]
European Parliament and Council. 2008. Regulation (EC) No 1272/2008 (CLP) — Hazard classes and H-statements. Official Journal of the European Union L 353.
[link ↗]
National Institute for Occupational Safety and Health (NIOSH). 2023. Pocket Guide to Chemical Hazards — NIOSH Pocket Guide to Chemical Hazards. CDC.
[link ↗]
U.S. Occupational Safety and Health Administration. 2024. 29 CFR 1910.120 — Hazardous Waste Operations and Emergency Response (HAZWOPER). U.S. Code of Federal Regulations.
[link ↗]
National Fire Protection Association. 2018. NFPA 472: Standard for Competence of Responders to Hazardous Materials/Weapons of Mass Destruction Incidents. NFPA.
[link ↗]
European Parliament and Council. 2012. Directive 2012/18/EU on the Control of Major-Accident Hazards Involving Dangerous Substances (Seveso III). Official Journal of the European Union L 197: 1–37.
[link ↗]
U.S. National Institute for Occupational Safety and Health. 2024. NIOSH Pocket Guide to Chemical Hazards. Centers for Disease Control and Prevention.
[link ↗]
European Chemicals Agency. 2020. Guidance on the Compilation of Safety Data Sheets (SDS), Version 3.1. ECHA.
[link ↗]
Sources: GHS/CLP classification (PubChem/SDS) — generic fallback · ECHA Guidance on SDS (section 6) · NIOSH Pocket Guide.
Indicative data only — in an emergency, always follow the supplier's instructions and local occupational health and safety (OHS) regulations.
☠️ Visual PPE guide (personal protective equipment)Toxic
🧤 Gloves
Double nitrile (double-glove) >0.2 mm (each layer) EN 374-1 typ B
Replace every 30 min or immediately after contact
👁️ Safety Glasses / Goggles
EN 166 B
Full side protection; sealed goggles for toxic dusts
🥼 Lab Coat / Coverall
Full buttoned lab coat + disposable sleeves EN 13688
Airborne concentration < OEL (NDS) per Dz.U. 2024 item 1017
😷 Respirator Required
P2 half-mask (fine aerosols) or P3 (>10× OEL); full-face mask with A1B1E1K1-P3 filter for toxic organic vapors
📚 Scientific references (Chicago Author-Date)
European Committee for Standardization (CEN). 2016. EN 374-1:2016 — Protective gloves against dangerous chemicals and micro-organisms — Part 1: Terminology and performance requirements for chemical risks. CEN, Brussels. EN 374-1:2016. [link ↗] — Classification of chemical-resistant gloves type A/B/C; JKLPT permeation tests
European Committee for Standardization (CEN). 2001. EN 166:2001 — Personal eye-protection — Specifications. CEN, Brussels. EN 166:2001. [link ↗] — Markings: B = medium-energy impact, T = extreme temperatures, 9 = molten metals and hot solids
European Committee for Standardization (CEN). 2009. EN 14605:2005+A1:2009 — Protective clothing against liquid chemicals — Performance requirements for clothing with liquid-tight (Type 3) or spray-tight (Type 4) connections. CEN, Brussels. EN 14605:2009. [link ↗] — Type 3 (jet-tight) and Type 4 (spray-tight) protection against liquid chemicals
National Institute for Occupational Safety and Health (NIOSH). 2017. Recommendations for Chemical Protective Clothing: A Companion to the NIOSH Pocket Guide. U.S. Department of Health & Human Services / CDC. [link ↗] — Practical guide to CPC (chemical protective clothing) selection per substance and exposure scenario
Occupational Safety and Health Administration (OSHA). 2011. Personal Protective Equipment — General requirements. U.S. Department of Labor — 29 CFR 1910.132. 29 CFR 1910.132. [link ↗] — The employer must provide PPE + training + a documented written hazard assessment
ℹ️ Regulatory obligations checklist for CAS 683-18-1.
Status based on: ADR 2025 (Table A), REACH Annex XVII, CLP Annex VI (harmonised classification), hazard class from the m14-spill DB, SVHC, GIS and the Polish OEL list. Principle: no data = no claim (we do NOT declare "no restrictions" without a basis).
✅SDS (Safety Data Sheet) availablefulfilled
How to comply: Requirement: current SDS compliant with Reg. 1907/2006 (REACH) Annex II, 16-section format.
Legal basis: Regulation (EC) No 1907/2006 (REACH) Art. 31 + Annex II
▣Compliant CLP label (pictograms + signal word + H/P)required
How to comply: The label must include: GHS pictograms, the signal word (Danger/Warning), hazard (H) and precautionary (P) statements, and manufacturer details. Required since 2010 (substances) and 2015 (mixtures). For this substance a HARMONISED CLASSIFICATION applies (CLP Annex VI) — see below; it takes precedence over self-classification.
Legal basis: Regulation (EC) No 1272/2008 (CLP) Art. 17-33 + Annex VI (harmonised classification)
❓ADR transport (international agreement)to be verified
How to comply: No ADR data in the MOL-GOD dataset for this CAS number. Do NOT assume there are no restrictions — before shipping, verify the transport classification in ADR 2025 (Table A) and in section 14 of the safety data sheet (SDS).
Legal basis: ADR 2025 European Agreement + Polish Act of 19 August 2011 on the Transport of Dangerous Goods National rules — Poland
🔵REACH registration (>1 t/year EU import)conditional
How to comply: Importers/manufacturers ≥1 tonne/year must register the substance with ECHA (technical dossier + Chemical Safety Report if ≥10 t). Check the ECHA Annex VI / registered substances list.
Legal basis: Regulation (EC) No 1907/2006 (REACH) Art. 5-22
▣REACH Annex XVII (use/marketing restrictions)required
How to comply: Substance subject to a REACH Annex XVII restriction (entry 28–30): CMR category 1A/1B — not for supply to the general public (professional users only). Check the conditions for placing on the market/use and the note in SDS section 15.
Legal basis: Regulation (EC) No 1907/2006 (REACH) Annex XVII — restrictions on manufacture, placing on the market and use
⚠️ REACH Annex XVII (entry 28–30): CMR category 1A/1B — not for supply to the general public (professional users only).
European Parliament and Council. 2008. Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP). Official Journal of the European Union L 353/1. CLP Regulation 1272/2008. [link ↗] — Classification, labelling and packaging of substances + mixtures (GHS implementation in the EU)
European Parliament and Council. 2006. Regulation (EC) No 1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). Official Journal of the European Union L 396/1. REACH Regulation 1907/2006. [link ↗] — REACH — registration, evaluation and authorisation of chemicals; SVHC; SDS Annex II
Ministerstwo Rodziny i Polityki Społecznej Rzeczypospolitej Polskiej. 2024. Rozporządzenie Ministra Rodziny i Polityki Społecznej z dnia 4 września 2024 r. w sprawie najwyższych dopuszczalnych stężeń i natężeń czynników szkodliwych dla zdrowia w środowisku pracy. Dziennik Ustaw RP 2024 poz. 1017. National rules — Poland[link ↗] — NDS and NDSCh for ~600 chemical substances — current Polish occupational exposure limits
United Nations Economic Commission for Europe (UNECE). 2025. European Agreement concerning the International Carriage of Dangerous Goods by Road (ADR), 2025 Edition. United Nations, Geneva. ADR 2025. [link ↗] — International agreement on the road transport of dangerous goods — UN numbers, classes, packaging
📚 Consolidated scientific references — Chicago Author-Date 10 sources
References collected from all Safety Hub tabs. CAS: 683-18-1 ·
PubChem ↗
Parlament Europejski i Rada UE. 2008. "Regulation (EC) nr 1272/2008 w sprawie klasyfikacji, oznakowania i pakowania substancji (CLP)." Dz.Urz. UE L 353. [↗]
GHS, Regulations
United Nations Economic Commission for Europe (UNECE). 2021. "Globally Harmonized System of Classification and Labelling of Chemicals (GHS), Ninth Revised Edition." United Nations, Geneva. [↗]
GHS
Goldfrank, Lewis R., Robert S. Hoffman, Mary Ann Howland, et al.. 2019. "Goldfrank's Toxicologic Emergencies, 11th ed.." McGraw-Hill Education, New York. ISBN 978-1-25-985961-8.
First aid, Toxicology
National Institute for Occupational Safety and Health (NIOSH). 2023. "NIOSH Pocket Guide to Chemical Hazards (DHHS Publ. 2005-149)." U.S. Department of Health and Human Services / CDC, Cincinnati, OH. [↗]
First aid, PPE, Toxicology
European Committee for Standardization (CEN). 2016. "EN 374-1:2016 — Protective gloves against dangerous chemicals and micro-organisms." CEN, Brussels. [↗]
PPE
UNECE. 2023. "European Agreement Concerning the International Carriage of Dangerous Goods by Road (ADR 2025)." United Nations, Geneva. [↗]
Disposal, Regulations
National Fire Protection Association (NFPA). 2022. "NFPA 400 — Hazardous Materials Code." NFPA, Quincy, MA. [↗]
Storage
Urben, P.G. (ed.). 2017. "Bretherick's Handbook of Reactive Chemical Hazards, 8th ed.." Butterworth-Heinemann / Elsevier, Oxford. [↗]
Storage
Ministerstwo Klimatu i Środowiska RP. 2023. "Baza danych o produktach i opakowaniach oraz o gospodarce odpadami (BDO)." Ministerstwo Klimatu i Środowiska, Warszawa. National rules — Poland[↗]
Disposal
International Agency for Research on Cancer (IARC / WHO). 2024. "IARC Monographs on the Identification of Carcinogenic Hazards to Humans — List of Classifications." WHO, Lyon. [↗]
Toxicology
Tabs with their own references (Emergency, PPE, Storage, Waste) contain additional bibliographic entries within their respective sections.
Paste a series of replicate measurements (CSV, or one number per line). The calculator computes the mean, standard deviation and 95% CI, and detects outliers (Grubbs + Dixon Q).
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📐 Statistical formulas
x̄ = Σxᵢ / n — arithmetic mean
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s = √s² — standard deviation
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🧪 Solubility and solvent compatibility
Molecule
Dibutyltin dichloride
Formula
C₈H₁₈Cl₂Sn
logP (XLogP3)
—
Mass (g/mol)
303.84
Polarity
—
⚠️ GC estimate (Hoftyzer–Van Krevelen). No literature HSP data for this CAS — precision ±2 MPa½. Verify experimentally.
Solvent compatibility table not available for this substance.
The Hansen parameters fall outside the range of the method, so the distance Ra cannot be calculated, and the database holds no solubility measurement to put in its place. Rather than eleven ratings with nothing behind them, we show none. Base the solvent choice on the safety data sheet and on experimental data.
Solubility theory (applied in compatibility prediction):
Yalkowsky, Samuel H., and Shri C. Valvani. 1980. "Solubility and Partitioning I: Solubility of Nonelectrolytes in Water." Journal of Pharmaceutical Sciences 69 (8): 912–922. https://doi.org/10.1002/jps.2600690814 — General Solubility Equation (GSE): logS = 0.5 − logP − 0.01(MP−25).
Hansen, Charles M. 2007. Hansen Solubility Parameters: A User's Handbook. 2nd ed. CRC Press. https://doi.org/10.1201/9781420006834 — HSP triplet (dD, dP, dH) + Ra formula.
Stefanis, E., and C. Panayiotou. 2008. "Prediction of Hansen Solubility Parameters with a New Group-Contribution Method." Int J Thermophys 29: 568–585. https://doi.org/10.1007/s10765-008-0415-z
Reichardt, Christian, and Thomas Welton. 2011. Solvents and Solvent Effects in Organic Chemistry. 4th ed. Wiley-VCH. https://doi.org/10.1002/9783527632220 — E_T(30) polarity scale, solvatochromism.
Snyder, Lloyd R., Joseph J. Kirkland, and John W. Dolan. 2010. Introduction to Modern Liquid Chromatography. 3rd ed. Wiley. https://doi.org/10.1002/9780470508183 — Eluotropic series, polarity index.
Van Krevelen, D. W., and K. Te Nijenhuis. 2009. Properties of Polymers. 4th ed. Elsevier. https://doi.org/10.1016/B978-0-08-054819-7.X0001-5 — Hoftyzer–Van Krevelen group contribution for dD/dP/dH from SMILES.
Marcus, Yizhak. 1998. The Properties of Solvents. Wiley Series in Solution Chemistry, Vol. 4. ISBN 9780471983699 — Complete tabular set of 250+ solvents (ε, μ, donicity, acceptor numbers).
PubChem Compound Database — CAS 683-18-1 lookup ↗ — logP (XLogP3), water solubility experimental + predicted.
Full bibliography in the REFERENCES accordion (at the bottom of the page) — Chicago Manual of Style 17th ed., Author-Date.
🧮 Solubility calculator
Solubility:—
logS:—
Method:—
⚠️ —
Solubility vs temperature
🌐 Hansen Solubility Sphere (3D)
⚠️ The Hansen parameters for this substance fall outside the range of the method.
At least one of the δD/δP/δH parameters fell outside the domain of validity of the group contribution method (Hoftyzer–Van Krevelen), so the position of the molecule in Hansen space is unknown. The distance Ra is measured FROM THAT POINT — it cannot be calculated without knowing the point. The sphere and the distance table have been omitted rather than filled with numbers that have nothing behind them. Where a solubility measurement exists, it is shown in the table below.
Ra < R₀ = good miscibility · Ra < 1,5×R₀ = borderline · above = poor (R₀ — radius of the Hansen sphere of this molecule) Target molecule: δD=outside the method's range,
δP=outside the method's range,
δH=outside the method's range8
📊 Automatically extracted topics from the abstracts of 12 publications for CAS 683-18-1.
Algorithm: TF-IDF (Salton & Buckley 1988) — term frequency × inverse document frequency.
📊 Citation graph for CAS 683-18-1.
Each node = a research paper; an A→B edge = paper A cites B. Data from OpenAlex (Priem 2022).
⚡ Fetch network data
Network built on-demand from the OpenAlex API (24h cache).
Why this page can be checked
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Data
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Classification
Read against the harmonised entry where one exists, with the index number stated. Self-classification is shown separately and labelled.
Regulatory
Inventory, restriction, authorisation and candidate-list status, each stated individually. Where a status is not established, this page says so — it never says no restrictions apply.
Documentation
Which documents exist, at what review level, in which languages, and when each was issued.
Supplier
Who is selling this, and what they have published about themselves.
Nothing on this page is a certification. It is a record you can audit.
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If a signed card is rejected by an authority or by a customer’s compliance officer on one of the points we checked and reported as passed, we re-issue it corrected at no charge and credit the original fee.
This covers the checks we performed and named. It does not cover registration status, tonnage, or your role in the supply chain — those are not ours to hold, and a guarantee that pretended otherwise would be worth nothing.
For dibutyltin dichloride (CAS 683-18-1) the documentation obligation begins before the first shipment. This page sets out what the safety data sheet has to establish.
dibutyltin dichloride (CAS 683-18-1) at a glance
Substance – dibutyltin dichloride
CAS number – 683-18-1
EC number – 211-670-0
CLP Annex VI index number – 050-022-00-X
Also known as – (DBTC)
Hazard statements – H341 (suspected of causing genetic defects); H360FD (may damage fertility and the unborn child); H330 (fatal if inhaled); H312 (harmful in contact with skin); H301 (toxic if swallowed); H372 (causes damage to organs through prolonged or repeated exposure)
Concentration limits / M-factor / ATE – Skin Corr. 1B;H314: C ≥ 5.0%;Skin Irrit. 2;H315: 0.01% ≤ C < 5.0%;Eye Dam. 1;H318: 3.0% ≤ C < 5.0%;Eye Irrit. 2;H319: 0.01% ≤ C < 3.0%;M = 10
Entry current as of – ATP01
CMR classification – yes, classified as carcinogenic, mutagenic or toxic for reproduction
Documentation issued – safety data sheet in REACH Annex II structure; working draft or signed card
What is supplied – a document. MolGod.org does not sell, supply or ship chemical substances.
Is dibutyltin dichloride on the SVHC candidate list?
Yes — dibutyltin dichloride appears on the candidate list of substances of very high concern. That triggers duties that classification alone does not: notification to ECHA above the tonnage threshold, and an obligation to inform recipients where the substance is present in an article above 0.1 % by weight.
Aquatic hazard and disposal
Aquatic hazard classification (H400, H410) for CAS 683-18-1 reaches beyond the label. It governs the environmental section of the safety data sheet, the disposal route stated in section 13, and in several Member States the reporting threshold for storage. Consignments carrying an aquatic hazard also attract marine pollutant marking when moved by sea.
Which GHS pictograms apply to dibutyltin dichloride?
The label for dibutyltin dichloride carries GHS05 (corrosion), GHS06 (skull and crossbones), GHS08 (health hazard), GHS09 (environment), with the signal word Danger. These are not chosen by the supplier: CLP Annex VI states them for CAS 683-18-1, and the precedence rules in Annex I decide which pictogram is dropped when two would say the same thing. A label showing a different set from the register is wrong even if every hazard statement on it is correct.
Identifiers that must agree
Three identifiers travel with this substance and all three have to agree: CAS 683-18-1, the Annex VI index number 050-022-00-X, and the name as it appears in the register. Mismatched identifiers are the quietest defect in a documentation set, because every individual document looks correct and only a cross-check reveals that they describe different things.
What is the EC number for dibutyltin dichloride?
Alongside CAS 683-18-1, this substance carries EC number 211-670-0 and Annex VI index 050-022-00-X. European documentation is built around the EC number as often as around the CAS: registration dossiers, the candidate list and customs systems key on it. A safety data sheet quoting only one of the two forces every downstream reader to look up the other.
What is the CLP classification of dibutyltin dichloride?
The harmonised classification for CAS 683-18-1 carries 9 hazard statements: H341, H360FD, H330, H312, H301, H372, H314, H400, H410. In plain terms this means suspected of causing genetic defects; may damage fertility and the unborn child; fatal if inhaled; harmful in contact with skin. A harmonised entry is binding across the Union — an importer may not soften it, and a self-classification that diverges from it will not survive an enforcement check.
What must the label for dibutyltin dichloride contain?
The supply label for dibutyltin dichloride is generated from the same classification that drives the safety data sheet: pictograms selected by precedence, one signal word derived from the highest hazard class present, and the hazard statements H341, H360FD, H330… reproduced in full. Where the container is too small to carry the complete set at a legible size, there are lawful ways to handle it and unlawful ones that look identical to a non-specialist.
What concentration limits apply to dibutyltin dichloride?
The harmonised entry for dibutyltin dichloride carries specific concentration limits: H314: C ≥ 5 %; H315: 0,01 % ≤ C < 5 %; H318: 3 % ≤ C< 5 %; H319: 0,01 % ≤ C < 3 %. These override the generic cut-off values, so a mixture containing dibutyltin dichloride is classified against these figures and not against the default thresholds. M-factor on record: 10. The M-factor multiplies the contribution of this substance in the aquatic hazard calculation for a mixture, which is where it is most often overlooked.
How is dibutyltin dichloride classified for road, sea and air transport?
Transport classification for dibutyltin dichloride sits in section 14 and differs by mode: ADR for road, IMDG for sea, IATA for air. A sheet that prints all three without stating which applies leaves the shipper to choose, and the shipper is the one penalised for choosing wrong.
How do I check if my SDS for dibutyltin dichloride is still valid?
Prior to requesting documentation for dibutyltin dichloride, confirm whether the existing sheet is capable of undergoing an inspection. Perform a section-by-section evaluation against Annex II to assess compliance in a single pass; if it fulfils the requirements, the honest assessment will validate its validity.
Is dibutyltin dichloride classified as a CMR substance?
CAS 683-18-1 is classified as a CMR substance (H360FD). That status changes the obligations attached to every shipment: workplace exposure documentation, restrictions on supply to the general public, and substitution pressure from downstream users who must justify continued use. A safety data sheet for a CMR substance is read more closely than any other, because the classification itself invites scrutiny.
What Annex VI notes and concentration limits apply to dibutyltin dichloride?
The register also records Skin Corr. 1B;H314: C ≥ 5.0%;Skin Irrit. 2;H315: 0.01% ≤ C < 5.0%;Eye Dam. 1;H318: 3.0% ≤ C < 5.0%;Eye Irrit. 2;H319: 0.01% ≤ C < 3.0%;M = 10 for this entry. Specific concentration limits, M-factors and acute toxicity estimates override the generic cut-off values, so a mixture calculation that ignores them will classify the mixture wrongly in both directions.
Why a correct sheet stops being correct
Classification under CLP moves with each Adaptation to Technical Progress. A sheet for CAS 683-18-1 written before the amendment that touched its entry keeps stating a classification the register no longer holds. Nothing in the document announces this — it reads exactly as it did on the day it was issued, which is precisely why revision dates are checked before content.
Disposal route and waste classification
Disposal of dibutyltin dichloride and of its packaging is section 13, and it has to align with the classification: a substance with an aquatic hazard cannot be routed to drain, and the waste code assigned by the holder follows from the hazard profile, not from convenience.
Which SDS sections decide whether a shipment clears?
A sheet for CAS 683-18-1 must be read numerically rather than narratively; subsections carry equal weight as sections: an inspector seeking information under point 3.1 will not accept data folded into a paragraph elsewhere, irrespective of that paragraph’s completeness. Completeness is assessed initially by structure, then by content.
Questions about documentation for dibutyltin dichloride
Is dibutyltin dichloride a CMR substance?
Yes. The harmonised classification places it among substances classified as carcinogenic, mutagenic or toxic for reproduction, which changes workplace documentation and supply restrictions.
What hazard statements apply to CAS 683-18-1?
The harmonised entry lists H341, H360FD, H330, H312. These are binding across the Union and may not be softened by a self-classification.
In which language must the sheet be supplied?
In an official language of each Member State where dibutyltin dichloride is placed on the market, unless that State has stated otherwise.
Can I check whether my existing sheet is still valid?
Yes. A section-by-section reading against Annex II and the current harmonised entry establishes that in one pass, and a sheet that passes is reported as passing.
MolGod.org issues documentation and does not sell, supply or ship chemical substances. CAS 683-18-1 identifies the subject of this document.
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Nothing stops you sending a draft to anyone. "Not written for this" means exactly that: it carries no signature and no fields adapted to your company, so it will not answer the questions the recipient is about to ask.
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Who prepares the document
The document is generated by the MolGod engine from ECHA CLP Annex VI and the cited public sources, then read section by section by a qualified scientific reviewer with a degree in chemistry or a related scientific field.
What the review covers
The sheet is read section by section against the REACH Annex II structure. GHS classification and transport entries are checked against the sources cited in the document, and the sheet is adapted to the company, product grade and identified use you provide.
What is NOT verified
We do not test your material and we cannot confirm what is physically in your container: composition, concentration, impurities or manufacturing route. Those come from you and are reproduced as supplied.
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The signature records that a qualified scientific reviewer read the document. It is not a government approval, not an ECHA approval, and not a legal certification — no such certification exists for safety data sheets in the EU. A signature does not by itself make a document legally valid or make your business compliant.
What you receive
A PDF in the 16-section REACH Annex II structure, signed and dated, with version information and a list of anything we could not establish. Five rounds of corrections are included.
Delivery
Within 72 hours of receiving complete input from you. The clock pauses whenever we are waiting on an answer.
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Full refund before review begins. If the evidence is insufficient, you choose a refund, store credit or a gap report. See the refund policy.
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If the available evidence is insufficient to support a defensible document for this CAS number and your product specification, we will not invent the missing values. You may choose a refund, store credit or a documented gap report.
The supplier placing the substance or mixture on the market remains responsible for ensuring that the final safety data sheet matches the material, its identified uses and their legal role in the supply chain.
📚 Scientific references (Chicago Author-Date) — click to expand
Batch management and laboratory certification standards — 13 independent sources (ICH Q1/Q3/Q6/Q7/Q10 + ISO 17025 + WHO TRS + 21 CFR 211 + EMA + USP + Ph.Eur. + PIC/S + IPEC-PQG).
International Council for Harmonisation (ICH). 2000. "Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients." ICH Expert Working Group. [link ↗] — GMP for APIs — adopted by EMA, FDA, MHLW
International Organization for Standardization. 2017. "ISO/IEC 17025:2017 General requirements for the competence of testing and calibration laboratories." ISO. [link ↗] — Lab accreditation standard underpinning every CoA
World Health Organization. 2010. "WHO Good Manufacturing Practices for Pharmaceutical Products: Main Principles (WHO Technical Report Series No. 957, Annex 3)." WHO Press. [link ↗] — WHO TRS No. 957 — global reference for GMP
International Council for Harmonisation (ICH). 2003. "ICH Q1A(R2): Stability Testing of New Drug Substances and Products." International Council for Harmonisation. [link ↗] — Source for batch shelf-life and retest dating
International Council for Harmonisation (ICH). 2006. "ICH Q3A(R2): Impurities in New Drug Substances." ICH. [link ↗]
International Council for Harmonisation (ICH). 1999. "ICH Q6A: Specifications for New Drug Substances and Products." ICH. [link ↗] — CoA acceptance-criteria specification standard
International Council for Harmonisation (ICH). 2008. "ICH Q10: Pharmaceutical Quality System." ICH. [link ↗]
U.S. Food and Drug Administration. 2024. "21 CFR Part 211: Current Good Manufacturing Practice for Finished Pharmaceuticals." US Code of Federal Regulations. [link ↗] — US legal mandate (Subpart J — Records and Reports)
European Medicines Agency. 2014. "Guideline on Process Validation for Finished Products — Information and Data to Be Provided EMA/CHMP/CVMP/QWP/BWP/70278/2012." European Medicines Agency. [link ↗]
United States Pharmacopeial Convention. 2024. "United States Pharmacopeia and National Formulary, USP 47-NF 42." USP. [link ↗]
European Pharmacopoeia Commission. 2024. "European Pharmacopoeia 11th Edition." Council of Europe — EDQM. [link ↗]
Pharmaceutical Inspection Co-operation Scheme (PIC/S). 2021. "Guide to Good Manufacturing Practice for Medicinal Products PE 009-15." PIC/S Secretariat, Geneva. [link ↗] — Cross-recognized GMP for 54 inspectorates worldwide
International Pharmaceutical Excipients Council (IPEC) and Pharmaceutical Quality Group (PQG). 2017. "Joint IPEC-PQG Good Manufacturing Practices Guide for Pharmaceutical Excipients." IPEC-Americas. [link ↗] — Excipient-grade CoA standard for non-API ingredients
📜 Patents (public metadata)
no data
No public patent metadata was found for this substance in Crossref / OpenAlex at this time. Data will be updated automatically after the next cache refresh (24h).
📚 References (Chicago Author-Date) — click to expand
Lu Y, Tang H, Wang X et al.. (2022). "Dibutyltin dichloride exposure affects mouse oocyte quality by inducing spindle defects and mitochondria dysfunction.". Chemosphere. https://doi.org/10.1016/j.chemosphere.2022.133959
Xu X, Yu H, Sun L et al.. (2020). "Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway.". Molecular medicine reports. https://doi.org/10.3892/mmr.2020.10995
Lütt F, Ehlers L, Nizze H et al.. (2020). "Different characteristics of chronic dibutyltin dichloride-induced pancreatitis and cholangitis in mouse and rat.". Hepatobiliary & pancreatic diseases international : HBPD INT. https://doi.org/10.1016/j.hbpd.2019.10.007
Xiande Huang, Taoye Ma, Yongsheng Yin. (2018). "Dibutyltin Dichloride Retards Leydig Cell Developmental Regeneration in Adult Rat Testis". Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2018.01320
Lee JM, Lee KG, Choi HS et al.. (2018). "Increased heat shock protein 70 expression attenuates pancreatic fibrosis induced by dibutyltin dichloride.". Scandinavian journal of gastroenterology. https://doi.org/10.1080/00365521.2018.1516799
Furukawa S, Tsuji N, Kobayashi Y et al.. (2017). "Effect of dibutyltin on placental and fetal toxicity in rat.". The Journal of toxicological sciences. https://doi.org/10.2131/jts.42.741
M Ema. (2003). "Protective effects of progesterone on implantation failure induced by dibutyltin dichloride in rats". Toxicology Letters. https://doi.org/10.1016/s0378-4274(03)00152-8
Nagashio Y, Hirohata Y, Akiyama T et al.. (2002). "Dibutyltin dichloride modifies amylase release from isolated rat pancreatic acini.". Pancreas. https://doi.org/10.1097/00006676-200207000-00014
M Ema. (2000). "Adverse effects of dibutyltin dichloride on initiation and maintenance of rat pregnancy". Reproductive Toxicology. https://doi.org/10.1016/s0890-6238(00)00095-2
K.W. Thomulka, J.H. Lange. (1996). "A Mixture Toxicity Study Employing Combinations of Tributyltin Chloride, Dibutyltin Dichloride, and Tin Chloride Using the Marine BacteriumVibrio harveyias the Test Organism". Ecotoxicology and Environmental Safety. https://doi.org/10.1006/eesa.1996.0047
J. Merkord, G. Hennighausen. (1989). "Acute pancreatitis and bile duct lesions in rat induced by dibutyltin dichloride". Experimental pathology. https://doi.org/10.1016/s0232-1513(89)80113-6
A.P. Li, A.R. Dahl, J.O. Hill. (1982). "In vitro cytotoxicity and genotoxicity of dibutyltin dichloride and dibutylgermanium dichloride". Toxicology and Applied Pharmacology. https://doi.org/10.1016/0041-008x(82)90245-9
R. T. Skeel, C. E. Bricker. (1961). "Spectrophotometric Determination of Dibutyltin Dichloride". Analytical Chemistry. https://doi.org/10.1021/ac60171a036
World Intellectual Property Organization. 2024. "Patent Cooperation Treaty (PCT)." https://www.wipo.int/pct/.
U.S. Patent and Trademark Office. 2024. "USPTO Patent Public Search." https://ppubs.uspto.gov/.
European Patent Office. 2024. "Espacenet Patent Search." https://worldwide.espacenet.com/.
Newman, David J., and Gordon M. Cragg. 2020. "Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019." Journal of Natural Products 83 (3): 770-803.
Davies, Mark, Michał Nowotka, George Papadatos, et al. 2015. "ChEMBL Web Services: Streamlining Access to Drug Discovery Data and Utilities." Nucleic Acids Research 43 (W1): W612-W620.
Bickerton, G. Richard, Gaia V. Paolini, Jérémy Besnard, Sorel Muresan, and Andrew L. Hopkins. 2012. "Quantifying the Chemical Beauty of Drugs." Nature Chemistry 4 (2): 90-98.
Meanwell, Nicholas A. 2011. "Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design." Journal of Medicinal Chemistry 54 (8): 2529-2591.
Ertl, Peter, and Ansgar Schuffenhauer. 2009. "Estimation of Synthetic Accessibility Score of Drug-Like Molecules Based on Molecular Complexity and Fragment Contributions." Journal of Cheminformatics 1: 8.
Hopkins, Andrew L., and Colin R. Groom. 2002. "The Druggable Genome." Nature Reviews Drug Discovery 1 (9): 727-730.
Allison, John R., and Mark A. Lemley. 1998. "Empirical Evidence on the Validity of Litigated Patents." AIPLA Quarterly Journal 26 (3): 185-275.
Patani, George A., and Edmond J. LaVoie. 1996. "Bioisosterism: A Rational Approach in Drug Design." Chemical Reviews 96 (8): 3147-3176.
Lerner, Josh. 1994. "The Importance of Patent Scope: An Empirical Analysis." RAND Journal of Economics 25 (2): 319-333.
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📚 REFERENCES (Aggregate bibliography, Chicago Author-Date) 78 items
All scientific sources cited in the accordions above for CAS 683-18-1. Format: Chicago Manual of Style 17th ed., Author-Date system.
🗄️ Scientific databases
PubChem. n.d. PubChem Compound Summary: CAS 683-18-1. Bethesda, MD: National Center for Biotechnology Information (NCBI), National Library of Medicine.
AIST. n.d. Spectral Database for Organic Compounds (SDBS): CAS 683-18-1. Tsukuba, Japan: National Institute of Advanced Industrial Science and Technology. https://sdbs.db.aist.go.jp/.
Linstrom, Peter J., and William G. Mallard, eds. n.d. NIST Chemistry WebBook: NIST Standard Reference Database Number 69. Gaithersburg, MD: National Institute of Standards and Technology. https://doi.org/10.18434/T4D303.
European Chemicals Agency (ECHA). 2024. "Annex VI to Regulation (EC) No 1272/2008 (CLP) — Harmonised Classification and Labelling." ECHA, Helsinki / Official Journal of the European Union. https://echa.europa.eu/regulations/clp/clp-classification.
National Institute for Occupational Safety and Health (NIOSH). 2017. "Recommendations for Chemical Protective Clothing: A Companion to the NIOSH Pocket Guide." U.S. Department of Health & Human Services / CDC. https://www.cdc.gov/niosh/ncpc/default.html.
Connors, Kenneth A., Gordon L. Amidon, and Valentino J. Stella. 1986. Chemical Stability of Pharmaceuticals: A Handbook for Pharmacists, 2nd ed.. New York: Wiley. https://doi.org/10.1002/0471734683.
Rumble, John R., ed. 2019. CRC Handbook of Chemistry and Physics: 100th Edition. Boca Raton, FL: CRC Press. https://hbcp.chemnetbase.com/.
Stefanis, Emmanuel, and Costas Panayiotou. 2008. "Prediction of Hansen Solubility Parameters with a New Group-Contribution Method." International Journal of Thermophysics 29: 568-585. https://doi.org/10.1007/s10765-008-0415-z.
Stoll, Vincent S., and John S. Blanchard. 1990. "Buffers: Principles and Practice: In Methods in Enzymology, vol. 182." San Diego: Academic Press. https://doi.org/10.1016/0076-6879(90)82008-P.
European Parliament. 2008. "Regulation (EC) No 1272/2008 on Classification, Labelling and Packaging of Substances and Mixtures (CLP)." Official Journal of the European Union L 353: 1–1355.
United Nations. 2021. Globally Harmonized System of Classification and Labelling of Chemicals (GHS). 9th revised ed. ST/SG/AC.10/30/Rev.9. New York and Geneva: United Nations. https://unece.org/ghs-rev9-2021.
United States Pharmacopeial Convention. 2024. "USP <621> Chromatography." In United States Pharmacopeia and National Formulary, USP 47-NF 42. Rockville, MD: USP. https://www.uspnf.com/.
International Organization for Standardization. 2017. "ISO/IEC 17025:2017 General Requirements for the Competence of Testing and Calibration Laboratories." Geneva: ISO. https://www.iso.org/standard/66912.html.
Kolthoff, Izaak Maurits, and Philip J. Elving, eds. 1978. Treatise on Analytical Chemistry, Part I: Theory and Practice. 2nd ed. New York: Wiley-Interscience.
Skoog, Douglas A., F. James Holler, and Stanley R. Crouch. 2018. Principles of Instrumental Analysis. 7th ed. Boston: Cengage Learning.
Christian, Gary D., Purnendu K. Dasgupta, and Kevin A. Schug. 2014. Analytical Chemistry. 7th ed. Hoboken, NJ: Wiley.
International Organization for Standardization. 1994. "ISO 5725-2:1994 Accuracy (Trueness and Precision) of Measurement Methods and Results — Part 2: Basic Method for the Determination of Repeatability and Reproducibility of a Standard Measurement Method." Geneva: ISO. https://www.iso.org/standard/11834.html.
Heckert, N. A., and J. J. Filliben. 2003. "NIST/SEMATECH e-Handbook of Statistical Methods." NIST Handbook 151. Gaithersburg, MD: National Institute of Standards and Technology. https://www.itl.nist.gov/div898/handbook/.
Grubbs, Frank E. 1950. "Sample Criteria for Testing Outlying Observations." Annals of Mathematical Statistics 21 (1): 27–58.
Dixon, Wilfrid J. 1950. "Analysis of Extreme Values." Annals of Mathematical Statistics 21 (4): 488–506.
Snedecor, George W., and William G. Cochran. 1989. Statistical Methods. 8th ed. Ames, IA: Iowa State University Press.
Student [William Sealy Gosset]. 1908. "The Probable Error of a Mean." Biometrika 6 (1): 1–25.
International Organization for Standardization. 2005. "ISO 3534-1:2006 Statistics — Vocabulary and Symbols — Part 1: General Statistical Terms and Terms Used in Probability." Geneva: ISO. https://www.iso.org/standard/40145.html.
Thompson, Michael, Stephen L. R. Ellison, and Roger Wood. 2002. "Harmonized Guidelines for Single-Laboratory Validation of Methods of Analysis." Pure and Applied Chemistry 74 (5): 835–855.
United Nations Economic Commission for Europe. 2024. European Agreement Concerning the International Carriage of Dangerous Goods by Road (ADR), Applicable as from 1 January 2025 (ECE/TRANS/352). Geneva: UNECE. https://unece.org/transport/dangerous-goods/adr-2025-edition.
Ministerstwo Klimatu i Środowiska Rzeczypospolitej Polskiej. 2020. "Rozporządzenie Ministra Klimatu z dnia 2 stycznia 2020 r. w sprawie katalogu odpadów." Dziennik Ustaw RP 2020 poz. 10. https://isap.sejm.gov.pl/isap.nsf/DocDetails.xsp?id=WDU20200000010. National rules — Poland
Główny Inspektorat Ochrony Środowiska (GIOŚ). 2024. "Baza Danych O Odpadach (BDO) — System rejestracji firm utylizacyjnych." Ministerstwo Klimatu i Środowiska. https://bdo.mos.gov.pl/. National rules — Poland
International Organization for Standardization. 2017. "ISO/IEC 17025:2017 General requirements for the competence of testing and calibration laboratories." ISO. https://www.iso.org/standard/66912.html.
World Health Organization. 2010. "WHO Good Manufacturing Practices for Pharmaceutical Products: Main Principles (WHO Technical Report Series No. 957, Annex 3)." WHO Press. https://www.who.int/publications/m/item/trs957-annex3.
Pharmaceutical Inspection Co-operation Scheme (PIC/S). 2021. "Guide to Good Manufacturing Practice for Medicinal Products PE 009-15." PIC/S Secretariat, Geneva. https://picscheme.org/en/publications.
📜 License & provenancePREDICTED MODEL · NOT VERIFIED
PREDICTED MODEL — NOT VERIFIED computed by MolGod Scientific · experimental feature (beta) · may contain errors
No source 3-D conformer was available to MolGod for this substance. MolGod Scientific computed this geometry from the structural formula with RDKit 2026.03.6 (ETKDGv3 conformer generation, UFF force-field optimisation; lowest-energy converged conformer of a fixed-seed set). It is not a measured structure, it does not come from PubChem, and it has not been compared with experimental data. It shows one possible conformation.
Methods and references
RDKit: Open-source cheminformatics, version 2026.03.6. Zenodo. doi:10.5281/zenodo.22140358 (all versions: doi:10.5281/zenodo.591637)
Riniker S, Landrum GA. Better Informed Distance Geometry: Using What We Know To Improve Conformation Generation. J. Chem. Inf. Model. 2015, 55, 2562-2574. doi:10.1021/acs.jcim.5b00654
Wang S, Witek J, Landrum GA, Riniker S. Improving Conformer Generation for Small Rings and Macrocycles Based on Distance Geometry and Experimental Torsional-Angle Preferences. J. Chem. Inf. Model. 2020, 60, 2044-2058. doi:10.1021/acs.jcim.0c00025
Rappe AK, Casewit CJ, Colwell KS, Goddard WA III, Skiff WM. UFF, a full periodic table force field for molecular mechanics and molecular dynamics simulations. J. Am. Chem. Soc. 1992, 114, 10024-10035. doi:10.1021/ja00051a040
Heller SR, McNaught A, Pletnev I, Stein S, Tchekhovskoi D. InChI, the IUPAC International Chemical Identifier. J. Cheminform. 2015, 7, 23. doi:10.1186/s13321-015-0068-4
