nickel-bissulfamidate-CAS-13770-89-3-—-Safety-Data-Sheet CAS_NUMBER 13770-89-3 (zh_CN)

nickel bis(sulfamidate) (CAS 13770-89-3) — Safety Data Sheet

Safety data sheet documentation for nickel bis(sulfamidate) (CAS 13770-89-3), compiled to REACH Annex II with classification read against the harmonised entry in CLP Annex VI (H350i, H341, H360D, H302). Two options: a working draft sent by e-mail immediately, or a signed card issued within 72 hours of complete input. The item supplied is a document — MolGod.org does not sell, supply or ship chemical substances.

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🧬 3D分子可视化器
正在加载分子...
3D模型Nickel sulfamate，CAS 13770-89-3，分子式H₄N₂NiO₆S₂, 摩尔质量 250.87 g/mol

数据转录自法规登记册和专业文献，并注明来源与版本。不能替代供应商的安全数据表。未记录来源的字段已作相应标注。

📊 物理化学数据 — CAS 13770-89-3
📊 物理化学性质

快速参考

化学式： H₄N₂NiO₆S₂
分子量： 250.87 g/mol
CAS号： 13770-89-3
🔬 高级属性

化学标识符

SMILES: NS(=O)(=O)[O-].NS(=O)(=O)[O-].[Ni+2]

最后更新： 2026-08-25

化学概述: Nickel sulfamate
分子式H₄N₂NiO₆S₂[1]
分子量250.87 g/mol[1]
IUPAC名称nickel(2+) disulfamate[1]
SMILESNS(=O)(=O)[O-].NS(=O)(=O)[O-].[Ni+2][1]
InChIKeyKERTUBUCQCSNJU-UHFFFAOYSA-L[1]

同义词: Nickel sulfamate · 13770-89-3 · nickel(2+) disulfamate · Sulfamic acid, nickel(2+) salt (2:1) · EINECS 237-396-1

数据来源： PubChem (NLM/NIH)
最后更新： 2026-08-25

📚 科学参考文献（芝加哥作者-日期格式） (1 来源)
  1. PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. ↗ applies to: 分子式 · 分子量 · IUPAC名称 · SMILES · InChIKey

科学研究

[1]PubMed2025
Targeting Mycolic Acid Biosynthesis with Cyclic Sulfamates: A New Strategy against Mycobacterium tuberculosis.
Bartolomeu Halicki PC, Kim JH, Griffin AF et al.. (2025). "Targeting Mycolic Acid Biosynthesis with Cyclic Sulfamates: A New Strategy against Mycobacterium tuberculosis.". ACS infectious diseases. htt
查看完整研究 ↗
[2]PubMed2025
A single amino acid substitution in TAS1R2 defines species-specific sweet sensitivity to sulfamates in humans and mice.
Sanematsu K, Nagasato Y, Lee Y et al.. (2025). "A single amino acid substitution in TAS1R2 defines species-specific sweet sensitivity to sulfamates in humans and mice.". Food chemistry. https://doi.or
查看完整研究 ↗
[3]PubMed2024
An overview of the latest outlook of sulfamate derivatives as anticancer candidates (2020-2024).
Mustafa EM, Shahin AI, Alrashed AS et al.. (2024). "An overview of the latest outlook of sulfamate derivatives as anticancer candidates (2020-2024).". Archiv der Pharmazie. https://doi.org/10.1002/ard
查看完整研究 ↗
[4]PubMed2023
Novel anti-Acanthamoebic properties of raloxifene sulfonate/sulfamate derivatives.
Siddiqui R, El-Gamal MI, Sajeev S et al.. (2023). "Novel anti-Acanthamoebic properties of raloxifene sulfonate/sulfamate derivatives.". Molecular and biochemical parasitology. https://doi.org/10.1016/
查看完整研究 ↗
[5]PubMed2023
2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca(2+) entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis.
Hosang L, Löhndorf A, Dohle W et al.. (2023). "2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca(2+) entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis.".
查看完整研究 ↗
[6]PubMed2022
Adenosine sulfamates: Next generation of antimalarials.
Sundararaman SA, Odom John AR. (2022). "Adenosine sulfamates: Next generation of antimalarials.". Cell host & microbe. https://doi.org/10.1016/j.chom.2022.07.007
查看完整研究 ↗
[7]PubMed2022
The Design, Structure-Activity, and kinetic studies of 3-Benzyl-5-oxa-1,2,3,4-Tetrahydro-2H-chromeno-(3,4-c)pyridin-8-yl sulfamates as Steroid sulfatase inhibitors.
Chang CN, Lin IC, Lin TS et al.. (2022). "The Design, Structure-Activity, and kinetic studies of 3-Benzyl-5-oxa-1,2,3,4-Tetrahydro-2H-chromeno-(3,4-c)pyridin-8-yl sulfamates as Steroid sulfatase inhib
查看完整研究 ↗
[8]PubMed2021
Biosynthesis of sulfonamide and sulfamate antibiotics in actinomycete.
Awakawa T, Barra L, Abe I. (2021). "Biosynthesis of sulfonamide and sulfamate antibiotics in actinomycete.". Journal of industrial microbiology & biotechnology. https://doi.org/10.1093/jimb/kuab001
查看完整研究 ↗
📚 科学参考文献（芝加哥作者-日期格式） 12 refs · 2 baz

MOLECULE 按CAS号参考文献（实时来自13+数据库）

来源： db:pubmed (11) · db:crossref (1)

  1. db:pubmed Bartolomeu Halicki PC, Kim JH, Griffin AF et al.. (2025). "Targeting Mycolic Acid Biosynthesis with Cyclic Sulfamates: A New Strategy against Mycobacterium tuberculosis.". ACS infectious diseases. https://doi.org/10.1021/acsinfecdis.5c00419 →
  2. db:pubmed Sanematsu K, Nagasato Y, Lee Y et al.. (2025). "A single amino acid substitution in TAS1R2 defines species-specific sweet sensitivity to sulfamates in humans and mice.". Food chemistry. https://doi.org/10.1016/j.foodchem.2025.145563 →
  3. db:pubmed Mustafa EM, Shahin AI, Alrashed AS et al.. (2024). "An overview of the latest outlook of sulfamate derivatives as anticancer candidates (2020-2024).". Archiv der Pharmazie. https://doi.org/10.1002/ardp.202400331 →
  4. db:pubmed Siddiqui R, El-Gamal MI, Sajeev S et al.. (2023). "Novel anti-Acanthamoebic properties of raloxifene sulfonate/sulfamate derivatives.". Molecular and biochemical parasitology. https://doi.org/10.1016/j.molbiopara.2023.111582 →
  5. db:pubmed Hosang L, Löhndorf A, Dohle W et al.. (2023). "2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca(2+) entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis.". Biochimica et biophysica acta. Molecular cell research. https://doi.org/10.1016/j.bbamcr.2023.119485 →
  6. db:pubmed Sundararaman SA, Odom John AR. (2022). "Adenosine sulfamates: Next generation of antimalarials.". Cell host & microbe. https://doi.org/10.1016/j.chom.2022.07.007 →
  7. db:pubmed Chang CN, Lin IC, Lin TS et al.. (2022). "The Design, Structure-Activity, and kinetic studies of 3-Benzyl-5-oxa-1,2,3,4-Tetrahydro-2H-chromeno-(3,4-c)pyridin-8-yl sulfamates as Steroid sulfatase inhibitors.". Bioorganic chemistry. https://doi.org/10.1016/j.bioorg.2022.106148 →
  8. db:pubmed Awakawa T, Barra L, Abe I. (2021). "Biosynthesis of sulfonamide and sulfamate antibiotics in actinomycete.". Journal of industrial microbiology & biotechnology. https://doi.org/10.1093/jimb/kuab001 →
  9. db:pubmed Mazo N, Navo CD, Peregrina JM et al.. (2020). "Selective modification of sulfamidate-containing peptides.". Organic & biomolecular chemistry. https://doi.org/10.1039/d0ob01061h →
  10. db:pubmed Potter BVL. (2018). "SULFATION PATHWAYS: Steroid sulphatase inhibition via aryl sulphamates: clinical progress, mechanism and future prospects.". Journal of molecular endocrinology. https://doi.org/10.1530/JME-18-0045 →
  11. db:pubmed Winum JY, Scozzafava A, Montero JL et al.. (2005). "Sulfamates and their therapeutic potential.". Medicinal research reviews. https://doi.org/10.1002/med.20021 →
  12. db:crossref (2004). "Nickel ( II ) Sulfamate 13770‐89‐3". Sax's Dangerous Properties of Industrial Materials. https://doi.org/10.1002/0471701343.sdp18463 →
物质监管状态
该物质受监管要求约束： 危险废物管理（BDO——波兰国家规定）. 详细信息请参见“法规状态（REACH/ECHA/CLP）”章节及安全数据表。 监管信息——不限制在本店购买。
🧮 化学计量计算器
🧪 化学数据
CAS号
13770-89-3
分子式
H₄N₂NiO₆S₂
摩尔质量
250.87 g/mol
IUPAC名称 (EN)
nickel(2+) disulfamate
SMILES
NS(=O)(=O)[O-].NS(=O)(=O)[O-].[Ni+2]
InChIKey
KERTUBUCQCSNJU-UHFFFAOYSA-L
📚 Related literature (5 篇文章)

Matched automatically from public bibliographic databases by text similarity. Not curated for this substance, and not part of the safety data sheet.

Alok Kumar Chaudhari, V.B. Singh · (2014) · International Journal of Electrochemical Science
ZHAO Yaomin, WU Xueling, FANG Xiangqian et al. · (2020) · Jin'gangshi yu moliao moju gongcheng
A. Hankin, G. H. Kelsall · (2012) · Journal of Applied Electrochemistry
Don Baudrand · (1996) · Metal Finishing
M. Saitou · (2016) · International Journal of Electrochemical Science
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📡 Data sources

The data in this widget comes from the following verified scientific sources:

  • PubChem — National Center for Biotechnology Information (NCBI/NIH), USA
  • ChEMBL — European Bioinformatics Institute (EMBL-EBI), UK
  • NIST WebBook — National Institute of Standards and Technology, USA

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🔍 外部标识符
9 / 16个ID系统56%
数据库标识符操作
CAS Registry Number13770-89-3打开 →
PubChem CID83720[1]打开 →
InChIKeyKERTUBUCQCSNJU-UHFFFAOYSA-L[1]打开 →
InChIInChI=1S/2H3NO3S.Ni/c2*1-5(2,3)4;/h2*(H3,1,2,3,4…[1]
SMILESNS(=O)(=O)[O-].NS(=O)(=O)[O-].[Ni+2][1]
EC Number237-396-1[2]打开 →
ChemSpider75542[3]打开 →
NSC Number (NCI)78888打开 →
WikiData QIDQ10373228打开 →

来源：PubChem (NIH)、Wikidata SPARQL、KEGG、ChEMBL (EBI)、CompTox CTX (EPA)。

📚 科学参考文献（芝加哥作者-日期格式） (3 来源)
  1. PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. ↗ applies to: PubChem CID · InChIKey · InChI · SMILES
  2. ECHA. EC Inventory — EINECS, ELINCS, NLP and List Numbers assigned under REACH. Helsinki: European Chemicals Agency. ↗ applies to: EC Number
  3. ChemSpider. Royal Society of Chemistry, chemical structure database. ↗ applies to: ChemSpider

Further reading

Publications thematically related to this CAS. They are not the source of any value shown on this card.

扩展参考文献 (1)

  1. ★★☆☆☆ CROSSREF 🔓 开放 ❓ 未验证 Sopok, Samuel. 1991. "Determination of Nickel, Nickel Chloride Hexahydrate and Boric Acid in Nickel Sulfamate Plating Solutions by Titration.". https://doi.org/10.21236/ada420005. 链接 [访问日期: 2026-10-11] CC0 (metadata)
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结构性质

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❓ 常见问题 (3)
What is Nickel sulfamate?
Nickel sulfamate (CAS 13770-89-3) is a chemical compound with the molecular formula H₄N₂NiO₆S₂ and a molecular weight of 250.87 g/mol.
有帮助吗？
What is the CAS number of Nickel sulfamate?
The CAS number for Nickel sulfamate is 13770-89-3.
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What is the chemical formula of Nickel sulfamate?
The molecular formula of Nickel sulfamate is H₄N₂NiO₆S₂.
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➕ 建议问题
下载结构文件

来自PubChem数据库（NIH）的分子结构文件。兼容Avogadro、PyMOL、Jmol和ChemDraw等程序。

来源：PubChem，美国国家医学图书馆（NIH）。 CID: 83720

🔄 浓度单位转换器 实时

输入Nickel sulfamate浓度（任意单位），其余将自动计算。

分子量： 250.87 g/mol · IUPAC Gold Book ↗

⚗️ 转换公式及引用（每个公式）
转换分子式准确度来源
% (w/v) ↔ molarityc (mol/L) = (% × 10) / MW±0.5% rel. when density ≈ 1.0 g/mLIUPAC (2019)
millimolar ↔ molarc (mol/L) = mM × 10⁻³ExactCohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
molarity (mol/L)c = n/V = (m/MW)/V±0.1% (depends on MW precision)IUPAC (2019)
parts per million (mg/L) ↔ molarityc (mol/L) = ppm / (1000 × MW); equivalently ppm = mg/L for dilute aqueous±1% (density-independent for dilute solutions)IUPAC (2019)
mg/mL ↔ molarityc (mol/L) = (mg/mL × 1000) / MW / 1000 = mg/mL / MW × 1±0.2%Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
g/L ↔ molarityc (mol/L) = (g/L) / MW±0.1% (depends on MW precision)Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
mmol/L ↔ molarityc (mol/L) = mmol/L × 10⁻³ExactCohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
Celsius ↔ KelvinT(K) = t(°C) + 273.15±0.01 K (ITS-90 scale)BIPM (Bureau International des Poids et Mesures) (2019)
Celsius ↔ FahrenheitT(°F) = T(°C) × 9/5 + 32±0.1 °FThompson A, Taylor BN (2008)
density-corrected % ↔ molarityc (mol/L) = (%w/w × ρ × 10) / MW, ρ in g/mL±0.1% when ρ known to 3 decimalsCohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
📚 参考文献（8个权威来源）
  1. Thompson A, Taylor BN (2008). Guide for the Use of the International System of Units (SI). NIST Special Publication 811 · DOI: 10.6028/NIST.SP.811-2008
    → Primary SI standard for US scientific usage
  2. Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007). Quantities, Units and Symbols in Physical Chemistry — The IUPAC Green Book. RSC Publishing, 3rd ed. · DOI: 10.1039/9781847557889 · ISBN: 978-0-85404-433-7
    → Canonical IUPAC guide for chemistry quantities/units
  3. BIPM (Bureau International des Poids et Mesures) (2019). The International System of Units (SI), 9th edition. BIPM · ↗
    → International SI definitions (incl. redefined kilogram 2019)
  4. ISO/IEC (2022). Quantities and units — Part 1: General. International Organization for Standardization — ISO 80000-1:2022 · ↗
    → General rules for physical quantities and units
  5. ISO/IEC (2019). Quantities and units — Part 9: Physical chemistry and molecular physics. International Organization for Standardization — ISO 80000-9:2019 · ↗
    → Concentration / molality / amount-of-substance conventions
  6. Tiesinga E, Mohr PJ, Newell DB, Taylor BN (2021). CODATA recommended values of the fundamental physical constants: 2018. Rev. Mod. Phys. 93(2):025010 · DOI: 10.1103/RevModPhys.93.025010
    → Avogadro, gas constant, molar volume (2019 SI revision)
  7. IUPAC (2019). Compendium of Chemical Terminology — the IUPAC Gold Book (online). IUPAC · DOI: 10.1351/goldbook
    → Definitions of mass fraction, molality, normality, ppm, activity
  8. Mills IM, Cvitaš T, Homann K, Kallay N, Kuchitsu K (1988). Quantities, Units and Symbols in Physical Chemistry. Blackwell Scientific Publications, 1st ed. · ISBN: 0-632-01773-5
    → Historical predecessor of IUPAC Green Book
相似分子结构

正在加载相似结构...

🧪 溶液制备向导 WIZARD
① 选择浓度
② 目标体积
③ 溶剂

计算依据： IUPAC Gold Book ↗, Merck ↗

计算化学

正在加载计算数据...

🛡️ 安全 — CAS 13770-89-3
数据限制说明。 本页安全信息仅供参考，不能替代完整的安全数据表（SDS）。使用产品前，请查阅制造商当前的安全数据表以及GHS/CLP指南。CLP分类适用于纯散装物质，不适用于商业制剂。

GHS/CLP分类——(EC) No 1272/2008法规 + UN GHS Rev. 9 (2021)。

⚠️ 危险 (Danger)
GHS07 — 刺激性/有害
GHS07 刺激性/有害
GHS08 — 健康危害
GHS08 健康危害
GHS09 — 环境危害
GHS09 环境危害

🚨 危险说明（H）

  • H350i — 吸入可能致癌
  • H341 — 怀疑会导致遗传性缺陷(说明接触途径――如已确证无其他接触途径造成这一危害)
  • H360D — 可能对胎儿造成伤害
  • H302 — 吞咽有害
  • H372 — 长期或反复接触会对器官造成伤害(说明已知的所有受影响器官)( 说明接触途径――如已确证无其他接触途径造成这一危害)
  • H334 — 吸入可能导致过敏或哮喘病症状或呼吸困难
  • H317 — 可能导致皮肤过敏反应
  • H400 — 对水生生物毒性极大
  • H410 — 对水生生物毒性极大并具有长期持续影响

🛡 防范说明（P）

  • P203 — 使用前取得、阅读并遵循所有安全说明书。

✓ 根据CLP法规(EC) 1272/2008附件VI的统一分类（官方、具有约束力的分类）。 索引号：028-018-00-4。

参考文献（芝加哥格式）： European Chemicals Agency. "nickel bis(sulfamidate); nickel sulfamate, Index No. 028-018-00-4." In Table 3 of Annex VI to Regulation (EC) No 1272/2008 (CLP Regulation), 23rd Adaptation to Technical Progress (harmonised list as of 2026-07-07). Helsinki: European Chemicals Agency, 2026. https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp.

翻译：CLP 法规 (EC) 1272/2008，附件 III 和 IV。数据：PubChem/NLM。

📚 综合科学参考文献 — Chicago Author-Date 10 来源

从所有Safety Hub选项卡收集的参考文献。CAS号： 13770-89-3 · PubChem ↗

  1. Parlament Europejski i Rada UE. 2008. "Regulation (EC) nr 1272/2008 w sprawie klasyfikacji, oznakowania i pakowania substancji (CLP)." Dz.Urz. UE L 353. [↗] GHS，法规
  2. United Nations Economic Commission for Europe (UNECE). 2021. "Globally Harmonized System of Classification and Labelling of Chemicals (GHS), Ninth Revised Edition." United Nations, Geneva. [↗] GHS
  3. Goldfrank, Lewis R., Robert S. Hoffman, Mary Ann Howland, et al.. 2019. "Goldfrank's Toxicologic Emergencies, 11th ed.." McGraw-Hill Education, New York. ISBN 978-1-25-985961-8. 急救、毒理学
  4. National Institute for Occupational Safety and Health (NIOSH). 2023. "NIOSH Pocket Guide to Chemical Hazards (DHHS Publ. 2005-149)." U.S. Department of Health and Human Services / CDC, Cincinnati, OH. [↗] 急救、个人防护装备、毒理学
  5. European Committee for Standardization (CEN). 2016. "EN 374-1:2016 — Protective gloves against dangerous chemicals and micro-organisms." CEN, Brussels. [↗] 个人防护装备
  6. UNECE. 2023. "European Agreement Concerning the International Carriage of Dangerous Goods by Road (ADR 2025)." United Nations, Geneva. [↗] 处置、法规
  7. National Fire Protection Association (NFPA). 2022. "NFPA 400 — Hazardous Materials Code." NFPA, Quincy, MA. [↗] 储存
  8. Urben, P.G. (ed.). 2017. "Bretherick's Handbook of Reactive Chemical Hazards, 8th ed.." Butterworth-Heinemann / Elsevier, Oxford. [↗] 储存
  9. Ministerstwo Klimatu i Środowiska RP. 2023. "Baza danych o produktach i opakowaniach oraz o gospodarce odpadami (BDO)." Ministerstwo Klimatu i Środowiska, Warszawa. 国家规定——波兰 [↗] 废物处置
  10. International Agency for Research on Cancer (IARC / WHO). 2024. "IARC Monographs on the Identification of Carcinogenic Hazards to Humans — List of Classifications." WHO, Lyon. [↗] 毒理学

具有自身参考文献的选项卡（紧急情况、个人防护装备、储存、废物）在其各自章节中包含额外的书目条目。

📈 分析统计（t检验·RSD·Grubbs·Q-Dixon） ICH Q2

粘贴一系列重复测量结果（CSV或每行一个数字）。计算器将计算平均值、标准差和95%置信区间，并检测异常值（Grubbs + Dixon Q）。

分隔符：逗号、空格、制表符、换行。至少3个测量值。
📐 统计公式
  • x̄ = Σxᵢ / n — 算术平均值
  • s² = Σ(xᵢ - x̄)² / (n-1) — 样本方差
  • s = √s² — 标准差
  • RSD% = (s / x̄) × 100% — 相对标准差
  • CI₉₅ = x̄ ± t(0.05, n-1) × s / √n — Student's t
  • G = |xᵢ - x̄| / s — Grubbs检验
  • Q = |xsuspect - xnearest| / |xmax - xmin| — Dixon Q-test

来源：ICH Q2(R2) 分析方法验证 · ICH PDF ↗

🧪 缓冲液配方计算器 唯一
参考文献： pKa值来自 Goldberg NIST 81 · CRC Handbook 100th ed. · Stoll & Blanchard 1990 (DOI)

从 20 种常用缓冲体系列表中选择 → 输入目标 pH → 获得精确配方，包括称量质量。

步骤 1：选择缓冲体系

📜 配方历史记录（最近 10 条）
📅 项目规划器——实验室实验管理器 新品

规划您的整个实验室项目：添加实验（含试剂、重复次数和持续时间）。您将获得甘特图、购物清单（含商店链接！）、预算（含10%余量）和GHS风险矩阵。

🧪 溶解性和溶剂兼容性
分子
Nickel sulfamate
分子式
H₄N₂NiO₆S₂
logP (XLogP3)
—
摩尔质量（g/mol）
250.87
极性
—

⚠️ 离子/无机化合物——汉森参数（δD/δP/δH）不适用：溶解由晶格能和离子溶剂化控制，而非分子间内聚力。HSP模块和汉森球已省略。HSP相关列（相容性/Ra/可视化）标记为“n/a”——请基于实验数据选择溶剂。

该物质暂无溶剂相容性表。
Hansen 参数超出该方法的范围，因此无法计算距离 Ra，且数据库中也没有可替代的溶解度实测数据。与其给出十一项毫无依据的评级，我们选择不显示。请依据安全数据表和实验数据选择溶剂。
📚 溶剂科学参考文献（芝加哥作者-日期格式）——点击展开

11 种溶剂 · 54 条完整引用（NIST/CRC/IARC/Hansen/Reichardt/Smallwood/Wypych/Armarego/Snyder/GESTIS）— 见下文。

Water (H₂O)
  1. NIST — NIST Chemistry WebBook — Water (CAS 7732-18-5)
  2. CRC — CRC Handbook of Chemistry and Physics, 104th ed., Sec. 8 (Properties of Water)
  3. IAPWS — IAPWS Release on Static Dielectric Constant of Water
  4. Reichardt 2011 — Solvents and Solvent Effects in Organic Chemistry
  5. GESTIS — GESTIS Substance Database — Water
Ethanol (EtOH)
  1. NIST — NIST Chemistry WebBook — Ethanol (CAS 64-17-5)
  2. CRC — CRC Handbook — Ethanol physical constants
  3. Snyder & Kirkland — Modern Liquid Chromatography — Ethanol eluotropic
  4. Smallwood — Handbook of Organic Solvent Properties — Ethanol
  5. GESTIS — GESTIS Substance Database — Ethanol
Methanol (MeOH)
  1. NIST — NIST Chemistry WebBook — Methanol (CAS 67-56-1)
  2. CRC — CRC Handbook — Methanol physical constants
  3. Snyder & Kirkland — Modern Liquid Chromatography — MeOH eluotropic, eo=0.95
  4. GESTIS — GESTIS Substance Database — Methanol
Acetone
  1. NIST — NIST Chemistry WebBook — Acetone (CAS 67-64-1)
  2. CRC — CRC Handbook — Acetone physical & thermodynamic constants
  3. Hansen 2007 — Hansen Solubility Parameters — Acetone (dD=15.5, dP=10.4, dH=7.0)
  4. Smallwood — Handbook of Organic Solvent Properties — Acetone
  5. GESTIS — GESTIS Substance Database — Acetone
Acetonitrile (ACN)
  1. NIST — NIST Chemistry WebBook — Acetonitrile (CAS 75-05-8)
  2. CRC — CRC Handbook — Acetonitrile constants
  3. Snyder & Kirkland — Modern Liquid Chromatography — ACN gold-standard HPLC eluent
  4. Reichardt 2011 — Solvents and Solvent Effects — ACN dipolar aprotic
  5. GESTIS — GESTIS Substance Database — Acetonitrile
DMSO
  1. NIST — NIST Chemistry WebBook — DMSO (CAS 67-68-5)
  2. Wypych 2019 — Handbook of Solvents Vol. 1 — DMSO comprehensive properties
  3. Hansen 2007 — HSP — DMSO (dD=18.4, dP=16.4, dH=10.2)
  4. Reichardt 2011 — Solvents and Solvent Effects — DMSO E_T(30)=45.1, dipolar aprotic
  5. GESTIS — GESTIS Substance Database — DMSO
THF
  1. NIST — NIST Chemistry WebBook — THF (CAS 109-99-9)
  2. Armarego 2009 — Purification of Laboratory Chemicals — THF drying & peroxide test
  3. Hansen 2007 — Hansen Solubility Parameters — THF (dD=16.8, dP=5.7, dH=8.0)
  4. Smallwood — Handbook of Organic Solvent Properties — THF
  5. GESTIS — GESTIS Substance Database — Tetrahydrofuran
DCM (CH₂Cl₂)
  1. NIST — NIST Chemistry WebBook — Dichloromethane (CAS 75-09-2)
  2. IARC 71 — IARC Monograph 71 — DCM (Group 2A carcinogen)
  3. Hansen 2007 — Hansen Solubility Parameters — DCM (dD=18.2, dP=6.3, dH=6.1)
  4. Reichardt 2011 — Solvents and Solvent Effects — DCM polarity index
  5. GESTIS — GESTIS Substance Database — Dichloromethane
Chloroform (CHCl₃)
  1. NIST — NIST Chemistry WebBook — Chloroform (CAS 67-66-3)
  2. IARC 73 — IARC Monograph 73 — Chloroform (Group 2B carcinogen)
  3. Hansen 2007 — Hansen Solubility Parameters — CHCl3 (dD=17.8, dP=3.1, dH=5.7)
  4. Reichardt 2011 — Solvents and Solvent Effects — CHCl3 H-bond donor strength
  5. GESTIS — GESTIS Substance Database — Chloroform
n-Hexane
  1. NIST — NIST Chemistry WebBook — n-Hexane (CAS 110-54-3)
  2. ATSDR n-Hexane — ATSDR Toxicological Profile for n-Hexane — 周围神经病变（正己烷并非 IARC 致癌物）
  3. Hansen 2007 — Hansen Solubility Parameters — n-Hexane (dD=14.9, dP=0, dH=0)
  4. Snyder & Kirkland — Modern Liquid Chromatography — n-Hexane NP standard, eo=0.00
  5. GESTIS — GESTIS Substance Database — n-Hexane
Toluene
  1. NIST — NIST Chemistry WebBook — Toluene (CAS 108-88-3)
  2. IARC 71 — IARC Monograph 71 — Toluene
  3. Hansen 2007 — Hansen Solubility Parameters — Toluene (dD=18.0, dP=1.4, dH=2.0)
  4. Smallwood — Handbook of Organic Solvent Properties — Toluene
  5. GESTIS — GESTIS Substance Database — Toluene
溶解性理论（应用于相容性预测）：
  1. Yalkowsky, Samuel H., and Shri C. Valvani. 1980. "Solubility and Partitioning I: Solubility of Nonelectrolytes in Water." Journal of Pharmaceutical Sciences 69 (8): 912–922. https://doi.org/10.1002/jps.2600690814 — General Solubility Equation (GSE): logS = 0.5 − logP − 0.01(MP−25).
  2. Hansen, Charles M. 2007. Hansen Solubility Parameters: A User's Handbook. 2nd ed. CRC Press. https://doi.org/10.1201/9781420006834 — HSP三元组（dD, dP, dH）+ Ra公式。
  3. Stefanis, E., and C. Panayiotou. 2008. "Prediction of Hansen Solubility Parameters with a New Group-Contribution Method." Int J Thermophys 29: 568–585. https://doi.org/10.1007/s10765-008-0415-z
  4. Reichardt, Christian, and Thomas Welton. 2011. Solvents and Solvent Effects in Organic Chemistry. 4th ed. Wiley-VCH. https://doi.org/10.1002/9783527632220 — E_T(30) polarity scale, solvatochromism.
  5. Snyder, Lloyd R., Joseph J. Kirkland, and John W. Dolan. 2010. Introduction to Modern Liquid Chromatography. 3rd ed. Wiley. https://doi.org/10.1002/9780470508183 — Eluotropic series, polarity index.
  6. Van Krevelen, D. W., and K. Te Nijenhuis. 2009. Properties of Polymers. 4th ed. Elsevier. https://doi.org/10.1016/B978-0-08-054819-7.X0001-5 — Hoftyzer–Van Krevelen group contribution for dD/dP/dH from SMILES.
  7. Marcus, Yizhak. 1998. The Properties of Solvents. Wiley Series in Solution Chemistry, Vol. 4. ISBN 9780471983699 — 250+溶剂的完整表格数据集（ε、μ、供体数、受体数）。
  8. PubChem Compound Database — CAS 13770-89-3 lookup ↗ — logP (XLogP3), water solubility experimental + predicted.

完整参考文献位于页面底部的参考文献折叠面板——芝加哥格式手册第17版作者-日期格式。

⚗️ 检查反应兼容性

检查Nickel sulfamate是否与另一种试剂兼容

📦 储存兼容性矩阵
酸类 碱 氧化剂 易燃 毒性 Gazy
酸类 ✓ ✗ ✗ ✗ ⚠ ✗
碱 ✗ ✓ ⚠ ⚠ ⚠ ⚠
氧化剂 ✗ ⚠ ✓ ✗ ⚠ ✗
易燃 ✗ ⚠ ✗ ✓ ⚠ ✗
毒性 ⚠ ⚠ ⚠ ⚠ ✓ ⚠
Gazy ✗ ⚠ ✗ ✗ ⚠ ✓
✓ 可一起储存 · ⚠ 谨慎 · ✗ 禁止一起储存 · OSHA Chemical Segregation ↗

兼容性数据来源： Bretherick's Handbook (7th ed.) ↗, GESTIS ↗, ECHA REACH ↗, NFPA 704 ↗

🧮 实验室计算器（8个）
稀释（C₁V₁=C₂V₂）
摩尔浓度（M=n/V）
pH缓冲液（Henderson-Hasselbalch）
Beer-Lambert（A=εcl）
质量→摩尔
浓度%→M
ppm→mg/L
温度 C↔F↔K

已验证的配方： IUPAC Gold Book ↗, DOI ↗

📊 光谱数据库
📋 实验室方案生成器

方案基于以下内容生成： GHS SDS, Aldrich Lab Guide ↗

🏷️ 标签生成器（QR码）
Nickel Bis(Sulfamidate)• Nickel sulfamate / nickel(2+) disulfamate• IUPAC: nickel(2+) disulfamate• CAS: 13770-89-3• EC: 237-396-1• 分子式: H4N2NiO6S2• 摩尔质量: 250.87 g/mol危险GHS危险说明：H350i H341 H360D H302 H372 H334 H317 H400 H410P203: 使用前取得、阅读并遵循所有安全说明书。仅供实验室使用！Nonsensia Ltd124-128 City Road, EC1V 2NX London[email protected]molgod.org批号: 净含量:
🧪 溶液配制助手（Smart Prep）

输入您要制备的内容——我将生成SOP

示例如下——点击插入：
预设配方：
📚 科学文献概览 — CAS 13770-89-3
⭐ 关键发现（科学文献） 13 出版物
🏆 CAS 13770-89-3 — multi-criteria ranking (W12): 30%引用·20%近期性·20%主题·15%历史·15%开放获取.
  1. #1
    M. Saitou (2016) · International Journal of Electrochemical Science
    重要性： Open access
    SCORE 6.76 机制 引用： 7 Open Access DOI ↗
  2. #2
    Bartolomeu Halicki PC; Kim JH; Griffin AF et al. (2025) · ACS infectious diseases
    重要性： 必引文献（经典） · 近期（2025）
    SCORE 5.6 机制 MUST-CITE DOI ↗
  3. #3
    ZHANG Lan, SONG Wentao, LI Na et al. (2021) · Jin'gangshi yu moliao moju gongcheng
    重要性： Open access
    SCORE 5.55 机制 Open Access
  4. #4
    ZHAO Yaomin, WU Xueling, FANG Xiangqian et al. (2020) · Jin'gangshi yu moliao moju gongcheng
    重要性： Open access
    SCORE 5.25 机制 Open Access
  5. #5
    Don Baudrand (1996) · Metal Finishing
    重要性： 通过多标准评分选择（引用+近期性+主题+历史+开放获取）。
    SCORE 4.84 机制 引用： 40 DOI ↗
  6. #6
    A. Hankin, G. H. Kelsall (2012) · Journal of Applied Electrochemistry
    重要性： 通过多标准评分选择（引用+近期性+主题+历史+开放获取）。
    SCORE 4.04 机制 引用： 13 DOI ↗
  7. #7
    H.K. Srivastava (1995) · Metal Finishing
    重要性： 通过多标准评分选择（引用+近期性+主题+历史+开放获取）。
    SCORE 3.92 机制 引用： 10 DOI ↗
  8. #8
    Siddiqui R; El-Gamal MI; Sajeev S et al. (2023) · Molecular and biochemical parasitology
    重要性： 必引文献（经典） · 近期（2023）
    SCORE 3.9 机制 MUST-CITE DOI ↗
  9. #9
    Sundararaman SA; Odom John AR (2022) · Cell host & microbe
    重要性： 必引文献（经典）
    SCORE 3.6 机制 MUST-CITE DOI ↗
  10. #10
    Atsushi Chiba, Takayuki Gotou, Katsuyoshi Kobayashi et al. (2000) · Metal Finishing
    重要性： 通过多标准评分选择（引用+近期性+主题+历史+开放获取）。
    SCORE 2.86 机制 引用： 8 DOI ↗
  11. #11
    V. I. Maksin, O. Z. Standritchuk (2007) · Russian Journal of Applied Chemistry
    重要性： 通过多标准评分选择（引用+近期性+主题+历史+开放获取）。
    SCORE 1.43 机制 引用： 2 DOI ↗
  12. #12
    Samuel Sopok (1991)
    重要性： 通过多标准评分选择（引用+近期性+主题+历史+开放获取）。
    SCORE 0.8 分析 DOI ↗
  13. #13
    Winum JY; Scozzafava A; Montero JL et al. (2005) · Medicinal research reviews
    重要性： 必引文献（经典） · 综述
    SCORE 0 综述 MUST-CITE DOI ↗

为什么本页可以核查

标识

CAS、EC 和分子式，已在买方使用的各标识符系统中完成解析。页面显示已解析的系统数量，让您看到该物质的表征程度，而不是凭假设。

数据

每个理化数值都标明其来源及该来源的查阅日期。任何一条都可以打开查看。

分类

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法规

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A safety data sheet for nickel bis(sulfamidate), CAS 13770-89-3, in the sixteen-section structure required across the European Union. The deliverable is the document itself.

nickel bis(sulfamidate) (CAS 13770-89-3) at a glance

  • Substance – nickel bis(sulfamidate)
  • CAS number – 13770-89-3
  • EC number – 237-396-1
  • CLP Annex VI index number – 028-018-00-4
  • Also known as – nickel sulfamate
  • Hazard statements – H350i; H341 (suspected of causing genetic defects); H360D (may damage the unborn child); H302 (harmful if swallowed); H372 (causes damage to organs through prolonged or repeated exposure); H334 (may cause allergy or asthma symptoms if inhaled)
  • Hazard classes – Carc. 1A, Muta. 2, Repr. 1B, Acute Tox. 4, STOT RE 1, Resp. Sens. 1
  • Label pictograms – GHS07, GHS08, GHS09
  • Signal word – Danger
  • Concentration limits / M-factor / ATE – oral: ATE = 853.0 mg/kg bw (anhydrate);oral: ATE = 1098.0 mg/kg bw (tetrahydrate);STOT RE 1;H372: C ≥ 1.0%;STOT RE 2;H373: 0.1% ≤ C < 1.0%;Skin Sens. 1;H317: C ≥ 0.01%;M = 1
  • Entry current as of – ATP14
  • CMR classification – yes, classified as carcinogenic, mutagenic or toxic for reproduction
  • Documentation issued – safety data sheet in REACH Annex II structure; working draft or signed card
  • What is supplied – a document. MolGod.org does not sell, supply or ship chemical substances.

Who is responsible for REACH compliance for nickel bis(sulfamidate)?

Anyone importing nickel bis(sulfamidate) into the European Union is responsible for providing the required documentation, and this obligation does not revert to previous entities in the supply chain through contractual means. Section 1 mandates the designation of a contactable entity within the Union; a foreign address is considered invalid for this purpose and is one of the first elements verified by inspectors due to its straightforward confirmation.

Purity, certificates and what the sheet does not say

A laboratory receiving nickel bis(sulfamidate) from its supplier holds two documents that must agree with each other: the safety data sheet for the substance and the certificate for the batch in hand. Where identity or supplier details diverge between them, both become questionable. MolGod prepares and audits those documents; the material itself comes from your supplier.

Which GHS pictograms apply to nickel bis(sulfamidate)?

The label for nickel bis(sulfamidate) carries GHS07 (exclamation mark), GHS08 (health hazard), GHS09 (environment), with the signal word Danger. These are not chosen by the supplier: CLP Annex VI states them for CAS 13770-89-3, and the precedence rules in Annex I decide which pictogram is dropped when two would say the same thing. A label showing a different set from the register is wrong even if every hazard statement on it is correct.

What happens if a consignment of nickel bis(sulfamidate) is refused?

When a consignment of nickel bis(sulfamidate) is held, the cost is rarely the document itself. It is the storage, the demurrage and the customer waiting. That arithmetic is why the sheet is worth checking before dispatch rather than after a call from the border.

What is the CLP classification of nickel bis(sulfamidate)?

The harmonised classification for CAS 13770-89-3 carries 9 hazard statements: H350i, H341, H360D, H302, H372, H334, H317, H400, H410. In plain terms this means H350i; suspected of causing genetic defects; may damage the unborn child; harmful if swallowed. A harmonised entry is binding across the Union — an importer may not soften it, and a self-classification that diverges from it will not survive an enforcement check.

Storage and handling in the document

The store manager responsible for managing material with CAS number 13770-89-3 must review Section 7 first to determine its compatibility with adjacent materials, required atmosphere conditions, and any segregation rules arising from its classification. The necessary information regarding these aspects must be explicitly stated in the documentation provided, rather than relying on supplier email correspondence.

What is the EC number for nickel bis(sulfamidate)?

Alongside CAS 13770-89-3, this substance carries EC number 237-396-1 and Annex VI index 028-018-00-4. European documentation is built around the EC number as often as around the CAS: registration dossiers, the candidate list and customs systems key on it. A safety data sheet quoting only one of the two forces every downstream reader to look up the other.

What concentration limits apply to nickel bis(sulfamidate)?

The harmonised entry for nickel bis(sulfamidate) carries specific concentration limits: H372: C ≥ 1 %; H373: 0,1 % ≤ C < 1 %; H317: C ≥ 0,01 %. These override the generic cut-off values, so a mixture containing nickel bis(sulfamidate) is classified against these figures and not against the default thresholds. M-factor on record: 1. The M-factor multiplies the contribution of this substance in the aquatic hazard calculation for a mixture, which is where it is most often overlooked. Acute toxicity estimates stated in the register: oral: ATE = 853 mg/kg; oral: ATE = 1098 mg/kg.

Is nickel bis(sulfamidate) classified as a CMR substance?

CAS 13770-89-3 is classified as a CMR substance (H350i, H360D). That status changes the obligations attached to every shipment: workplace exposure documentation, restrictions on supply to the general public, and substitution pressure from downstream users who must justify continued use. A safety data sheet for a CMR substance is read more closely than any other, because the classification itself invites scrutiny.

What must the label for nickel bis(sulfamidate) contain?

The supply label for nickel bis(sulfamidate) is generated from the same classification that drives the safety data sheet: pictograms selected by precedence, one signal word derived from the highest hazard class present, and the hazard statements H350i, H341, H360D… reproduced in full. Where the container is too small to carry the complete set at a legible size, there are lawful ways to handle it and unlawful ones that look identical to a non-specialist.

What Annex VI notes and concentration limits apply to nickel bis(sulfamidate)?

The register also records oral: ATE = 853.0 mg/kg bw (anhydrate);oral: ATE = 1098.0 mg/kg bw (tetrahydrate);STOT RE 1;H372: C ≥ 1.0%;STOT RE 2;H373: 0.1% ≤ C < 1.0%;Skin Sens. 1;H317: C ≥ 0.01%;M = 1 for this entry. Specific concentration limits, M-factors and acute toxicity estimates override the generic cut-off values, so a mixture calculation that ignores them will classify the mixture wrongly in both directions.

Where is regulatory status recorded for nickel bis(sulfamidate)?

The regulatory status of nickel bis(sulfamidate) evolves separately from its hazard classification. A substance may maintain consistent hazard characteristics over extended periods while gaining additional obligations under Section 15, leading to this section becoming outdated more rapidly than Section 2.

Identifiers that must agree

The CAS 13770-89-3 number and index number 028-018-00-4 are not interchangeable or decorative elements; they serve distinct purposes. The index number connects to the harmonised classification system, whereas the CAS number links to chemical literature. A document containing one without the other requires readers to independently reconstruct this relationship, which may lead to errors during reconstruction.

How is nickel bis(sulfamidate) classified for road, sea and air transport?

The transport classification for nickel bis(sulfamidate) falls under section 14 and varies depending on the mode of transport: ADR for road, IMDG for sea, and IATA for air. A document that prints all three classifications without specifying which one applies places the responsibility on the shipper to select the correct one, and it is the shipper who faces penalties for making an incorrect choice.

Sensitisation and declaration thresholds

Sensitisation (H334, H317) carries consequences beyond the label: a threshold for declaring the substance in mixtures far below the general cut-off, and — where the entry is on the candidate list — an obligation to inform recipients. Importers frequently discover this at the point where a customer asks for a declaration they had not prepared.

Questions about documentation for nickel bis(sulfamidate)

Can I check whether my existing sheet is still valid?

Yes. A section-by-section reading against Annex II and the current harmonised entry establishes that in one pass, and a sheet that passes is reported as passing.

Do I need a safety data sheet to import nickel bis(sulfamidate) into the EU?

Yes. A sheet compiled to Annex II of REACH must exist before the first consignment moves, and it must be held by the entity placing the substance on the Union market.

What is the CAS number of nickel bis(sulfamidate)?

CAS 13770-89-3. In CLP Annex VI the same substance carries index number 028-018-00-4, and both identifiers should appear in the documentation.

Is nickel bis(sulfamidate) a CMR substance?

Yes. The harmonised classification places it among substances classified as carcinogenic, mutagenic or toxic for reproduction, which changes workplace documentation and supply restrictions.

MolGod.org issues documentation and does not sell, supply or ship chemical substances. CAS 13770-89-3 identifies the subject of this document.

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Related products

📄 分析证书（CoA） CAS 13770-89-3 无

数据库中无此产品的证书。

📚 科学参考文献（芝加哥作者-日期格式）——点击展开

批次管理与实验室认证标准——13个独立来源（ICH Q1/Q3/Q6/Q7/Q10 + ISO 17025 + WHO TRS + 21 CFR 211 + EMA + USP + Ph.Eur. + PIC/S + IPEC-PQG）。

  1. International Council for Harmonisation (ICH). 2000. "Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients." ICH Expert Working Group. [链接 ↗] — GMP for APIs — adopted by EMA, FDA, MHLW
  2. International Organization for Standardization. 2017. "ISO/IEC 17025:2017 General requirements for the competence of testing and calibration laboratories." ISO. [链接 ↗] — Lab accreditation standard underpinning every CoA
  3. World Health Organization. 2010. "WHO Good Manufacturing Practices for Pharmaceutical Products: Main Principles (WHO Technical Report Series No. 957, Annex 3)." WHO Press. [链接 ↗] — WHO TRS No. 957 — global reference for GMP
  4. International Council for Harmonisation (ICH). 2003. "ICH Q1A(R2): Stability Testing of New Drug Substances and Products." International Council for Harmonisation. [链接 ↗] — Source for batch shelf-life and retest dating
  5. International Council for Harmonisation (ICH). 2006. "ICH Q3A(R2): Impurities in New Drug Substances." ICH. [链接 ↗]
  6. International Council for Harmonisation (ICH). 1999. "ICH Q6A: Specifications for New Drug Substances and Products." ICH. [链接 ↗] — CoA acceptance-criteria specification standard
  7. International Council for Harmonisation (ICH). 2008. "ICH Q10: Pharmaceutical Quality System." ICH. [链接 ↗]
  8. U.S. Food and Drug Administration. 2024. "21 CFR Part 211: Current Good Manufacturing Practice for Finished Pharmaceuticals." US Code of Federal Regulations. [链接 ↗] — US legal mandate (Subpart J — Records and Reports)
  9. European Medicines Agency. 2014. "Guideline on Process Validation for Finished Products — Information and Data to Be Provided EMA/CHMP/CVMP/QWP/BWP/70278/2012." European Medicines Agency. [链接 ↗]
  10. United States Pharmacopeial Convention. 2024. "United States Pharmacopeia and National Formulary, USP 47-NF 42." USP. [链接 ↗]
  11. European Pharmacopoeia Commission. 2024. "European Pharmacopoeia 11th Edition." Council of Europe — EDQM. [链接 ↗]
  12. Pharmaceutical Inspection Co-operation Scheme (PIC/S). 2021. "Guide to Good Manufacturing Practice for Medicinal Products PE 009-15." PIC/S Secretariat, Geneva. [链接 ↗] — Cross-recognized GMP for 54 inspectorates worldwide
  13. International Pharmaceutical Excipients Council (IPEC) and Pharmaceutical Quality Group (PQG). 2017. "Joint IPEC-PQG Good Manufacturing Practices Guide for Pharmaceutical Excipients." IPEC-Americas. [链接 ↗] — Excipient-grade CoA standard for non-API ingredients
📜 专利（公开元数据） 无数据

目前未在Crossref/OpenAlex中找到该物质的公开专利元数据。数据将在下次缓存刷新（24小时）后自动更新。

📚 参考文献（芝加哥作者-日期格式）——点击展开
  1. Bartolomeu Halicki PC, Kim JH, Griffin AF et al.. (2025). "Targeting Mycolic Acid Biosynthesis with Cyclic Sulfamates: A New Strategy against Mycobacterium tuberculosis.". ACS infectious diseases. https://doi.org/10.1021/acsinfecdis.5c00419
  2. Sanematsu K, Nagasato Y, Lee Y et al.. (2025). "A single amino acid substitution in TAS1R2 defines species-specific sweet sensitivity to sulfamates in humans and mice.". Food chemistry. https://doi.org/10.1016/j.foodchem.2025.145563
  3. Mustafa EM, Shahin AI, Alrashed AS et al.. (2024). "An overview of the latest outlook of sulfamate derivatives as anticancer candidates (2020-2024).". Archiv der Pharmazie. https://doi.org/10.1002/ardp.202400331
  4. Siddiqui R, El-Gamal MI, Sajeev S et al.. (2023). "Novel anti-Acanthamoebic properties of raloxifene sulfonate/sulfamate derivatives.". Molecular and biochemical parasitology. https://doi.org/10.1016/j.molbiopara.2023.111582
  5. Hosang L, Löhndorf A, Dohle W et al.. (2023). "2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca(2+) entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis.". Biochimica et biophysica acta. Molecular cell research. https://doi.org/10.1016/j.bbamcr.2023.119485
  6. Sundararaman SA, Odom John AR. (2022). "Adenosine sulfamates: Next generation of antimalarials.". Cell host & microbe. https://doi.org/10.1016/j.chom.2022.07.007
  7. Chang CN, Lin IC, Lin TS et al.. (2022). "The Design, Structure-Activity, and kinetic studies of 3-Benzyl-5-oxa-1,2,3,4-Tetrahydro-2H-chromeno-(3,4-c)pyridin-8-yl sulfamates as Steroid sulfatase inhibitors.". Bioorganic chemistry. https://doi.org/10.1016/j.bioorg.2022.106148
  8. Awakawa T, Barra L, Abe I. (2021). "Biosynthesis of sulfonamide and sulfamate antibiotics in actinomycete.". Journal of industrial microbiology & biotechnology. https://doi.org/10.1093/jimb/kuab001
  9. Mazo N, Navo CD, Peregrina JM et al.. (2020). "Selective modification of sulfamidate-containing peptides.". Organic & biomolecular chemistry. https://doi.org/10.1039/d0ob01061h
  10. Potter BVL. (2018). "SULFATION PATHWAYS: Steroid sulphatase inhibition via aryl sulphamates: clinical progress, mechanism and future prospects.". Journal of molecular endocrinology. https://doi.org/10.1530/JME-18-0045
  11. Winum JY, Scozzafava A, Montero JL et al.. (2005). "Sulfamates and their therapeutic potential.". Medicinal research reviews. https://doi.org/10.1002/med.20021
  12. (2004). "Nickel ( II ) Sulfamate 13770‐89‐3". Sax's Dangerous Properties of Industrial Materials. https://doi.org/10.1002/0471701343.sdp18463
  13. World Intellectual Property Organization. 2024. "Patent Cooperation Treaty (PCT)." https://www.wipo.int/pct/.
  14. U.S. Patent and Trademark Office. 2024. "USPTO Patent Public Search." https://ppubs.uspto.gov/.
  15. European Patent Office. 2024. "Espacenet Patent Search." https://worldwide.espacenet.com/.
  16. Newman, David J., and Gordon M. Cragg. 2020. "Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019." Journal of Natural Products 83 (3): 770-803.
  17. Davies, Mark, Michał Nowotka, George Papadatos, et al. 2015. "ChEMBL Web Services: Streamlining Access to Drug Discovery Data and Utilities." Nucleic Acids Research 43 (W1): W612-W620.
  18. Bickerton, G. Richard, Gaia V. Paolini, Jérémy Besnard, Sorel Muresan, and Andrew L. Hopkins. 2012. "Quantifying the Chemical Beauty of Drugs." Nature Chemistry 4 (2): 90-98.
  19. Meanwell, Nicholas A. 2011. "Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design." Journal of Medicinal Chemistry 54 (8): 2529-2591.
  20. Ertl, Peter, and Ansgar Schuffenhauer. 2009. "Estimation of Synthetic Accessibility Score of Drug-Like Molecules Based on Molecular Complexity and Fragment Contributions." Journal of Cheminformatics 1: 8.
  21. Hopkins, Andrew L., and Colin R. Groom. 2002. "The Druggable Genome." Nature Reviews Drug Discovery 1 (9): 727-730.
  22. Allison, John R., and Mark A. Lemley. 1998. "Empirical Evidence on the Validity of Litigated Patents." AIPLA Quarterly Journal 26 (3): 185-275.
  23. Patani, George A., and Edmond J. LaVoie. 1996. "Bioisosterism: A Rational Approach in Drug Design." Chemical Reviews 96 (8): 3147-3176.
  24. Lerner, Josh. 1994. "The Importance of Patent Scope: An Empirical Analysis." RAND Journal of Economics 25 (2): 319-333.

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📚 参考文献（综合书目，芝加哥作者-日期格式） 78 条目

以上折叠面板中针对CAS号13770-89-3引用的所有科学来源。格式： 《芝加哥格式手册》第17版，作者-日期系统.

🗄️ 科学数据库

  1. NIST. n.d. NIST Chemistry WebBook: CAS 13770-89-3. Gaithersburg, MD: National Institute of Standards and Technology. https://webbook.nist.gov/cgi/cbook.cgi?ID=13770-89-3.
  2. AIST. n.d. Spectral Database for Organic Compounds (SDBS): CAS 13770-89-3. Tsukuba, Japan: National Institute of Advanced Industrial Science and Technology. https://sdbs.db.aist.go.jp/.
  3. Linstrom, Peter J., and William G. Mallard, eds. n.d. NIST Chemistry WebBook: NIST Standard Reference Database Number 69. Gaithersburg, MD: National Institute of Standards and Technology. https://doi.org/10.18434/T4D303.
  4. PubChem. n.d. PubChem Compound Summary: CAS 13770-89-3. Bethesda, MD: National Center for Biotechnology Information (NCBI), National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/#query=13770-89-3.
  5. ECHA. n.d. C&L Inventory and REACH Registration: CAS 13770-89-3. Helsinki: European Chemicals Agency. https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp.

📐 标准/指南

  1. ICH. 2003. "Stability Testing of New Drug Substances and Products: Q1A(R2)." Geneva: International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. https://database.ich.org/sites/default/files/Q1A%28R2%29%20Guideline.pdf.
  2. National Fire Protection Association (NFPA). 2024. "NFPA 30: Flammable and Combustible Liquids Code." NFPA, Quincy, MA. https://www.nfpa.org/codes-and-standards/all-codes-and-standards/list-of-codes-and-standards/detail?code=30.
  3. Occupational Safety and Health Administration (OSHA). 2023. "29 CFR 1910.106 — Flammable Liquids." U.S. Department of Labor, Federal Register. https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.106.
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  5. European Committee for Standardization (CEN). 2016. "EN 374-1:2016 — Protective gloves against dangerous chemicals and micro-organisms — Part 1: Terminology and performance requirements for chemical risks." CEN, Brussels. https://standards.cencenelec.eu/dyn/www/f?p=205:110:::::FSP_PROJECT,FSP_ORG_ID:38536,6080&cs=1B0DAA8B85DF42E4A2C70E5D71F0BFA32.
  6. European Committee for Standardization (CEN). 2001. "EN 166:2001 — Personal eye-protection — Specifications." CEN, Brussels. https://standards.cencenelec.eu/dyn/www/f?p=CEN:110:0::::FSP_PROJECT:6541&cs=1F1A4E0A78C4DB6A28DBE2E8C29D89DCF.
  7. European Committee for Standardization (CEN). 2009. "EN 14605:2005+A1:2009 — Protective clothing against liquid chemicals — Performance requirements for clothing with liquid-tight (Type 3) or spray-tight (Type 4) connections." CEN, Brussels. https://standards.cencenelec.eu/dyn/www/f?p=CEN:110:0::::FSP_PROJECT:21581&cs=1A04A2D3C7CC58E9E6CB58D55F7EBFB7E.
  8. National Institute for Occupational Safety and Health (NIOSH). 2017. "Recommendations for Chemical Protective Clothing: A Companion to the NIOSH Pocket Guide." U.S. Department of Health & Human Services / CDC. https://www.cdc.gov/niosh/ncpc/default.html.
  9. Occupational Safety and Health Administration (OSHA). 2011. "Personal Protective Equipment — General requirements." U.S. Department of Labor — 29 CFR 1910.132. https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.132.

📖 书籍

  1. Hansen, Charles M. 2007. Hansen Solubility Parameters: A User's Handbook, 2nd ed.. Boca Raton, FL: CRC Press. https://www.routledge.com/Hansen-Solubility-Parameters-A-Users-Handbook/Hansen/p/book/9780849372483.
  2. Barton, Allan F. M. 1991. CRC Handbook of Solubility Parameters and Other Cohesion Parameters: 2nd ed.. Boca Raton, FL: CRC Press. https://www.routledge.com/CRC-Handbook-of-Solubility-Parameters-and-Other-Cohesion-Parameters/Barton/p/book/9780849301766.
  3. Connors, Kenneth A., Gordon L. Amidon, and Valentino J. Stella. 1986. Chemical Stability of Pharmaceuticals: A Handbook for Pharmacists, 2nd ed.. New York: Wiley. https://doi.org/10.1002/0471734683.
  4. Rumble, John R., ed. 2019. CRC Handbook of Chemistry and Physics: 100th Edition. Boca Raton, FL: CRC Press. https://hbcp.chemnetbase.com/.
  5. Urben, Peter G. 2017. Bretherick's Handbook of Reactive Chemical Hazards, 8th Edition. Academic Press / Elsevier, Oxford. https://www.sciencedirect.com/book/9780081010594.

📄 科学文章（同行评审）

  1. Stefanis, Emmanuel, and Costas Panayiotou. 2008. "Prediction of Hansen Solubility Parameters with a New Group-Contribution Method." International Journal of Thermophysics 29: 568-585. https://doi.org/10.1007/s10765-008-0415-z.
  2. Stoll, Vincent S., and John S. Blanchard. 1990. "Buffers: Principles and Practice: In Methods in Enzymology, vol. 182." San Diego: Academic Press. https://doi.org/10.1016/0076-6879(90)82008-P.

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📜 许可与来源
模型
Nickel sulfamate · 13770-89-3
InChIKey
KERTUBUCQCSNJU-UHFFFAOYSA-L
许可与来源记录
Nickel sulfamate (CAS 13770-89-3) →
MolGod 分子记录
Nickel sulfamate →
源数据
PubChem CID 83720 ↗
模型信息
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本许可适用于 MolGod 创建的 STL 网格，不自动适用于第三方源材料。