acetic anhydride (CAS 108-24-7) — Safety Data Sheet

Regulatory paperwork for CAS 108-24-7 (acetic anhydride), written against REACH Annex II and the harmonised classification in force. MolGod issues the documentation and does not supply chemicals.

acetic anhydride (CAS 108-24-7) at a glance

• Substance – acetic anhydride
• CAS number – 108-24-7
• EC number – 203-564-8
• CLP Annex VI index number – 607-[CAS?]
• Hazard statements – H226 (flammable liquid and vapour); H332 (harmful if inhaled); H302 (harmful if swallowed); H314 (causes severe skin burns and eye damage)
• Hazard classes – Flam. Liq. 3, Acute Tox. 4 *, Acute Tox. 4 *, Skin Corr. 1B
• Label pictograms – GHS02, GHS05, GHS07
• Signal word – Danger
• Concentration limits / M-factor / ATE – Skin Corr. 1B;H314: C ≥ 25.0%;Skin Irrit. 2;H315: 5.0% ≤ C < 25.0%;Eye Dam. 1;H318: 5.0% ≤ C < 25.0%;Eye Irrit. 2;H319: 1.0% ≤ C < 5.0%;STOT SE 3;H335: C ≥ 5.0%
• Entry current as of – CLP00
• CMR classification – not classified as CMR in the harmonised entry
• Documentation issued – safety data sheet in REACH Annex II structure; working draft or signed card
• What is supplied – a document. MolGod.org does not sell, supply or ship chemical substances.

Can I import acetic anhydride into the EU?

Bringing acetic anhydride into the Union is a documentation exercise before it is a logistics one. The file has to exist at the moment of import, not at the moment somebody asks for it, and for carboxylic acid esters it is examined in the context of solvent and intermediate shipments. Index 607-[CAS?] fixes the classification that section 2 must reproduce.

How do I check if my SDS for acetic anhydride is still valid?

If a sheet for acetic anhydride is already in circulation, the useful first question is not whether to replace it but whether it is wrong, and if so in which section. Defects repeat across a catalogue, so three documents usually reveal what three hundred need.

Is acetic anhydride a controlled substance?

Storage requirement on record: Heroin precursor; reportable transactions and export licences per EC 273/2004 Annex I Cat. 2. None of this appears in the CLP classification, so a sheet built from Annex VI alone will be silent on it.

Identifiers that must agree

The CAS 108-24-7 number and index number 607-[CAS?] are not interchangeable or decorative elements; they serve distinct purposes. The index number connects to the harmonised classification system, whereas the CAS number links to chemical literature. A document containing one without the other requires readers to independently reconstruct this relationship, which may lead to errors during reconstruction.

What is the CLP classification of acetic anhydride?

The harmonised classification for CAS 108-24-7 carries 4 hazard statements: H226, H332, H302, H314. In plain terms this means flammable liquid and vapour; harmful if inhaled; harmful if swallowed; causes severe skin burns and eye damage. A harmonised entry is binding across the Union — an importer may not soften it, and a self-classification that diverges from it will not survive an enforcement check.

Storage and handling in the document

Storage requirements for acetic anhydride must be addressed in Section 7 and should align with Section 10, which outlines prohibited conditions and materials. If discrepancies arise between the two sections, the documentation is considered internally inconsistent, and a laboratory auditor will deem both sections unreliable.

Protective equipment and exposure controls

Section 8 details exposure controls and personal protective equipment (PPE) for acetic anhydride: appropriate glove materials, eye protection, respiratory protection when required by the hazard classification, and any established occupational exposure limits. The selection of glove material is more important than merely wearing gloves; nitrile gloves are not universally suitable.

Who is responsible for REACH compliance for acetic anhydride?

Anyone importing acetic anhydride into the European Union must provide the necessary documentation, and this responsibility cannot be transferred back to previous entities in the supply chain through contractual arrangements. Section 1 requires the designation of a contactable entity within the Union; a foreign address is not acceptable for this purpose and is one of the first elements inspected due to its straightforward verification.

Why a correct sheet stops being correct

Classification under CLP moves with each Adaptation to Technical Progress. A sheet for CAS 108-24-7 written before the amendment that touched its entry keeps stating a classification the register no longer holds. Nothing in the document announces this — it reads exactly as it did on the day it was issued, which is precisely why revision dates are checked before content.

What happens if a consignment of acetic anhydride is refused?

When a shipment of acetic anhydride is detained, the expense is typically not the document itself. It is the storage costs, demurrage fees, and the delay incurred by the customer. This financial calculation underscores the importance of verifying the documentation prior to dispatch rather than after receiving a notification from the border.

Stability, reactivity and incompatibilities

Section 10 records stability and reactivity for acetic anhydride: conditions to avoid, incompatible materials, and hazardous decomposition products. This is the section a laboratory consults before placing two substances on the same shelf.

What is the EC number for acetic anhydride?

Alongside CAS 108-24-7, this substance carries EC number 203-564-8 and Annex VI index 607-[CAS?]. European documentation is built around the EC number as often as around the CAS: registration dossiers, the candidate list and customs systems key on it. A safety data sheet quoting only one of the two forces every downstream reader to look up the other.

What concentration limits apply to acetic anhydride?

The harmonised entry for acetic anhydride carries specific concentration limits: H314: C ≥ 2 %; H315: 5 % ≤C < 25 %; H318: 5 % ≤ C < 25 %; H319: 1 % ≤C < 5 %. These override the generic cut-off values, so a mixture containing acetic anhydride is classified against these figures and not against the default thresholds.

Where is regulatory status recorded for acetic anhydride?

Section 15 records regulatory status for acetic anhydride: whether it appears on the candidate list, whether it is subject to authorisation or restriction, and any national provisions. Downstream users ask this question routinely, and a sheet that answers it saves an exchange of emails per customer.

Which GHS pictograms apply to acetic anhydride?

The label for acetic anhydride carries GHS02 (flame), GHS05 (corrosion), GHS07 (exclamation mark), with the signal word Danger. These are not chosen by the supplier: CLP Annex VI states them for CAS 108-24-7, and the precedence rules in Annex I decide which pictogram is dropped when two would say the same thing. A label showing a different set from the register is wrong even if every hazard statement on it is correct.

How is acetic anhydride classified for road, sea and air transport?

Carriers and forwarders handling acetic anhydride compare section 14 against the shipping papers before loading. Any disagreement stops the consignment at the point where correcting it is most expensive.

What Annex VI notes and concentration limits apply to acetic anhydride?

The register also records Skin Corr. 1B;H314: C ≥ 25.0%;Skin Irrit. 2;H315: 5.0% ≤ C < 25.0%;Eye Dam. 1;H318: 5.0% ≤ C < 25.0%;Eye Irrit. 2;H319: 1.0% ≤ C < 5.0%;STOT SE 3;H335: C ≥ 5.0% for this entry. Specific concentration limits, M-factors and acute toxicity estimates override the generic cut-off values, so a mixture calculation that ignores them will classify the mixture wrongly in both directions.

What must the label for acetic anhydride contain?

The supply label for acetic anhydride is generated from the same classification that drives the safety data sheet: pictograms selected by precedence, one signal word derived from the highest hazard class present, and the hazard statements H226, H332, H302… reproduced in full. Where the container is too small to carry the complete set at a legible size, there are lawful ways to handle it and unlawful ones that look identical to a non-specialist.

Questions about documentation for acetic anhydride

What is the CAS number of acetic anhydride?

CAS 108-24-7. In CLP Annex VI the same substance carries index number 607-[CAS?], and both identifiers should appear in the documentation.

What hazard statements apply to CAS 108-24-7?

The harmonised entry lists H226, H332, H302, H314. These are binding across the Union and may not be softened by a self-classification.

In which language must the sheet be supplied?

In an official language of each Member State where acetic anhydride is placed on the market, unless that State has stated otherwise.

Can I check whether my existing sheet is still valid?

Yes. A section-by-section reading against Annex II and the current harmonised entry establishes that in one pass, and a sheet that passes is reported as passing.

MolGod.org issues documentation and does not sell, supply or ship chemical substances. CAS 108-24-7 identifies the subject of this document.