1-chloro-2,3-epoxypropane (CAS 106-89-8) — Safety Data Sheet

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CAS: 106-89-8 | Źródło IARC

Safety data sheet documentation for 1-chloro-2,3-epoxypropane (CAS 106-89-8), compiled to REACH Annex II with classification read against the harmonised entry in CLP Annex VI (H226, H350, H331, H311). Two options: a working draft sent by e-mail immediately, or a signed card issued within 72 hours. The item supplied is a document — MolGod.org does not sell, supply or ship chemical substances.

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Model 3D Epichlorohydrin, CAS 106-89-8, wzór sumaryczny C3H5ClO, masa molowa 92.52 g/mol
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Documentation for 1-chloro-2,3-epoxypropane, CAS 106-89-8, prepared to the structure European enforcement expects. What is sold here is paperwork; the substance itself is not offered.

1-chloro-2,3-epoxypropane (CAS 106-89-8) at a glance

  • Substance – 1-chloro-2,3-epoxypropane
  • CAS number – 106-89-8
  • EC number – 203-439-8
  • CLP Annex VI index number – 603-026-00-6
  • Also known as – epichlorhydrin
  • Hazard statements – H226 (flammable liquid and vapour); H350 (may cause cancer); H331 (toxic if inhaled); H311 (toxic in contact with skin); H301 (toxic if swallowed); H314 (causes severe skin burns and eye damage)
  • Hazard classes – Flam. Liq. 3, Carc. 1B, Acute Tox. 3 *, Acute Tox. 3 *, Acute Tox. 3 *, Skin Corr. 1B
  • Label pictograms – GHS02, GHS05, GHS06, GHS08
  • Signal word – Danger
  • Concentration limits / M-factor / ATE – *
  • Entry current as of – CLP00
  • CMR classification – yes, classified as carcinogenic, mutagenic or toxic for reproduction
  • Documentation issued – safety data sheet in REACH Annex II structure; working draft or signed card
  • What is supplied – a document. MolGod.org does not sell, supply or ship chemical substances.

Other names for this substance

The same substance appears in trade and in the literature under several names: epichlorhydrin. A safety data sheet has to carry the name used in the harmonised entry, but a purchase order, a customs declaration and a certificate of analysis may each use a different one. Where the names diverge, CAS 106-89-8 is the identifier that reconciles them — and a document set that relies on trade names alone will eventually be read as describing three different materials.

Which SDS sections decide whether a shipment clears?

A sheet for CAS 106-89-8 is read by number, not as a narrative. Subsections matter as much as sections: an inspector looking for 3.1 will not accept the information folded into a paragraph elsewhere, however complete that paragraph is. Completeness is judged by structure first and content second.

What is the CLP classification of 1-chloro-2,3-epoxypropane?

The harmonised classification for CAS 106-89-8 carries 7 hazard statements: H226, H350, H331, H311, H301, H314, H317. In plain terms this means flammable liquid and vapour; may cause cancer; toxic if inhaled; toxic in contact with skin. A harmonised entry is binding across the Union — an importer may not soften it, and a self-classification that diverges from it will not survive an enforcement check.

What is the EC number for 1-chloro-2,3-epoxypropane?

Alongside CAS 106-89-8, this substance carries EC number 203-439-8 and Annex VI index 603-026-00-6. European documentation is built around the EC number as often as around the CAS: registration dossiers, the candidate list and customs systems key on it. A safety data sheet quoting only one of the two forces every downstream reader to look up the other.

Is 1-chloro-2,3-epoxypropane classified as a CMR substance?

CAS 106-89-8 is classified as a CMR substance (H350). That status changes the obligations attached to every shipment: workplace exposure documentation, restrictions on supply to the general public, and substitution pressure from downstream users who must justify continued use. A safety data sheet for a CMR substance is read more closely than any other, because the classification itself invites scrutiny.

How is 1-chloro-2,3-epoxypropane classified for road, sea and air transport?

Section 14 for CAS 106-89-8 carries the UN number, proper shipping name, class, packing group and environmental hazard where these apply. Where the substance is not dangerous for carriage, the section says so explicitly rather than being left empty — an empty section 14 reads as an omission, not as an absence of hazard.

What happens if a consignment of 1-chloro-2,3-epoxypropane is refused?

When a shipment of 1-chloro-2,3-epoxypropane is detained, the expense is typically not the document itself. It is the storage costs, demurrage fees, and the delay incurred by the customer. This financial calculation underscores the importance of verifying the documentation prior to dispatch rather than after receiving a notification from the border.

Who is responsible for REACH compliance for 1-chloro-2,3-epoxypropane?

Anyone importing 1-chloro-2,3-epoxypropane into the European Union must provide the necessary documentation, and this responsibility cannot be transferred back to previous entities in the supply chain through contractual arrangements. Section 1 requires the designation of a contactable entity within the Union; a foreign address is not acceptable for this purpose and is one of the first elements inspected due to its straightforward verification.

Identifiers that must agree

Three identifiers travel with this substance and all three have to agree: CAS 106-89-8, the Annex VI index number 603-026-00-6, and the name as it appears in the register. Mismatched identifiers are the quietest defect in a documentation set, because every individual document looks correct and only a cross-check reveals that they describe different things.

Can I import 1-chloro-2,3-epoxypropane into the EU?

The introduction of 1-chloro-2,3-epoxypropane into the Union necessitates the preparation of documentation prior to logistical arrangements. The documentation file must be available at the time of import, not merely upon request; for this purpose, alcohols and ethers is assessed within the context of solvent shipments. Index 603-026-00-6 establishes the classification that Section 2 must reflect accordingly.

What must the label for 1-chloro-2,3-epoxypropane contain?

The supply label for 1-chloro-2,3-epoxypropane is generated from the same classification that drives the safety data sheet: pictograms selected by precedence, one signal word derived from the highest hazard class present, and the hazard statements H226, H350, H331… reproduced in full. Where the container is too small to carry the complete set at a legible size, there are lawful ways to handle it and unlawful ones that look identical to a non-specialist.

How do I check if my SDS for 1-chloro-2,3-epoxypropane is still valid?

When dealing with a document about 1-chloro-2,3-epoxypropane that is already in use, the primary concern should be verifying its accuracy rather than immediately considering replacement. If inaccuracies are found, it is essential to identify the specific sections requiring correction. Errors frequently appear across multiple documents; thus, reviewing three documents can often yield insights that would otherwise necessitate examining three hundred.

What Annex VI notes and concentration limits apply to 1-chloro-2,3-epoxypropane?

The register also records * for this entry. Specific concentration limits, M-factors and acute toxicity estimates override the generic cut-off values, so a mixture calculation that ignores them will classify the mixture wrongly in both directions.

Where is regulatory status recorded for 1-chloro-2,3-epoxypropane?

The regulatory status of 1-chloro-2,3-epoxypropane evolves separately from its hazard classification. A substance may maintain consistent hazard characteristics over extended periods while gaining additional obligations under Section 15, leading to this section becoming outdated more rapidly than Section 2.

Accidental release and containment

A spill involving substance with CAS number 106-89-8 must be managed according to Section 6, which should clearly specify the required containment materials and personal protective equipment necessary for personnel approaching the spill site. An operational sheet outlining the cleanup process without detailing the appropriate attire for workers is considered incomplete.

Stability, reactivity and incompatibilities

Incompatibilities for 1-chloro-2,3-epoxypropane belong in section 10 and must not contradict the storage guidance in section 7. Where a sheet lists a material as incompatible in one section and acceptable in another, the document has stopped being usable.

Which GHS pictograms apply to 1-chloro-2,3-epoxypropane?

The label for 1-chloro-2,3-epoxypropane carries GHS02 (flame), GHS05 (corrosion), GHS06 (skull and crossbones), GHS08 (health hazard), with the signal word Danger. These are not chosen by the supplier: CLP Annex VI states them for CAS 106-89-8, and the precedence rules in Annex I decide which pictogram is dropped when two would say the same thing. A label showing a different set from the register is wrong even if every hazard statement on it is correct.

Why a correct sheet stops being correct

Classification under CLP moves with each Adaptation to Technical Progress. A sheet for CAS 106-89-8 written before the amendment that touched its entry keeps stating a classification the register no longer holds. Nothing in the document announces this — it reads exactly as it did on the day it was issued, which is precisely why revision dates are checked before content.

Questions about documentation for 1-chloro-2,3-epoxypropane

What is the CAS number of 1-chloro-2,3-epoxypropane?

CAS 106-89-8. In CLP Annex VI the same substance carries index number 603-026-00-6, and both identifiers should appear in the documentation.

Is 1-chloro-2,3-epoxypropane a CMR substance?

Yes. The harmonised classification places it among substances classified as carcinogenic, mutagenic or toxic for reproduction, which changes workplace documentation and supply restrictions.

What hazard statements apply to CAS 106-89-8?

The harmonised entry lists H226, H350, H331, H311. These are binding across the Union and may not be softened by a self-classification.

In which language must the sheet be supplied?

In an official language of each Member State where 1-chloro-2,3-epoxypropane is placed on the market, unless that State has stated otherwise.

MolGod.org issues documentation and does not sell, supply or ship chemical substances. CAS 106-89-8 identifies the subject of this document.

Bibliografia (rozszerzona) (5)

  1. ★★☆☆☆ CROSSREF 🔓 OPEN ❓ unverified Lee, Hee-Yoon, Sampath, Vasu, Yoon, Yeokwon. 2009. "A Facile Total Synthesis of All Stereoisomers of Tarchonanthuslactone and Euscapholide from Chiral Epichlorohydrin." Synlett 2009 (02): 249-252. https://doi.org/10.1055/s-0028-1087524. link [dostep: 2026-08-25] CC0 (metadata)
  2. ★★☆☆☆ CROSSREF 🔓 OPEN ❓ unverified Anonymous. 1978. "Current intelligence bulletin 30 - epichlorohydrin.". https://doi.org/10.26616/nioshpub79105. link [dostep: 2026-08-25] CC0 (metadata)
  3. ★★☆☆☆ CROSSREF 🔓 OPEN ❓ unverified Anonymous. "Water quality. Determination of epichlorohydrin.". https://doi.org/10.3403/02806841u. link [dostep: 2026-08-25] CC0 (metadata)
  4. ★★☆☆☆ CROSSREF 🔓 OPEN ❓ unverified Anonymous. "Water quality. Determination of epichlorohydrin.". https://doi.org/10.3403/02806841. link [dostep: 2026-08-25] CC0 (metadata)
  5. ★★☆☆☆ CROSSREF 🔓 OPEN ❓ unverified Anonymous. "Chlorinated Solvent-Free Living Cationic Ring-Opening Polymerization of Epichlorohydrin Using BF3OEt2 as Co-Initiator: Toward Perfectly Functionalized Poly(epichlorohydrin) Diols.". https://doi.org/10.1021/acsapm.3c01105.s001. link [dostep: 2026-08-25] CC0 (metadata)
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