4-Quinolinecarboxylic acid
CAS 486-74-8 · C10H7NO2 · MW 173.17 g/mol
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16 articles · 3 open access · Sources: PubMed, OpenAlex, Semantic Scholar
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Compound 6f dose-dependently attenuated both the incidence and frequency of emetic episodes induced by cisplatin in the dog more potently than ondansetron and is now under further investigation as a drug for treating gastrointestinal disorder.
The Atophan scaffold is a valuable basis for designing multitarget bioactive molecules and promising lead compounds for further development as antidepressants, antibacterial, antifungal, and anticancer agents are confirmed.
In vitro antibacterial activities of the compounds (8-15) against Staphylococcus aureus, Escherichia coli-26 and Pseudomonas aeruginosa-17 were lower than control of ciprofloxacin.
Compounds (23, 24 and 26) showed excellent antibacterial activity in vitro and in vivo and should be worth further investigation.
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