Capsaicin (CAS 404-86-4)

Capsaicin

CAS 404-86-4 · C₁₈H₂₇NO₃ · MW 305.4 g/mol

关于 Capsaicin (CAS 404-86-4)

Capsaicin (CAS 404-86-4) 是一种化学品，登记号为 CAS 404-86-4，分子式为 C₁₈H₂₇NO₃，摩尔质量为 305.4 g/mol。

该分子包含 49 个原子，通过 49 个化学键连接。该化合物的完整系统 IUPAC 名称为 (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide。上方的交互式 3D 模型可查看原子的空间排列——您可以用鼠标旋转、用滚轮缩放，并在骨架 / 球棍 (Ball & Stick) / 空间填充 (Space Fill) 显示模式之间切换。

在理化性质方面，分配系数 logP = 3.6 (正值，亲脂性化合物)，极性表面积 PSA = 58.6 Å²，2 个氢键供体和 3 个氢键受体。这些参数对于评估生物利用度以及与生物分子的相互作用至关重要。

该化合物的化学数据来自 PubChem（NIH NLM NCBI），全球最大的化学数据库之一。所有信息均自动更新，并附有符合 CLP 法规（EC 1272/2008）的 GHS 危险说明翻译。上方的小部件可用于教育、研究和商业用途。

理化性质

Molecular formula	C₁₈H₂₇NO₃
Masa molowa	305.4 g/mol
IUPAC	(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
SMILES	`CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC`
InChIKey	`YKPUWZUDDOIDPM-SOFGYWHQSA-N`
logP (XLogP3)	3.6
PSA	58.6 Å²
HBD / HBA	2 / 3
PubChem CID	CID 1548943 ↗

GHS 安全

Signal word: Danger

GHS05

GHS06

GHS07

GHS08

H302 — Działa szkodliwie po połknięciu

H315 — Działa drażniąco na skórę

H318 — Powoduje poważne uszkodzenie oczu

H301 — Działa toksycznie po połknięciu

H317 — Może powodować reakcję alergiczną skóry

H319 — Działa drażniąco na oczy

H334 — Może powodować objawy alergii lub astmy lub trudności w oddychaniu w następstwie wdychania

H335 — Może powodować podrażnienie dróg oddechowych

科学文献

Related literature

8 articles · 4 open access · Sources: PubMed, OpenAlex, Semantic Scholar

📈 Publication timeline (8 articles)

Bar height = number of articles per year. Hover dla szczegółów.

Administration of Ciprofloxacin and Capsaicin in Rats to Achieve Higher Maximal Serum Concentrations

H. Sumano-López, Lilia Gutiérrez-Olvera, Rita Aguilera-Jiménez et al. (2007) · Arzneimittelforschung

AI Summary
Results revealed that capsaicin increased ciprofloxacin bioavailability by approximately 70% in groups receiving preparations containing Capsaicin at a rate of 0.01, 0.1 and 0.5%.

Cytowania: 7Influential: 1$ PaywallDOI ↗PubMed ↗

Enhanced aqueous solubility and bioavailability of capsaicin by the preparation of an inclusion complex

Xiao-Yu Chen, Xun Sun, Ke Ren et al. (2010) · Arzneimittelforschung

AI Summary
The present results indicate the potential of utilizing HP-β-CD to improve the subcutaneous absorption and bioavailability of capsaicin.

Cytowania: 17$ PaywallDOI ↗PubMed ↗

RAPID QUANTIFICATION OF CAPSAICIN AND DIHYDROCAPSAICIN IN HUMAN SKIN EXTRACTS AFTER DERMAL ADMINISTRATION USING HPLC-ESI-MS

R. Wolf, C. Huschka, K. Raith et al. (1999)

AI Summary
An HPLC electrospray mass spectrometric method for the specific and sensitive quantification of Capsaicin and Dihydrocapsaicin in extracts from human skin is presented and the fragmentation pattern in the positive mode is explained.

Cytowania: 11Influential: 1$ PaywallDOI ↗

Efficacy of Capsaicin for Non-allergic Rhinitis: An Updated Systematic Review and Meta-analysis.

Wang J, Zhang L, Zheng K (2024) · Clinical reviews in allergy & immunology

Review$ PaywallDOI ↗PubMed ↗

🔓

Capsaicin Alleviates Autophagy-Lysosomal Dysfunction via PPARA-Mediated V-ATPase Subunit ATP6V0E1 Signaling in 3xTg-AD Mice.

Yu H, Chen J, Wang F et al. (2025) · Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Open AccessDOI ↗PubMed ↗PDF ↗

🔓

Capsaicin diet drives gut inflammation and exosomal miR-17-3p elevation in idiopathic short stature.

Wang Y, Wu Z, Yuan J et al. (2025) · Nature communications

Open AccessDOI ↗PubMed ↗PDF ↗

🔓

Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer's disease-like pathology in mice.

Li Y, Wang H, Zhang D et al. (2026) · Nature communications

Open AccessDOI ↗PubMed ↗PDF ↗

🔓

Separable cryo-microneedle patches delivery with capsaicin integrated mesoporous dopamine for obesity treatment.

Gan J, Sun L, Tang W et al. (2025) · Journal of nanobiotechnology

Open AccessDOI ↗PubMed ↗PDF ↗

Dane z PubMed (NIH NLM), OpenAlex (CC0), Semantic Scholar (AI2). AI Summary wygenerowane przez Semantic Scholar TLDR. Artykuły z ikoną wymagają płatnego dostępu.

同义词

Capsaicin · 404-86-4 · Zostrix · CAPSAICINE · trans-Capsaicin · Qutenza · Styptysat · Axsain · Ausanil · Isodecenoic acid vanillylamide · trans-8-Methyl-N-vanillyl-6-nonenamide · Mioton · NGX-4010 · Dolenon · Ovocap

数据来源

📊 PubChem CID 1548943 — NIH
🔬 NIST WebBook — spektroskopia
🌐 Wikidata
💊 ChEMBL — bioaktywność

在商店购买

capsaicin (CAS 404-86-4) — Safety Data Sheet →

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📜 许可与来源MolGod_License_1

GRAVEREDNORMAL

Capsaicin (CAS 404-86-4), C18H27NO3 - 3D ball-and-stick molecular model, engraved element symbols (C H N O), MolGod STL preview

MG-STL-404-86-4-GRAVERED · 578,670 △ · 28 MB · SHA-256 d2244f2a8b0c7007

下载 3D 模型 · C H N O

Capsaicin (CAS 404-86-4), C18H27NO3 - 3D ball-and-stick molecular model, MolGod STL preview

MG-STL-404-86-4-NORMAL · 20,384 △ · 995 KB · SHA-256 757ac037188ae01e

下载 3D 模型

模型: Capsaicin · 404-86-4
InChIKey: YKPUWZUDDOIDPM-SOFGYWHQSA-N
许可协议: CC BY-SA 4.0 International
署名: MolGod Scientific — Capsaicin (CAS 404-86-4)
许可与来源记录: Capsaicin (CAS 404-86-4) →
MolGod 分子记录: Capsaicin →
源数据: PubChem CID 1548943 ↗
模型信息: 由 MolGod 生成的 STL · MolGod STL Exporter build a53b3c2cff9c · 生成于 2026-10-01
SHA-256 (STL): 757ac037188ae01efaf8855bb1a9617847ad51b15dbde0b6447ae5a8b6958528
MD5 (STL): 4bc38083c4aebe664388da7930d810ae
模型标识符: MG-STL-404-86-4
转换: MolGod Scientific 球棍模型网格
更改: 转换为三角化分子网格；原子坐标与连接关系未改变。
Wikimedia Commons: 尚未发布

📄 下载 3D 模型 (995 KB)📄 下载 3D 模型 · C H N O · (28 MB)

本许可适用于 MolGod 创建的 STL 网格，不自动适用于第三方源材料。