quinolin-8-ol-CAS-148-24-3-—-Safety-Data-Sheet CAS_NUMBER 148-24-3 (zh_CN)

quinolin-8-ol (CAS 148-24-3) — Safety Data Sheet

Safety data sheet documentation for quinolin-8-ol (CAS 148-24-3), compiled to REACH Annex II with classification read against the harmonised entry in CLP Annex VI (H360D, H301, H318, H317). Two options: a working draft sent by e-mail immediately, or a signed card issued within 72 hours of complete input. The item supplied is a document — MolGod.org does not sell, supply or ship chemical substances.

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REACH 2020/878
v4 · 07.09.2026
下载安全数据表 (PDF)CAS 148-24-3 · PDF · 194 KB工作草稿 — 尚未经过审核和批准。

第 9 部分 — 理化特性：已确定 8 项，共 22 项。

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SKU: SDS-148-24-3 Category: Tags: , , , , , , , , , , , , ,

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🧬 3D分子可视化器
正在加载分子...
3D模型8-Hydroxyquinoline，CAS 148-24-3，分子式C9H7NO, 摩尔质量 145.16 g/mol

数据转录自法规登记册和专业文献，并注明来源与版本。不能替代供应商的安全数据表。未记录来源的字段已作相应标注。

📊 物理化学数据 — CAS 148-24-3
📊 物理化学性质

快速参考

化学式： C9H7NO
分子量： 145.16 g/mol
CAS号： 148-24-3
外观： 白色晶体或白色结晶性粉末
气味： 酚类气味
🔬 高级属性

化学标识符

SMILES: C1=CC2=C(C(=C1)O)N=CC=C2

最后更新： 2026-08-25

化学概述: 8-Hydroxyquinoline
分子式C9H7NO[1]
分子量145.16 g/mol[1]
熔点76 °C[2]
沸点267 °C
LogP（亲脂性）2[1]
IUPAC名称quinolin-8-ol[1]
SMILESC1=CC2=C(C(=C1)O)N=CC=C2[1]
InChIKeyMCJGNVYPOGVAJF-UHFFFAOYSA-N[1]

同义词: 8-HYDROXYQUINOLINE · quinolin-8-ol · 148-24-3 · 8-quinolinol · Oxyquinoline

数据来源： PubChem (NLM/NIH)
最后更新： 2026-08-25

📚 科学参考文献（芝加哥作者-日期格式） (2 来源)
  1. PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. ↗ applies to: 分子式 · 分子量 · LogP（亲脂性） · IUPAC名称 · SMILES · InChIKey
  2. NIST. Chemistry WebBook, SRD 69. National Institute of Standards and Technology. ↗ applies to: 熔点

科学研究

[1]PubMed2024
The 8-hydroxyquinoline derivative, clioquinol, is an alpha-1 adrenoceptor antagonist.
Betrie AH, Abdul-Ridha A, Hartono H et al.. (2024). "The 8-hydroxyquinoline derivative, clioquinol, is an alpha-1 adrenoceptor antagonist.". Biochemical pharmacology. https://doi.org/10.1016/j.bcp.202
查看完整研究 ↗
[2]PubMed2024
Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways.
Huang XQ, Wu RC, Liang JM et al.. (2024). "Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways.". European journal of medicinal chemistry.
查看完整研究 ↗
[3]PubMed2024
Mitochondria-localizing triphenylphosphine-8-hydroxyquinoline Ru complexes induce ferroptosis and their antitumor evaluation.
Meng T, Xu Z, Wang HJ et al.. (2024). "Mitochondria-localizing triphenylphosphine-8-hydroxyquinoline Ru complexes induce ferroptosis and their antitumor evaluation.". Journal of inorganic biochemistry
查看完整研究 ↗
[4]PubMed2021
Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry.
Gupta R, Luxami V, Paul K. (2021). "Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry.". Bioorganic chemistry. https://doi.org/10.1016/j.bioorg.2021.104633
查看完整研究 ↗
[5]PubMed2021
Inorganic radiopharmaceutical chemistry of oxine.
Southcott L, Orvig C. (2021). "Inorganic radiopharmaceutical chemistry of oxine.". Dalton transactions (Cambridge, England : 2003). https://doi.org/10.1039/d1dt02685b
查看完整研究 ↗
[6]PubMed2020
Drug design strategies with metal-hydroxyquinoline complexes.
Savić-Gajić IM, Savić IM. (2020). "Drug design strategies with metal-hydroxyquinoline complexes.". Expert opinion on drug discovery. https://doi.org/10.1080/17460441.2020.1702964
查看完整研究 ↗
[7]CrossRef2019
5-{[(2-Hydroxyethyl)sulfanyl]methyl}quinolin-8-ol
Mohamed Rbaa, Youssef Ramli, Younes Lakhrissi et al.. (2019). "5-{[(2-Hydroxyethyl)sulfanyl]methyl}quinolin-8-ol". IUCrData. https://doi.org/10.1107/s2414314619006254
查看完整研究 ↗
[8]Europe PMC1985
NTP Toxicology and Carcinogenesis Studies of 8-Hydroxyquinoline (CAS No. 148-24-3) in F344/N Rats and B6C3F1 Mice (Feed Studies).
(1985). "NTP Toxicology and Carcinogenesis Studies of 8-Hydroxyquinoline (CAS No. 148-24-3) in F344/N Rats and B6C3F1 Mice (Feed Studies).".
查看完整研究 ↗
📚 科学参考文献（芝加哥作者-日期格式） 8 refs · 3 baz

MOLECULE 按CAS号参考文献（实时来自13+数据库）

来源： db:pubmed (6) · db:crossref (1) · db:Europe PMC (1)

  1. db:pubmed Betrie AH, Abdul-Ridha A, Hartono H et al.. (2024). "The 8-hydroxyquinoline derivative, clioquinol, is an alpha-1 adrenoceptor antagonist.". Biochemical pharmacology. https://doi.org/10.1016/j.bcp.2024.116092 →
  2. db:pubmed Huang XQ, Wu RC, Liang JM et al.. (2024). "Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways.". European journal of medicinal chemistry. https://doi.org/10.1016/j.ejmech.2024.116478 →
  3. db:pubmed Meng T, Xu Z, Wang HJ et al.. (2024). "Mitochondria-localizing triphenylphosphine-8-hydroxyquinoline Ru complexes induce ferroptosis and their antitumor evaluation.". Journal of inorganic biochemistry. https://doi.org/10.1016/j.jinorgbio.2024.112585 →
  4. db:pubmed Gupta R, Luxami V, Paul K. (2021). "Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry.". Bioorganic chemistry. https://doi.org/10.1016/j.bioorg.2021.104633 →
  5. db:pubmed Southcott L, Orvig C. (2021). "Inorganic radiopharmaceutical chemistry of oxine.". Dalton transactions (Cambridge, England : 2003). https://doi.org/10.1039/d1dt02685b →
  6. db:pubmed Savić-Gajić IM, Savić IM. (2020). "Drug design strategies with metal-hydroxyquinoline complexes.". Expert opinion on drug discovery. https://doi.org/10.1080/17460441.2020.1702964 →
  7. db:crossref Mohamed Rbaa, Youssef Ramli, Younes Lakhrissi et al.. (2019). "5-{[(2-Hydroxyethyl)sulfanyl]methyl}quinolin-8-ol". IUCrData. https://doi.org/10.1107/s2414314619006254 →
  8. db:Europe PMC (1985). "NTP Toxicology and Carcinogenesis Studies of 8-Hydroxyquinoline (CAS No. 148-24-3) in F344/N Rats and B6C3F1 Mice (Feed Studies).".
物质监管状态
该物质受监管要求约束： 危险废物管理（BDO——波兰国家规定）. 详细信息请参见“法规状态（REACH/ECHA/CLP）”章节及安全数据表。 监管信息——不限制在本店购买。
🧮 化学计量计算器
🧪 化学数据
CAS号
148-24-3
分子式
C9H7NO
摩尔质量
145.16 g/mol
IUPAC名称 (EN)
quinolin-8-ol
SMILES
C1=CC2=C(C(=C1)O)N=CC=C2
InChIKey
MCJGNVYPOGVAJF-UHFFFAOYSA-N
📚 Related literature (20 篇文章)

Matched automatically from public bibliographic databases by text similarity. Not curated for this substance, and not part of the safety data sheet.

Virapong Prachayasittikul, Veda Prachayasittikul, Supaluk Prachayasittikul et al. · (2013) · Drug Design Development and Therapy
筛选：
排序：
📈 出版时间线
1985
2010
2012
2013
2015
2016
2020
2021
2022
2023
2025
2026
📡 Data sources

The data in this widget comes from the following verified scientific sources:

  • PubChem — National Center for Biotechnology Information (NCBI/NIH), USA
  • ChEMBL — European Bioinformatics Institute (EMBL-EBI), UK
  • NIST WebBook — National Institute of Standards and Technology, USA

Data is cached locally for speed — the widget also works offline.

⚗️ Physicochemical properties
Temp. topnienia
74.5
Density
1.034

Source: PubChem, NIST WebBook. Last updated: 2026-08-25

🔍 外部标识符
14 / 16个ID系统88%
数据库标识符操作
CAS Registry Number148-24-3打开 →
PubChem CID1923[1]打开 →
InChIKeyMCJGNVYPOGVAJF-UHFFFAOYSA-N[1]打开 →
InChIInChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-…[1]
SMILESC1=CC2=C(C(=C1)O)N=CC=C2[1]
EC Number205-711-1[2]打开 →
ChEMBLCHEMBL310555[3]打开 →
DrugBankDB11145打开 →
KEGG CompoundD05321打开 →
ChemSpider1847[4]打开 →
MeSH UID (NLM)D015125打开 →
UNII (FDA)5UTX5635HP打开 →
NSC Number (NCI)2039打开 →
WikiData QIDQ270162打开 →

来源：PubChem (NIH)、Wikidata SPARQL、KEGG、ChEMBL (EBI)、CompTox CTX (EPA)。

📚 科学参考文献（芝加哥作者-日期格式） (4 来源)
  1. PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. ↗ applies to: PubChem CID · InChIKey · InChI · SMILES
  2. ECHA. EC Inventory — EINECS, ELINCS, NLP and List Numbers assigned under REACH. Helsinki: European Chemicals Agency. ↗ applies to: EC Number
  3. ChEMBL. European Bioinformatics Institute (EMBL-EBI), bioactivity database. ↗ applies to: ChEMBL
  4. ChemSpider. Royal Society of Chemistry, chemical structure database. ↗ applies to: ChemSpider

Further reading

Publications thematically related to this CAS. They are not the source of any value shown on this card.

扩展参考文献 (1)

  1. ★★☆☆☆ CROSSREF 🔓 开放 ❓ 未验证 Anonymous. "8-Hydroxyquinoline.". https://doi.org/10.31003/uspnf_r2085_01_01. 链接 [访问日期: 2026-08-25]
📡 光谱学 — CAS 148-24-3
📊 光谱（NMR、IR、MS、UV-Vis） (1)

可用光谱类型： IR

红外光谱 (KBr, 4000-400 cm⁻¹)

440个数据点 · 来源： NIST WebBook · NIST ↗ · 📥 JCAMP-DX
🎓 谱图解析指南（供学生使用）
如何解读IR光谱
  • 3200-3600 cm⁻¹ — O-H 伸缩 (宽峰 = 氢键)
  • 2850-3000 cm⁻¹ — C-H 伸缩 (sp³)
  • 1650-1750 cm⁻¹ — C=O 伸缩 (酮、醛、酯)
  • 1400-1600 cm⁻¹ — 芳香环振动
  • 1000-1300 cm⁻¹ — C-O 伸缩 (醚、醇)
  • 无吸收=无官能团→与参考谱图比较

来源： LibreTexts ↗, Silverstein (Spectrometric ID) ↗

📚 科学参考文献（芝加哥作者-日期格式） (7 来源)
  1. National Institute of Standards and Technology. 2024. "NIST Chemistry WebBook, SRD 69." Gaithersburg, MD: NIST. Accessed 2025-01-01. ↗
  2. Spectral Database for Organic Structure Determination (SDBS). 2024. National Institute of Advanced Industrial Science and Technology (AIST), Japan. Accessed 2025-01-01. ↗
  3. Ulrich, Eldon L., Hideo Akutsu, John F. Doreleijers, Yoko Harano, Yannis E. Ioannidis, Jundong Lin, Miron Livny, et al. 2008. "BioMagResBank." Nucleic Acids Research 36 (D1): D402–D408. [DOI ↗]
  4. Horai, Hisayuki, Masanori Arita, Shigehiko Kanaya, Yoshito Nihei, Tasuku Ikeda, Kazuhiro Suwa, Yuya Ojima, et al. 2010. "MassBank: A Public Repository for Sharing Mass Spectral Data for Life Sciences." Journal of Mass Spectrometry 45 (7): 703–714. [DOI ↗]
  5. Linstrom, P.J., and W.G. Mallard, eds. 2024. NIST Chemistry WebBook, NIST Standard Reference Database Number 69. Gaithersburg, MD: National Institute of Standards and Technology. ↗
  6. McDonald, M. Shane, Mike McAvoy, and Ajit Bhalerao. 1988. "JCAMP-DX: A Standard Form for Exchange of Infrared Spectra in Computer Readable Form." Applied Spectroscopy 42 (1): 151–162. [DOI ↗]
  7. PubChem. 2024. "PubChem Compound Database." National Library of Medicine, National Institutes of Health. Accessed 2025-01-01. ↗
结构性质

正在加载结构数据...

❓ 常见问题 (3)
What is 8-Hydroxyquinoline?
8-Hydroxyquinoline (CAS 148-24-3) is a chemical compound with the molecular formula C9H7NO and a molecular weight of 145.16 g/mol.
有帮助吗？
What is the CAS number of 8-Hydroxyquinoline?
The CAS number for 8-Hydroxyquinoline is 148-24-3.
有帮助吗？
What is the chemical formula of 8-Hydroxyquinoline?
The molecular formula of 8-Hydroxyquinoline is C9H7NO.
有帮助吗？
➕ 建议问题
下载结构文件

来自PubChem数据库（NIH）的分子结构文件。兼容Avogadro、PyMOL、Jmol和ChemDraw等程序。

来源：PubChem，美国国家医学图书馆（NIH）。 CID: 1923

🔄 浓度单位转换器 实时

输入8-Hydroxyquinoline浓度（任意单位），其余将自动计算。

分子量： 145.16 g/mol · IUPAC Gold Book ↗

⚗️ 转换公式及引用（每个公式）
转换分子式准确度来源
% (w/v) ↔ molarityc (mol/L) = (% × 10) / MW±0.5% rel. when density ≈ 1.0 g/mLIUPAC (2019)
millimolar ↔ molarc (mol/L) = mM × 10⁻³ExactCohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
molarity (mol/L)c = n/V = (m/MW)/V±0.1% (depends on MW precision)IUPAC (2019)
parts per million (mg/L) ↔ molarityc (mol/L) = ppm / (1000 × MW); equivalently ppm = mg/L for dilute aqueous±1% (density-independent for dilute solutions)IUPAC (2019)
mg/mL ↔ molarityc (mol/L) = (mg/mL × 1000) / MW / 1000 = mg/mL / MW × 1±0.2%Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
g/L ↔ molarityc (mol/L) = (g/L) / MW±0.1% (depends on MW precision)Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
mmol/L ↔ molarityc (mol/L) = mmol/L × 10⁻³ExactCohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
Celsius ↔ KelvinT(K) = t(°C) + 273.15±0.01 K (ITS-90 scale)BIPM (Bureau International des Poids et Mesures) (2019)
Celsius ↔ FahrenheitT(°F) = T(°C) × 9/5 + 32±0.1 °FThompson A, Taylor BN (2008)
density-corrected % ↔ molarityc (mol/L) = (%w/w × ρ × 10) / MW, ρ in g/mL±0.1% when ρ known to 3 decimalsCohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
📚 参考文献（8个权威来源）
  1. Thompson A, Taylor BN (2008). Guide for the Use of the International System of Units (SI). NIST Special Publication 811 · DOI: 10.6028/NIST.SP.811-2008
    → Primary SI standard for US scientific usage
  2. Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007). Quantities, Units and Symbols in Physical Chemistry — The IUPAC Green Book. RSC Publishing, 3rd ed. · DOI: 10.1039/9781847557889 · ISBN: 978-0-85404-433-7
    → Canonical IUPAC guide for chemistry quantities/units
  3. BIPM (Bureau International des Poids et Mesures) (2019). The International System of Units (SI), 9th edition. BIPM · ↗
    → International SI definitions (incl. redefined kilogram 2019)
  4. ISO/IEC (2022). Quantities and units — Part 1: General. International Organization for Standardization — ISO 80000-1:2022 · ↗
    → General rules for physical quantities and units
  5. ISO/IEC (2019). Quantities and units — Part 9: Physical chemistry and molecular physics. International Organization for Standardization — ISO 80000-9:2019 · ↗
    → Concentration / molality / amount-of-substance conventions
  6. Tiesinga E, Mohr PJ, Newell DB, Taylor BN (2021). CODATA recommended values of the fundamental physical constants: 2018. Rev. Mod. Phys. 93(2):025010 · DOI: 10.1103/RevModPhys.93.025010
    → Avogadro, gas constant, molar volume (2019 SI revision)
  7. IUPAC (2019). Compendium of Chemical Terminology — the IUPAC Gold Book (online). IUPAC · DOI: 10.1351/goldbook
    → Definitions of mass fraction, molality, normality, ppm, activity
  8. Mills IM, Cvitaš T, Homann K, Kallay N, Kuchitsu K (1988). Quantities, Units and Symbols in Physical Chemistry. Blackwell Scientific Publications, 1st ed. · ISBN: 0-632-01773-5
    → Historical predecessor of IUPAC Green Book
相似分子结构

正在加载相似结构...

🧪 溶液制备向导 WIZARD
① 选择浓度
② 目标体积
③ 溶剂

计算依据： IUPAC Gold Book ↗, Merck ↗

计算化学

正在加载计算数据...

🛡️ 安全 — CAS 148-24-3
数据限制说明。 本页安全信息仅供参考，不能替代完整的安全数据表（SDS）。使用产品前，请查阅制造商当前的安全数据表以及GHS/CLP指南。CLP分类适用于纯散装物质，不适用于商业制剂。

GHS/CLP分类——(EC) No 1272/2008法规 + UN GHS Rev. 9 (2021)。

⚠️ 危险 (Danger)
GHS05 — 腐蚀性
GHS05 腐蚀性
GHS06 — 毒性
GHS06 毒性
GHS07 — 刺激性/有害
GHS07 刺激性/有害
GHS08 — 健康危害
GHS08 健康危害
GHS09 — 环境危害
GHS09 环境危害

🚨 危险说明（H）

  • H360D — 可能对胎儿造成伤害
  • H301 — 吞咽可中毒
  • H318 — 造成严重眼损伤
  • H317 — 可能导致皮肤过敏反应
  • H400 — 对水生生物毒性极大
  • H410 — 对水生生物毒性极大并具有长期持续影响

🛡 防范说明（P）

  • P203 — 使用前取得、阅读并遵循所有安全说明书。
  • P261 — 避免吸入粉尘/烟/气体/气雾/蒸气/喷雾。
  • P262 — 严防进入眼中、接触皮肤或衣服。

✓ 根据CLP法规(EC) 1272/2008附件VI的统一分类（官方、具有约束力的分类）。 索引号：613-324-00-8。

参考文献（芝加哥格式）： European Chemicals Agency. "quinolin-8-ol; 8-hydroxyquinoline, Index No. 613-324-00-8." In Table 3 of Annex VI to Regulation (EC) No 1272/2008 (CLP Regulation), 23rd Adaptation to Technical Progress (harmonised list as of 2026-07-07). Helsinki: European Chemicals Agency, 2026. https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp.

⚠ IARC — 组 3: 对人类致癌性无法分类（经IARC评估）. (IARC/WHO对致癌性证据的独立评估 — 补充上述CLP分类。)
参考文献（芝加哥格式）： IARC. n.d. IARC Monographs on the Identification of Carcinogenic Hazards to Humans: CAS 148-24-3. Lyon, France: International Agency for Research on Cancer, World Health Organization. https://monographs.iarc.who.int/list-of-classifications/.
来自本地MOL-GOD列表（快照）的分类 — 未与当前IARC列表核实。 验证

翻译：CLP 法规 (EC) 1272/2008，附件 III 和 IV。数据：PubChem/NLM。

📚 综合科学参考文献 — Chicago Author-Date 10 来源

从所有Safety Hub选项卡收集的参考文献。CAS号： 148-24-3 · PubChem ↗

  1. Parlament Europejski i Rada UE. 2008. "Regulation (EC) nr 1272/2008 w sprawie klasyfikacji, oznakowania i pakowania substancji (CLP)." Dz.Urz. UE L 353. [↗] GHS，法规
  2. United Nations Economic Commission for Europe (UNECE). 2021. "Globally Harmonized System of Classification and Labelling of Chemicals (GHS), Ninth Revised Edition." United Nations, Geneva. [↗] GHS
  3. Goldfrank, Lewis R., Robert S. Hoffman, Mary Ann Howland, et al.. 2019. "Goldfrank's Toxicologic Emergencies, 11th ed.." McGraw-Hill Education, New York. ISBN 978-1-25-985961-8. 急救、毒理学
  4. National Institute for Occupational Safety and Health (NIOSH). 2023. "NIOSH Pocket Guide to Chemical Hazards (DHHS Publ. 2005-149)." U.S. Department of Health and Human Services / CDC, Cincinnati, OH. [↗] 急救、个人防护装备、毒理学
  5. European Committee for Standardization (CEN). 2016. "EN 374-1:2016 — Protective gloves against dangerous chemicals and micro-organisms." CEN, Brussels. [↗] 个人防护装备
  6. UNECE. 2023. "European Agreement Concerning the International Carriage of Dangerous Goods by Road (ADR 2025)." United Nations, Geneva. [↗] 处置、法规
  7. National Fire Protection Association (NFPA). 2022. "NFPA 400 — Hazardous Materials Code." NFPA, Quincy, MA. [↗] 储存
  8. Urben, P.G. (ed.). 2017. "Bretherick's Handbook of Reactive Chemical Hazards, 8th ed.." Butterworth-Heinemann / Elsevier, Oxford. [↗] 储存
  9. Ministerstwo Klimatu i Środowiska RP. 2023. "Baza danych o produktach i opakowaniach oraz o gospodarce odpadami (BDO)." Ministerstwo Klimatu i Środowiska, Warszawa. 国家规定——波兰 [↗] 废物处置
  10. International Agency for Research on Cancer (IARC / WHO). 2024. "IARC Monographs on the Identification of Carcinogenic Hazards to Humans — List of Classifications." WHO, Lyon. [↗] 毒理学

具有自身参考文献的选项卡（紧急情况、个人防护装备、储存、废物）在其各自章节中包含额外的书目条目。

📈 分析统计（t检验·RSD·Grubbs·Q-Dixon） ICH Q2

粘贴一系列重复测量结果（CSV或每行一个数字）。计算器将计算平均值、标准差和95%置信区间，并检测异常值（Grubbs + Dixon Q）。

分隔符：逗号、空格、制表符、换行。至少3个测量值。
📐 统计公式
  • x̄ = Σxᵢ / n — 算术平均值
  • s² = Σ(xᵢ - x̄)² / (n-1) — 样本方差
  • s = √s² — 标准差
  • RSD% = (s / x̄) × 100% — 相对标准差
  • CI₉₅ = x̄ ± t(0.05, n-1) × s / √n — Student's t
  • G = |xᵢ - x̄| / s — Grubbs检验
  • Q = |xsuspect - xnearest| / |xmax - xmin| — Dixon Q-test

来源：ICH Q2(R2) 分析方法验证 · ICH PDF ↗

🧪 缓冲液配方计算器 唯一
参考文献： pKa值来自 Goldberg NIST 81 · CRC Handbook 100th ed. · Stoll & Blanchard 1990 (DOI)

从 20 种常用缓冲体系列表中选择 → 输入目标 pH → 获得精确配方，包括称量质量。

步骤 1：选择缓冲体系

📜 配方历史记录（最近 10 条）
📅 项目规划器——实验室实验管理器 新品

规划您的整个实验室项目：添加实验（含试剂、重复次数和持续时间）。您将获得甘特图、购物清单（含商店链接！）、预算（含10%余量）和GHS风险矩阵。

🧪 溶解性和溶剂兼容性
分子
8-Hydroxyquinoline
分子式
C9H7NO
logP (XLogP3)
2.00
摩尔质量（g/mol）
145.16
极性
疏水性（非极性）

⚠️ GC估算（Hoftyzer-Van Krevelen）。该CAS无文献HSP数据——精度±2 MPa½。请实验验证。

Ra < R₀ = 混溶性良好 · Ra < 1,5×R₀ = 临界 · 以上 = 较差（R₀ — 该分子 Hansen 溶解度球的半径） 该分子的 R₀ = 8.。

溶剂 兼容性 Ra 可视化 GC-MS HPLC 应用 参考文献
Water (H₂O)0.556 g/L（实测）—
✗ NoA (aqueous) (RP)
buffercell cultureanalyticalextraction (hydrophilic)
Ethanol (EtOH)——无依据✗ NoA/B modifier (RP/NP)
extractionspectroscopy (UV-Vis)synthesisHPLC modifier
Methanol (MeOH)——无依据✗ NoA/B (RP) (RP)
HPLC (eluent)LC-MSKarl FischerUV-transparent to 205 nm
Acetone——无依据✗ NoB modifier (NP)
GC headspacecrystallisationdegreasingsynthesis
Acetonitrile (ACN)——无依据✗ NoB (RP) (RP)
HPLC eluent (gold standard)LC-MS (low UV cut-off, 190 nm)peptide analysis
DMSO——无依据✗ NoN/A (N/A)
NMR (d6-DMSO)cell biology (cryopreservation)drug deliverysynthesis
THF——无依据✗ NoB (NP) (NP)
GPC/SEC (polymer analysis)Grignard synthesisorganometallics
DCM (CH₂Cl₂)——无依据✓ YesB (NP) (NP)
extractionNP-HPLCGC-MScrystallisation (anti-solvent)
Chloroform (CHCl₃)——无依据✓ YesN/A (toxic) (N/A)
NMR (CDCl3)lipid extraction (Folch method)NP-TLC
Hexane——无依据✓ YesA (NP) (NP)
NP-HPLCoil extraction (lipids)GC-MSTLC (NP)
Toluene——无依据✓ YesB (NP) (NP)
NMR (d8-toluene)synthesisazeotropic drying (Dean-Stark)
📚 溶剂科学参考文献（芝加哥作者-日期格式）——点击展开

11 种溶剂 · 54 条完整引用（NIST/CRC/IARC/Hansen/Reichardt/Smallwood/Wypych/Armarego/Snyder/GESTIS）— 见下文。

Water (H₂O)
  1. NIST — NIST Chemistry WebBook — Water (CAS 7732-18-5)
  2. CRC — CRC Handbook of Chemistry and Physics, 104th ed., Sec. 8 (Properties of Water)
  3. IAPWS — IAPWS Release on Static Dielectric Constant of Water
  4. Reichardt 2011 — Solvents and Solvent Effects in Organic Chemistry
  5. GESTIS — GESTIS Substance Database — Water
Ethanol (EtOH)
  1. NIST — NIST Chemistry WebBook — Ethanol (CAS 64-17-5)
  2. CRC — CRC Handbook — Ethanol physical constants
  3. Snyder & Kirkland — Modern Liquid Chromatography — Ethanol eluotropic
  4. Smallwood — Handbook of Organic Solvent Properties — Ethanol
  5. GESTIS — GESTIS Substance Database — Ethanol
Methanol (MeOH)
  1. NIST — NIST Chemistry WebBook — Methanol (CAS 67-56-1)
  2. CRC — CRC Handbook — Methanol physical constants
  3. Snyder & Kirkland — Modern Liquid Chromatography — MeOH eluotropic, eo=0.95
  4. GESTIS — GESTIS Substance Database — Methanol
Acetone
  1. NIST — NIST Chemistry WebBook — Acetone (CAS 67-64-1)
  2. CRC — CRC Handbook — Acetone physical & thermodynamic constants
  3. Hansen 2007 — Hansen Solubility Parameters — Acetone (dD=15.5, dP=10.4, dH=7.0)
  4. Smallwood — Handbook of Organic Solvent Properties — Acetone
  5. GESTIS — GESTIS Substance Database — Acetone
Acetonitrile (ACN)
  1. NIST — NIST Chemistry WebBook — Acetonitrile (CAS 75-05-8)
  2. CRC — CRC Handbook — Acetonitrile constants
  3. Snyder & Kirkland — Modern Liquid Chromatography — ACN gold-standard HPLC eluent
  4. Reichardt 2011 — Solvents and Solvent Effects — ACN dipolar aprotic
  5. GESTIS — GESTIS Substance Database — Acetonitrile
DMSO
  1. NIST — NIST Chemistry WebBook — DMSO (CAS 67-68-5)
  2. Wypych 2019 — Handbook of Solvents Vol. 1 — DMSO comprehensive properties
  3. Hansen 2007 — HSP — DMSO (dD=18.4, dP=16.4, dH=10.2)
  4. Reichardt 2011 — Solvents and Solvent Effects — DMSO E_T(30)=45.1, dipolar aprotic
  5. GESTIS — GESTIS Substance Database — DMSO
THF
  1. NIST — NIST Chemistry WebBook — THF (CAS 109-99-9)
  2. Armarego 2009 — Purification of Laboratory Chemicals — THF drying & peroxide test
  3. Hansen 2007 — Hansen Solubility Parameters — THF (dD=16.8, dP=5.7, dH=8.0)
  4. Smallwood — Handbook of Organic Solvent Properties — THF
  5. GESTIS — GESTIS Substance Database — Tetrahydrofuran
DCM (CH₂Cl₂)
  1. NIST — NIST Chemistry WebBook — Dichloromethane (CAS 75-09-2)
  2. IARC 71 — IARC Monograph 71 — DCM (Group 2A carcinogen)
  3. Hansen 2007 — Hansen Solubility Parameters — DCM (dD=18.2, dP=6.3, dH=6.1)
  4. Reichardt 2011 — Solvents and Solvent Effects — DCM polarity index
  5. GESTIS — GESTIS Substance Database — Dichloromethane
Chloroform (CHCl₃)
  1. NIST — NIST Chemistry WebBook — Chloroform (CAS 67-66-3)
  2. IARC 73 — IARC Monograph 73 — Chloroform (Group 2B carcinogen)
  3. Hansen 2007 — Hansen Solubility Parameters — CHCl3 (dD=17.8, dP=3.1, dH=5.7)
  4. Reichardt 2011 — Solvents and Solvent Effects — CHCl3 H-bond donor strength
  5. GESTIS — GESTIS Substance Database — Chloroform
n-Hexane
  1. NIST — NIST Chemistry WebBook — n-Hexane (CAS 110-54-3)
  2. ATSDR n-Hexane — ATSDR Toxicological Profile for n-Hexane — 周围神经病变（正己烷并非 IARC 致癌物）
  3. Hansen 2007 — Hansen Solubility Parameters — n-Hexane (dD=14.9, dP=0, dH=0)
  4. Snyder & Kirkland — Modern Liquid Chromatography — n-Hexane NP standard, eo=0.00
  5. GESTIS — GESTIS Substance Database — n-Hexane
Toluene
  1. NIST — NIST Chemistry WebBook — Toluene (CAS 108-88-3)
  2. IARC 71 — IARC Monograph 71 — Toluene
  3. Hansen 2007 — Hansen Solubility Parameters — Toluene (dD=18.0, dP=1.4, dH=2.0)
  4. Smallwood — Handbook of Organic Solvent Properties — Toluene
  5. GESTIS — GESTIS Substance Database — Toluene
溶解性理论（应用于相容性预测）：
  1. Yalkowsky, Samuel H., and Shri C. Valvani. 1980. "Solubility and Partitioning I: Solubility of Nonelectrolytes in Water." Journal of Pharmaceutical Sciences 69 (8): 912–922. https://doi.org/10.1002/jps.2600690814 — General Solubility Equation (GSE): logS = 0.5 − logP − 0.01(MP−25).
  2. Hansen, Charles M. 2007. Hansen Solubility Parameters: A User's Handbook. 2nd ed. CRC Press. https://doi.org/10.1201/9781420006834 — HSP三元组（dD, dP, dH）+ Ra公式。
  3. Stefanis, E., and C. Panayiotou. 2008. "Prediction of Hansen Solubility Parameters with a New Group-Contribution Method." Int J Thermophys 29: 568–585. https://doi.org/10.1007/s10765-008-0415-z
  4. Reichardt, Christian, and Thomas Welton. 2011. Solvents and Solvent Effects in Organic Chemistry. 4th ed. Wiley-VCH. https://doi.org/10.1002/9783527632220 — E_T(30) polarity scale, solvatochromism.
  5. Snyder, Lloyd R., Joseph J. Kirkland, and John W. Dolan. 2010. Introduction to Modern Liquid Chromatography. 3rd ed. Wiley. https://doi.org/10.1002/9780470508183 — Eluotropic series, polarity index.
  6. Van Krevelen, D. W., and K. Te Nijenhuis. 2009. Properties of Polymers. 4th ed. Elsevier. https://doi.org/10.1016/B978-0-08-054819-7.X0001-5 — Hoftyzer–Van Krevelen group contribution for dD/dP/dH from SMILES.
  7. Marcus, Yizhak. 1998. The Properties of Solvents. Wiley Series in Solution Chemistry, Vol. 4. ISBN 9780471983699 — 250+溶剂的完整表格数据集（ε、μ、供体数、受体数）。
  8. PubChem Compound Database — CAS 148-24-3 lookup ↗ — logP (XLogP3), water solubility experimental + predicted.

完整参考文献位于页面底部的参考文献折叠面板——芝加哥格式手册第17版作者-日期格式。

⚗️ 检查反应兼容性
3 0 0
健康： 3/4
易燃性： 0/4
反应性： 0/4
根据NFPA 704 / 由H代码计算

检查8-Hydroxyquinoline是否与另一种试剂兼容

📦 储存兼容性矩阵
酸类 碱 氧化剂 易燃 毒性 Gazy
酸类 ✓ ✗ ✗ ✗ ⚠ ✗
碱 ✗ ✓ ⚠ ⚠ ⚠ ⚠
氧化剂 ✗ ⚠ ✓ ✗ ⚠ ✗
易燃 ✗ ⚠ ✗ ✓ ⚠ ✗
毒性 ⚠ ⚠ ⚠ ⚠ ✓ ⚠
Gazy ✗ ⚠ ✗ ✗ ⚠ ✓
✓ 可一起储存 · ⚠ 谨慎 · ✗ 禁止一起储存 · OSHA Chemical Segregation ↗

兼容性数据来源： Bretherick's Handbook (7th ed.) ↗, GESTIS ↗, ECHA REACH ↗, NFPA 704 ↗

🧮 实验室计算器（8个）
稀释（C₁V₁=C₂V₂）
摩尔浓度（M=n/V）
pH缓冲液（Henderson-Hasselbalch）
Beer-Lambert（A=εcl）
质量→摩尔
浓度%→M
ppm→mg/L
温度 C↔F↔K

已验证的配方： IUPAC Gold Book ↗, DOI ↗

📊 光谱数据库
📋 实验室方案生成器

方案基于以下内容生成： GHS SDS, Aldrich Lab Guide ↗

🏷️ 标签生成器（QR码）
Quinolin-8-Ol• 8-hydroxyquinoline / 8-quinolinol• IUPAC: quinolin-8-ol• CAS: 148-24-3• EC: 205-711-1• 分子式: C9H7NO• 摩尔质量: 145.16 g/mol危险GHS危险说明：H360D H301 H318 H317 H400 H410P203 P261 P262Nonsensia Ltd124-128 City Road, EC1V 2NX London[email protected]molgod.org批号: 净含量:
🧪 溶液配制助手（Smart Prep）

输入您要制备的内容——我将生成SOP

示例如下——点击插入：
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📚 科学文献概览 — CAS 148-24-3
⭐ 关键发现（科学文献） 19 出版物
🏆 CAS 148-24-3 — multi-criteria ranking (W12): 30%引用·20%近期性·20%主题·15%历史·15%开放获取.
  1. #1
    Virapong Prachayasittikul, Veda Prachayasittikul, Supaluk Prachayasittikul et al. (2013) · Drug Design Development and Therapy
    重要性： 444 次引用 · open access
    SCORE 11.1 机制 引用： 444 Open Access DOI ↗
  2. #2
    Nádia Ribeiro, Pedro Farinha, Jacinta O. Pinho et al. (2022) · Pharmaceutics
    重要性： Open access
    SCORE 10.24 机制 引用： 28 Open Access DOI ↗
  3. #3
    Fatima Zahra Guerguer, Bouchra Rossafi, Oussama Abchır et al. (2025) · PLoS ONE
    重要性： 近期（2025） · open access
    SCORE 10.22 机制 引用： 20 Open Access DOI ↗
  4. #4
    Waralee Ruankham, Kamonrat Phopin, Ratchanok Pingaew et al. (2021) · Scientific Reports
    重要性： Open access
    SCORE 9.79 分析 引用： 25 Open Access DOI ↗
  5. #5
    Csuvik O, Szatmári I (2023) · International journal of molecular sciences
    重要性： 近期（2023） · 综述 · open access
    SCORE 9.66 综述 引用： 7 Open Access DOI ↗ PubMed ↗
  6. #6
    Hamid Rashidnejad, Mohammad Ramezanitaghartapeh, Nader Noroozi Pesyan et al. (2020) · Journal of Molecular Structure
    重要性： Open access
    SCORE 9.44 分析 引用： 24 Open Access DOI ↗
  7. #7
    et al. (2025) · Future Medicinal Chemistry
    重要性： 近期（2025） · open access
    SCORE 8.48 机制 引用： 2 Open Access DOI ↗ PubMed ↗
  8. #8
    Sara Braun, Anke Schwarzer, Monika Mazik (2026) · Molbank
    重要性： 近期（2026） · open access
    SCORE 7.85 机制 Open Access DOI ↗
  9. #9
    et al. (2025) · Chemistry & Biodiversity
    重要性： 近期（2025） · open access
    SCORE 7.68 机制 引用： 2 Open Access DOI ↗ PubMed ↗
  10. #10
    Shohei Yamaguchi, Kazunori Matsui (2016) · Materials
    重要性： Open access
    SCORE 7.17 分析 引用： 10 Open Access DOI ↗
  11. #11
    et al. (2025) · RSC Advances
    重要性： 近期（2025） · open access
    SCORE 7.15 机制 引用： 1 Open Access DOI ↗ PubMed ↗
  12. #12
    et al. (2026) · Journal of Inorganic Biochemistry
    重要性： 近期（2026） · open access
    SCORE 7.05 机制 Open Access DOI ↗ PubMed ↗
  13. #13
    et al. (2026) · Pharmaceuticals
    重要性： 近期（2026） · open access
    SCORE 7.05 机制 Open Access DOI ↗ PubMed ↗
  14. #14
    Wei Jiang, Miao Zhou, Zheng Liu et al. (2015) · arXiv (1501.04926v1)
    重要性： Open access
    SCORE 6.99 机制 引用： 11 Open Access DOI ↗
  15. #15
    Feng Li, Linyuan Xin, Shiyong Liu et al. (2010) · arXiv (1003.2695v1)
    重要性： Open access
    SCORE 6.88 机制 引用： 34 Open Access DOI ↗
  16. #16
    et al. (2026) · RSC Advances
    重要性： 近期（2026） · open access
    SCORE 6.25 机制 Open Access DOI ↗ PubMed ↗
  17. #17
    et al. (2026) · Inorganic Chemistry
    重要性： 近期（2026） · open access
    SCORE 6.25 机制 Open Access DOI ↗ PubMed ↗
  18. #18
    et al. (2025) · International Journal of Molecular Sciences
    重要性： 近期（2025） · open access
    SCORE 6.25 机制 Open Access DOI ↗ PubMed ↗
  19. #19
    NTP Toxicology and Carcinogenesis Studies of 8-Hydroxyquinoline (CAS No. 148-24-3) in F344/N Rats and B6C3F1 Mice (Feed Studies).
    (1985) · PubMed
    重要性： 通过多标准评分选择（引用+近期性+主题+历史+开放获取）。
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quinolin-8-ol carries a harmonised entry in CLP Annex VI under index 613-324-00-8. This page covers the safety data sheet issued for it — a document, not a supply of the material.

quinolin-8-ol (CAS 148-24-3) at a glance

  • Substance – quinolin-8-ol
  • CAS number – 148-24-3
  • EC number – 205-711-1
  • CLP Annex VI index number – 613-324-00-8
  • Also known as – 8-hydroxyquinoline
  • Hazard statements – H360D (may damage the unborn child); H301 (toxic if swallowed); H318 (causes serious eye damage); H317 (may cause an allergic skin reaction); H400 (very toxic to aquatic life); H410 (very toxic to aquatic life with long lasting effects)
  • Hazard classes – Repr. 1B, Acute Tox. 3, Eye Dam. 1, Skin Sens. 1, Aquatic Acute 1, Aquatic Chronic 1
  • Label pictograms – GHS05, GHS06, GHS08, GHS09
  • Signal word – Danger
  • Concentration limits / M-factor / ATE – M = 1;M = 1
  • Entry current as of – ATP10
  • CMR classification – yes, classified as carcinogenic, mutagenic or toxic for reproduction
  • Documentation issued – safety data sheet in REACH Annex II structure; working draft or signed card
  • What is supplied – a document. MolGod.org does not sell, supply or ship chemical substances.

Storage and handling in the document

Section 7 of the documentation for quinolin-8-ol details handling and storage procedures, including incompatible materials, conditions to be avoided, and any segregation requirements resulting from its classification. Laboratories reviewing this section need explicit instructions rather than general warnings; for example, a statement like ‘store in a cool dry place’ is insufficient because it leaves the responsibility of specifying precise storage conditions to the personnel.

First-aid content and why it is read first

When an exposure to quinolin-8-ol happens, nobody reads sixteen sections. They read section 4, and they read it in the language of the person holding the sheet. Both facts should shape how that section is written and translated.

How is quinolin-8-ol classified for road, sea and air transport?

Section 14 for CAS 148-24-3 includes the UN number, correct shipping name, class, packing group, and environmental hazard where applicable. If the substance is not hazardous for transportation, Section 14 explicitly states this rather than being left empty; an empty Section 14 is interpreted as an omission rather than a lack of hazard.

What is the EC number for quinolin-8-ol?

Alongside CAS 148-24-3, this substance carries EC number 205-711-1 and Annex VI index 613-324-00-8. European documentation is built around the EC number as often as around the CAS: registration dossiers, the candidate list and customs systems key on it. A safety data sheet quoting only one of the two forces every downstream reader to look up the other.

What Annex VI notes and concentration limits apply to quinolin-8-ol?

The register also records M = 1;M = 1 for this entry. Specific concentration limits, M-factors and acute toxicity estimates override the generic cut-off values, so a mixture calculation that ignores them will classify the mixture wrongly in both directions.

What is the CLP classification of quinolin-8-ol?

The harmonised classification for CAS 148-24-3 carries 6 hazard statements: H360D, H301, H318, H317, H400, H410. In plain terms this means may damage the unborn child; toxic if swallowed; causes serious eye damage; may cause an allergic skin reaction. A harmonised entry is binding across the Union — an importer may not soften it, and a self-classification that diverges from it will not survive an enforcement check.

Accidental release and containment

A spill involving substance with CAS number 148-24-3 must be managed according to Section 6, which should clearly specify the required containment materials and personal protective equipment necessary for personnel approaching the spill site. An operational sheet outlining the cleanup process without detailing the appropriate attire for workers is considered incomplete.

Which GHS pictograms apply to quinolin-8-ol?

The label for quinolin-8-ol carries GHS05 (corrosion), GHS06 (skull and crossbones), GHS08 (health hazard), GHS09 (environment), with the signal word Danger. These are not chosen by the supplier: CLP Annex VI states them for CAS 148-24-3, and the precedence rules in Annex I decide which pictogram is dropped when two would say the same thing. A label showing a different set from the register is wrong even if every hazard statement on it is correct.

Sensitisation and declaration thresholds

Sensitisation (H317) carries consequences beyond the label: a threshold for declaring the substance in mixtures far below the general cut-off, and — where the entry is on the candidate list — an obligation to inform recipients. Importers frequently discover this at the point where a customer asks for a declaration they had not prepared.

What concentration limits apply to quinolin-8-ol?

M-factor on record: 1. The M-factor multiplies the contribution of this substance in the aquatic hazard calculation for a mixture, which is where it is most often overlooked.

Can I import quinolin-8-ol into the EU?

The introduction of quinolin-8-ol into the Union necessitates the preparation of documentation prior to logistical arrangements. The documentation file must be available at the time of import, not merely upon request; for this purpose, heterocyclic compounds is assessed within the context of active-ingredient and intermediate imports. Index 613-324-00-8 establishes the classification that Section 2 must reflect accordingly.

Is quinolin-8-ol classified as a CMR substance?

CAS 148-24-3 is classified as a CMR substance (H360D). That status changes the obligations attached to every shipment: workplace exposure documentation, restrictions on supply to the general public, and substitution pressure from downstream users who must justify continued use. A safety data sheet for a CMR substance is read more closely than any other, because the classification itself invites scrutiny.

Identifiers that must agree

CAS 148-24-3 and index number 613-324-00-8 are not interchangeable and not decorative. The index number ties the entry to the harmonised classification; the CAS number ties it to the chemical literature. A file carrying one without the other forces every reader to reconstruct the link, and reconstruction is where errors enter.

What must the label for quinolin-8-ol contain?

The supply label for quinolin-8-ol is generated from the same classification that drives the safety data sheet: pictograms selected by precedence, one signal word derived from the highest hazard class present, and the hazard statements H360D, H301, H318… reproduced in full. Where the container is too small to carry the complete set at a legible size, there are lawful ways to handle it and unlawful ones that look identical to a non-specialist.

Where is regulatory status recorded for quinolin-8-ol?

The regulatory status of quinolin-8-ol evolves separately from its hazard classification. A substance may maintain consistent hazard characteristics over extended periods while gaining additional obligations under Section 15, leading to this section becoming outdated more rapidly than Section 2.

Questions about documentation for quinolin-8-ol

Can I check whether my existing sheet is still valid?

Yes. A section-by-section reading against Annex II and the current harmonised entry establishes that in one pass, and a sheet that passes is reported as passing.

Do I need a safety data sheet to import quinolin-8-ol into the EU?

Yes. A sheet compiled to Annex II of REACH must exist before the first consignment moves, and it must be held by the entity placing the substance on the Union market.

What is the CAS number of quinolin-8-ol?

CAS 148-24-3. In CLP Annex VI the same substance carries index number 613-324-00-8, and both identifiers should appear in the documentation.

Is quinolin-8-ol a CMR substance?

Yes. The harmonised classification places it among substances classified as carcinogenic, mutagenic or toxic for reproduction, which changes workplace documentation and supply restrictions.

MolGod.org issues documentation and does not sell, supply or ship chemical substances. CAS 148-24-3 identifies the subject of this document.

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Related products

📄 分析证书（CoA） CAS 148-24-3 无

数据库中无此产品的证书。

📚 科学参考文献（芝加哥作者-日期格式）——点击展开

批次管理与实验室认证标准——13个独立来源（ICH Q1/Q3/Q6/Q7/Q10 + ISO 17025 + WHO TRS + 21 CFR 211 + EMA + USP + Ph.Eur. + PIC/S + IPEC-PQG）。

  1. International Council for Harmonisation (ICH). 2000. "Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients." ICH Expert Working Group. [链接 ↗] — GMP for APIs — adopted by EMA, FDA, MHLW
  2. International Organization for Standardization. 2017. "ISO/IEC 17025:2017 General requirements for the competence of testing and calibration laboratories." ISO. [链接 ↗] — Lab accreditation standard underpinning every CoA
  3. World Health Organization. 2010. "WHO Good Manufacturing Practices for Pharmaceutical Products: Main Principles (WHO Technical Report Series No. 957, Annex 3)." WHO Press. [链接 ↗] — WHO TRS No. 957 — global reference for GMP
  4. International Council for Harmonisation (ICH). 2003. "ICH Q1A(R2): Stability Testing of New Drug Substances and Products." International Council for Harmonisation. [链接 ↗] — Source for batch shelf-life and retest dating
  5. International Council for Harmonisation (ICH). 2006. "ICH Q3A(R2): Impurities in New Drug Substances." ICH. [链接 ↗]
  6. International Council for Harmonisation (ICH). 1999. "ICH Q6A: Specifications for New Drug Substances and Products." ICH. [链接 ↗] — CoA acceptance-criteria specification standard
  7. International Council for Harmonisation (ICH). 2008. "ICH Q10: Pharmaceutical Quality System." ICH. [链接 ↗]
  8. U.S. Food and Drug Administration. 2024. "21 CFR Part 211: Current Good Manufacturing Practice for Finished Pharmaceuticals." US Code of Federal Regulations. [链接 ↗] — US legal mandate (Subpart J — Records and Reports)
  9. European Medicines Agency. 2014. "Guideline on Process Validation for Finished Products — Information and Data to Be Provided EMA/CHMP/CVMP/QWP/BWP/70278/2012." European Medicines Agency. [链接 ↗]
  10. United States Pharmacopeial Convention. 2024. "United States Pharmacopeia and National Formulary, USP 47-NF 42." USP. [链接 ↗]
  11. European Pharmacopoeia Commission. 2024. "European Pharmacopoeia 11th Edition." Council of Europe — EDQM. [链接 ↗]
  12. Pharmaceutical Inspection Co-operation Scheme (PIC/S). 2021. "Guide to Good Manufacturing Practice for Medicinal Products PE 009-15." PIC/S Secretariat, Geneva. [链接 ↗] — Cross-recognized GMP for 54 inspectorates worldwide
  13. International Pharmaceutical Excipients Council (IPEC) and Pharmaceutical Quality Group (PQG). 2017. "Joint IPEC-PQG Good Manufacturing Practices Guide for Pharmaceutical Excipients." IPEC-Americas. [链接 ↗] — Excipient-grade CoA standard for non-API ingredients
📜 专利（公开元数据） 无数据

目前未在Crossref/OpenAlex中找到该物质的公开专利元数据。数据将在下次缓存刷新（24小时）后自动更新。

📚 参考文献（芝加哥作者-日期格式）——点击展开
  1. Betrie AH, Abdul-Ridha A, Hartono H et al.. (2024). "The 8-hydroxyquinoline derivative, clioquinol, is an alpha-1 adrenoceptor antagonist.". Biochemical pharmacology. https://doi.org/10.1016/j.bcp.2024.116092
  2. Huang XQ, Wu RC, Liang JM et al.. (2024). "Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways.". European journal of medicinal chemistry. https://doi.org/10.1016/j.ejmech.2024.116478
  3. Meng T, Xu Z, Wang HJ et al.. (2024). "Mitochondria-localizing triphenylphosphine-8-hydroxyquinoline Ru complexes induce ferroptosis and their antitumor evaluation.". Journal of inorganic biochemistry. https://doi.org/10.1016/j.jinorgbio.2024.112585
  4. Gupta R, Luxami V, Paul K. (2021). "Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry.". Bioorganic chemistry. https://doi.org/10.1016/j.bioorg.2021.104633
  5. Southcott L, Orvig C. (2021). "Inorganic radiopharmaceutical chemistry of oxine.". Dalton transactions (Cambridge, England : 2003). https://doi.org/10.1039/d1dt02685b
  6. Savić-Gajić IM, Savić IM. (2020). "Drug design strategies with metal-hydroxyquinoline complexes.". Expert opinion on drug discovery. https://doi.org/10.1080/17460441.2020.1702964
  7. Mohamed Rbaa, Youssef Ramli, Younes Lakhrissi et al.. (2019). "5-{[(2-Hydroxyethyl)sulfanyl]methyl}quinolin-8-ol". IUCrData. https://doi.org/10.1107/s2414314619006254
  8. (1985). "NTP Toxicology and Carcinogenesis Studies of 8-Hydroxyquinoline (CAS No. 148-24-3) in F344/N Rats and B6C3F1 Mice (Feed Studies).".
  9. World Intellectual Property Organization. 2024. "Patent Cooperation Treaty (PCT)." https://www.wipo.int/pct/.
  10. U.S. Patent and Trademark Office. 2024. "USPTO Patent Public Search." https://ppubs.uspto.gov/.
  11. European Patent Office. 2024. "Espacenet Patent Search." https://worldwide.espacenet.com/.
  12. Newman, David J., and Gordon M. Cragg. 2020. "Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019." Journal of Natural Products 83 (3): 770-803.
  13. Davies, Mark, Michał Nowotka, George Papadatos, et al. 2015. "ChEMBL Web Services: Streamlining Access to Drug Discovery Data and Utilities." Nucleic Acids Research 43 (W1): W612-W620.
  14. Bickerton, G. Richard, Gaia V. Paolini, Jérémy Besnard, Sorel Muresan, and Andrew L. Hopkins. 2012. "Quantifying the Chemical Beauty of Drugs." Nature Chemistry 4 (2): 90-98.
  15. Meanwell, Nicholas A. 2011. "Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design." Journal of Medicinal Chemistry 54 (8): 2529-2591.
  16. Ertl, Peter, and Ansgar Schuffenhauer. 2009. "Estimation of Synthetic Accessibility Score of Drug-Like Molecules Based on Molecular Complexity and Fragment Contributions." Journal of Cheminformatics 1: 8.
  17. Hopkins, Andrew L., and Colin R. Groom. 2002. "The Druggable Genome." Nature Reviews Drug Discovery 1 (9): 727-730.
  18. Allison, John R., and Mark A. Lemley. 1998. "Empirical Evidence on the Validity of Litigated Patents." AIPLA Quarterly Journal 26 (3): 185-275.
  19. Patani, George A., and Edmond J. LaVoie. 1996. "Bioisosterism: A Rational Approach in Drug Design." Chemical Reviews 96 (8): 3147-3176.
  20. Lerner, Josh. 1994. "The Importance of Patent Scope: An Empirical Analysis." RAND Journal of Economics 25 (2): 319-333.

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📚 参考文献（综合书目，芝加哥作者-日期格式） 79 条目

以上折叠面板中针对CAS号148-24-3引用的所有科学来源。格式： 《芝加哥格式手册》第17版，作者-日期系统.

🗄️ 科学数据库

  1. NIST. n.d. NIST Chemistry WebBook: CAS 148-24-3. Gaithersburg, MD: National Institute of Standards and Technology. https://webbook.nist.gov/cgi/cbook.cgi?ID=148-24-3.
  2. AIST. n.d. Spectral Database for Organic Compounds (SDBS): CAS 148-24-3. Tsukuba, Japan: National Institute of Advanced Industrial Science and Technology. https://sdbs.db.aist.go.jp/.
  3. Linstrom, Peter J., and William G. Mallard, eds. n.d. NIST Chemistry WebBook: NIST Standard Reference Database Number 69. Gaithersburg, MD: National Institute of Standards and Technology. https://doi.org/10.18434/T4D303.
  4. PubChem. n.d. PubChem Compound Summary: CAS 148-24-3. Bethesda, MD: National Center for Biotechnology Information (NCBI), National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/#query=148-24-3.
  5. ECHA. n.d. C&L Inventory and REACH Registration: CAS 148-24-3. Helsinki: European Chemicals Agency. https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp.

📐 标准/指南

  1. ICH. 2003. "Stability Testing of New Drug Substances and Products: Q1A(R2)." Geneva: International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. https://database.ich.org/sites/default/files/Q1A%28R2%29%20Guideline.pdf.
  2. National Fire Protection Association (NFPA). 2024. "NFPA 30: Flammable and Combustible Liquids Code." NFPA, Quincy, MA. https://www.nfpa.org/codes-and-standards/all-codes-and-standards/list-of-codes-and-standards/detail?code=30.
  3. Occupational Safety and Health Administration (OSHA). 2023. "29 CFR 1910.106 — Flammable Liquids." U.S. Department of Labor, Federal Register. https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.106.
  4. European Chemicals Agency (ECHA). 2024. "Annex VI to Regulation (EC) No 1272/2008 (CLP) — Harmonised Classification and Labelling." ECHA, Helsinki / Official Journal of the European Union. https://echa.europa.eu/regulations/clp/clp-classification.
  5. European Committee for Standardization (CEN). 2016. "EN 374-1:2016 — Protective gloves against dangerous chemicals and micro-organisms — Part 1: Terminology and performance requirements for chemical risks." CEN, Brussels. https://standards.cencenelec.eu/dyn/www/f?p=205:110:::::FSP_PROJECT,FSP_ORG_ID:38536,6080&cs=1B0DAA8B85DF42E4A2C70E5D71F0BFA32.
  6. European Committee for Standardization (CEN). 2001. "EN 166:2001 — Personal eye-protection — Specifications." CEN, Brussels. https://standards.cencenelec.eu/dyn/www/f?p=CEN:110:0::::FSP_PROJECT:6541&cs=1F1A4E0A78C4DB6A28DBE2E8C29D89DCF.
  7. European Committee for Standardization (CEN). 2009. "EN 14605:2005+A1:2009 — Protective clothing against liquid chemicals — Performance requirements for clothing with liquid-tight (Type 3) or spray-tight (Type 4) connections." CEN, Brussels. https://standards.cencenelec.eu/dyn/www/f?p=CEN:110:0::::FSP_PROJECT:21581&cs=1A04A2D3C7CC58E9E6CB58D55F7EBFB7E.
  8. National Institute for Occupational Safety and Health (NIOSH). 2017. "Recommendations for Chemical Protective Clothing: A Companion to the NIOSH Pocket Guide." U.S. Department of Health & Human Services / CDC. https://www.cdc.gov/niosh/ncpc/default.html.
  9. Occupational Safety and Health Administration (OSHA). 2011. "Personal Protective Equipment — General requirements." U.S. Department of Labor — 29 CFR 1910.132. https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.132.

📖 书籍

  1. Hansen, Charles M. 2007. Hansen Solubility Parameters: A User's Handbook, 2nd ed.. Boca Raton, FL: CRC Press. https://www.routledge.com/Hansen-Solubility-Parameters-A-Users-Handbook/Hansen/p/book/9780849372483.
  2. Barton, Allan F. M. 1991. CRC Handbook of Solubility Parameters and Other Cohesion Parameters: 2nd ed.. Boca Raton, FL: CRC Press. https://www.routledge.com/CRC-Handbook-of-Solubility-Parameters-and-Other-Cohesion-Parameters/Barton/p/book/9780849301766.
  3. Connors, Kenneth A., Gordon L. Amidon, and Valentino J. Stella. 1986. Chemical Stability of Pharmaceuticals: A Handbook for Pharmacists, 2nd ed.. New York: Wiley. https://doi.org/10.1002/0471734683.
  4. Rumble, John R., ed. 2019. CRC Handbook of Chemistry and Physics: 100th Edition. Boca Raton, FL: CRC Press. https://hbcp.chemnetbase.com/.
  5. Urben, Peter G. 2017. Bretherick's Handbook of Reactive Chemical Hazards, 8th Edition. Academic Press / Elsevier, Oxford. https://www.sciencedirect.com/book/9780081010594.

📘 专著

  1. IARC. n.d. IARC Monographs on the Identification of Carcinogenic Hazards to Humans: CAS 148-24-3. Lyon, France: International Agency for Research on Cancer, World Health Organization. https://monographs.iarc.who.int/list-of-classifications/.

📄 科学文章（同行评审）

  1. Stefanis, Emmanuel, and Costas Panayiotou. 2008. "Prediction of Hansen Solubility Parameters with a New Group-Contribution Method." International Journal of Thermophysics 29: 568-585. https://doi.org/10.1007/s10765-008-0415-z.
  2. Stoll, Vincent S., and John S. Blanchard. 1990. "Buffers: Principles and Practice: In Methods in Enzymology, vol. 182." San Diego: Academic Press. https://doi.org/10.1016/0076-6879(90)82008-P.

🌐 网站

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This 3D model is also published on: Zenodo (DOI 10.5281/zenodo.23277296) · NIH 3D (3DPX-023720) · Wikimedia Commons
Source structure: PubChem (CID 1923)
📜 许可与来源
COMPUTED — PubChem3D · 3D conformer computed by PubChem using OMEGA; not an experimental structure.
8-Hydroxyquinoline (CAS 148-24-3), C9H7NO - 3D ball-and-stick molecular model, engraved element symbols (C H N O), MolGod STL preview下载图片

MG_259-537-449-58 · engraved · 251,112 △ · 12 MB · SHA-256 b6a0139cda618eba

下载 3D 模型 · ENGRAVED · C H N O

8-Hydroxyquinoline (CAS 148-24-3), C9H7NO - 3D ball-and-stick molecular model, MolGod STL preview下载图片

MG_259-537-449-58 · normal · 7,584 △ · 370 KB · SHA-256 0fb2045cf4529bb8

下载 3D 模型

模型
8-Hydroxyquinoline · 148-24-3
InChIKey
MCJGNVYPOGVAJF-UHFFFAOYSA-N
许可协议
CC BY-SA 4.0 International
署名
MolGod Scientific — 8-Hydroxyquinoline (CAS 148-24-3)
许可与来源记录
8-Hydroxyquinoline (CAS 148-24-3) →
MolGod 分子记录
8-Hydroxyquinoline →
源数据
PubChem CID 1923 ↗
模型信息
由 MolGod 生成的 STL · MolGod STL Exporter build 97d4498f28a7 · 生成于 2026-10-04
SHA-256 (STL)
0fb2045cf4529bb8c43932633b0d682a58dec7f38de6ca32bed41fd6a71b3fd6
MD5 (STL)
978474365ac3712c8f0339bc81f1d640
MolGod Identification Number
MG_259-537-449-58
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MolGod Scientific 球棍模型网格
更改
转换为三角化分子网格；原子坐标与连接关系未改变。
Wikimedia Commons
STL · PNG

本许可适用于 MolGod 创建的 STL 网格，不自动适用于第三方源材料。