warfarin (CAS 81-81-2) — Safety Data Sheet

warfarin (ISO) — CAS 81-81-2, Annex VI index 607-[CAS?]. Below: what the regulatory file for this substance must contain and where such files usually fail.

warfarin (CAS 81-81-2) at a glance

• Substance – warfarin
• CAS number – 81-81-2
• EC number – 201-377-6 [1];226-907-3 [2];226-908-9 [3]
• CLP Annex VI index number – 607-[CAS?]
• Also known as – 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
• Hazard statements – H360D (may damage the unborn child); H330 (fatal if inhaled); H310 (fatal in contact with skin); H300 (fatal if swallowed); H372 (causes damage to organs through prolonged or repeated exposure); H411 (toxic to aquatic life with long lasting effects)
• Hazard classes – Repr. 1A, Acute Tox. 1, Acute Tox. 1, Acute Tox. 2, STOT RE 1, Aquatic Chronic 2
• Label pictograms – GHS06, GHS08, GHS09
• Signal word – Danger
• Concentration limits / M-factor / ATE – Repr. 1A;H360D: C ≥ 0.003%;STOT RE 1;H372: C ≥ 0.5%;STOT RE 2;H373: 0.05% ≤ C < 0.5%
• Entry current as of – ATP09
• CMR classification – yes, classified as carcinogenic, mutagenic or toxic for reproduction
• Documentation issued – safety data sheet in REACH Annex II structure; working draft or signed card
• What is supplied – a document. MolGod.org does not sell, supply or ship chemical substances.

Is warfarin (ISO) a controlled substance?

It is prescription-only in PL,US,EU,UK,CA,JP. None of this appears in the CLP classification, so a sheet built from Annex VI alone will be silent on it.

What is the EC number for warfarin (ISO)?

Alongside CAS 81-81-2, this substance carries EC number 201-377-6 [1];226-907-3 [2];226-908-9 [3] and Annex VI index 607-[CAS?]. European documentation is built around the EC number as often as around the CAS: registration dossiers, the candidate list and customs systems key on it. A safety data sheet quoting only one of the two forces every downstream reader to look up the other.

How is warfarin (ISO) classified for road, sea and air transport?

Carriers and forwarders handling warfarin compare section 14 against the shipping papers before loading. Any disagreement stops the consignment at the point where correcting it is most expensive.

What is the CLP classification of warfarin (ISO)?

The harmonised classification for CAS 81-81-2 carries 6 hazard statements: H360D, H330, H310, H300, H372, H411. In plain terms this means may damage the unborn child; fatal if inhaled; fatal in contact with skin; fatal if swallowed. A harmonised entry is binding across the Union — an importer may not soften it, and a self-classification that diverges from it will not survive an enforcement check.

Which GHS pictograms apply to warfarin (ISO)?

The label for warfarin carries GHS06 (skull and crossbones), GHS08 (health hazard), GHS09 (environment), with the signal word Danger. These are not chosen by the supplier: CLP Annex VI states them for CAS 81-81-2, and the precedence rules in Annex I decide which pictogram is dropped when two would say the same thing. A label showing a different set from the register is wrong even if every hazard statement on it is correct.

Can I import warfarin (ISO) into the EU?

An import of CAS 81-81-2 is successful or unsuccessful based on whether the accompanying document matches the register entry. Among carboxylic acid esters, a common failure arises from classification carried over from a supplier outside the Union, where the same substance may be classified differently. The binding reference is index 607-[CAS?], and discrepancies occur in solvent and intermediate shipments.

Who is responsible for REACH compliance for warfarin (ISO)?

The responsibility for documentation accompanying warfarin (ISO) rests with the entity introducing it into the Union market, rather than with any external supplier. Importers share the same obligations as manufacturers, including designating a identifiable EU contact in section 1. A non-EU supplier may appoint a sole representative, but this appointment must be established prior to the movement of goods, not in response to subsequent inquiries.

Is warfarin (ISO) classified as a CMR substance?

CAS 81-81-2 is classified as a CMR substance (H360D). That status changes the obligations attached to every shipment: workplace exposure documentation, restrictions on supply to the general public, and substitution pressure from downstream users who must justify continued use. A safety data sheet for a CMR substance is read more closely than any other, because the classification itself invites scrutiny.

Identifiers that must agree

CAS 81-81-2 and index number 607-[CAS?] are not interchangeable and not decorative. The index number ties the entry to the harmonised classification; the CAS number ties it to the chemical literature. A file carrying one without the other forces every reader to reconstruct the link, and reconstruction is where errors enter.

What must the label for warfarin (ISO) contain?

The supply label for warfarin (ISO) is generated from the same classification that drives the safety data sheet: pictograms selected by precedence, one signal word derived from the highest hazard class present, and the hazard statements H360D, H330, H310… reproduced in full. Where the container is too small to carry the complete set at a legible size, there are lawful ways to handle it and unlawful ones that look identical to a non-specialist.

How do I check if my SDS for warfarin (ISO) is still valid?

If a sheet for warfarin (ISO) is already in circulation, the useful first question is not whether to replace it but whether it is wrong, and if so in which section. Defects repeat across a catalogue, so three documents usually reveal what three hundred need.

What concentration limits apply to warfarin (ISO)?

The harmonised entry for warfarin carries specific concentration limits: H360D: C ≥ 0,003 %; H372 (blood): C ≥ 0,5 %; H373 (blood): 0,05 % ≤ C < 0,5 %. These override the generic cut-off values, so a mixture containing warfarin is classified against these figures and not against the default thresholds.

Where is regulatory status recorded for warfarin (ISO)?

Regulatory status for warfarin changes independently of its hazard classification. A substance can keep the same hazard profile for years and acquire new obligations in section 15, which is why that section dates faster than section 2.

Why a correct sheet stops being correct

Classification under CLP moves with each Adaptation to Technical Progress. A sheet for CAS 81-81-2 written before the amendment that touched its entry keeps stating a classification the register no longer holds. Nothing in the document announces this — it reads exactly as it did on the day it was issued, which is precisely why revision dates are checked before content.

What Annex VI notes and concentration limits apply to warfarin (ISO)?

The register also records Repr. 1A;H360D: C ≥ 0.003%;STOT RE 1;H372: C ≥ 0.5%;STOT RE 2;H373: 0.05% ≤ C < 0.5% for this entry. Specific concentration limits, M-factors and acute toxicity estimates override the generic cut-off values, so a mixture calculation that ignores them will classify the mixture wrongly in both directions.

Disposal route and waste classification

Section 13 for CAS 81-81-2 states the disposal route and any contaminated-packaging handling. Laboratories are audited on whether their waste stream matches what the sheet declares, so a vague section here becomes a finding on the laboratory rather than on the supplier.

Protective equipment and exposure controls

When conducting a risk assessment for warfarin, laboratories must begin by referring to Section 8. If an occupational exposure limit is in place, it is essential to clearly state this limit along with its source and the corresponding averaging period. In cases where no such limit exists, the documentation should explicitly indicate this fact rather than leaving the relevant field blank.

Other names for this substance

The same substance appears in trade and in the literature under several names: 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one. A safety data sheet has to carry the name used in the harmonised entry, but a purchase order, a customs declaration and a certificate of analysis may each use a different one. Where the names diverge, CAS 81-81-2 is the identifier that reconciles them — and a document set that relies on trade names alone will eventually be read as describing three different materials.

Questions about documentation for warfarin

Is warfarin a CMR substance?

Yes. The harmonised classification places it among substances classified as carcinogenic, mutagenic or toxic for reproduction, which changes workplace documentation and supply restrictions.

What hazard statements apply to CAS 81-81-2?

The harmonised entry lists H360D, H330, H310, H300. These are binding across the Union and may not be softened by a self-classification.

In which language must the sheet be supplied?

In an official language of each Member State where warfarin is placed on the market, unless that State has stated otherwise.

Can I check whether my existing sheet is still valid?

Yes. A section-by-section reading against Annex II and the current harmonised entry establishes that in one pass, and a sheet that passes is reported as passing.

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