Trichloromethane CAS No 67-66 (CAS 67-66-3) — Xilong Scientific, CAS 67-66-3 — chemical product label

Trichloromethane (CAS 67-66-3)

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Trichloromethane. CAS 67-66-3.

Free, and generated automatically from the sources listed on this page. No person has reviewed it, and it describes the substance in general — not your material, your process or your intended market.

REACH 2020/878
v3 · 27.08.2026

Section 9 — physicochemical properties: 10 of 22 established.

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🧬 Visualiseur de molécule 3D
Chargement de la molécule...
Modèle 3D Chloroform, CAS 67-66-3, formule brute CHCl3, masse molaire 119.37 g/mol

Données transcrites à partir de registres réglementaires et de la littérature spécialisée, avec indication de la source et de l'édition. Elles ne remplacent pas la fiche de données de sécurité du fournisseur. Les champs sans source enregistrée sont signalés comme tels.

📊 Données physicochimiques — CAS 67-66-3
📊 Propriétés physicochimiques

Aperçu rapide

Formule : CHCl3
MW : 119.37 g/mol
CAS : 67-66-3

Propriétés détaillées

Uzupełnienie tabeli „Physicochemical properties (baza danych)” poniżej — powtórzone wartości pokazujemy tylko raz.

Propriété Valeur Unité Conditions Source
Indice de réfraction (nD) 1.4459[1] 20 °C, D-line Reid, Prausnitz, Poling 4th ed. (1987)
🔬 Propriétés avancées

Identifiants chimiques

SMILES: C(Cl)(Cl)Cl

Sources de données : Reid, Prausnitz, Poling 4th ed. (1987) (ISBN 9780070517998)

Dernière mise à jour : 2026-09-02

📚 Références scientifiques (Chicago Author-Date) (1 sources)
  1. PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. ↗ dotyczy: Indice de réfraction (nD)
Aperçu chimique: Chloroform
Formule bruteCHCl3[1]
Masse moléculaire119.37 g/mol[1]
Point de fusion-63.5 °C[1][2]
Point d'ébullition61.15 °C (760 mmHg)[1][2]
Densité1.4832 g/cm³[1]
LogP (lipophilie)1.97[1]
Nom IUPACchloroform[1]
SMILESC(Cl)(Cl)Cl[1]
InChIKeyHEDRZPFGACZZDS-UHFFFAOYSA-N[1]

Synonymes: CHLOROFORM · Trichloromethane · 67-66-3 · Trichlormethan · Trichloroform

Sources de données : PubChem (NLM/NIH), Reid, Prausnitz, Poling 4th ed. (1987)
Dernière mise à jour : 2026-08-25

📚 Références scientifiques (Chicago Author-Date) (2 sources)
  1. PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. ↗ dotyczy: Formule brute · Masse moléculaire · Point de fusion · Point d'ébullition · Densité · LogP (lipophilie) · Nom IUPAC · SMILES · InChIKey
  2. NIST. Chemistry WebBook, SRD 69. National Institute of Standards and Technology. ↗ dotyczy: Point de fusion · Point d'ébullition

RECHERCHE SCIENTIFIQUE

[1]Europe PMC2026
Safety Assessment of Pseudomonas fluorescens DS17R Chloroform Extract: Low Acute But Dose-Dependent Subacute Oral Toxicity in Rats.
et al.. (2026). "Safety Assessment of Pseudomonas fluorescens DS17R Chloroform Extract: Low Acute But Dose-Dependent Subacute Oral Toxicity in Rats.". https://doi.org/10.1155/jt/8893441
Accéder à l'étude complète ↗
[2]Europe PMC2026
Unveiling the anti-inflammatory activity of chloroform fraction of curcuma wallichii and its phytoconstituents by in vivo and in…
et al.. (2026). "Unveiling the anti-inflammatory activity of chloroform fraction of curcuma wallichii and its phytoconstituents by in vivo and in silico studies.". https://doi.org/10.1038/s41598-025-2
Accéder à l'étude complète ↗
[3]Europe PMC2026
In silico anticancer, antioxidant and anti-inflammatory study on GC-MS-based profiling of chloroform and hexane extracts of Erigeron multiradiatus.
et al.. (2026). "In silico anticancer, antioxidant and anti-inflammatory study on GC-MS-based profiling of chloroform and hexane extracts of Erigeron multiradiatus.". https://doi.org/10.1007/s40203-02
Accéder à l'étude complète ↗
[4]Europe PMC2026
Computational and Experimental Analysis of Sophora alopecuroides L. Chloroform Fraction: Active Components and Anti-Breast Cancer Resistance Mechanisms.
et al.. (2026). "Computational and Experimental Analysis of Sophora alopecuroides L. Chloroform Fraction: Active Components and Anti-Breast Cancer Resistance Mechanisms.". https://doi.org/10.3390/mole
Accéder à l'étude complète ↗
[5]Europe PMC2026
Chloroform Toxicity
(2026). "Chloroform Toxicity".
Accéder à l'étude complète ↗
[6]Europe PMC2025
Chloroform: MAK Value Documentation, addendum - Translation of the German version from 2022.
(2025). "Chloroform: MAK Value Documentation, addendum - Translation of the German version from 2022.". https://doi.org/10.34865/mb6766e10_1ad
Accéder à l'étude complète ↗
[7]Europe PMC2025
Towards sustainable lipidomics: computational screening and experimental validation of chloroform-free alternatives for lipid extraction.
et al.. (2025). "Towards sustainable lipidomics: computational screening and experimental validation of chloroform-free alternatives for lipid extraction.". https://doi.org/10.1007/s00216-025-06136-z
Accéder à l'étude complète ↗
[8]Europe PMC2025
Conformational Evolution of Bicalutamide in Chloroform: A Comprehensive NMR Study.
(2025). "Conformational Evolution of Bicalutamide in Chloroform: A Comprehensive NMR Study.". https://doi.org/10.3390/molecules30224479
Accéder à l'étude complète ↗
📚 Références scientifiques (Chicago Author-Date) 20 refs · 5 baz

MOLECULE Bibliographie par CAS (en direct depuis 13+ bases de données)

Sources : db:Europe PMC (10) · db:arxiv (2) · db:openalex (6) · db:crossref (1) · db:molgod_data_citations:crossref (1)

  1. db:Europe PMC et al.. (2026). "Safety Assessment of Pseudomonas fluorescens DS17R Chloroform Extract: Low Acute But Dose-Dependent Subacute Oral Toxicity in Rats.". https://doi.org/10.1155/jt/8893441 →
  2. db:Europe PMC et al.. (2026). "Unveiling the anti-inflammatory activity of chloroform fraction of curcuma wallichii and its phytoconstituents by in vivo and in silico studies.". https://doi.org/10.1038/s41598-025-28248-3 →
  3. db:Europe PMC et al.. (2026). "In silico anticancer, antioxidant and anti-inflammatory study on GC-MS-based profiling of chloroform and hexane extracts of Erigeron multiradiatus.". https://doi.org/10.1007/s40203-026-00645-0 →
  4. db:Europe PMC et al.. (2026). "Computational and Experimental Analysis of Sophora alopecuroides L. Chloroform Fraction: Active Components and Anti-Breast Cancer Resistance Mechanisms.". https://doi.org/10.3390/molecules31040660 →
  5. db:Europe PMC (2026). "Chloroform Toxicity".
  6. db:arxiv Anirban Polley. (2026). "Concentration-Dependent Membrane Destabilization in DPPC Bilayers: Distinct Insertion Mechanisms and Stress Redistribution by Chloroform and Alkanols". arXiv (2605.08780v1).
  7. db:Europe PMC (2025). "Chloroform: MAK Value Documentation, addendum - Translation of the German version from 2022.". https://doi.org/10.34865/mb6766e10_1ad →
  8. db:Europe PMC et al.. (2025). "Towards sustainable lipidomics: computational screening and experimental validation of chloroform-free alternatives for lipid extraction.". https://doi.org/10.1007/s00216-025-06136-z →
  9. db:Europe PMC (2025). "Conformational Evolution of Bicalutamide in Chloroform: A Comprehensive NMR Study.". https://doi.org/10.3390/molecules30224479 →
  10. db:Europe PMC (2025). "Modeling reveals a metabolic basis of competition among Dehalobacter strains during tandem chloroform and dichloromethane metabolism.". https://doi.org/10.1128/msystems.00847-25 →
  11. db:Europe PMC et al.. (2025). "Chloroform exposure and risk of leukemia: systematic review and meta-analysis.". https://doi.org/10.3389/fpubh.2025.1491075 →
  12. db:arxiv R. D. Nimantha Karunathilaka, Athige Rajith Niloshan Silva, Chathuranga Bharathee Ranaweera et al.. (2025). "In Vitro Antibacterial activity of hexane, Chloroform and methanolic extracts of different parts of Acronychia pedunculata grown in Sri Lanka". arXiv (2506.13121v1). https://doi.org/10.21474/ijar01/1364 →
  13. db:openalex Clara Torrentó, Jordi Palau, Diana Rodríguez-Fernández et al.. (2017). "Carbon and Chlorine Isotope Fractionation Patterns Associated with Different Engineered Chloroform Transformation Reactions". Environmental Science & Technology. https://doi.org/10.1021/acs.est.7b00679 →
  14. db:crossref (2014). "Phenol/chloroform extraction v1". https://doi.org/10.17504/protocols.io.cdts6m →
  15. db:openalex Joel Åkesson, Oskar Sundborg, Olof Wahlström et al.. (2012). "A van der Waals density functional study of chloroform and other trihalomethanes on graphene". The Journal of Chemical Physics. https://doi.org/10.1063/1.4764356 →
  16. db:openalex Michael A. Lyons, Raymond S. H. Yang, Arthur N. Mayeno et al.. (2008). "Computational Toxicology of Chloroform: Reverse Dosimetry Using Bayesian Inference, Markov Chain Monte Carlo Simulation, and Human Biomonitoring Data". Environmental Health Perspectives. https://doi.org/10.1289/ehp.11079 →
  17. db:molgod_data_citations:crossref (2004). "Chloroform 67-66-3.". https://doi.org/10.1002/0471701343.sdp05774 →
  18. db:openalex M.D. Reuber. (1979). "Carcinogenicity of chloroform.". Environmental Health Perspectives. https://doi.org/10.1289/ehp.7931171 →
  19. db:openalex (1976). "Report on the Carcinogenesis Bioassay of Chloroform (CAS No. 67-66-3).". PubMed.
  20. db:openalex John A. Secrist, Marshall W. Logue. (1972). "Amine hydrochlorides by reduction in the presence of chloroform". The Journal of Organic Chemistry. https://doi.org/10.1021/jo00967a042 →
Statut réglementaire de la substance
Aucune entrée pour ce CAS dans les listes de restrictions vérifiées (liste candidate SVHC, REACH Annexe XVII ; ensembles de données incomplets - il ne s'agit pas d'une confirmation de conformité). Classification CLP et statut de transport (ADR) : voir la section GHS et la fiche de données de sécurité (SDS).
🧮 Calculateur stœchiométrique
🧪 Données chimiques
Numéro CAS
67-66-3
Formule brute
CHCl3
Masse molaire
119.37 g/mol
Nom IUPAC (EN)
chloroform
SMILES
C(Cl)(Cl)Cl
InChIKey
HEDRZPFGACZZDS-UHFFFAOYSA-N
📚 Related literature (20 matched automatically)

Matched automatically from public bibliographic databases by text similarity. Not curated for this substance, and not part of the safety data sheet.

R. D. Nimantha Karunathilaka, Athige Rajith Niloshan Silva, Chathuranga Bharathee Ranaweera et al. · (2025) · arXiv (2506.13121v1)
Michael A. Lyons, Raymond S. H. Yang, Arthur N. Mayeno et al. · (2008) · Environmental Health Perspectives
Clara Torrentó, Jordi Palau, Diana Rodríguez-Fernández et al. · (2017) · Environmental Science & Technology
Filtrer :
Trier :
📈 Chronologie des publications
1972
1976
1979
2008
2012
2014
2017
2022
2025
2026
📡 Data sources

The data in this widget comes from the following verified scientific sources:

  • PubChem — National Center for Biotechnology Information (NCBI/NIH), USA
  • ChEMBL — European Bioinformatics Institute (EMBL-EBI), UK
  • NIST WebBook — National Institute of Standards and Technology, USA

Data is cached locally for speed — the widget also works offline.

⚗️ Physicochemical properties
Temp. wrzenia
61.2
Temp. topnienia
-63.2
Density
1.482

Source: PubChem, NIST WebBook. Last updated: 2026-09-02

🔍 Identifiants externes
15 sur 16 systèmes d'ID94%
Base de donnéesIdentifiantActions
CAS Registry Number67-66-3Ouvrir →
PubChem CID6212[1]Ouvrir →
InChIKeyHEDRZPFGACZZDS-UHFFFAOYSA-N[1]Ouvrir →
InChIInChI=1S/CHCl3/c2-1(3)4/h1H[1]
SMILESC(Cl)(Cl)Cl[1]
EC Number200-663-8[2]Ouvrir →
ChEMBLCHEMBL44618[3]Ouvrir →
DrugBankDB11387Ouvrir →
KEGG CompoundC13827Ouvrir →
HMDBHMDB0029596Ouvrir →
ChemSpider5977[4]Ouvrir →
MeSH UID (NLM)D002725Ouvrir →
UNII (FDA)7V31YC746XOuvrir →
NSC Number (NCI)77361Ouvrir →
WikiData QIDQ172275Ouvrir →

Sources : PubChem (NIH), Wikidata SPARQL, KEGG, ChEMBL (EBI), CompTox CTX (EPA).

📚 Références scientifiques (Chicago Author-Date) (4 sources)
  1. PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. ↗ dotyczy: PubChem CID · InChIKey · InChI · SMILES
  2. ECHA. EC Inventory — EINECS, ELINCS, NLP and List Numbers assigned under REACH. Helsinki: European Chemicals Agency. ↗ dotyczy: EC Number
  3. ChEMBL. European Bioinformatics Institute (EMBL-EBI), bioactivity database. ↗ dotyczy: ChEMBL
  4. ChemSpider. Royal Society of Chemistry, chemical structure database. ↗ dotyczy: ChemSpider

Dalsza literatura

Publications topically related to this CAS. They are not the source of any value given on this card.

Bibliographie (étendue) (1)

  1. ★★☆☆☆ CROSSREF 🔓 LIBRE ❓ non vérifié Anonymous. 2004. "Chloroform 67-66-3." Sax's Dangerous Properties of Industrial Materials. https://doi.org/10.1002/0471701343.sdp05774. lien [consulté: 2026-08-25]
📡 Spectroscopie — CAS 67-66-3
📊 Spectres (NMR, IR, MS, UV-Vis) (1)

Types de spectres disponibles : IR

Spectre IR (KBr, 4000-400 cm⁻¹)

440 points de données · Source : NIST WebBook · NIST ↗ · 📥 JCAMP-DX
🎓 Guide d'interprétation des spectres (pour étudiants)
Comment lire un spectre IR
  • 3200-3600 cm⁻¹ — élongation O-H (pic large = liaison hydrogène)
  • 2850-3000 cm⁻¹ — élongation C-H (sp³)
  • 1650-1750 cm⁻¹ — élongation C=O (cétones, aldéhydes, esters)
  • 1400-1600 cm⁻¹ — vibrations du cycle aromatique
  • 1000-1300 cm⁻¹ — élongation C-O (éthers, alcools)
  • Aucune absorption = aucun groupe fonctionnel → comparer avec une référence

Sources : LibreTexts ↗, Silverstein (Spectrometric ID) ↗

📚 Références scientifiques (Chicago Author-Date) (7 sources)
  1. National Institute of Standards and Technology. 2024. "NIST Chemistry WebBook, SRD 69." Gaithersburg, MD: NIST. Accessed 2025-01-01. ↗
  2. Spectral Database for Organic Structure Determination (SDBS). 2024. National Institute of Advanced Industrial Science and Technology (AIST), Japan. Accessed 2025-01-01. ↗
  3. Ulrich, Eldon L., Hideo Akutsu, John F. Doreleijers, Yoko Harano, Yannis E. Ioannidis, Jundong Lin, Miron Livny, et al. 2008. "BioMagResBank." Nucleic Acids Research 36 (D1): D402–D408. [DOI ↗]
  4. Horai, Hisayuki, Masanori Arita, Shigehiko Kanaya, Yoshito Nihei, Tasuku Ikeda, Kazuhiro Suwa, Yuya Ojima, et al. 2010. "MassBank: A Public Repository for Sharing Mass Spectral Data for Life Sciences." Journal of Mass Spectrometry 45 (7): 703–714. [DOI ↗]
  5. Linstrom, P.J., and W.G. Mallard, eds. 2024. NIST Chemistry WebBook, NIST Standard Reference Database Number 69. Gaithersburg, MD: National Institute of Standards and Technology. ↗
  6. McDonald, M. Shane, Mike McAvoy, and Ajit Bhalerao. 1988. "JCAMP-DX: A Standard Form for Exchange of Infrared Spectra in Computer Readable Form." Applied Spectroscopy 42 (1): 151–162. [DOI ↗]
  7. PubChem. 2024. "PubChem Compound Database." National Library of Medicine, National Institutes of Health. Accessed 2025-01-01. ↗
Propriétés structurelles

Chargement des données structurelles...

❓ Questions fréquentes (3)
What is 67-66-3?
67-66-3 (CAS 67-66-3) is a chemical compound. The chemical data comes from PubChem (National Institutes of Health, USA).
Utile ?
What is the CAS number of 67-66-3?
The CAS number for 67-66-3 is 67-66-3. A CAS Registry Number is the standard identifier for a chemical substance in scientific literature and in trade.
Utile ?
How should 67-66-3 be stored?
67-66-3 should be stored as its safety data sheet directs \— typically in a dry, cool, well-ventilated place, away from heat and from materials it is incompatible with.
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Télécharger les fichiers de structure

Fichiers de structure moléculaire issus de la base PubChem (NIH). Compatibles avec les logiciels : Avogadro, PyMOL, Jmol, ChemDraw.

Source : PubChem, National Library of Medicine (NIH). CID: 6212

🔄 Convertisseur d'unités de concentration LIVE

Saisissez la concentration Chloroform dans n'importe quelle unité — le reste sera calculé automatiquement.

MW : 119.37 g/mol · IUPAC Gold Book ↗

⚗️ Formules de conversion + citations (par formule)
ConversionFormulePrécisionSource
% (w/v) ↔ molarityc (mol/L) = (% × 10) / MW±0.5% rel. when density ≈ 1.0 g/mLIUPAC (2019)
millimolar ↔ molarc (mol/L) = mM × 10⁻³ExactCohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
molarity (mol/L)c = n/V = (m/MW)/V±0.1% (depends on MW precision)IUPAC (2019)
parts per million (mg/L) ↔ molarityc (mol/L) = ppm / (1000 × MW); equivalently ppm = mg/L for dilute aqueous±1% (density-independent for dilute solutions)IUPAC (2019)
mg/mL ↔ molarityc (mol/L) = (mg/mL × 1000) / MW / 1000 = mg/mL / MW × 1±0.2%Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
g/L ↔ molarityc (mol/L) = (g/L) / MW±0.1% (depends on MW precision)Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
mmol/L ↔ molarityc (mol/L) = mmol/L × 10⁻³ExactCohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
Celsius ↔ KelvinT(K) = t(°C) + 273.15±0.01 K (ITS-90 scale)BIPM (Bureau International des Poids et Mesures) (2019)
Celsius ↔ FahrenheitT(°F) = T(°C) × 9/5 + 32±0.1 °FThompson A, Taylor BN (2008)
density-corrected % ↔ molarityc (mol/L) = (%w/w × ρ × 10) / MW, ρ in g/mL±0.1% when ρ known to 3 decimalsCohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007)
📚 Bibliographie (8 sources faisant autorité)
  1. Thompson A, Taylor BN (2008). Guide for the Use of the International System of Units (SI). NIST Special Publication 811 · DOI: 10.6028/NIST.SP.811-2008
    → Primary SI standard for US scientific usage
  2. Cohen ER, Cvitaš T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor AJ (2007). Quantities, Units and Symbols in Physical Chemistry — The IUPAC Green Book. RSC Publishing, 3rd ed. · DOI: 10.1039/9781847557889 · ISBN: 978-0-85404-433-7
    → Canonical IUPAC guide for chemistry quantities/units
  3. BIPM (Bureau International des Poids et Mesures) (2019). The International System of Units (SI), 9th edition. BIPM · ↗
    → International SI definitions (incl. redefined kilogram 2019)
  4. ISO/IEC (2022). Quantities and units — Part 1: General. International Organization for Standardization — ISO 80000-1:2022 · ↗
    → General rules for physical quantities and units
  5. ISO/IEC (2019). Quantities and units — Part 9: Physical chemistry and molecular physics. International Organization for Standardization — ISO 80000-9:2019 · ↗
    → Concentration / molality / amount-of-substance conventions
  6. Tiesinga E, Mohr PJ, Newell DB, Taylor BN (2021). CODATA recommended values of the fundamental physical constants: 2018. Rev. Mod. Phys. 93(2):025010 · DOI: 10.1103/RevModPhys.93.025010
    → Avogadro, gas constant, molar volume (2019 SI revision)
  7. IUPAC (2019). Compendium of Chemical Terminology — the IUPAC Gold Book (online). IUPAC · DOI: 10.1351/goldbook
    → Definitions of mass fraction, molality, normality, ppm, activity
  8. Mills IM, Cvitaš T, Homann K, Kallay N, Kuchitsu K (1988). Quantities, Units and Symbols in Physical Chemistry. Blackwell Scientific Publications, 1st ed. · ISBN: 0-632-01773-5
    → Historical predecessor of IUPAC Green Book
Structures moléculaires similaires

Chargement des structures similaires...

🧪 Assistant de préparation de solution WIZARD
① Sélectionnez la concentration
② Volume cible
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Calculs selon : IUPAC Gold Book ↗, Merck ↗

Chimie computationnelle

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🔬 Guide de contrôle de la pureté Contrôle qualité

Vérifiez la pureté du réactif à l'aide de méthodes analytiques normalisées. Sélectionnez une méthode d'essai ci-dessous et saisissez vos résultats de mesure pour un calcul automatisé.

🛡️ Sécurité — CAS 67-66-3
Avis sur les limitations des données. Les informations de sécurité figurant sur cette page sont fournies à titre indicatif et ne remplacent pas une fiche de données de sécurité (SDS) complète. Avant d'utiliser le produit, consultez la fiche de données de sécurité actuelle du fabricant ainsi que les directives GHS/CLP. La classification CLP s'applique à la substance pure en vrac, et non aux préparations commerciales.

Classification GHS/CLP — Règlement (CE) n° 1272/2008 + UN GHS Rev. 9 (2021).

⚠️ Danger
GHS06 — Toxique
GHS06 Toxique
GHS07 — Irritant / nocif
GHS07 Irritant / nocif
GHS08 — Danger pour la santé
GHS08 Danger pour la santé

🚨 Mentions de danger (H)

  • H351 — Susceptible de provoquer le cancer.
  • H361d — Susceptible de nuire au fœtus.
  • H331 — Toxique par inhalation.
  • H302 — Nocif en cas d'ingestion.
  • H372 — Risque avéré d'effets graves pour les organes à la suite d'expositions répétées ou d'une exposition prolongée.
  • H315 — Provoque une irritation cutanée.
  • H319 — Provoque une sévère irritation des yeux.

🛡 Conseils de prudence (P)

  • P203 — Se procurer, lire et suivre toutes les instructions de sécurité avant l’utilisation.
  • P261 — Éviter de respirer les poussières/fumées/gaz/brouillards/vapeurs/aérosols.
  • P273 — Éviter le rejet dans l'environnement.

✓ Classification harmonisée conformément à l'annexe VI du règlement CLP (CE) 1272/2008 (classification officielle, contraignante). Numéro d'index : 602-006-00-4.

Référence (Chicago) : European Chemicals Agency. "chloroform; trichloromethane, Index No. 602-006-00-4." In Table 3 of Annex VI to Regulation (EC) No 1272/2008 (CLP Regulation), 23rd Adaptation to Technical Progress (harmonised list as of 2026-07-07). Helsinki: European Chemicals Agency, 2026. https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp.

⚠ IARC — Groupe 2B: peut-être cancérogène pour l'homme. (Évaluation indépendante des preuves de cancérogénicité par l'IARC/OMS — complète la classification CLP ci-dessus.)
Référence (Chicago) : IARC. n.d. IARC Monographs on the Identification of Carcinogenic Hazards to Humans: CAS 67-66-3. Lyon, France: International Agency for Research on Cancer, World Health Organization. https://monographs.iarc.who.int/list-of-classifications/.
Classification issue de la liste locale MOL-GOD (snapshot) — non vérifiée par rapport à la liste IARC actuelle. Vérifier

Traductions : Règlement CLP (CE) 1272/2008, Annexe III et IV. Données : PubChem/NLM.

📚 Références scientifiques consolidées — Chicago auteur-date 10 sources

Références collectées dans tous les onglets du Safety Hub. CAS : 67-66-3 · PubChem ↗

  1. Parlament Europejski i Rada UE. 2008. "Rozporządzenie (WE) nr 1272/2008 w sprawie klasyfikacji, oznakowania i pakowania substancji (CLP)." Dz.Urz. UE L 353. [↗] GHS, Réglementations
  2. United Nations Economic Commission for Europe (UNECE). 2021. "Globally Harmonized System of Classification and Labelling of Chemicals (GHS), Ninth Revised Edition." United Nations, Geneva. [↗] GHS
  3. Goldfrank, Lewis R., Robert S. Hoffman, Mary Ann Howland, et al.. 2019. "Goldfrank's Toxicologic Emergencies, 11th ed.." McGraw-Hill Education, New York. ISBN 978-1-25-985961-8. Pierwsza pomoc, Toksykologia
  4. National Institute for Occupational Safety and Health (NIOSH). 2023. "NIOSH Pocket Guide to Chemical Hazards (DHHS Publ. 2005-149)." U.S. Department of Health and Human Services / CDC, Cincinnati, OH. [↗] Pierwsza pomoc, PPE, Toksykologia
  5. European Committee for Standardization (CEN). 2016. "EN 374-1:2016 — Protective gloves against dangerous chemicals and micro-organisms." CEN, Brussels. [↗] PPE
  6. UNECE. 2023. "European Agreement Concerning the International Carriage of Dangerous Goods by Road (ADR 2025)." United Nations, Geneva. [↗] Utylizacja, Regulacje
  7. National Fire Protection Association (NFPA). 2022. "NFPA 400 — Hazardous Materials Code." NFPA, Quincy, MA. [↗] Magazynowanie
  8. Urben, P.G. (ed.). 2017. "Bretherick's Handbook of Reactive Chemical Hazards, 8th ed.." Butterworth-Heinemann / Elsevier, Oxford. [↗] Magazynowanie
  9. Ministerstwo Klimatu i Środowiska RP. 2023. "Baza danych o produktach i opakowaniach oraz o gospodarce odpadami (BDO)." Ministerstwo Klimatu i Środowiska, Warszawa. [↗] Utylizacja
  10. International Agency for Research on Cancer (IARC / WHO). 2024. "IARC Monographs on the Identification of Carcinogenic Hazards to Humans — List of Classifications." WHO, Lyon. [↗] Toksykologia

Les onglets possédant leurs propres références (Emergency, PPE, Storage, Waste) contiennent des entrées bibliographiques supplémentaires au sein de leurs sections respectives.

📈 Statistiques analytiques (test t · RSD · Grubbs · Q-Dixon) ICH Q2

Collez une série de mesures répétées (CSV ou un nombre par ligne). Le calculateur calculera la moyenne, l'écart-type, l'IC à 95 %, et détectera les valeurs aberrantes (Grubbs + Dixon Q).

Séparateur : virgule, espace, tabulation, nouvelle ligne. Min. 3 mesures.
📐 Formules statistiques
  • x̄ = Σxᵢ / n — moyenne arithmétique
  • s² = Σ(xᵢ - x̄)² / (n-1) — variance de l'échantillon
  • s = √s² — écart-type
  • RSD% = (s / x̄) × 100% — écart-type relatif
  • CI₉₅ = x̄ ± t(0.05, n-1) × s / √n — Student's t
  • G = |xᵢ - x̄| / s — test de Grubbs
  • Q = |xsuspect - xnearest| / |xmax - xmin| — Dixon Q-test

Source : ICH Q2(R2) Validation of Analytical Procedures · ICH PDF ↗

🧪 Calculateur de recettes de tampons UNIQUE
Références : Valeurs de pKa issues de Goldberg NIST 81 · CRC Handbook 100th ed. · Stoll & Blanchard 1990 (DOI)

Choisissez un tampon dans la liste de 20 systèmes courants → saisissez le pH cible → vous obtiendrez une recette exacte avec les masses à peser.

Étape 1 : Choisissez un système tampon

📜 Historique des recettes (10 dernières)
Statut pharmacologique

Lek zatwierdzony (Faza 4)

Phase I
Phase II
Phase III
Approuvé

Autorisé à la commercialisation par les autorités réglementaires.

ChEMBL CHEMBL44618 ↗

🚚 Classification pour le transport (ADR / IATA / IMDG) UN 1888
Numéro UN
UN 1888
Chloroform
Classification de transport selon l'ADR / le Règlement type de l'ONU (numéro ONU, classe et groupe d'emballage ci-dessus). Vérifier l'édition ADR/IMDG/IATA en vigueur à la date d'expédition.
Source: Karta SDS sek.14 (kanon zmaterializowany)

🛣️ ADR Transport routier

Classe:
6.1
Groupe d'emballage:
III
Désignation d'expédition:
Chloroform

Sources : ADR 2025 ↗ · IATA DGR ↗ · IMDG Code ↗

📅 Project Planner — Gestionnaire d'expériences de laboratoire NOUVEAU

Planifiez l'ensemble de votre projet de laboratoire : ajoutez des expériences avec réactifs, réplicats et durée. Vous obtiendrez un diagramme de Gantt, une liste d'achats (avec des liens vers la boutique !), un budget avec une marge de 10 % et une matrice de risques GHS.

🧪 Solubilité et compatibilité avec les solvants
Molécule
Chloroform
Formule
CHCl3
logP (XLogP3)
2.30
Masse (g/mol)
119.37
Polarité
Hydrophobe (apolaire)

⚠️ Estimation HSP (littérature / contribution de groupes). Données indicatives — ne remplacent pas les études expérimentales.

Ra < R₀ = good miscibility · Ra < 1,5×R₀ = borderline · above = poor (R₀ — radius of the Hansen sphere of this molecule) For this molecule R₀ = 7.5.

Solvant Compat. Ra Visuel GC-MS HPLC Applications Références
Water (H₂O)8 g/L (pomiar)39.1
✗ NieA (aqueous) (RP)
buffercell cultureanalyticalextraction (hydrophilic)
Ethanol (EtOH)− Faible15.4
✗ NieA/B modifier (RP/NP)
extractionspectroscopy (UV-Vis)synthesisHPLC modifier
Methanol (MeOH)− Faible19.7
✗ NieA/B (RP) (RP)
HPLC (eluent)LC-MSKarl FischerUV-transparent to 205 nm
Acetone~ Moy.8.7
✗ NieB modifier (NP)
GC headspacecrystallisationdegreasingsynthesis
Acetonitrile (ACN)− Faible15.7
✗ NieB (RP) (RP)
HPLC eluent (gold standard)LC-MS (low UV cut-off, 190 nm)peptide analysis
DMSO− Faible14.1
✗ NieN/A (N/A)
NMR (d6-DMSO)cell biology (cryopreservation)drug deliverysynthesis
THF+ Bonne4.0
✗ NieB (NP) (NP)
GPC/SEC (polymer analysis)Grignard synthesisorganometallics
DCM (CH₂Cl₂)+ Bonne3.3
✓ TakB (NP) (NP)
extractionNP-HPLCGC-MScrystallisation (anti-solvent)
Chloroform (CHCl₃)+ Bonne0.0
✓ TakN/A (toxic) (N/A)
NMR (CDCl3)lipid extraction (Folch method)NP-TLC
Hexane~ Moy.8.7
✓ TakA (NP) (NP)
NP-HPLCoil extraction (lipids)GC-MSTLC (NP)
Toluene+ Bonne4.1
✓ TakB (NP) (NP)
NMR (d8-toluene)synthesisazeotropic drying (Dean-Stark)
📚 Références scientifiques pour les solvants (Chicago Author-Date) — cliquez pour développer

11 solwentów · 54 pełnych citations (NIST/CRC/IARC/Hansen/Reichardt/Smallwood/Wypych/Armarego/Snyder/GESTIS) — poniżej.

Water (H₂O)
  1. NIST — NIST Chemistry WebBook — Water (CAS 7732-18-5)
  2. CRC — CRC Handbook of Chemistry and Physics, 104th ed., Sec. 8 (Properties of Water)
  3. IAPWS — IAPWS Release on Static Dielectric Constant of Water
  4. Reichardt 2011 — Solvents and Solvent Effects in Organic Chemistry
  5. GESTIS — GESTIS Substance Database — Water
Ethanol (EtOH)
  1. NIST — NIST Chemistry WebBook — Ethanol (CAS 64-17-5)
  2. CRC — CRC Handbook — Ethanol physical constants
  3. Snyder & Kirkland — Modern Liquid Chromatography — Ethanol eluotropic
  4. Smallwood — Handbook of Organic Solvent Properties — Ethanol
  5. GESTIS — GESTIS Substance Database — Ethanol
Methanol (MeOH)
  1. NIST — NIST Chemistry WebBook — Methanol (CAS 67-56-1)
  2. CRC — CRC Handbook — Methanol physical constants
  3. Snyder & Kirkland — Modern Liquid Chromatography — MeOH eluotropic, eo=0.95
  4. GESTIS — GESTIS Substance Database — Methanol
Acetone
  1. NIST — NIST Chemistry WebBook — Acetone (CAS 67-64-1)
  2. CRC — CRC Handbook — Acetone physical & thermodynamic constants
  3. Hansen 2007 — Hansen Solubility Parameters — Acetone (dD=15.5, dP=10.4, dH=7.0)
  4. Smallwood — Handbook of Organic Solvent Properties — Acetone
  5. GESTIS — GESTIS Substance Database — Acetone
Acetonitrile (ACN)
  1. NIST — NIST Chemistry WebBook — Acetonitrile (CAS 75-05-8)
  2. CRC — CRC Handbook — Acetonitrile constants
  3. Snyder & Kirkland — Modern Liquid Chromatography — ACN gold-standard HPLC eluent
  4. Reichardt 2011 — Solvents and Solvent Effects — ACN dipolar aprotic
  5. GESTIS — GESTIS Substance Database — Acetonitrile
DMSO
  1. NIST — NIST Chemistry WebBook — DMSO (CAS 67-68-5)
  2. Wypych 2019 — Handbook of Solvents Vol. 1 — DMSO comprehensive properties
  3. Hansen 2007 — HSP — DMSO (dD=18.4, dP=16.4, dH=10.2)
  4. Reichardt 2011 — Solvents and Solvent Effects — DMSO E_T(30)=45.1, dipolar aprotic
  5. GESTIS — GESTIS Substance Database — DMSO
THF
  1. NIST — NIST Chemistry WebBook — THF (CAS 109-99-9)
  2. Armarego 2009 — Purification of Laboratory Chemicals — THF drying & peroxide test
  3. Hansen 2007 — Hansen Solubility Parameters — THF (dD=16.8, dP=5.7, dH=8.0)
  4. Smallwood — Handbook of Organic Solvent Properties — THF
  5. GESTIS — GESTIS Substance Database — Tetrahydrofuran
DCM (CH₂Cl₂)
  1. NIST — NIST Chemistry WebBook — Dichloromethane (CAS 75-09-2)
  2. IARC 71 — IARC Monograph 71 — DCM (Group 2A carcinogen)
  3. Hansen 2007 — Hansen Solubility Parameters — DCM (dD=18.2, dP=6.3, dH=6.1)
  4. Reichardt 2011 — Solvents and Solvent Effects — DCM polarity index
  5. GESTIS — GESTIS Substance Database — Dichloromethane
Chloroform (CHCl₃)
  1. NIST — NIST Chemistry WebBook — Chloroform (CAS 67-66-3)
  2. IARC 73 — IARC Monograph 73 — Chloroform (Group 2B carcinogen)
  3. Hansen 2007 — Hansen Solubility Parameters — CHCl3 (dD=17.8, dP=3.1, dH=5.7)
  4. Reichardt 2011 — Solvents and Solvent Effects — CHCl3 H-bond donor strength
  5. GESTIS — GESTIS Substance Database — Chloroform
n-Hexane
  1. NIST — NIST Chemistry WebBook — n-Hexane (CAS 110-54-3)
  2. ATSDR n-Hexane — ATSDR Toxicological Profile for n-Hexane — neuropatia obwodowa (n-Heksan NIE jest kancerogenem IARC)
  3. Hansen 2007 — Hansen Solubility Parameters — n-Hexane (dD=14.9, dP=0, dH=0)
  4. Snyder & Kirkland — Modern Liquid Chromatography — n-Hexane NP standard, eo=0.00
  5. GESTIS — GESTIS Substance Database — n-Hexane
Toluene
  1. NIST — NIST Chemistry WebBook — Toluene (CAS 108-88-3)
  2. IARC 71 — IARC Monograph 71 — Toluene
  3. Hansen 2007 — Hansen Solubility Parameters — Toluene (dD=18.0, dP=1.4, dH=2.0)
  4. Smallwood — Handbook of Organic Solvent Properties — Toluene
  5. GESTIS — GESTIS Substance Database — Toluene
Théorie de la solubilité (appliquée à la prédiction de la compatibilité) :
  1. Yalkowsky, Samuel H., and Shri C. Valvani. 1980. "Solubility and Partitioning I: Solubility of Nonelectrolytes in Water." Journal of Pharmaceutical Sciences 69 (8): 912–922. https://doi.org/10.1002/jps.2600690814 — General Solubility Equation (GSE): logS = 0.5 − logP − 0.01(MP−25).
  2. Hansen, Charles M. 2007. Hansen Solubility Parameters: A User's Handbook. 2nd ed. CRC Press. https://doi.org/10.1201/9781420006834 — Triplet HSP (dD, dP, dH) + formule Ra.
  3. Stefanis, E., and C. Panayiotou. 2008. "Prediction of Hansen Solubility Parameters with a New Group-Contribution Method." Int J Thermophys 29: 568–585. https://doi.org/10.1007/s10765-008-0415-z
  4. Reichardt, Christian, and Thomas Welton. 2011. Solvents and Solvent Effects in Organic Chemistry. 4th ed. Wiley-VCH. https://doi.org/10.1002/9783527632220 — E_T(30) polarity scale, solwatochromia.
  5. Snyder, Lloyd R., Joseph J. Kirkland, and John W. Dolan. 2010. Introduction to Modern Liquid Chromatography. 3rd ed. Wiley. https://doi.org/10.1002/9780470508183 — Eluotropic series, polarity index.
  6. Van Krevelen, D. W., and K. Te Nijenhuis. 2009. Properties of Polymers. 4th ed. Elsevier. https://doi.org/10.1016/B978-0-08-054819-7.X0001-5 — Hoftyzer–Van Krevelen group contribution dla dD/dP/dH z SMILES.
  7. Marcus, Yizhak. 1998. The Properties of Solvents. Wiley Series in Solution Chemistry, Vol. 4. ISBN 9780471983699 — Ensemble tabulaire complet de 250+ solvants (ε, μ, donicité, nombres accepteurs).
  8. PubChem Compound Database — CAS 67-66-3 lookup ↗ — logP (XLogP3), water solubility experimental + predicted.

Bibliographie complète dans l'accordéon RÉFÉRENCES (en bas de la page) — Chicago Manual of Style 17th ed., Author-Date.

⚗️ Vérifier la compatibilité de la réaction
3 0 0
Santé : 3/4
Inflammabilité : 0/4
Réactivité : 0/4
Selon NFPA 704 / calculé à partir des codes H

Vérifiez si Chloroform est compatible avec un autre réactif

📦 Matrice de compatibilité de stockage
Acides Bases Oxydants Inflammable Toxique Gazy
Acides ✓ ✗ ✗ ✗ ⚠ ✗
Bases ✗ ✓ ⚠ ⚠ ⚠ ⚠
Oxydants ✗ ⚠ ✓ ✗ ⚠ ✗
Inflammable ✗ ⚠ ✗ ✓ ⚠ ✗
Toxique ⚠ ⚠ ⚠ ⚠ ✓ ⚠
Gazy ✗ ⚠ ✗ ✗ ⚠ ✓
✓ Stockage commun possible · ⚠ Prudence · ✗ NE PAS stocker ensemble · OSHA Chemical Segregation ↗

Données de compatibilité issues de : Bretherick's Handbook (7th ed.) ↗, GESTIS ↗, ECHA REACH ↗, NFPA 704 ↗

🧮 Calculateurs de laboratoire (8)
Dilution (C₁V₁=C₂V₂)
Molarité (M=n/V)
Tampon pH (Henderson-Hasselbalch)
Beer-Lambert (A=εcl)
Masse → Moles
Concentration % → M
ppm → mg/L
Température C↔F↔K

Formules vérifiées : IUPAC Gold Book ↗, DOI ↗

📊 Bases de spectres spectroscopiques
📋 Générateur de protocole de laboratoire

Protocole généré à partir de : GHS SDS, Aldrich Lab Guide ↗

🏷️ Générateur d'étiquette (QR)
Chloroform• CHLOROFORM / Trichloromethane• IUPAC: chloroform• CAS: 67-66-3• Formule: CHCl3• Masse: 119.37 g/molDANGERMENTIONS DE DANGER GHS :H351 H361d H331 H302 H372 H315 H319P203: Se procurer, lire et suivre toutes les instructions de sécurité avantl’utilisation.P261: Éviter de respirer les poussières/fumées/gaz/brouillards/vapeurs/aérosols.Nonsensia Ltd124-128 City Road, EC1V 2NX Londonpure@molgod.orgmolgod.orgN° de lot: Masse nette:
Deskryptory Lipinskiego (struktura)
Chargement des prédictions ADMET…
⏳ Conseiller de stabilité & durée de conservation Arrhenius
Méthodologie : Arrhenius equation k = A·exp(-Ea/RT). Citation : Connors KA et al. 1986 · ICH Q1A(R2)

Saisissez les conditions de stockage → l'algorithme d'Arrhenius prédira la concentration restante, la demi-vie et une recommandation d'utilisation.

Signes visuels de dégradation :
  • Yellowing = phosgene formation
  • Odor of phosgene (musty hay)
❄️ Recommandations de conservation
Temperature:
2-8°C
Light:
Amber glass MANDATORY
Stabilizers:
Ethanol 0.5-1% or amylene
Container:
Glass only
Incompatible:
Bases, aluminum; forms phosgene on light/O₂ exposure
🧪 Assistant de préparation de solution (Smart Prep)

Saisissez ce que vous souhaitez préparer — je générerai un SOP

Exemples ci-dessous — cliquez pour insérer :
Recettes prédéfinies :
📚 Aperçu de la littérature scientifique — CAS 67-66-3
⭐ Principales découvertes (littérature scientifique) 20 publications
🏆 CAS 67-66-3 — multi-criteria ranking (W12): 30% citations · 20% actualité · 20% thème · 15% historique · 15% open access.
  1. #1
    Toshiyuki Sugimoto, Tomoya Kuwahara, Fengying Liang et al. (2022) · ACS Omega
    Pourquoi c'est important : Open access
    SCORE 9.89 Mécanisme Citations: 11 Open Access DOI ↗
  2. #2
    Clara Torrentó, Jordi Palau, Diana Rodríguez-Fernández et al. (2017) · Environmental Science & Technology
    Pourquoi c'est important : Open access
    SCORE 9.55 Mécanisme Citations: 53 Open Access DOI ↗
  3. #3
    John A. Secrist, Marshall W. Logue (1972) · The Journal of Organic Chemistry
    Pourquoi c'est important : Open access
    SCORE 8.96 Mécanisme Citations: 92 Open Access DOI ↗
  4. #4
    R. D. Nimantha Karunathilaka, Athige Rajith Niloshan Silva, Chathuranga Bharathee Ranaweera et al. (2025) · arXiv (2506.13121v1)
    Pourquoi c'est important : Récente (2025) · open access
    SCORE 8.35 Mécanisme Citations: 4 Open Access DOI ↗
  5. #5
    M.D. Reuber (1979) · Environmental Health Perspectives
    Pourquoi c'est important : Open access
    SCORE 8.01 Mécanisme Citations: 82 Open Access DOI ↗
  6. #6
    et al. (2025) · Analytical and Bioanalytical Chemistry
    Pourquoi c'est important : Récente (2025) · open access
    SCORE 7.95 Analytique Citations: 1 Open Access DOI ↗ PubMed ↗
  7. #7
    Konstantin Belov; Ilya Khodov (2025) · Molecules
    Pourquoi c'est important : Récente (2025) · open access
    SCORE 7.95 Analytique Citations: 1 Open Access DOI ↗ PubMed ↗
  8. #8
    (2026)
    Pourquoi c'est important : Récente (2026) · open access
    SCORE 7.85 Pharmacologie Open Access PubMed ↗
  9. #9
    Anirban Polley (2026) · arXiv (2605.08780v1)
    Pourquoi c'est important : Récente (2026) · open access
    SCORE 7.85 Mécanisme Open Access
  10. #10
    Michael A. Lyons, Raymond S. H. Yang, Arthur N. Mayeno et al. (2008) · Environmental Health Perspectives
    Pourquoi c'est important : Open access
    SCORE 7.75 Mécanisme Citations: 67 Open Access DOI ↗
  11. #11
    Joel Åkesson, Oskar Sundborg, Olof Wahlström et al. (2012) · The Journal of Chemical Physics
    Pourquoi c'est important : Open access
    SCORE 7.55 Mécanisme Citations: 36 Open Access DOI ↗
  12. #12
    et al. (2026) · Molecules
    Pourquoi c'est important : Récente (2026) · open access
    SCORE 7.05 Mécanisme Open Access DOI ↗ PubMed ↗
  13. #13
    Olivia Bulka; Elizabeth A. Edwards; Radhakrishnan Mahadevan (2025) · mSystems
    Pourquoi c'est important : Récente (2025) · open access
    SCORE 7.05 Pharmacologie Open Access DOI ↗ PubMed ↗
  14. #14
    (2025)
    Pourquoi c'est important : Récente (2025) · open access
    SCORE 6.25 Mécanisme Open Access DOI ↗ PubMed ↗
  15. #15
    et al. (2026) · Journal of Toxicology
    Pourquoi c'est important : Récente (2026) · open access
    SCORE 6.25 Pharmacologie Open Access DOI ↗ PubMed ↗
  16. #16
    et al. (2026) · Scientific Reports
    Pourquoi c'est important : Récente (2026) · open access
    SCORE 6.25 Mécanisme Open Access DOI ↗ PubMed ↗
  17. #17
    et al. (2026) · In Silico Pharmacology
    Pourquoi c'est important : Récente (2026) · open access
    SCORE 6.25 Mécanisme Open Access DOI ↗ PubMed ↗
  18. #18
    et al. (2025) · Frontiers in Public Health
    Pourquoi c'est important : Récente (2025) · open access
    SCORE 6.25 Mécanisme Open Access DOI ↗ PubMed ↗
  19. #19
    (2014)
    Pourquoi c'est important : Open access
    SCORE 4.35 Mécanisme Citations: 1 Open Access DOI ↗
  20. #20
    Report on the Carcinogenesis Bioassay of Chloroform (CAS No. 67-66-3).
    (1976) · PubMed
    Pourquoi c'est important : Sélectionné par un score multicritère (citations + actualité + thème + historique + OA).
    SCORE 4.14 Analytique Citations: 12

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Trichloromethane — CAS 67-66-3. Listed by Xilong Scientific. Prepared from the supplier’s public catalogue; not verified against their internal data.

📄 Certificats d'analyse (CoA) CAS 67-66-3 aucun

Aucun certificat pour ce produit dans la base de données.

📚 Références scientifiques (Chicago Author-Date) — cliquez pour développer

Normes de gestion des lots et de certification en laboratoire — 13 sources indépendantes (ICH Q1/Q3/Q6/Q7/Q10 + ISO 17025 + WHO TRS + 21 CFR 211 + EMA + USP + Ph.Eur. + PIC/S + IPEC-PQG).

  1. International Council for Harmonisation (ICH). 2000. "Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients." ICH Expert Working Group. [lien ↗] — GMP for APIs — adopted by EMA, FDA, MHLW
  2. International Organization for Standardization. 2017. "ISO/IEC 17025:2017 General requirements for the competence of testing and calibration laboratories." ISO. [lien ↗] — Lab accreditation standard underpinning every CoA
  3. World Health Organization. 2010. "WHO Good Manufacturing Practices for Pharmaceutical Products: Main Principles (WHO Technical Report Series No. 957, Annex 3)." WHO Press. [lien ↗] — WHO TRS No. 957 — global reference for GMP
  4. International Council for Harmonisation (ICH). 2003. "ICH Q1A(R2): Stability Testing of New Drug Substances and Products." International Council for Harmonisation. [lien ↗] — Source for batch shelf-life and retest dating
  5. International Council for Harmonisation (ICH). 2006. "ICH Q3A(R2): Impurities in New Drug Substances." ICH. [lien ↗]
  6. International Council for Harmonisation (ICH). 1999. "ICH Q6A: Specifications for New Drug Substances and Products." ICH. [lien ↗] — CoA acceptance-criteria specification standard
  7. International Council for Harmonisation (ICH). 2008. "ICH Q10: Pharmaceutical Quality System." ICH. [lien ↗]
  8. U.S. Food and Drug Administration. 2024. "21 CFR Part 211: Current Good Manufacturing Practice for Finished Pharmaceuticals." US Code of Federal Regulations. [lien ↗] — US legal mandate (Subpart J — Records and Reports)
  9. European Medicines Agency. 2014. "Guideline on Process Validation for Finished Products — Information and Data to Be Provided EMA/CHMP/CVMP/QWP/BWP/70278/2012." European Medicines Agency. [lien ↗]
  10. United States Pharmacopeial Convention. 2024. "United States Pharmacopeia and National Formulary, USP 47-NF 42." USP. [lien ↗]
  11. European Pharmacopoeia Commission. 2024. "European Pharmacopoeia 11th Edition." Council of Europe — EDQM. [lien ↗]
  12. Pharmaceutical Inspection Co-operation Scheme (PIC/S). 2021. "Guide to Good Manufacturing Practice for Medicinal Products PE 009-15." PIC/S Secretariat, Geneva. [lien ↗] — Cross-recognized GMP for 54 inspectorates worldwide
  13. International Pharmaceutical Excipients Council (IPEC) and Pharmaceutical Quality Group (PQG). 2017. "Joint IPEC-PQG Good Manufacturing Practices Guide for Pharmaceutical Excipients." IPEC-Americas. [lien ↗] — Excipient-grade CoA standard for non-API ingredients
📈 Prédicteur de spectre UV-VIS (200-400 nm) λmax 247 nm
0%25%50%75%100%200250300350400247 nmA = ε·c·lA / Aₘₐₓ (%)
ComposéChloroform (UV cutoff)
λmax247 nm
λmin—
εmax (M⁻¹·cm⁻¹)—
Solvant (requête)water
Solvant (référence)self
Concentration (M)1e-4
Longueur du trajet optique (cm)1
FWHM de la courbe30 nm

Modèle : courbe de Gauss centrée sur λmax avec mise à l'échelle selon la loi de Beer-Lambert A = ε · c · l. Transmittance T = 10^(-A) · 100%.

📚 Références scientifiques (Chicago Author-Date)
  1. et al.. (2026). "Safety Assessment of Pseudomonas fluorescens DS17R Chloroform Extract: Low Acute But Dose-Dependent Subacute Oral Toxicity in Rats.". https://doi.org/10.1155/jt/8893441 [DOI]
  2. et al.. (2026). "Unveiling the anti-inflammatory activity of chloroform fraction of curcuma wallichii and its phytoconstituents by in vivo and in silico studies.". https://doi.org/10.1038/s41598-025-28248-3 [DOI]
  3. et al.. (2026). "In silico anticancer, antioxidant and anti-inflammatory study on GC-MS-based profiling of chloroform and hexane extracts of Erigeron multiradiatus.". https://doi.org/10.1007/s40203-026-00645-0 [DOI]
  4. et al.. (2026). "Computational and Experimental Analysis of Sophora alopecuroides L. Chloroform Fraction: Active Components and Anti-Breast Cancer Resistance Mechanisms.". https://doi.org/10.3390/molecules31040660 [DOI]
  5. (2026). "Chloroform Toxicity".
  6. (2025). "Chloroform: MAK Value Documentation, addendum - Translation of the German version from 2022.". https://doi.org/10.34865/mb6766e10_1ad [DOI]
  7. et al.. (2025). "Towards sustainable lipidomics: computational screening and experimental validation of chloroform-free alternatives for lipid extraction.". https://doi.org/10.1007/s00216-025-06136-z [DOI]
  8. (2025). "Conformational Evolution of Bicalutamide in Chloroform: A Comprehensive NMR Study.". https://doi.org/10.3390/molecules30224479 [DOI]
  9. (2025). "Modeling reveals a metabolic basis of competition among Dehalobacter strains during tandem chloroform and dichloromethane metabolism.". https://doi.org/10.1128/msystems.00847-25 [DOI]
  10. et al.. (2025). "Chloroform exposure and risk of leukemia: systematic review and meta-analysis.". https://doi.org/10.3389/fpubh.2025.1491075 [DOI]
  11. Clara Torrentó, Jordi Palau, Diana Rodríguez-Fernández et al.. (2017). "Carbon and Chlorine Isotope Fractionation Patterns Associated with Different Engineered Chloroform Transformation Reactions". Environmental Science & Technology. https://doi.org/10.1021/acs.est.7b00679 [DOI]
  12. (2014). "Phenol/chloroform extraction v1". https://doi.org/10.17504/protocols.io.cdts6m [DOI]
  13. Joel Åkesson, Oskar Sundborg, Olof Wahlström et al.. (2012). "A van der Waals density functional study of chloroform and other trihalomethanes on graphene". The Journal of Chemical Physics. https://doi.org/10.1063/1.4764356 [DOI]
  14. Michael A. Lyons, Raymond S. H. Yang, Arthur N. Mayeno et al.. (2008). "Computational Toxicology of Chloroform: Reverse Dosimetry Using Bayesian Inference, Markov Chain Monte Carlo Simulation, and Human Biomonitoring Data". Environmental Health Perspectives. https://doi.org/10.1289/ehp.11079 [DOI]
  15. (2004). "Chloroform 67-66-3.". https://doi.org/10.1002/0471701343.sdp05774 [DOI]
  16. M.D. Reuber. (1979). "Carcinogenicity of chloroform.". Environmental Health Perspectives. https://doi.org/10.1289/ehp.7931171 [DOI]
  17. (1976). "Report on the Carcinogenesis Bioassay of Chloroform (CAS No. 67-66-3).". PubMed.
  18. John A. Secrist, Marshall W. Logue. (1972). "Amine hydrochlorides by reduction in the presence of chloroform". The Journal of Organic Chemistry. https://doi.org/10.1021/jo00967a042 [DOI]
  19. Linstrom, Peter J., and William G. Mallard, eds. 2023. NIST Chemistry WebBook, NIST Standard Reference Database Number 69. Gaithersburg, MD: National Institute of Standards and Technology. [DOI]
  20. Mayerhöfer, Thomas G., Samir Pahlow, and Jürgen Popp. 2020. "The Bouguer-Beer-Lambert Law: Shining Light on the Obscure." ChemPhysChem 21 (18): 2029-2046. [DOI]
  21. Skoog, Douglas A., F. James Holler, and Stanley R. Crouch. 2017. Principles of Instrumental Analysis. 7th ed. Boston: Cengage Learning. ISBN 978-1-305-57721-3.
  22. Lindon, John C., George E. Tranter, and David W. Koppenaal, eds. 2017. "Encyclopedia of Spectroscopy and Spectrometry." 3rd ed. Amsterdam: Academic Press. ISBN 978-0-12-803224-4.
  23. Field, Leslie D., Sev Sternhell, and John R. Kalman. 2013. "Organic Structures from Spectra." 5th ed. Chichester: Wiley. ISBN 978-1-119-96582-6.
  24. Reusch, William. 2013. "Virtual Textbook of Organic Chemistry: Spectroscopy." East Lansing, MI: Michigan State University.
  25. Lampman, Gary M., Donald L. Pavia, George S. Kriz, and James R. Vyvyan. 2010. "Spectroscopy." 4th ed. Belmont, CA: Cengage Learning. ISBN 978-0-495-88992-9.
  26. Kalsi, P. S. 2010. "Spectroscopy of Organic Compounds." 6th ed. New Delhi: New Age International. ISBN 978-81-224-2032-9.
  27. Williams, Dudley H., and Ian Fleming. 2008. "Spectroscopic Methods in Organic Chemistry." 6th ed. London: McGraw-Hill. ISBN 978-0-07-711559-0.
  28. Sadek, Paul C. 2002. The HPLC Solvent Guide. 2nd ed. Hoboken: Wiley. ISBN 978-0-471-41242-2.
  29. Banwell, Colin N., and Elaine M. McCash. 1994. "Fundamentals of Molecular Spectroscopy." 4th ed. London: McGraw-Hill. ISBN 978-0-07-707976-1.
  30. Perkampus, Heinz-Helmut. 1992. UV-VIS Spectroscopy and Its Applications. Berlin: Springer. https://doi.org/10.1007/978-3-642-77479-9.
  31. Fieser, Louis F. 1949. "Extension of Woodward's Rules for Prediction of Conjugated Diene Absorption." Journal of the American Chemical Society 71 (5): 1854-1857. [DOI]
  32. Woodward, Robert B. 1942. "Structure and the Absorption Spectra of Alpha,Beta-Unsaturated Ketones." Journal of the American Chemical Society 64 (1): 72-75. [DOI]
  33. Beer, August. 1852. "Bestimmung der Absorption des rothen Lichts in farbigen Flüssigkeiten." Annalen der Physik und Chemie 86: 78-88. https://doi.org/10.1002/andp.18521620505.
  34. Lambert, Johann Heinrich. 1760. Photometria. Augsburg: Sumptibus Vidae.

📖 Wartość λmax = 247 nm pochodzi z bazy/literatury. Brak niezależnego potwierdzenia krzyżowego (NIST / CrossRef / PubChem) — weryfikacja krzyżowa niedostępna.

REST: /wp-json/molgod/v1/spectra/uv-vis/67-66-3?solvent=water&path_length_cm=1

☣️ Toxicité (LD50 / LC50) GHS Cat 4 — Faible
LD50
695 mg/kg[1][2]
Gatunek / droga
Rat / doustnie
Klasyfikacja
Slightly toxic[3][4]
Skala GHS (Acute Toxicity, oral, mg/kg bw):
Cat 1 (≤5)
Cat 2 (5–50)
Cat 3 (50–300)
Cat 4 (300–2000)
Cat 5 (2000–5000)

Source : RTECS FS9100000; IARC Mono 73; ATSDR Chloroform 1997 (1997). CAS 67-66-3.

Les données DL50/CL50 sont fournies à titre indicatif uniquement ; elles ne remplacent ni la fiche de données de sécurité (FDS) ni l'évaluation d'un expert toxicologue. Classification GHS pour la voie orale (mg/kg pc) selon UN GHS, 10e rév. 2023, Annexe 1 §3.1.1.

Bibliographie (Chicago)
  1. NIOSH. Registry of Toxic Effects of Chemical Substances (RTECS). Cincinnati: NIOSH.
  2. Agency for Toxic Substances and Disease Registry (ATSDR). Medical Management Guidelines / Toxicological Profile. Atlanta, GA: U.S. Department of Health and Human Services.
  3. United Nations. 2023. "Globally Harmonized System of Classification and Labelling of Chemicals (GHS)." 10th rev. ed. New York: UN.
  4. Hodge, Harold C., and James H. Sterner. 1949. "Tabulation of toxicity classes." American Industrial Hygiene Association Quarterly 10 (4): 93-96.
Dalsze źródła (metodyka, nie cytowane bezpośrednio):
  • U.S. EPA. 2024. "ChemView." https://chemview.epa.gov/.
  • Lipnick, Robert L., et al. 1995. "Comparison of the up-and-down, conventional LD50, and fixed-dose acute toxicity procedures." Food and Chemical Toxicology 33 (3): 223-231.
  • ATSDR. 2024. "Toxicological Profiles." Agency for Toxic Substances and Disease Registry. https://www.atsdr.cdc.gov/.
  • Hayes, Wallace, and Claire L. Kruger, eds. 2014. "Hayes' Principles and Methods of Toxicology." 6th ed. CRC Press.
  • Lewis, Richard J. 2012. "Sax's Dangerous Properties of Industrial Materials." 12th ed. Wiley.
  • IARC. 2024. "Monographs on the Evaluation of Carcinogenic Risks to Humans." International Agency for Research on Cancer (per kryteria klasyfikacji rakotwórczości IARC Group 1/2A/2B).
  • Pohanish, Richard P. 2017. "Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens." 7th ed. Elsevier.
  • Bingham, Eula, Barbara Cohrssen, and Charles H. Powell, eds. 2012. "Patty's Toxicology." 6th ed. Wiley.
  • WHO. 2023. "Recommended Classification of Pesticides by Hazard." World Health Organization (zgodne z UN GHS Annex 1 §3.1.1).
📜 Brevets (métadonnées publiques) aucune donnée

Aucune métadonnée de brevet publique n'a été trouvée pour cette substance dans Crossref / OpenAlex pour le moment. Les données seront complétées automatiquement après le rafraîchissement du cache (24h).

📚 Références (Chicago Author-Date) — cliquez pour développer
  1. et al.. (2026). "Safety Assessment of Pseudomonas fluorescens DS17R Chloroform Extract: Low Acute But Dose-Dependent Subacute Oral Toxicity in Rats.". https://doi.org/10.1155/jt/8893441
  2. et al.. (2026). "Unveiling the anti-inflammatory activity of chloroform fraction of curcuma wallichii and its phytoconstituents by in vivo and in silico studies.". https://doi.org/10.1038/s41598-025-28248-3
  3. et al.. (2026). "In silico anticancer, antioxidant and anti-inflammatory study on GC-MS-based profiling of chloroform and hexane extracts of Erigeron multiradiatus.". https://doi.org/10.1007/s40203-026-00645-0
  4. et al.. (2026). "Computational and Experimental Analysis of Sophora alopecuroides L. Chloroform Fraction: Active Components and Anti-Breast Cancer Resistance Mechanisms.". https://doi.org/10.3390/molecules31040660
  5. (2026). "Chloroform Toxicity".
  6. (2025). "Chloroform: MAK Value Documentation, addendum - Translation of the German version from 2022.". https://doi.org/10.34865/mb6766e10_1ad
  7. et al.. (2025). "Towards sustainable lipidomics: computational screening and experimental validation of chloroform-free alternatives for lipid extraction.". https://doi.org/10.1007/s00216-025-06136-z
  8. (2025). "Conformational Evolution of Bicalutamide in Chloroform: A Comprehensive NMR Study.". https://doi.org/10.3390/molecules30224479
  9. (2025). "Modeling reveals a metabolic basis of competition among Dehalobacter strains during tandem chloroform and dichloromethane metabolism.". https://doi.org/10.1128/msystems.00847-25
  10. et al.. (2025). "Chloroform exposure and risk of leukemia: systematic review and meta-analysis.". https://doi.org/10.3389/fpubh.2025.1491075
  11. Clara Torrentó, Jordi Palau, Diana Rodríguez-Fernández et al.. (2017). "Carbon and Chlorine Isotope Fractionation Patterns Associated with Different Engineered Chloroform Transformation Reactions". Environmental Science & Technology. https://doi.org/10.1021/acs.est.7b00679
  12. (2014). "Phenol/chloroform extraction v1". https://doi.org/10.17504/protocols.io.cdts6m
  13. Joel Åkesson, Oskar Sundborg, Olof Wahlström et al.. (2012). "A van der Waals density functional study of chloroform and other trihalomethanes on graphene". The Journal of Chemical Physics. https://doi.org/10.1063/1.4764356
  14. Michael A. Lyons, Raymond S. H. Yang, Arthur N. Mayeno et al.. (2008). "Computational Toxicology of Chloroform: Reverse Dosimetry Using Bayesian Inference, Markov Chain Monte Carlo Simulation, and Human Biomonitoring Data". Environmental Health Perspectives. https://doi.org/10.1289/ehp.11079
  15. (2004). "Chloroform 67-66-3.". https://doi.org/10.1002/0471701343.sdp05774
  16. M.D. Reuber. (1979). "Carcinogenicity of chloroform.". Environmental Health Perspectives. https://doi.org/10.1289/ehp.7931171
  17. (1976). "Report on the Carcinogenesis Bioassay of Chloroform (CAS No. 67-66-3).". PubMed.
  18. John A. Secrist, Marshall W. Logue. (1972). "Amine hydrochlorides by reduction in the presence of chloroform". The Journal of Organic Chemistry. https://doi.org/10.1021/jo00967a042
  19. World Intellectual Property Organization. 2024. "Patent Cooperation Treaty (PCT)." https://www.wipo.int/pct/.
  20. U.S. Patent and Trademark Office. 2024. "USPTO Patent Public Search." https://ppubs.uspto.gov/.
  21. European Patent Office. 2024. "Espacenet Patent Search." https://worldwide.espacenet.com/.
  22. Newman, David J., and Gordon M. Cragg. 2020. "Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019." Journal of Natural Products 83 (3): 770-803.
  23. Davies, Mark, Michał Nowotka, George Papadatos, et al. 2015. "ChEMBL Web Services: Streamlining Access to Drug Discovery Data and Utilities." Nucleic Acids Research 43 (W1): W612-W620.
  24. Bickerton, G. Richard, Gaia V. Paolini, Jérémy Besnard, Sorel Muresan, and Andrew L. Hopkins. 2012. "Quantifying the Chemical Beauty of Drugs." Nature Chemistry 4 (2): 90-98.
  25. Meanwell, Nicholas A. 2011. "Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design." Journal of Medicinal Chemistry 54 (8): 2529-2591.
  26. Ertl, Peter, and Ansgar Schuffenhauer. 2009. "Estimation of Synthetic Accessibility Score of Drug-Like Molecules Based on Molecular Complexity and Fragment Contributions." Journal of Cheminformatics 1: 8.
  27. Hopkins, Andrew L., and Colin R. Groom. 2002. "The Druggable Genome." Nature Reviews Drug Discovery 1 (9): 727-730.
  28. Allison, John R., and Mark A. Lemley. 1998. "Empirical Evidence on the Validity of Litigated Patents." AIPLA Quarterly Journal 26 (3): 185-275.
  29. Patani, George A., and Edmond J. LaVoie. 1996. "Bioisosterism: A Rational Approach in Drug Design." Chemical Reviews 96 (8): 3147-3176.
  30. Lerner, Josh. 1994. "The Importance of Patent Scope: An Empirical Analysis." RAND Journal of Economics 25 (2): 319-333.

REST: /wp-json/molgod/v1/patents/67-66-3?status=active&limit=10

Données de PubChemSource : PubChem (NIH) · ChEMBL
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📚 RÉFÉRENCES (Bibliographie agrégée, Chicago Author-Date) 79 éléments

Toutes les sources scientifiques citées dans les accordéons ci-dessus pour le CAS 67-66-3. Format : Chicago Manual of Style, 17e éd., système Auteur-Date.

🗄️ Bases de données scientifiques

  1. NIST. n.d. NIST Chemistry WebBook: CAS 67-66-3. Gaithersburg, MD: National Institute of Standards and Technology. https://webbook.nist.gov/cgi/cbook.cgi?ID=67-66-3.
  2. AIST. n.d. Spectral Database for Organic Compounds (SDBS): CAS 67-66-3. Tsukuba, Japan: National Institute of Advanced Industrial Science and Technology. https://sdbs.db.aist.go.jp/.
  3. Linstrom, Peter J., and William G. Mallard, eds. n.d. NIST Chemistry WebBook: NIST Standard Reference Database Number 69. Gaithersburg, MD: National Institute of Standards and Technology. https://doi.org/10.18434/T4D303.
  4. PubChem. n.d. PubChem Compound Summary: CAS 67-66-3. Bethesda, MD: National Center for Biotechnology Information (NCBI), National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/#query=67-66-3.

📐 Normes / Lignes directrices

  1. ICH. 2003. "Stability Testing of New Drug Substances and Products: Q1A(R2)." Geneva: International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. https://database.ich.org/sites/default/files/Q1A%28R2%29%20Guideline.pdf.
  2. National Fire Protection Association (NFPA). 2024. "NFPA 30: Flammable and Combustible Liquids Code." NFPA, Quincy, MA. https://www.nfpa.org/codes-and-standards/all-codes-and-standards/list-of-codes-and-standards/detail?code=30.
  3. Occupational Safety and Health Administration (OSHA). 2023. "29 CFR 1910.106 — Flammable Liquids." U.S. Department of Labor, Federal Register. https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.106.
  4. European Chemicals Agency (ECHA). 2024. "Annex VI to Regulation (EC) No 1272/2008 (CLP) — Harmonised Classification and Labelling." ECHA, Helsinki / Official Journal of the European Union. https://echa.europa.eu/regulations/clp/clp-classification.
  5. European Committee for Standardization (CEN). 2016. "EN 374-1:2016 — Protective gloves against dangerous chemicals and micro-organisms — Part 1: Terminology and performance requirements for chemical risks." CEN, Brussels. https://standards.cencenelec.eu/dyn/www/f?p=205:110:::::FSP_PROJECT,FSP_ORG_ID:38536,6080&cs=1B0DAA8B85DF42E4A2C70E5D71F0BFA32.
  6. European Committee for Standardization (CEN). 2001. "EN 166:2001 — Personal eye-protection — Specifications." CEN, Brussels. https://standards.cencenelec.eu/dyn/www/f?p=CEN:110:0::::FSP_PROJECT:6541&cs=1F1A4E0A78C4DB6A28DBE2E8C29D89DCF.
  7. European Committee for Standardization (CEN). 2009. "EN 14605:2005+A1:2009 — Protective clothing against liquid chemicals — Performance requirements for clothing with liquid-tight (Type 3) or spray-tight (Type 4) connections." CEN, Brussels. https://standards.cencenelec.eu/dyn/www/f?p=CEN:110:0::::FSP_PROJECT:21581&cs=1A04A2D3C7CC58E9E6CB58D55F7EBFB7E.
  8. National Institute for Occupational Safety and Health (NIOSH). 2017. "Recommendations for Chemical Protective Clothing: A Companion to the NIOSH Pocket Guide." U.S. Department of Health & Human Services / CDC. https://www.cdc.gov/niosh/ncpc/default.html.
  9. Occupational Safety and Health Administration (OSHA). 2011. "Personal Protective Equipment — General requirements." U.S. Department of Labor — 29 CFR 1910.132. https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.132.

📖 Livres

  1. Hansen, Charles M. 2007. Hansen Solubility Parameters: A User's Handbook, 2nd ed.. Boca Raton, FL: CRC Press. https://www.routledge.com/Hansen-Solubility-Parameters-A-Users-Handbook/Hansen/p/book/9780849372483.
  2. Barton, Allan F. M. 1991. CRC Handbook of Solubility Parameters and Other Cohesion Parameters: 2nd ed.. Boca Raton, FL: CRC Press. https://www.routledge.com/CRC-Handbook-of-Solubility-Parameters-and-Other-Cohesion-Parameters/Barton/p/book/9780849301766.
  3. Connors, Kenneth A., Gordon L. Amidon, and Valentino J. Stella. 1986. Chemical Stability of Pharmaceuticals: A Handbook for Pharmacists, 2nd ed.. New York: Wiley. https://doi.org/10.1002/0471734683.
  4. Rumble, John R., ed. 2019. CRC Handbook of Chemistry and Physics: 100th Edition. Boca Raton, FL: CRC Press. https://hbcp.chemnetbase.com/.
  5. Urben, Peter G. 2017. Bretherick's Handbook of Reactive Chemical Hazards, 8th Edition. Academic Press / Elsevier, Oxford. https://www.sciencedirect.com/book/9780081010594.

📘 Monographies

  1. IARC. n.d. IARC Monographs on the Identification of Carcinogenic Hazards to Humans: CAS 67-66-3. Lyon, France: International Agency for Research on Cancer, World Health Organization. https://monographs.iarc.who.int/list-of-classifications/.

📄 Articles scientifiques (évalués par les pairs)

  1. Stefanis, Emmanuel, and Costas Panayiotou. 2008. "Prediction of Hansen Solubility Parameters with a New Group-Contribution Method." International Journal of Thermophysics 29: 568-585. https://doi.org/10.1007/s10765-008-0415-z.
  2. Stoll, Vincent S., and John S. Blanchard. 1990. "Buffers: Principles and Practice: In Methods in Enzymology, vol. 182." San Diego: Academic Press. https://doi.org/10.1016/0076-6879(90)82008-P.

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