n-hexane (CAS 110-54-3) — Safety Data Sheet

For n-hexane (CAS 110-54-3) the documentation obligation begins before the first shipment. This page sets out what the safety data sheet has to establish.

n-hexane (CAS 110-54-3) at a glance

• Substance – n-hexane
• CAS number – 110-54-3
• EC number – 203-777-6
• CLP Annex VI index number – 601-[CAS?]
• Hazard statements – H225 (highly flammable liquid and vapour); H361f; H304 (may be fatal if swallowed and enters airways); H336 (may cause drowsiness or dizziness); H372 (nervous system) (causes damage to organs through prolonged or repeated exposure); H315 (causes skin irritation)
• Hazard classes – Flam. Liq. 2, Repr. 2, Asp. Tox. 1, STOT SE 3, STOT RE 1, Skin Irrit. 2
• Label pictograms – GHS02, GHS07, GHS08, GHS09
• Signal word – Danger
• Entry current as of – ATP22
• CMR classification – not classified as CMR in the harmonised entry
• Documentation issued – safety data sheet in REACH Annex II structure; working draft or signed card
• What is supplied – a document. MolGod.org does not sell, supply or ship chemical substances.

Can I import n-hexane into the EU?

An import of CAS 110-54-3 succeeds or fails on whether the accompanying sheet matches the register. Among substances listed in CLP Annex VI the recurring failure is a classification carried over from a supplier outside the Union, where the same substance may be classified differently. Index 601-[CAS?] is the binding reference, and it is in regulated consignments that the discrepancy surfaces.

First-aid content and why it is read first

The first-aid information for CAS 110-54-3 must be understandable and actionable by someone without a chemistry background when following instructions under time pressure. Section 4 includes additional notes intended for medical professionals, where the classification’s clinical relevance is detailed.

What concentration limits apply to n-hexane?

The harmonised entry for n-hexane carries specific concentration limits: H373: C ≥ 5 %. These override the generic cut-off values, so a mixture containing n-hexane is classified against these figures and not against the default thresholds.

What is the EC number for n-hexane?

Alongside CAS 110-54-3, this substance carries EC number 203-777-6 and Annex VI index 601-[CAS?]. European documentation is built around the EC number as often as around the CAS: registration dossiers, the candidate list and customs systems key on it. A safety data sheet quoting only one of the two forces every downstream reader to look up the other.

What is the CLP classification of n-hexane?

The harmonised classification for CAS 110-54-3 carries 7 hazard statements: H225, H361f, H304, H336, H372 (nervous system), H315, H411. In plain terms this means highly flammable liquid and vapour; H361f; may be fatal if swallowed and enters airways; may cause drowsiness or dizziness. A harmonised entry is binding across the Union — an importer may not soften it, and a self-classification that diverges from it will not survive an enforcement check.

What happens if a consignment of n-hexane is refused?

A rejected document is generally complete and properly formatted but may be outdated or contain an incorrect consignment identifier. When a shipment of n-hexane is refused, the authority’s notification typically indicates the problematic section. Reviewing this notice is more efficient than revisiting the entire file.

Accidental release and containment

A spill of CAS 110-54-3 is handled from section 6, which has to state the containment material and the protective equipment needed to approach. A sheet that describes cleanup without stating what to wear while doing it is incomplete.

Is n-hexane on the SVHC candidate list?

Yes — n-hexane appears on the candidate list of substances of very high concern. That triggers duties that classification alone does not: notification to ECHA above the tonnage threshold, and an obligation to inform recipients where the substance is present in an article above 0.1 % by weight.

What is the UN number for n-hexane?

For carriage, n-hexane is assigned UN 1208, transport class 3, packing group II. These entries belong in section 14 of the safety data sheet and must match the shipping papers exactly. A consignment where the sheet and the transport document disagree on the UN number is stopped before anyone reads the remaining fifteen sections.

How is n-hexane classified for road, sea and air transport?

Carriers and forwarders handling n-hexane compare section 14 against the shipping papers before loading. Any disagreement stops the consignment at the point where correcting it is most expensive.

Documentation demand on the EU market

CAS 110-54-3 has a recorded presence on the European trading market, which means documentation for it is requested routinely rather than exceptionally. Substances that move in commerce attract repeat scrutiny: the same sheet is read by successive customers, carriers and authorities, and a defect that survives the first reading rarely survives the tenth.

Storage and handling in the document

Section 7 of the documentation for n-hexane outlines handling and storage procedures, including incompatible materials, conditions to be avoided, and any segregation requirements arising from its classification. Laboratories reviewing this section require explicit instructions rather than general warnings; for instance, a statement such as ‘store in a cool dry place’ is insufficient, as it leaves the responsibility of defining specific storage conditions to the personnel.

Which GHS pictograms apply to n-hexane?

The label for n-hexane carries GHS02 (flame), GHS07 (exclamation mark), GHS08 (health hazard), GHS09 (environment), with the signal word Danger. These are not chosen by the supplier: CLP Annex VI states them for CAS 110-54-3, and the precedence rules in Annex I decide which pictogram is dropped when two would say the same thing. A label showing a different set from the register is wrong even if every hazard statement on it is correct.

What must the label for n-hexane contain?

The supply label for n-hexane is generated from the same classification that drives the safety data sheet: pictograms selected by precedence, one signal word derived from the highest hazard class present, and the hazard statements H225, H361f, H304… reproduced in full. Where the container is too small to carry the complete set at a legible size, there are lawful ways to handle it and unlawful ones that look identical to a non-specialist.

Which SDS sections decide whether a shipment clears?

The sixteen sections in Annex II are not merely a formatting requirement; each section serves a specific purpose, and inspectors evaluate them sequentially. For the CAS registry number 110-54-3, key sections for acceptance typically include 2 (harmonised entry classification), 3 (composition and identifiers), 14 (transport) and 15 (regulatory status). It is crucial not to merge, renumber or omit any sections, as placeholders must remain unchanged.

What do customs check when importing n-hexane?

When a consignment of n-hexane is stopped at the border, the document examined first is rarely the invoice. It is section 14 of the safety data sheet and its agreement with the transport papers. A missing packing group, an absent UN number or a proper shipping name that contradicts the classification of CAS 110-54-3 will hold the pallet regardless of how complete the remaining fifteen sections are.

Protective equipment and exposure controls

Section 8 outlines exposure controls and personal protective equipment (PPE) for n-hexane: appropriate glove materials, eye protection, respiratory protection when warranted by the hazard classification, and any established occupational exposure limits. The choice of glove material is more critical than merely wearing gloves; nitrile gloves are not universally suitable.

Identifiers that must agree

Three identifiers accompany this substance, and all must align: the CAS number 110-54-3, the Annex VI index number 601-[CAS?], and the name as listed in the register. Incongruent identifiers represent the subtlest flaw in a documentation set, as each individual document appears correct until a cross-check reveals they describe distinct entities.

Questions about documentation for n-hexane

What is the CAS number of n-hexane?

CAS 110-54-3. In CLP Annex VI the same substance carries index number 601-[CAS?], and both identifiers should appear in the documentation.

What hazard statements apply to CAS 110-54-3?

The harmonised entry lists H225, H361f, H304, H336. These are binding across the Union and may not be softened by a self-classification.

In which language must the sheet be supplied?

In an official language of each Member State where n-hexane is placed on the market, unless that State has stated otherwise.

Can I check whether my existing sheet is still valid?

Yes. A section-by-section reading against Annex II and the current harmonised entry establishes that in one pass, and a sheet that passes is reported as passing.

MolGod.org issues documentation and does not sell, supply or ship chemical substances. CAS 110-54-3 identifies the subject of this document.