Poly(N-isopropylacrylamide-co-methacrylic acid)

CAS 151954-97-1 · C₁₀H₁₇NO₃ · MW 199.25 g/mol

Model views

ball-and-stick 3D model
skeletal 3D model
space-filling 3D model
2D structure

About Poly(N-isopropylacrylamide-co-methacrylic acid)

Poly(N-isopropylacrylamide-co-methacrylic acid) is a chemical compound registered under number CAS 151954-97-1, with the molecular formula C₁₀H₁₇NO₃, and a molar mass of 199.25 g/mol.

The molecule contains 31 atoms connected by 29 chemical bonds. The full systematic IUPAC name of this compound is 2-methylprop-2-enoic acid;N-propan-2-ylprop-2-enamide. The interactive 3D model above lets you view the spatial arrangement of the atoms — you can rotate it with the mouse, zoom with the scroll wheel, and switch between skeletal / Ball & Stick / Space Fill visualization modes.

In terms of physicochemical properties, polar surface area PSA = 66.4 Å², 2 donors and 3 hydrogen bond acceptors. These parameters are key when assessing bioavailability and interaction with biomolecules.

Chemical data for this compound comes from PubChem (NIH NLM NCBI), one of the world's largest chemical databases. All information is updated automatically and enriched with GHS hazard statement translations compliant with the CLP Regulation (EC 1272/2008). The widget above may be used for educational, research and commercial purposes.

Physicochemical properties

Molecular formula	C₁₀H₁₇NO₃
Molar mass	199.25 g/mol
IUPAC	2-methylprop-2-enoic acid;N-propan-2-ylprop-2-enamide
SMILES	`CC(C)NC(=O)C=C.CC(=C)C(=O)O`
InChIKey	`BGJOTKHBFYMJST-UHFFFAOYSA-N`
logP (XLogP3)	—
PSA	66.4 Å²
HBD / HBA	2 / 3
PubChem CID	CID 3081324 ↗

Scientific literature

Related literature

2 articles · 0 open access · Sources: PubMed, OpenAlex, Semantic Scholar

📈 Publication timeline (number of articles: 2)

Bar height = number of articles in a given year. Hover over a bar to see details.

Poly(N-isopropylacrylamide-co-methacrylic acid) pH/thermo-responsive porous hydrogels as self-regulated drug delivery system.

Constantin M, Bucatariu S, Harabagiu V et al. (2014) · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

$ PaywallDOI ↗PubMed ↗

Temperature- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) microgels as a carrier for controlled protein adsorption and release.

Agnihotri P, Sangeeta, Aery S et al. (2021) · Soft matter

$ PaywallDOI ↗PubMed ↗

Data from PubMed (NIH NLM), OpenAlex (CC0), Semantic Scholar (AI2). AI Summary generated by Semantic Scholar TLDR. Articles marked with require paid access.

Synonyms

151954-97-1 · N-(isopropylacrylamide)methacrylic acid copolymer · DTXCID4087408 · NIPAM-MAA copolymer · P(NIPAM-co-MAA) · RefChem:175099 · 2-methylprop-2-enoic acid;N-propan-2-ylprop-2-enamide · SCHEMBL2527192 · Poly(N-isopropylacrylamide-r-methacrylic acid) random polymer · 2-Methylprop-2-enoic acid--N-(propan-2-yl)prop-2-enamide (1/1) · 2-Propenoic acid, 2-methyl-, polymer with N-(1-methylethyl)-2-propenamide

Data sources

📊 PubChem CID 3081324 — NIH
🔬 NIST WebBook — spectroscopy
🌐 Wikidata
💊 ChEMBL — bioactivity

Related molecules

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📜 License & provenancePREDICTED MODEL · NOT VERIFIEDMolGod_License_1

PREDICTED MODEL — NOT VERIFIED
computed by MolGod Scientific · experimental feature (beta) · may contain errors
ILLUSTRATIVE FRAGMENT ARRANGEMENT — relative positions are not structural data

No source 3-D conformer was available to MolGod for this substance. MolGod Scientific computed this geometry from the structural formula with RDKit 2026.03.6 (ETKDGv3 conformer generation, MMFF94 force-field optimisation; lowest-energy converged conformer of a fixed-seed set). It is not a measured structure, it does not come from PubChem, and it has not been compared with experimental data. It shows one possible conformation.

This substance consists of 2 separate components (for example ions). Each component was computed separately; they are arranged radially around a layout anchor for visualisation only (at least 3.0 Å apart). Their relative positions are not a crystal structure, coordination geometry, ionic contacts or any experimentally determined arrangement.

Methods and references

RDKit: Open-source cheminformatics, version 2026.03.6. Zenodo. doi:10.5281/zenodo.22140358 (all versions: doi:10.5281/zenodo.591637)
Riniker S, Landrum GA. Better Informed Distance Geometry: Using What We Know To Improve Conformation Generation. J. Chem. Inf. Model. 2015, 55, 2562-2574. doi:10.1021/acs.jcim.5b00654
Wang S, Witek J, Landrum GA, Riniker S. Improving Conformer Generation for Small Rings and Macrocycles Based on Distance Geometry and Experimental Torsional-Angle Preferences. J. Chem. Inf. Model. 2020, 60, 2044-2058. doi:10.1021/acs.jcim.0c00025
Halgren TA. Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94. J. Comput. Chem. 1996, 17, 490-519. doi:10.1002/(SICI)1096-987X(199604)17:5/6<490::AID-JCC1>3.0.CO;2-P
Tosco P, Stiefl N, Landrum G. Bringing the MMFF force field to the RDKit: implementation and validation. J. Cheminform. 2014, 6, 37. doi:10.1186/s13321-014-0037-3
Heller SR, McNaught A, Pletnev I, Stein S, Tchekhovskoi D. InChI, the IUPAC International Chemical Identifier. J. Cheminform. 2015, 7, 23. doi:10.1186/s13321-015-0068-4
Kim S, Chen J, Cheng T, et al. PubChem 2025 update. Nucleic Acids Res. 2025, 53, D1516-D1525. doi:10.1093/nar/gkae1059 Compound record: https://pubchem.ncbi.nlm.nih.gov/compound/3081324
Bolton EE, Kim S, Bryant SH. PubChem3D: Conformer generation. J. Cheminform. 2011, 3, 4. doi:10.1186/1758-2946-3-4 (cited for contrast: no source 3-D conformer was available to MolGod for this record)

ENGRAVEDNORMAL

Poly(N-isopropylacrylamide-co-methacrylic acid) (CAS 151954-97-1), C₁₀H₁₇NO₃ - 3D ball-and-stick molecular model, engraved element symbols (C H N O), MolGod STL preview

MG-STL-151954-97-1-ENGRAVED · 372,078 △ · 18 MB · SHA-256 98fec13172cd4189

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Poly(N-isopropylacrylamide-co-methacrylic acid) (CAS 151954-97-1), C₁₀H₁₇NO₃ - 3D ball-and-stick molecular model, MolGod STL preview

MG-STL-151954-97-1-NORMAL · 13,088 △ · 639 KB · SHA-256 4fc1a9e3823a6aeb

Download 3D model

Model: Poly(N-isopropylacrylamide-co-methacrylic acid) · 151954-97-1
InChIKey: BGJOTKHBFYMJST-UHFFFAOYSA-N
License: CC BY-SA 4.0 International (source rights undetermined — not yet granted)
Attribution: MolGod Scientific — Poly(N-isopropylacrylamide-co-methacrylic acid) (CAS 151954-97-1)
License & provenance record: Poly(N-isopropylacrylamide-co-methacrylic acid) (CAS 151954-97-1) →
MolGod molecule record: Poly(N-isopropylacrylamide-co-methacrylic acid) →
Source data: PubChem CID 3081324 ↗
Model information: STL generated by MolGod · MolGod STL Exporter build 48804cd20b0d · generated 2026-10-14
SHA-256 (STL): 4fc1a9e3823a6aebc632b214d90a46cca4af1e2ceeb7041e14ab326251759e0d
MD5 (STL): 3a4c7f2b05cb9739033b7f3b873b408a
Model identifier: MG-STL-151954-97-1
Transformation: MolGod Scientific ball-and-stick mesh
Changes: PREDICTED geometry computed by MolGod Scientific (RDKit), NOT verified; rendered as a triangulated mesh.
Wikimedia Commons: not published yet

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