L-Serine (CAS 56-45-1)
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我们编制的安全数据表依据的是欧盟法规—— (EC) No 1907/2006（REACH）附件 II 及 (EU) 2020/878。
中文版本是从欧盟版本翻译而来的，仅供参考。 它不是中国市场上具有法律效力的文件，不能用于在中国境内的 申报、备案、运输或流通。
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L-Serine. CAS 56-45-1.
⚠️ Note: This safety data sheet is provided in English; a localized version is being prepared.
Free, and generated automatically from the sources listed on this page. No person has reviewed it, and it describes the substance in general — not your material, your process or your intended market.
Section 9 — physicochemical properties: 2 of 22 established.
We show what is established and name what is not. Classification and identity are complete on every card; section 9 is where public data is thin.
Identity, structure, physical and chemical properties, analytical data and the literature — every value with the source it came from and the date that source was read. The full record is in the data sections further down this page.
- Identity CAS · EC · IUPAC · synonyms · molecular formula · molecular weight
- Structure 2D · 3D · SMILES · InChI · InChIKey
- Physical melting point · boiling point · density · vapour pressure · solubility
- Chemical reactivity · stability · incompatible materials
- Analytical spectra and methods where available
- References literature, with DOI where a DOI exists
Identifier coverage is shown as a count, not as a quality rating. It tells you how well characterised this substance is in public data — which is a different question from how good it is, and a more useful one when you are deciding whether the documentation behind it can be defended.
What a compliance officer checks, and where it sits in the document. The values themselves are in the regulatory sections further down.
- Classification harmonised entry with index number where one exists; self-classification shown separately and labelled, never merged
- Hazard statements the official text, in the page language
- Precautionary statements combined statements reproduced whole, never split
- Pictograms and signal word
- Inventory status per jurisdiction, each stated individually
- Restrictions entry and scope where one applies
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- Candidate list status and the supply-chain duty it triggers
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- Exposure limits per country, each naming the act it comes from
- Document status revision date and the amendment in force when issued
Fields with no established status say so. This page never states that no restrictions apply — absence from a dataset is not clearance, and a document that treats it as clearance is the most dangerous kind of document in this field.
What is in the buyer pack
Everything your compliance officer will ask for, in one file.
- The product page as PDF — the record as published, so what you forward matches what you read.
- The safety data sheet at your entitlement level — sixteen sections in the order set by REACH Annex II, for this substance, in the language you select.
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- The specification, and the certificate of analysis where batch data exists.
sources.txt— every citation with the date it was read.- An explicit list of what we could not establish — fields marked unavailable rather than filled with an estimate. This is the honest part of the document and we do not hide it in a footnote.
Your European buyer is going to forward this to somebody who was not on the call. The pack exists so that what they forward is complete, self-explanatory and traceable — rather than four attachments and a sentence beginning “I think this is everything”.
These switch the language of this page. Single substances. Mixtures on enquiry. One document, one language — additional languages are priced separately. Every version, including the Chinese one, is written to EU law — (EC) No 1907/2006 (REACH) Annex II and (EU) 2020/878 — and translated from it. The Chinese version is a reference translation, not a legally valid document for the Chinese market: an SDS for China must be compiled separately to GB/T 16483 and GB/T 17519.
数据转录自法规登记册和专业文献，并注明来源与版本。不能替代供应商的安全数据表。未记录来源的字段已作相应标注。
化学概述: L-Serine
| 分子式 | C3H7NO3[1] |
| 分子量 | 105.09 g/mol[1] |
| LogP（亲脂性） | -3.1[1] |
| IUPAC名称 | (2S)-2-amino-3-hydroxypropanoic acid[1] |
| SMILES | C([C@@H](C(=O)O)N)O[1] |
| InChIKey | MTCFGRXMJLQNBG-REOHCLBHSA-N[1] |
同义词: L-serine · serine · 56-45-1 · (S)-2-Amino-3-hydroxypropanoic acid · (S)-Serine
数据来源： PubChem (NLM/NIH)
最后更新： 2026-09-02
📚 科学参考文献（芝加哥作者-日期格式） (1 来源)
- PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. ↗ applies to: 分子式 · 分子量 · LogP（亲脂性） · IUPAC名称 · SMILES · InChIKey
科学研究
📚 科学参考文献（芝加哥作者-日期格式） 13 refs · 3 baz
MOLECULE 按CAS号参考文献（实时来自13+数据库）
来源： db:pubmed (10) · db:doaj (1) · db:crossref (2)
- db:pubmed Ortega AF, Vang CM, Rome FI et al.. (2026). "Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis.". Molecular metabolism. https://doi.org/10.1016/j.molmet.2026.102325 →
- db:pubmed Kay M, Samuelsson AM, Bharucha N et al.. (2026). "Enhancing cardiac serine biosynthesis mitigates the progression of dilated cardiomyopathy in mice.". Metabolism: clinical and experimental. https://doi.org/10.1016/j.metabol.2025.156395 →
- db:pubmed Cameron RB, Hammond NG, Faubert B. (2025). "Now you serine, now you don't.". Trends in pharmacological sciences. https://doi.org/10.1016/j.tips.2025.10.001 →
- db:pubmed Devaux A, Villéger R, Roche G et al.. (2025). "L-serine promotes pro-carcinogenic effects of colibactin-producing E. coli.". Gut microbes. https://doi.org/10.1080/19490976.2025.2515480 →
- db:pubmed Lim EW, Fallon RJ, Bates C et al.. (2024). "Serine and glycine physiology reversibly modulate retinal and peripheral nerve function.". Cell metabolism. https://doi.org/10.1016/j.cmet.2024.07.021 →
- db:pubmed Lu Y, Zhu J, Zhang Y et al.. (2024). "Lactylation-Driven IGF2BP3-Mediated Serine Metabolism Reprogramming and RNA m6A-Modification Promotes Lenvatinib Resistance in HCC.". Advanced science (Weinheim, Baden-Wurttemberg, Germany). https://doi.org/10.1002/advs.202401399 →
- db:pubmed Tong H, Jiang Z, Song L et al.. (2024). "Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation.". Cell metabolism. https://doi.org/10.1016/j.cmet.2024.10.019 →
- db:pubmed Conger KO, Chidley C, Ozgurses ME et al.. (2024). "ASCT2 is a major contributor to serine uptake in cancer cells.". Cell reports. https://doi.org/10.1016/j.celrep.2024.114552 →
- db:pubmed Chan FF, Kwan KK, Seoung DH et al.. (2024). "N6-Methyladenosine modification activates the serine synthesis pathway to mediate therapeutic resistance in liver cancer.". Molecular therapy : the journal of the American Society of Gene Therapy. https://doi.org/10.1016/j.ymthe.2024.10.025 →
- db:pubmed Cui J, Sendinc E, Liu Q et al.. (2024). "m(3)C32 tRNA modification controls serine codon-biased mRNA translation, cell cycle, and DNA-damage response.". Nature communications. https://doi.org/10.1038/s41467-024-50161-y →
- db:doaj Václav Pokorný, Vojtěch Štejfa, Jakub Havlín et al.. (2023). "Heat Capacities of L-Cysteine, L-Serine, L-Threonine, L-Lysine, and L-Methionine". Molecules. https://doi.org/10.3390/molecules28010451 →
- db:crossref Tetsuro Shinada, Yoko Yasuno, Shunsuke Yamaguchi et al.. (2021). "Stereoselective Synthesis of (2S,3R)- and (2S,3S)- 2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic Acid". HETEROCYCLES. https://doi.org/10.3987/com-20-s(k)70 →
- db:crossref (2011). "2-Hydroxypropanoic Acid". Encyclopedia of Astrobiology. https://doi.org/10.1007/978-3-642-11274-4_2040 →
Why this page can be checked
Identity
CAS, EC and molecular formula, resolved across the identifier systems a buyer uses. The count of systems resolved is shown, so you can see how well characterised this substance is rather than assuming.
Data
Every physicochemical value carries the source it came from and the date that source was read. Open any of them.
Classification
Read against the harmonised entry where one exists, with the index number stated. Self-classification is shown separately and labelled.
Regulatory
Inventory, restriction, authorisation and candidate-list status, each stated individually. Where a status is not established, this page says so — it never says no restrictions apply.
Documentation
Which documents exist, at what review level, in which languages, and when each was issued.
Supplier
Who is selling this, and what they have published about themselves.
Nothing on this page is a certification. It is a record you can audit.
Two guarantees, both with their limits stated
The Gap Report Guarantee
If the available evidence cannot support a defensible document for your CAS number and product specification, we will not invent the missing values. You receive a documented gap report and choose: a refund, store credit, or the report on its own.
A visible gap is worth more than a plausible number, because the plausible number is the one that fails when somebody checks it.
The Re-issue Promise
If a signed card is rejected by an authority or by a customer’s compliance officer on one of the points we checked and reported as passed, we re-issue it corrected at no charge and credit the original fee.
This covers the checks we performed and named. It does not cover registration status, tonnage, or your role in the supply chain — those are not ours to hold, and a guarantee that pretended otherwise would be worth nothing.
L-Serine — CAS 56-45-1. Listed by Xilong Scientific. Prepared from the supplier’s public catalogue; not verified against their internal data.