CAS 50-81-7

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Аскорбиновая кислота (Е300). CAS 50-81-7.

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化学概述: L-Ascorbic Acid
分子式C6H8O6
分子量176.12 g/mol
熔点190 °C[1]
密度1.65 g/cm³[1]
LogP(亲脂性)-1.85[1]
pKa4.17[1]
IUPAC名称(2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one
SMILESC([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O
InChIKeyCIWBSHSKHKDKBQ-JLAZNSOCSA-N

同义词: l-ascorbic acid · ascorbic acid · vitamin C · 50-81-7 · L(+)-Ascorbic acid

数据来源: PubChem (NLM/NIH), CRC Handbook 105th ed. (Haynes 2024)
最后更新: 2026-09-03

📚 科学参考文献(芝加哥作者-日期格式) (1 来源)
  1. Rumble, J.R., ed. CRC Handbook of Chemistry and Physics. 105th ed. Boca Raton: CRC Press, 2024. applies to: 熔点 · 密度 · LogP(亲脂性) · pKa

科学研究

[1]PubMed2026
Kazandjieva J, Bogdanov G, Bogdanov I et al.. (2026). "Vitamins and skin aging.". Clinics in dermatology. https://doi.org/10.1016/j.clindermatol.2026.04.010
[2]PubMed2026
Shi Y, Xu S, Zhang W. (2026). "Reparative Effects of a Topical Antioxidant Serum Containing Vitamin C, Vitamin E, and Ferulic Acid After Ablative Fractional CO(2) Laser Treatment for Atrophic Acne Sca
[3]PubMed2026
Rozemeijer S, Dubois EA, de Grooth HJ et al.. (2026). "Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial.". Intensive care medicine. https://doi.org/1
[4]PubMed2026
Kondo Y, Sato A, Osakabe N et al.. (2026). "Vitamin C is essential for proper myogenic differentiation.". Archives of biochemistry and biophysics. https://doi.org/10.1016/j.abb.2025.110704
[5]PubMed2026
Liu L, Zheng Z, You W et al.. (2026). "Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates.". Cell metabolism. https://doi.org/10.1016/j.cmet.2026.02.010
[6]PubMed2026
Ye Y, Zhang H, Xin Z et al.. (2026). "Vitamin C attenuates primate bone marrow aging at the molecular and progenitor level.". Cell stem cell. https://doi.org/10.1016/j.stem.2026.06.006
[7]PubMed2025
Chen G, Jun JH, Wijshake T et al.. (2025). "Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection.". Proceedings of the National Academy of Sciences of the United States
[8]PubMed2025
Xu C, Ying W, He Y et al.. (2025). "Vitamin C enhances cisplatin sensitivity in bladder cancer via 5hmC-mediated epigenetic modulation of ATF4.". Clinical epigenetics. https://doi.org/10.1186/s13148-0
📚 科学参考文献(芝加哥作者-日期格式) 7 refs · 1 baz

MOLECULE 按CAS号参考文献(实时来自13+数据库)

来源: db:pubmed (8)

  1. db:pubmed Kazandjieva J, Bogdanov G, Bogdanov I et al.. (2026). "Vitamins and skin aging.". Clinics in dermatology. https://doi.org/10.1016/j.clindermatol.2026.04.010
  2. db:pubmed Rozemeijer S, Dubois EA, de Grooth HJ et al.. (2026). "Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial.". Intensive care medicine. https://doi.org/10.1007/s00134-026-08492-5
  3. db:pubmed Kondo Y, Sato A, Osakabe N et al.. (2026). "Vitamin C is essential for proper myogenic differentiation.". Archives of biochemistry and biophysics. https://doi.org/10.1016/j.abb.2025.110704
  4. db:pubmed Liu L, Zheng Z, You W et al.. (2026). "Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates.". Cell metabolism. https://doi.org/10.1016/j.cmet.2026.02.010
  5. db:pubmed Ye Y, Zhang H, Xin Z et al.. (2026). "Vitamin C attenuates primate bone marrow aging at the molecular and progenitor level.". Cell stem cell. https://doi.org/10.1016/j.stem.2026.06.006
  6. db:pubmed Chen G, Jun JH, Wijshake T et al.. (2025). "Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection.". Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2517730122
  7. db:pubmed Xu C, Ying W, He Y et al.. (2025). "Vitamin C enhances cisplatin sensitivity in bladder cancer via 5hmC-mediated epigenetic modulation of ATF4.". Clinical epigenetics. https://doi.org/10.1186/s13148-025-02011-x
物质监管状态
在已检查的限制清单(SVHC候选清单、REACH附件XVII;数据集不完整——这不构成合规确认)中未找到该CAS号的条目。CLP分类和运输状态(ADR):请参见GHS章节及安全数据表(SDS)。
🧪 化学数据
CAS号
50-81-7
分子式
C6H8O6
摩尔质量
176.12 g/mol
IUPAC名称 (EN)
(2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one
SMILES
C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O
InChIKey
CIWBSHSKHKDKBQ-JLAZNSOCSA-N
⚗️ Physicochemical properties
Temp. topnienia
190.9
Density
1.65

Source: PubChem, NIST WebBook. Last updated: 2026-09-02

🔍 外部标识符
12 / 16个ID系统75%
数据库标识符操作
CAS Registry Number50-81-7打开 →
PubChem CID54670067[1]打开 →
InChIKeyCIWBSHSKHKDKBQ-JLAZNSOCSA-N[1]打开 →
SMILESC([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O[1]
EC Number200-066-2[2]打开 →
DrugBankDB00126打开 →
KEGG CompoundC00072打开 →
HMDBHMDB0000044打开 →
ChemSpider10189562[3]打开 →
UNII (FDA)PQ6CK8PD0R打开 →
NSC Number (NCI)33832打开 →
WikiData QIDQ199678打开 →

来源:PubChem (NIH)、Wikidata SPARQL、KEGG、ChEMBL (EBI)、CompTox CTX (EPA)。

📚 科学参考文献(芝加哥作者-日期格式) (3 来源)
  1. PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. applies to: PubChem CID · InChIKey · SMILES
  2. ECHA. EC Inventory — EINECS, ELINCS, NLP and List Numbers assigned under REACH. Helsinki: European Chemicals Agency. applies to: EC Number
  3. ChemSpider. Royal Society of Chemistry, chemical structure database. applies to: ChemSpider

Further reading

Publications thematically related to this CAS. They are not the source of any value shown on this card.

扩展参考文献 (5)

  1. ★★★★★ CANONICAL_PAPERS 💰 付费墙(可能) ✓ 已验证 Hancock, R.D.; Viola, R.. 2007. "Biosynthesis and catabolism of L-ascorbic acid in plants." Critical Reviews in Plant Sciences. 链接 [访问日期: 2026-09-04]
  2. ★★★★★ CANONICAL_PAPERS 💰 付费墙(可能) ✓ 已验证 Levine, M.; Conry-Cantilena, C.; Wang, Y.; Welch, R.W.; Washko, P.W. et al.. 1996. "Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance." Proceedings of the National Academy of Sciences. 链接 [访问日期: 2026-09-04]
  3. ★★★★½ CANONICAL_PAPERS 💰 付费墙(可能) ✓ 已验证 Nováková, L.; Solich, P.; Solichová, D.. 2002. "HPLC methods for simultaneous determination of ascorbic and dehydroascorbic acids." TrAC Trends in Analytical Chemistry. 链接 [访问日期: 2026-09-04]
  4. ★★★★☆ CANONICAL_PAPERS 💰 付费墙(可能) ✓ 已验证 Mandl, J.; Szarka, A.; Bánhegyi, G.. 2009. "Vitamin C: update on physiology and pharmacology." British Journal of Pharmacology. 链接 [访问日期: 2026-09-04]
  5. ★★★★☆ CANONICAL_PAPERS 💰 付费墙(可能) ✓ 已验证 Englard, S.; Seifter, S.. 1986. "The biochemical functions of ascorbic acid." Annual Review of Nutrition. 链接 [访问日期: 2026-09-04]

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Аскорбиновая кислота (Е300) — CAS 50-81-7. Listed by Uts Shanghai. Prepared from the supplier’s public catalogue; not verified against their internal data.

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