2-Methoxyethanol (CAS 109-86-4)

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2-Methoxyethanol. CAS 109-86-4.

⚠️ Note: This safety data sheet is provided in English; a localized version is being prepared.

Free, and generated automatically from the sources listed on this page. No person has reviewed it, and it describes the substance in general — not your material, your process or your intended market.

REACH 2020/878
v1 · 02.09.2026

Section 9 — physicochemical properties: 10 of 22 established.

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Panoramica chimica: 2-Methoxyethanol
Formula molecolareC3H8O2[1]
Peso molecolare76.09 g/mol[1]
LogP (lipofilia)-0.8[1]
Nome IUPAC2-methoxyethanol[1]
SMILESCOCCO[1]
InChIKeyXNWFRZJHXBZDAG-UHFFFAOYSA-N[1]

Sinonimi: 2-METHOXYETHANOL · 109-86-4 · Methyl cellosolve · Ethylene glycol monomethyl ether · Ethanol, 2-methoxy-

Fonti dei dati: PubChem (NLM/NIH)
Ultimo aggiornamento: 2026-09-02

📚 Riferimenti scientifici (Chicago Author-Date) (1 sources)
  1. PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. dotyczy: Formula molecolare · Peso molecolare · LogP (lipofilia) · Nome IUPAC · SMILES · InChIKey

RICERCA SCIENTIFICA

[1]Europe PMC2025
et al.. (2025). "Kinetic and Mechanism of the Photo-Oxidation of 2-Methoxyethanol with Chlorine Atoms in the Troposphere.". https://doi.org/10.1021/acs.jpca.5c04720
[2]Doaj2024
Badriatul Musyarofah, Putri Ayu Ika Setiyowati, Angella Ananda Syaputra et al.. (2024). "Antioxidant protective effect of Nelumbo nucifera extract against spermatogenic cells in male mice due to 2-met
[3]Doaj2023
Angella Ananda Syaputra, Putri Ayu Ika Setiyowati, Badriatul Musyarofah et al.. (2023). "Bioactivity of Nelumbo nucifera extract on sperm recovery due to 2-methoxyethanol exposure: In vivo and in sili
[4]PubMed2022
Lim C, Shin K, Seo D. (2022). "Genotoxicity study of 2-methoxyethanol and benzalkonium chloride through Comet assay using 3D cultured HepG2 cells.". Environmental analysis, health and toxicology. http
[5]Europe PMC2020
et al.. (2020). "Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats.". https://doi.org/10.1016/j.
[6]Europe PMC2019
et al.. (2019). "Thermochemistry and Kinetics of the Thermal Degradation of 2-Methoxyethanol as Possible Biofuel Additives.". https://doi.org/10.1038/s41598-019-40890-2
[7]Europe PMC2019
et al.. (2019). "Computational Studies on the Thermodynamic and Kinetic Parameters of Oxidation of 2-Methoxyethanol Biofuel via H-Atom Abstraction by Methyl Radical.". https://doi.org/10.1038/s41598-0
[8]Europe PMC2019
(2019). "The signal transduction of xanthone as a protector on 2-methoxyethanol-induced cardiac cell damage in mice.". https://doi.org/10.4103/japtr.japtr_57_19
📚 Riferimenti scientifici (Chicago Author-Date) 19 refs · 4 baz

MOLECULE Bibliografia per-CAS (live da 13+ banche dati)

Fonti: db:Europe PMC (14) · db:doaj (2) · db:pubmed (2) · db:crossref (1)

  1. db:Europe PMC et al.. (2025). "Kinetic and Mechanism of the Photo-Oxidation of 2-Methoxyethanol with Chlorine Atoms in the Troposphere.". https://doi.org/10.1021/acs.jpca.5c04720
  2. db:doaj Badriatul Musyarofah, Putri Ayu Ika Setiyowati, Angella Ananda Syaputra et al.. (2024). "Antioxidant protective effect of Nelumbo nucifera extract against spermatogenic cells in male mice due to 2-methoxyethanol exposure". Jurnal Teknologi Laboratorium. https://doi.org/10.29238/teknolabjournal.v13i1.466
  3. db:doaj Angella Ananda Syaputra, Putri Ayu Ika Setiyowati, Badriatul Musyarofah et al.. (2023). "Bioactivity of Nelumbo nucifera extract on sperm recovery due to 2-methoxyethanol exposure: In vivo and in silico study". Jurnal Teknologi Laboratorium. https://doi.org/10.29238/teknolabjournal.v12i2.450
  4. db:pubmed Lim C, Shin K, Seo D. (2022). "Genotoxicity study of 2-methoxyethanol and benzalkonium chloride through Comet assay using 3D cultured HepG2 cells.". Environmental analysis, health and toxicology. https://doi.org/10.5620/eaht.2022031
  5. db:Europe PMC et al.. (2020). "Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats.". https://doi.org/10.1016/j.bbrep.2020.100806
  6. db:Europe PMC et al.. (2019). "Thermochemistry and Kinetics of the Thermal Degradation of 2-Methoxyethanol as Possible Biofuel Additives.". https://doi.org/10.1038/s41598-019-40890-2
  7. db:Europe PMC et al.. (2019). "Computational Studies on the Thermodynamic and Kinetic Parameters of Oxidation of 2-Methoxyethanol Biofuel via H-Atom Abstraction by Methyl Radical.". https://doi.org/10.1038/s41598-019-51544-8
  8. db:Europe PMC (2019). "The signal transduction of xanthone as a protector on 2-methoxyethanol-induced cardiac cell damage in mice.". https://doi.org/10.4103/japtr.japtr_57_19
  9. db:Europe PMC et al.. (2018). "Aggregation prevention: reduction of graphene oxide in mixed medium of alkylphenol polyoxyethylene (7) ether and 2-methoxyethanol.". https://doi.org/10.1039/c8ra07263a
  10. db:Europe PMC et al.. (2015). "Testicular effect of a mixture of 2-methoxyethanol and 2-ethoxyethanol in rats.". https://doi.org/10.1016/j.pharep.2014.09.011
  11. db:crossref Arturo Bejarano, Juan C. de la Fuente. (2015). "Isobaric (vapor + liquid) equilibria for the binary systems (1-methoxy-2-propanol + 2-methoxyethanol), (2-butanone + 2-methoxyethanol) and (water + 2-methoxyethanol) at pressures of (74.5, 101.3, and 134.0) kPa". The Journal of Chemical Thermodynamics. https://doi.org/10.1016/j.jct.2015.03.013
  12. db:Europe PMC (2014). "Existence of vimentin and GFAP protein expressions as a result of 2-Methoxyethanol administration in cerebral cortex tissue of Swiss Webster mice (Mus musculus): an immunohistochemical analysis.". https://doi.org/10.3923/pjbs.2014.876.883
  13. db:Europe PMC et al.. (2009). "Testicular gene expression profiling following 2-methoxyethanol and 2-ethoxyethanol exposure in male rats reveals abnormal expression of the actin binding protein cortactin in degenerating spermatocytes.". https://doi.org/10.1016/j.toxlet.2009.07.017
  14. db:Europe PMC et al.. (2004). "Evaluation of the protective effectiveness of gloves from occupational exposure to 2-methoxyethanol using the biomarkers of 2-methoxyacetic acid levels in the urine and plasma.". https://doi.org/10.1136/oem.2003.011171
  15. db:Europe PMC et al.. (2003). "Follow up study of haematological effects in workers exposed to 2-methoxyethanol.". https://doi.org/10.1136/oem.60.2.130
  16. db:Europe PMC et al.. (2001). "2-Methoxyethanol metabolism, embryonic distribution, and macromolecular adduct formation in the rat: the effect of radiofrequency radiation-induced hyperthermia.". https://doi.org/10.1016/s0378-4274(01)00346-0
  17. db:Europe PMC et al.. (1995). "Species differences in testicular and hepatic biotransformation of 2-methoxyethanol.". https://doi.org/10.1016/0300-483x(94)02921-g
  18. db:Europe PMC (1993). "NTP technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice.".
  19. db:pubmed Dieter M. (1993). "NTP technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice.". Toxicity report series.
Stato normativo della sostanza
Questa sostanza è soggetta a requisiti normativi: gestione dei rifiuti pericolosi (BDO). Dettagli nella sezione "Stato normativo (REACH/ECHA/CLP)" e nella scheda SDS. Informazione normativa — non limita l'acquisto nel negozio.
🧪 Dati chimici
Numero CAS
109-86-4
Formula molecolare
C3H8O2
Massa molare
76.09 g/mol
Nome IUPAC (EN)
2-methoxyethanol
SMILES
COCCO
InChIKey
XNWFRZJHXBZDAG-UHFFFAOYSA-N
⚗️ Physicochemical properties
Temp. wrzenia
124.4
Density
0.965

Source: PubChem, NIST WebBook. Last updated: 2026-09-02

🔍 Identificatori esterni
15 su 16 sistemi ID94%
DatabaseIdentificatoreAzioni
CAS Registry Number109-86-4Apri →
PubChem CID8019[1]Apri →
InChIKeyXNWFRZJHXBZDAG-UHFFFAOYSA-N[1]Apri →
InChIInChI=1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3[1]
SMILESCOCCO[1]
EC Number203-713-7[2]Apri →
ChEMBLCHEMBL444144[3]Apri →
DrugBankDB02806Apri →
KEGG CompoundD05554Apri →
HMDBHMDB0245203Apri →
ChemSpider7728[4]Apri →
MeSH UID (NLM)C005219Apri →
UNII (FDA)EK1L6XWI56Apri →
NSC Number (NCI)1258Apri →
WikiData QIDQ903362Apri →

Fonti: PubChem (NIH), Wikidata SPARQL, KEGG, ChEMBL (EBI), CompTox CTX (EPA).

📚 Riferimenti scientifici (Chicago Author-Date) (4 sources)
  1. PubChem. National Center for Biotechnology Information (NIH/NLM), chemical compound database. dotyczy: PubChem CID · InChIKey · InChI · SMILES
  2. ECHA. EC Inventory — EINECS, ELINCS, NLP and List Numbers assigned under REACH. Helsinki: European Chemicals Agency. dotyczy: EC Number
  3. ChEMBL. European Bioinformatics Institute (EMBL-EBI), bioactivity database. dotyczy: ChEMBL
  4. ChemSpider. Royal Society of Chemistry, chemical structure database. dotyczy: ChemSpider

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2-Methoxyethanol — CAS 109-86-4. Listed by Xilong Scientific. Prepared from the supplier’s public catalogue; not verified against their internal data.

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