# Benzene

**CAS:** 71-43-2  
**PubChem CID:** [241](https://pubchem.ncbi.nlm.nih.gov/compound/241)  
**Molecular formula:** C6H6  
**Molar mass:** 78.11 g/mol  
**SMILES:** `c1ccccc1`  

## Physicochemical properties

| Parameter | Value |
|---|---|
| logP (XLogP3) | 2.13 |

## 3D structure

The molecule contains 12 atoms connected by 12 chemical bonds. Interactive 3D model available at: https://molgod.org/molekula/71-43-2/

## GHS classification

**Signal word:** Danger

**Pictograms:** GHS02, GHS07, GHS08

### Hazard statements (H)

- **H225** — Highly flammable liquid and vapour
- **H350** — May cause cancer
- **H340** — May cause genetic defects
- **H304** — May be fatal if swallowed and enters airways
- **H372** — Causes damage to organs through prolonged or repeated exposure
- **H315** — Causes skin irritation
- **H319** — Causes serious eye irritation

### Precautionary statements (P)

- **P201** — Obtain special instructions before use
- **P210** — Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking
- **P260** — Do not breathe dust/fume/gas/mist/vapours/spray
- **P280** — Wear protective gloves/protective clothing/eye protection/face protection

## Toxicology (LD50)

- LD50 (szczur, p.o.): 930 mg/kg

## Synonyms

- Benzene

## Available in the shop

[benzene (CAS 71-43-2) — Safety Data Sheet](https://molgod.org/sds-cards/benzene-cas-71-43-2-safety-data-sheet/)

## Regulatory compliance checklist

Status based on: ADR 2025 (Table A), REACH Annex XVII, CLP Annex VI (harmonised classification), hazard class from the m14-spill DB, SVHC, GIS and the Polish OEL list. Principle: no data = no claim (we do NOT declare "no restrictions" without a basis).

5 required / 12 items

### SDS (Safety Data Sheet) available

- **fulfilled** (met / sds)
- How to comply: Requirement: current SDS compliant with Reg. 1907/2006 (REACH) Annex II, 16-section format.
- [Source / form](https://echa.europa.eu/information-on-chemicals)

### Compliant CLP label (pictograms + signal word + H/P)

- **required** (required / clp_label)
- How to comply: The label must include: GHS pictograms, the signal word (Danger/Warning), hazard (H) and precautionary (P) statements, and manufacturer details. Required since 2010 (substances) and 2015 (mixtures). For this substance a HARMONISED CLASSIFICATION applies (CLP Annex VI) — see below; it takes precedence over self-classification.
- CLP VI: Flam. Liq. 2, Carc. 1A, Muta. 1B, Asp. Tox. 1, STOT RE 1, Skin Irrit. 2, Eye Irrit. 2 — H225, H350, H340, H304, H372, H315, H319
- [Source / form](https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272)

### Chemical OSH training (substance-specific)

- **required** (required / bhp_training)
- How to comply: Laboratory staff: initial training (general induction + job-specific) + refresher training every 5 years (or every 3 for engineering/technical positions). Documentation kept in personnel files.
- [Source / form](https://isap.sejm.gov.pl/isap.nsf/DocDetails.xsp?id=WDU20040180169)

### BDO registration (Polish Waste Database)

- **required** (required / bdo_registration)
- How to comply: The GHS classification of this substance indicates properties that may render the waste arising from it hazardous (Regulation 1357/2014, HP properties — with concentration thresholds calculated from the content in the waste, not in the reagent). Whether this gives rise to an obligation to keep BDO records depends on the waste producer and the scale of activity (Art. 50 of the Polish Waste Act; exemptions include up to 100 kg/year of hazardous waste). This is not a statement of obligation for the purchaser.
- [Source / form](https://bdo.mos.gov.pl/)

### ADR transport (international agreement)

- **to be verified** (unknown / adr_transport)
- How to comply: No ADR data in the MOL-GOD dataset for this CAS number. Do NOT assume there are no restrictions — before shipping, verify the transport classification in ADR 2025 (Table A) and in section 14 of the safety data sheet (SDS).
- [Source / form](https://unece.org/transport/dangerous-goods/adr-2025-files)

### REACH registration (>1 t/year EU import)

- **conditional** (conditional / reach_registration)
- How to comply: Importers/manufacturers ≥1 tonne/year must register the substance with ECHA (technical dossier + Chemical Safety Report if ≥10 t). Check the ECHA Annex VI / registered substances list.
- [Source / form](https://echa.europa.eu/regulations/reach/registration)

### SVHC notification (Substances of Very High Concern)

- **to be verified** (unknown / svhc_declaration)
- How to comply: In the MOL-GOD dataset flagged as a POSSIBLE SVHC candidate, but the entry is UNVERIFIED against the full ECHA candidate list — confirm in the ECHA Candidate List BEFORE any declaration (REACH art. 59).
- [Source / form](https://echa.europa.eu/candidate-list-table)

### REACH Annex XIV (authorisation list)

- **to be verified** (unknown / reach_annex_xiv)
- How to comply: Not verified against the ECHA Authorisation List — check REACH Annex XIV.
- [Source / form](https://echa.europa.eu/authorisation-list)

### REACH Annex XVII (use/marketing restrictions)

- **required** (required / reach_annex_xvii)
- How to comply: Substance subject to a REACH Annex XVII restriction (entry 5): Benzene — banned in toys; in substances and mixtures made available to the general public the permitted concentration is <= 0.1% by weight. Check the conditions for placing on the market/use and the note in SDS section 15.
- REACH XVII 5: Benzene — banned in toys; in substances and mixtures made available to the general public the permitted concentration is <= 0.1% by weight.
- [Source / form](https://echa.europa.eu/substances-restricted-under-reach)

### OEL — Occupational Exposure Limit in the working environment

- **required** (required / nds_workplace)
- How to comply: NDS (workplace exposure limit) for this substance: 0.66 mg/m³ (NDS 8h). Air concentration measurements at the workplace at least 1×/2 years (when ≤0.1 NDS) or 1×/year (when 0.1-0.5 NDS). Accredited measurement laboratory.
- NDS: 0.66 mg/m³ (NDS 8h)
- [Source / form](https://isap.sejm.gov.pl/isap.nsf/DocDetails.xsp?id=WDU20240001017)

### GIS register (precursors / psychotropics)

- **to be verified** (unknown / gis_register)
- How to comply: Does not appear in the available working set of precursors (list incomplete). Absence is NOT a confirmation — verify against Annex I of Reg. (EC) 273/2004 and the GIS list before placing on the market.
- [Source / form](https://www.gov.pl/web/gis)

### Safety Data Sheet in Polish

- **fulfilled** (met / sds_pl)
- How to comply: Requirement: SDS in Polish for trade in PL (Art. 31 REACH + Chemical Substances Act Art. 17).
- [Source / form](https://isap.sejm.gov.pl/isap.nsf/DocDetails.xsp?id=WDU20012112135)


## Data sources

- [PubChem CID 241](https://pubchem.ncbi.nlm.nih.gov/compound/241)
- [NIST WebBook](https://webbook.nist.gov/cgi/cbook.cgi?ID=71-43-2)
- [ChEMBL](https://www.ebi.ac.uk/chembl/g/#search_results/all/query=71-43-2)

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*Last updated: 2026-09-02 · Generator: MOL-GOD v3.12.33*