# 1-[2-Amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol hydrochloride (CAS 130198-05-9)

**CAS:** 130198-05-9  
**PubChem CID:** [9795856](https://pubchem.ncbi.nlm.nih.gov/compound/9795856)  
**Molecular formula:** C₁₅H₂₄ClNO₂  
**Molar mass:** 285.81 g/mol  
**IUPAC:** 1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride  
**SMILES:** `COC1=CC=C(C=C1)C(CN)C2(CCCCC2)O.Cl`  
**InChIKey:** `NTKXIDDUCSFBBF-UHFFFAOYSA-N`  
**InChI:** `InChI=1S/C15H23NO2.ClH/c1-18-13-7-5-12(6-8-13)14(11-16)15(17)9-3-2-4-10-15;/h5-8,14,17H,2-4,9-11,16H2,1H3;1H`  

## Physicochemical properties

| Parameter | Value |
|---|---|
| PSA | 55.5 Ų |
| Hydrogen bond donors | 3 |
| Hydrogen bond acceptors | 3 |
| Rotatable bonds | 4 |
| Heavy atoms | 19 |

## 3D structure

The molecule contains 43 atoms connected by 43 chemical bonds. Interactive 3D model available at: https://molgod.org/molekula/130198-05-9/

## GHS classification

**Signal word:** Warning

**Pictograms:** GHS07, GHS09

### Hazard statements (H)

- **H302** — Harmful if swallowed
- **H319** — Causes serious eye irritation
- **H332** — Harmful if inhaled
- **H362** — May cause harm to breast-fed children
- **H411** — Toxic to aquatic life with long lasting effects

### Precautionary statements (P)

- **P203** — Obtain, read and follow all safety instructions before use

## Synonyms

- 130198-05-9
- 1-(2-Amino-1-(4-methoxyphenyl)ethyl)cyclohexanol hydrochloride
- 1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride
- 1-[2-Amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol hydrochloride
- N,N-Didesmethylvenlafaxine hydrochloride
- UNII-O00PWS7DPA
- O00PWS7DPA
- Cyclohexanol, 1-[2-amino-1-(4-methoxyphenyl)ethyl]-, hydrochloride (1:1)
- 1-(2-Amino-1-(p-methoxyphenyl)ethyl)cyclohexanol hydrochloride
- EC 603-392-7

## Available in the shop

[1-[2-Amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol hydrochloride (CAS 130198-05-9) — Beijing Tong Guang](https://molgod.org/sds-cards/1-2-amino-1-4-methoxyphenyl-ethyl-cyclohexanol-hydrochloride-cas-130198-05-9-beijing-tong-guang/)

## Regulatory compliance checklist

Status based on: ADR 2025 (Table A), REACH Annex XVII, CLP Annex VI (harmonised classification), hazard class from the m14-spill DB, SVHC, GIS and the Polish OEL list. Principle: no data = no claim (we do NOT declare "no restrictions" without a basis).

4 required / 12 items

### SDS (Safety Data Sheet) available

- **required** (required / sds)
- How to comply: Requirement: current SDS compliant with Reg. 1907/2006 (REACH) Annex II, 16-section format.
- [Source / form](https://echa.europa.eu/information-on-chemicals)

### Compliant CLP label (pictograms + signal word + H/P)

- **required** (required / clp_label)
- How to comply: The label must include: GHS pictograms, the signal word (Danger/Warning), hazard (H) and precautionary (P) statements, and manufacturer details. Required since 2010 (substances) and 2015 (mixtures).
- [Source / form](https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272)

### Chemical OSH training (substance-specific)

- **required** (required / bhp_training)
- How to comply: Laboratory staff: initial training (general induction + job-specific) + refresher training every 5 years (or every 3 for engineering/technical positions). Documentation kept in personnel files.
- [Source / form](https://isap.sejm.gov.pl/isap.nsf/DocDetails.xsp?id=WDU20040180169)

### BDO registration (Polish Waste Database)

- **not applicable** (not_applicable / bdo_registration)
- How to comply: The verified GHS classification does not indicate classes resulting in hazardous waste — BDO registration for this substance is not required. Verify the EWC code for the specific waste form.
- [Source / form](https://bdo.mos.gov.pl/)

### ADR transport (international agreement)

- **to be verified** (unknown / adr_transport)
- How to comply: No ADR data in the MOL-GOD dataset for this CAS number. Do NOT assume there are no restrictions — before shipping, verify the transport classification in ADR 2025 (Table A) and in section 14 of the safety data sheet (SDS).
- [Source / form](https://unece.org/transport/dangerous-goods/adr-2025-files)

### REACH registration (>1 t/year EU import)

- **conditional** (conditional / reach_registration)
- How to comply: Importers/manufacturers ≥1 tonne/year must register the substance with ECHA (technical dossier + Chemical Safety Report if ≥10 t). Check the ECHA Annex VI / registered substances list.
- [Source / form](https://echa.europa.eu/regulations/reach/registration)

### SVHC notification (Substances of Very High Concern)

- **to be verified** (unknown / svhc_declaration)
- How to comply: SVHC status not verified against the available dataset — check the current ECHA candidate list; do not assume the absence of an entry.
- [Source / form](https://echa.europa.eu/candidate-list-table)

### REACH Annex XIV (authorisation list)

- **to be verified** (unknown / reach_annex_xiv)
- How to comply: Not verified against the ECHA Authorisation List — check REACH Annex XIV.
- [Source / form](https://echa.europa.eu/authorisation-list)

### REACH Annex XVII (use/marketing restrictions)

- **to be verified** (unknown / reach_annex_xvii)
- [Source / form](https://echa.europa.eu/substances-restricted-under-reach)

### OEL — Occupational Exposure Limit in the working environment

- **to be verified** (unknown / nds_workplace)
- How to comply: No NDS data in the MOL-GOD dataset (incomplete set — ~41 of ~600 substances in the list). Absence does NOT mean there is no NDS — check the full list in Dz.U. 2024 poz. 1017 (Regulation of the Ministry of Family and Social Policy of 4 September 2024), and where none exists apply the OEL from EU directives or values recommended by NIOSH/ACGIH.
- [Source / form](https://isap.sejm.gov.pl/isap.nsf/DocDetails.xsp?id=WDU20240001017)

### GIS register (precursors / psychotropics)

- **to be verified** (unknown / gis_register)
- How to comply: Does not appear in the available working set of precursors (list incomplete). Absence is NOT a confirmation — verify against Annex I of Reg. (EC) 273/2004 and the GIS list before placing on the market.
- [Source / form](https://www.gov.pl/web/gis)

### Safety Data Sheet in Polish

- **required** (required / sds_pl)
- How to comply: Requirement: SDS in Polish for trade in PL (Art. 31 REACH + Chemical Substances Act Art. 17).
- [Source / form](https://isap.sejm.gov.pl/isap.nsf/DocDetails.xsp?id=WDU20012112135)


## Data sources

- [PubChem CID 9795856](https://pubchem.ncbi.nlm.nih.gov/compound/9795856)
- [NIST WebBook](https://webbook.nist.gov/cgi/cbook.cgi?ID=130198-05-9)
- [ChEMBL](https://www.ebi.ac.uk/chembl/g/#search_results/all/query=130198-05-9)

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*Last updated: 2026-09-02 · Generator: MOL-GOD v3.12.33*